听障儿童认知抑制控制的脑电特点

通过认知抑制控制的Stroop范式运用事件相关电位考察听障儿童和对照组儿童在认知抑制控制方面的行为特点以及脑内时程特点。行为结果显示：（1）两类被试在一致条件下认知抑制控制的正确率显著高于不一致条件,反应时显著快于不一致条件,表现出冲突效应;（2）组间结果显示,听障儿童的认知抑制控制正确率显著低于对照组儿童,反应时上差异不显著。脑电结果显示：（1）不一致条件在N450上的负激活显著高于一致条件,听障儿童比对照组儿童诱发了更负的N450波幅;（2）不一致条件在SP上的正激活显著高于一致条件,两类被试在SP上差异不显著。结果提示听障儿童在认知抑制控制过程中的冲突监测功能存在障碍,这是由于冲突监测过程中注意分配能力受损所致。     

刻板印象的激活效应:行为和ERPs证据

以刻板印象表征中的核心内容——刻板特质词作为研究材料,采用分类-确认范式对刻板印象激活效应的时间进程及其认知机制进行了探讨。以性别范畴词"男"/"女"作为启动刺激,以性别刻板特质词作为靶子,特质词与范畴词构成一致和冲突两种情境,记录了34名被试(男女各半)对特质词与范畴词进行一致性判断时的行为反应和ERPs。结果发现:(1)刻板印象冲突情境下,因刻板印象激活效应的作用,被试的反应时要比刻板印象一致情境下更长;不同性别的被试均表现出性别内群体范畴词激活优势效应,即内群体范畴词启动条件下反应时更短。(2)刻板印象激活效应对早期ERP成分(P1、N170、N100、P2)没有影响,在刻板印象冲突情境下诱发了额-中区更显著的N400,该成分标志着刻板印象的激活效应;不同性别的被试均在内群体范畴词启动下诱发了波幅更大的P600。(3)刻板印象的激活效应以及内群体范畴词激活优势效应均发生在知觉后阶段。     

汉字识别侧抑制效应的实验研究

以汉字作为实验材料,采用侧抑制任务范式,考察了不同性质冲突任务下的汉字识别情况.结果发现:反应冲突条件下的反应时显著长于无冲突条件,侧抑制效应非常明显;刺激冲突任务中,只有字音干扰条件表现出了侧抑制效应,字形和字义干扰条件下的反应时与无冲突条件均无显著差异.实验结果说明,侧抑制效应可能受认知加工阶段的影响;汉字字音与形、义特征的加工过程可能并不相同,语音的激活可能要早于语义和字形的激活.     

视觉表象扫描的概念控制

将表象扫描和概念提示范式相结合, 在三个实验中通过考察概念控制下表象扫描加工中的参照系冲突效应以及概念参照系的优先性, 进而揭示表象扫描加工中的自上而下控制机制。结果发现：(1) 正立或旋转方位汉字提示下表象扫描加工中出现了参照轴效应, 箭头提示下不存在这种效应, 表明不同提示引发了不同空间关系计算过程; (2) 在表象扫描概念控制过程中, 概念参照系、环境(重力)参照系及提示汉字内在参照系同时被激活, 它们可能处于不同冲突状态, 解决这些冲突具有不同认知代价; (3) 在解决不同参照系冲突过程中, 反映自上而下加工的概念参照系总能通过抑制其它参照系而取得优先地位, 表明人的认知系统能够对表象加工进行自上而下的主动控制, 这种主动控制反映了一种执行功能。     

认知和情绪词Flanker任务的冲突效应和冲突适应效应分析

采用词汇flanker任务分析认知和情绪冲突及其冲突适应效应。结果发现,在认知和情绪flanker任务中,相对于目标词与干扰词一致的情况,被试在目标词和干扰词不一致的情况下反应更慢,正确率更低。这表明认知词和情绪词flanker任务都能诱发冲突效应。本研究还发现认知冲突适应效应的存在,但没有发现情绪冲突适应效应,该结果可能与刺激材料的复杂性和范式选取有关。此外,研究还发现,相对于目标刺激是金属的认知词和积极的情绪词,被试对目标刺激是水果的认知词和消极的情绪词反应更快。特别是在目标词与干扰词不一致的情况下,被试对水果词和消极词判断的正确率要显著高于对金属词和积极词的判断。未来的研究需要在刺激和范式的修正上进一步探索,并加强情绪冲突与认知冲突适应效应的关系及其影响因素、神经机制的研究。     

