Interval-timing deficits in individuals at high risk for schizophrenia

A duration-bisection procedure was used to study the effects of signal modality and divided attention on duration classification in participants at high genetic risk for schizophrenia (HrSz), major affective disorder (HrAff), and normal controls (NC). Participants learned short and long target durations during training and classified probe durations during test. All groups classified visual signals as shorter than equivalent duration auditory signals. However, the difference between auditory and visual signal classification was significantly larger for the HrSz group than for the NC group. We posit a model in which there is a clock rate difference between auditory and visual signals due to an attentional effect at the level of a mode switch that gates pulses into an accumulator. This attentionally mediated clock rate difference was larger for the HrSz participants than for the NC participants, resulting in a larger auditory/visual difference for the HrSz group.     

The impact of cortisol reactivity to acute stress on memory: sex differences in middle-aged people

Stress has been identified as a main factor involved in the cognitive changes that occur during the aging process. This study investigated sex differences in the relationship between the magnitude of the acute stress-induced salivary cortisol response and memory performance among middle-aged people. To this end, 16 men and 16 women (aged 54-72 years) were exposed to the Trier Social Stress Test and a control condition in a crossover design. Afterwards their memory performance was measured using a standardized memory test (Rey's Auditory Verbal Learning Test). Only among women, there was an acute impact of stress on memory performance and a significant relationship between a higher cortisol response to the stressor and poorer memory performance in both the stress and control conditions. Additionally, a poorer memory performance was related to earlier timing of sexual maturation (age at menarche), which was also marginally related to higher cortisol reactivity to stress. These results confirm that sex is a critical factor in the relationship between cortisol and poor memory performance. Furthermore, the findings emphasize a strong link between the individual cortisol response to stress and memory functioning among postmenopausal women.     

Motor impairment and antisocial behavior in adolescent males at high risk for schizophrenia

A familial link between schizophrenia and antisocial behavior has been established (e.g., Silverton, 1985). This study examined this relationship in a Danish cohort. The subjects were 36 high-risk males (offspring of a schizzophrenic parent) and 36 low-risk males (offspring of parents without psychopathology). This high-risk subjects exhibited more antisocial behavior than the low-risk subjects. We tested the hypothesis of a correlation between neurointegrative deficits, as defined by motor impairment, and antisocial behavior, rated at ages 10–13, in subjects at genetic risk for schizophrenia. Path analyses were conducted from motor impairment at 1 year and motor impairment at 10–13 years to antisocial behavior separately for high-risk and low-risk subjects. Adolescent motor impairment was a significant predictor of antisocial behavior for high-risk subjects. Motor impairment at 1 year was also associated with antisocial behavior for these subjects, although the association was partly due to the indirect effects of motor impairment at 1 year on motor impairment at 10–13 years, which, in turn, was associated with changes in antisocial behavior. As predicted, none of the path coefficients nor the effect coefficient was significant for low-risk subjects.     

Attachment styles and clinical correlates in people at ultra high risk for psychosis

Evidence suggests that attachment styles may influence subclinical psychosis phenotypes (schizotypy) and affective disorders and may play a part in the association between psychosis and childhood adversity. However, the role of attachment in the initial stages of psychosis remains poorly understood. Our main aim was to describe and compare attachment styles in 60 individuals at ultra high risk for psychosis (UHR) and a matched sample of 60 healthy volunteers (HV). The HV had lower anxious and avoidant attachment scores than the UHR individuals (p < .001). Sixty-nine percentage of the UHR group had more than one DSM-IV diagnosis, mainly affective and anxiety disorders. The UHR group experienced more trauma (p < .001) and more mood and anxiety symptoms (p < .001). Interestingly, in our UHR group, only schizotypy paranoia was correlated with insecure attachment. In the HV group, depression, anxiety, schizotypy paranoia, and social anxiety were correlated with insecure attachment. This difference and some discrepancies with previous studies involving UHR suggest that individuals at UHR may compose a heterogeneous group; some experience significant mood and/or anxiety symptoms that may not be explained by specific attachment styles. Nonetheless, measuring attachment in UHR individuals could help maximize therapeutic relationships to enhance recovery.     