不同刺激重复量对反应抑制后效应的影响

旨在探讨不同刺激重复量对反应抑制后效应的影响。在不同刺激重复量条件下,让被试完成停止信号任务。结果发现,从总体来看,刺激重复量因素上的主效应显著,重复类型因素上主效应不显著;信号抑制条件下不同刺激重复量后无信号试次反应时与总的无信号试次反应时差异不显著;信号反应条件下不同刺激重复量后无信号试次反应时与总的无信号试次反应时差异显著。本研究表明不同刺激重复量条件下的反应抑制后效应是认知控制的执行加工而非自动化的记忆提取。     

公平过程效应和结果公平效应的实证分析

通过对143位大学生的数据分析,文章探讨了公平过程效应和结果公平效应存在的条件以及在不同条件下人们对结果公平和结果满意度的反应。多元方差分析结果表明:在不知道他人结果的情况下,公平过程效应显著;在知道他人结果的条件下,结果公平效应显著。此外,研究还表明,人们对结果满意度和结果公平反应是不同的,在结果满意度上,得到多于他人结果的个体比得到少于他人结果的个体判断自己的结果更为满意,但是在结果公平判断上,二者不存在显著差异。     

不同认知方式对词—面孔任务Stroop效应的影响

该研究采用词—面孔Stroop任务,以76名大学生为被试,探讨了不同认知方式（场独立、场依存）对情绪冲突Stroop效应的影响。结果发现：（1）情绪冲突的Stroop效应显著,即,在词—面孔Stroop任务中,当词和面孔的情绪效价一致时,被试的反应时更短,正确率更高。（2）认知方式对情绪冲突Stroop任务的影响显著,表现为无论是一致还是不一致条件下,场独立者比场依存者的反应时都更短。（3）场依存者的情绪冲突Stroop效应更大,表现为其在词—面孔情绪效价一致和不一致条件下的反应时差异更大。     

刻板印象激活的无意图性及其大脑神经活动特征

采用启动Stroop范式, 对刻板印象激活的无意图性及其大脑神经活动特征进行了探讨。操纵了启动和“无启动”条件以及与启动所激活的刻板印象一致、冲突和无关的3类靶子词, 记录了36名大学生被试对靶子词进行颜色判别的行为反应和脑电图(EEG, electroencephalogram)。结果发现：(1)“无启动”条件下对3类靶子的反应时基本一致; 启动条件下对一致靶子做出颜色判别的反应时显著快于对冲突靶子的, 对无关靶子的反应时介于两者之间。(2)“无启动”条件下无关靶子诱发的N400波幅最大--显著大于一致和冲突靶子诱发的, 后两者诱发的N400无差异; 启动条件下一致靶子诱发的N400波幅显著小于冲突和无关靶子诱发的N400波幅, 无关靶子诱发的N400波幅也小于冲突靶子诱发的N400波幅。这表明刻板印象激活是一个发生在知觉后加工阶段的具有无意图性的自动化加工过程, 刻板印象激活效应具有抑制冲突信息加工同时促进一致信息加工的“双刃剑”模式, N400可以作为考察这一认知过程特征的电生理学指标。     

姿势干扰强度的心理预期效应

本研究基于经典快速举臂试验与落球试验范式, 采用表面肌电信号分析技术, 研究内、外姿势干扰强度的心理预期对腰部姿势肌肉和上肢动作肌肉预期姿势调节(APAs)和补偿姿势调节(CPAs)的影响, 探讨中枢神经系统(CNS)对内、外姿势干扰的控制策略。20名健康受试者先后完成不同负荷强度的快速举臂试验和落球试验, 同步采集腰部竖脊肌、腰部多裂肌和上肢肱二头肌的表面肌电信号, 计算肌肉预激活时间和APAs与CPAs积分肌电值, 观察内、外姿势干扰强度的心理预期对中枢APAs和CPAs控制机制的影响。结果显示内部姿势干扰条件下, 干扰强度的心理预期对腰部多裂肌、腰部竖脊肌和上肢肱二头肌的APAs强度有显著影响, 而对预激活时间和CPAs强度无显著影响; 外部姿势干扰条件下, 干扰强度的心理预期对腰部多裂肌、腰部竖脊肌和肱二头肌的APAs强度有显著影响, 对肱二头肌和腰部多裂肌预激活时间有显著影响, 而对CPAs强度无显著影响。突发可预期姿势干扰条件下姿势的快速反应是一个由CNS主导的神经肌肉运动控制过程。受姿势干扰强度心理预期的影响, CNS对内、外突发姿势干扰条件下腰部姿势肌肉的活动采取了不同的控制策略。在内部姿势干扰条件下, 干扰刺激发生时间明确, CNS主要通过对APAs强度的调节来实现姿势肌肉的优化控制; 而在外部姿势干扰条件下, 干扰刺激时间不明确, CNS则通过对局部稳定肌APAs预激活时间以及局部稳定肌和整体稳定肌APAs强度的双重调节实现姿势肌肉的优化控制。干扰强度的心理预期对姿势肌肉APAs和CPAs的作用表明, 心理预期效应主要源自于CNS对局部和整体稳定肌APAs控制机制的调制。     

Dissociation and association of the embodied representation of tool-use verbs and hand verbs: An fMRI study

Embodied semantic theories suppose that representation of word meaning and actual sensory-motor processing are implemented in overlapping systems. According to this view, association and dissociation of different word meaning should correspond to dissociation and association of the described sensory-motor processing. Previous studies demonstrate that although tool-use actions and hand actions have overlapping neural substrates, tool-use actions show greater activations in frontal–parietal–temporal regions that are responsible for motor control and tool knowledge processing. In the present study, we examined the association and the dissociation of the semantic representation of tool-use verbs and hand action verbs. Chinese verbs describing tool-use or hand actions without tools were included, and a passive reading task was employed. All verb conditions showed common activations in areas of left middle frontal gyrus, left inferior frontal gyrus (BA 44/45) and left inferior parietal lobule relative to rest, and all conditions showed significant effects in premotor areas within the mask of hand motion effects. Contrasts between tool-use verbs and hand verbs demonstrated that tool verbs elicited stronger activity in left superior parietal lobule, left middle frontal gyrus and left posterior middle temporal gyrus. Additionally, psychophysiological interaction analyses demonstrated that tool verbs indicated greater connectivity among these regions. These results suggest that the brain regions involved in tool-use action processing also play more important roles in tool-use verb processing and that similar systems may be responsible for word meaning representation and actual sensory-motor processing.     

A forced-attention dichotic listening fMRI study on 113 subjects

We report fMRI and behavioral data from 113 subjects on attention and cognitive control using a variant of the classic dichotic listening paradigm with pairwise presentations of consonant-vowel syllables. The syllable stimuli were presented in a block-design while subjects were in the MR scanner. The subjects were instructed to pay attention to and report either the left or right ear stimulus. The hypothesis was that paying attention to the left ear stimulus (FL condition) induces a cognitive conflict, requiring cognitive control processes, not seen when paying attention to the right ear stimulus (FR condition), due to the perceptual salience of the right ear stimulus in a dichotic situation. The FL condition resulted in distinct activations in the left inferior prefrontal gyrus and caudate nucleus, while the right inferior frontal gyrus and caudate were activated in both the FL and FR conditions, and in a non-instructed (NF) baseline condition.     