Sex differences in interaction style as a product of perceived sex differences in competence

Males' and females' interaction styles were observed while they worked in four-person, mixed-sex groups on a discussion task. In some groups, members were only given information about each others' names and gender. In this circumstance, men were perceived by themselves and other group members to be higher in competence than women. Further, men engaged in a greater amount of active task behavior than women (e.g., giving information, giving opinions), and women exhibited a greater amount of positive social behavior than men (e.g., agreeing, acting friendly). In other groups, members' competency-based status was manipulated by providing false feedback that they were high or low relative to their group in intellectual and moral aptitude. High status members were then perceived to be more competent than low status ones and, further, high status individuals engaged in more active task and less positive social behavior than low status ones. In this condition, no sex differences were obtained on perceived competence or on active task or positive social behavior. Overall, these findings support the idea that the gender differences obtained in interaction when status was not specified were partially a function of group members' belief that the sexes differ in competence. Direct information concerning members' intellectual and moral competence apparently blocked the perceived gender-to-competence link, and status alone affected perceived competence and interaction style.     

Individual differences in risk perception versus risk taking: handedness and interhemispheric interaction

Research indicates that right-hemisphere mechanisms are specifically sensitive to and averse to risk. Research also indicates that mixed degree of handedness is associated with increased access to right hemisphere processing. Accordingly, it was predicted that mixed-handers would exhibit greater risk aversion. Participants were presented with various risky activities and were asked to rate (i) the perceived risk, (ii) the perceived benefit, and (iii) their likelihood to engage in each activity. No handedness differences were found for any of these ratings. Regression analyses, however, indicated that the likelihood to engage in risky activities was predicted primarily by the perceived risks in mixed-handers and by the perceived benefits in strong-handers.     

Psychometric deviance measured by MMPI in adoptees at high risk for schizophrenia and their adoptive controls

Psychometric deviance in personality traits as assessed by the Minnesota Multiphasic Personality Inventory (MMPI; Dahlstrom, Welsh, & Dahlstrom, 1982) was compared between adopted-away, high-risk (HR) offspring of schizophrenic biologic mothers and low-risk (LR) controls. A subsample of the Finnish Adoptive Family Study (Tienari et al., 2000) included 60 HR adoptees and 76 LR control adoptees who were tested by the MMPI before the onset of any psychiatric disorder at the mean age of 24 years. The HR group was found to be distinguishable based on deviant scores on the scales HOS and HYP, indicating emotional unresponsiveness, restricted affectivity, and decreased energy. These may also be considered possible premorbid and prodromal signs of future schizophrenia among the HR adoptees.     

Two adolescents at risk for schizophrenia: A family case study

This is a study of the complex factors that contributed to the development of adolescent psychoses in two stepbrothers, ages 12 and 15. The identified patient, the younger boy, was in what appeared to be a reversible stage of early adolescent psychosis and his 15 year old newly acquired stepbrother in a nonreversible stage. Each boy was a mentally gifted, neurologically handicapped adolescent who was inextricably vulnerable on the basis of his neurodevelopmental sensitivity to specific immobilizing parental fears and conflicts. Their inherent problems set them apart from their intact teenage sisters and affected the nature and quality of their total life experience. Those working with psychotic children and their families must bear these relationships in mind for optimal strategic intervention and change. In the management of psychotic adolescents and their families, the individual and family therapist could work to everyone's disadvantage if these important neurodevelopmental difficulties are not considered.1979, SummerThis study was supported in part by the Maternal and Child Health Services Training and Study Project No. 144, Department of Health, Education and Welfare.     

Two adolescents at risk for schizophrenia: A family case study

This is a study of the complex factors that contributed to the development of adolescent psychoses in two stepbrothers, ages 12 and 15. The identified patient, the younger boy, was in what appeared to be a reversible stage of early adolescent psychosis and his 15 year old newly acquired stepbrother in a nonreversible stage. Each boy was a mentally gifted, neurologically handicapped adolescent who was inextricably vulnerable on the basis of his neurodevelopmental sensitivity to specific immobilizing parental fears and conflicts. Their inherent problems set them apart from their intact teenage sisters and affected the nature and quality of their total life experience. Those working with psychotic children and their families must bear these relationships in mind for optimal strategic intervention and change. In the management of psychotic adolescents and their families, the individual and family therapist could work to everyone's disadvantage if these important neurodevelopmental difficulties are not considered.This study was supported in part by the Maternal and Child Health Services Training and Study Project No. 144, Department of Health, Education and Welfare.     