Effects of chewing on cognitive processing speed

In recent years, chewing has been discussed as producing effects of maintaining and sustaining cognitive performance. We have reported that chewing may improve or recover the process of working memory; however, the mechanisms underlying these phenomena are still to be elucidated. We investigated the effect of chewing on aspects of attention and cognitive processing speed, testing the hypothesis that this effect induces higher cognitive performance. Seventeen healthy adults (20–34 years old) were studied during attention task with blood oxygenation level-dependent functional (fMRI) at 3.0 T MRI. The attentional network test (ANT) within a single task fMRI containing two cue conditions (no cue and center cue) and two target conditions (congruent and incongruent) was conducted to examine the efficiency of alerting and executive control. Participants were instructed to press a button with the right or left thumb according to the direction of a centrally presented arrow. Each participant underwent two back-to-back ANT sessions with or without chewing gum, odorless and tasteless to remove any effect other than chewing. Behavioral results showed that mean reaction time was significantly decreased during chewing condition, regardless of speed-accuracy trade-off, although there were no significant changes in behavioral effects (both alerting and conflict effects). On the other hand, fMRI analysis revealed higher activations in the anterior cingulate cortex and left frontal gyrus for the executive network and motor-related regions for both attentional networks during chewing condition. These results suggested that chewing induced an increase in the arousal level and alertness in addition to an effect on motor control and, as a consequence, these effects could lead to improvements in cognitive performance.     

An fMRI study of working memory for schematic facial expressions

Functional magnetic resonance imaging (fMRI) was used to examine neuronal activation in relation to increasing working memory load in an n-back task, using schematic drawings of facial expressions and scrambled drawings of the same facial features as stimuli. The main objective was to investigate whether working memory for drawings of facial features would yield specific activations compared to memory for scrambled drawings based on the same visual features as those making up the face drawings. fMRI-BOLD responses were acquired with a 1.5 T Siemens MR scanner while subjects watched the facial drawings alternated with the scrambled drawings, in a block-design. Subjects had to hold either 1 or 2 items in working memory. We found that the main effect of increasing memory load from one to two items yielded significant activations in a bilaterally distributed cortical network consisting of regions in the occipitotemporal cortex, the inferior parietal lobule, the dorsolateral prefrontal cortex, supplementary motor area and the cerebellum. In addition, we found a memory load x drawings interaction in the right inferior frontal gyrus in favor of the facial drawings. These findings show that working memory is specific for facial features which interact with a general cognitive load component to produce significant activations in prefrontal regions of the brain.     

Using fMRI to study recovery from acquired dysphasia

We have used functional magnetic resonance imaging (fMRI) to characterize brain activations associated with two distinct language tasks performed by a 28-year-old woman after partial recovery from dysphasia due to a left frontal hemispheric ischemic stroke. MRI showed that her ischemic lesion extended posteriorly from the left inferior frontal to the perisylvian cortex. fMRI scans of both language tasks revealed substantial differences in activation pattern relative to controls. The nature of this difference was task-specific. During performance of a verbal semantic decision task, the patient, in contrast to controls, activated a network of brain areas that excluded the inferior frontal gyrus (in either hemisphere). A second task involving rhyme judgment was designed to place a heavier cognitive load on language production processes and activated the left inferior frontal gyrus (Broca's area) strongly in normal controls. During this task, the most prominent frontal activation in the patient occurred in the right homologue of Broca's area. Subsequent analysis of this data by methods able to deal with responses of changing amplitude revealed additional, less sustained recruitment by the patient of cortex adjacent to the infarct in the region inferior to Broca's area during rhyming. These results suggest that in addition to changes in cognitive strategy, recovery from dysphasia could be mediated by both the preservation of neuronal networks in and around the infarct and the use of homologous regions in the contralateral hemisphere.     

Neuromagnetic correlates of intra- and extra-dimensional set-shifting

Set-shifting is essential to cognitive flexibility and relies on frontal lobe function. Previous studies have mostly focused on feedback processes following shifting rather than set-shifting itself. We designed an MEG paradigm without feedback to directly investigate the neural correlates of set-shifting. Adults (n = 16) matched one of two coloured images with a third stimulus, the target, by either the colour or shape dimension of the target. Half of the shift trials involved colour-to-colour or shape-to-shape (intra-dimensional: ID) shifting and the other half involved colour-to-shape or shape-to-colour (extra-dimensional: ED) shifting. MEG was continuously recorded on a 151 channel CTF system. We used beamforming to analyze responses to the first (shift) and the third (repeat) trials in each set. These trials were contrasted separately for ID and ED sets. Shift versus repeat trials showed larger MEG activations for intra-dimensional shifting in the right inferior frontal gyrus (BA 47), left medial frontal gyrus (BA 10) and right superior frontal gyrus (BA 9) as early as 100 ms, and in left middle frontal gyrus (BA 11) between 250–500 ms. Activations related to extra-dimensional shifting were detected in left inferior frontal gyrus (BA 44), left middle frontal gyrus (BA 11), and right middle frontal gyrus (BA 46) between 100 ms and 350 ms, followed by superior frontal gyrus (BA 8/BA 10) between 250–500 ms. Intra-dimensional and extra-dimensional shifting also activated bilateral and right parietal areas, respectively. This study establishes the location and timing of frontal and parietal activations during an intra-dimensional versus extra-dimensional shifting task.     