Gender identity and adjustment: understanding the impact of individual and normative differences in sex typing

The relationship among gender identity, sex typing, and adjustment has attracted the attention of social and developmental psychologists for many years. However, they have explored this issue with different assumptions and different approaches. Generally the approaches differ regarding whether sex typing is considered adaptive versus maladaptive, measured as an individual or normative difference, and whether gender identity is regarded as a unidimensional or multidimensional construct. In this chapter, we consider both perspectives and suggest that the developmental timing and degree of sex typing, as well as the multidimensionality of gender identity, be considered when examining their relationship to adjustment.     

Narrative self and high risk for schizophrenia: remembering the past and imagining the future

ABSTRACT

We examined the narrative self of those at high psychometric risk for schizophrenia (HR). Eighty undergraduate students wrote personal narratives about a turning-point event in their life, and about a possible future. The turning-point narratives were coded for topic, specificity, event valence, valence of causal coherence link, overall level of causal coherence, and agency. The future narratives were coded for the number and valence of goals, topic of goals, and specificity of goals. Word count was applied to all narratives. The HR group expressed lower levels of agency and a trend of lower levels of causal coherence when narrating turning-point events. When imagining their futures, HR participants produced shorter narratives and showed a trend of having fewer goals. Including the dimensions of both the turning point and the future narratives revealed that the HR group membership was best predicted by lower levels of agency and of causal coherence in the turning-point narrative, and fewer words in the future narrative. Narratives differed specifically in those few elements that are critical for the achievement of narrative continuity. Consistent with the theory, people at high risk for schizophrenia already present, to some extent, an impoverishment in their narrative sense of self.     

Neuropsychology,genetic liability,and psychotic symptoms in those at high risk of schizophrenia

Neuropsychological assessments were compared among individuals at enhanced genetic risk of schizophrenia (n = 157) and controls (n = 34). The relationship between cognitive impairments and the presence of psychotic symptoms and measures of genetic risk was explored in the high-risk subjects. Neuropsychological differences were identified in many areas of function and were not accounted for by the presence of psychotic symptoms. Genetic liability was not associated with neuropsychological performance or with psychotic symptoms, but exploratory analysis showed some tests were associated with both liability measures. These results suggest that what is inherited is not the disorder itself but a state of vulnerability manifested by neuropsychological impairment, occurring in many more individuals than are predicted to develop the disorder.     

Failure to find differences in drinking behavior as a function of familial risk for alcoholism: a replication

Groups of high-risk (alcoholic fathers), middle-risk (second-degree alcoholic relatives) and low-risk (no first- or second-degree alcoholic relatives) male college students were compared with respect to drinking behavior, sociodemographic variables, personality, cognitive functioning, and mental health and drug use problems in themselves and in family members. The groups differed significantly on only one of a number of sociodemographic variables. No significant group differences were revealed in drinking behavior, or alcohol-related symptoms or consequences. High-risk subjects reported significantly more childhood attentional and social problems than did low-risk subjects. No group differences were found with respect to other childhood problem behaviors, cognitive functioning, subject or family drug use, or mental health problems. The findings are discussed in terms of the questions they raise concerning the results of high-risk studies and the contribution of genetic factors to alcoholism.     

Population sex differences in IQ at age 11: the Scottish mental survey 1932

There is uncertainty whether the sexes differ with respect to their mean levels and variabilities in mental ability test scores. Here we describe the cognitive ability distribution in 80,000+ children—almost everyone born in Scotland in 1921—tested at age 11 in 1932. There were no significant mean differences in cognitive test scores between boys and girls, but there was a highly significant difference in their standard deviations (P<.001). Boys were over-represented at the low and high extremes of cognitive ability. These findings, the first to be presented from a whole population, might in part explain such cognitive outcomes as the slight excess of men achieving first class university degrees, and the excess of males with learning difficulties.