动词论元结构复杂性加工的认知神经机制

动词论元结构复杂性表现在论元数量、论元范畴选择模式、题元角色指派模式和映射方式四个方面。大部分实证研究表明, 更多的论元数量、选择性论元范畴、选择性题元角色指派以及非典型映射, 使动词论元结构加工的认知神经机制更复杂。多论元加工功能脑区主要涉及左侧额下回和外侧裂周后部; 选择性论元范畴加工功能脑区主要涉及左侧额下回、额叶中后部、颞上回和颞叶中后部; 选择性题元角色指派加工功能脑区主要涉及外侧裂周后部、左侧额叶中后部和额下回; 非典型映射加工功能脑区主要涉及左侧额下回、颞上回、颞中回和颞叶后部。左侧额下回可能涉及初始句法加工、动词次范畴确定、句法移位和非宾格动词语义加工, 左侧额叶中后部可能涉及初始句法加工和动词次范畴确定, 左侧颞上回和颞叶中后部可能涉及表层句法加工和表层论元句法-语义整合, 外侧裂周后部可能涉及论元语义表征。动词论元结构加工过程和动词词汇特征表明, 复杂性某些方面存在交互作用。动词论元结构复杂性与加工难易的对应关系、复杂性加工难度层级和交互作用的认知神经机制以及汉语动词论元结构复杂性加工认知神经机制等议题, 有待进一步探讨。     

Aging effects on memory encoding in the frontal lobes

Functional magnetic resonance imaging (fMRI) was used to compare frontal-lobe activation in younger and older adults during encoding of words into memory. Participants made semantic or nonsemantic judgments about words. Younger adults exhibited greater activation for semantic relative to nonsemantic judgments in several regions, with the largest activation in the left inferior frontal gyrus. Older adults exhibited greater activation for semantic judgments in the same regions. but the extent of activation was reduced in left prefrontal regions. In older adults, there was a significant association between behavioral tests of declarative and working memory and extent of frontal activation. These results suggest that age-associated decreases in memory ability may be due to decreased frontal-lobe contributions to the initial encoding of experience.     

Cortical localisation of the visual and auditory word form areas: a reconsideration of the evidence

In this paper we examine the evidence for human brain areas dedicated to visual or auditory word form processing by comparing cortical activation for auditory word repetition, reading, picture naming, and environmental sound naming. Both reading and auditory word repetition activated left lateralised regions in the frontal operculum (Broca's area), posterior superior temporal gyrus (Wernicke's area), posterior inferior temporal cortex, and a region in the mid superior temporal sulcus relative to baseline conditions that controlled for sensory input and motor output processing. In addition, auditory word repetition increased activation in a lateral region of the left mid superior temporal gyrus but critically, this area is not specific to auditory word processing, it is also activated in response to environmental sounds. There were no reading specific activations, even in the areas previously claimed as visual word form areas: activations were either common to reading and auditory word repetition or common to reading and picture naming. We conclude that there is no current evidence for cortical sites dedicated to visual or auditory word form processing.     

Effective brain connectivity in children with reading difficulties during phonological processing

Using Dynamic Causal Modeling (DCM) and functional magnetic resonance imaging (fMRI), we examined effective connectivity between three left hemisphere brain regions (inferior frontal gyrus, inferior parietal lobule, fusiform gyrus) and bilateral medial frontal gyrus in 12 children with reading difficulties (M age=12.4, range: 8.11-14.10) and 12 control children (M age=12.3, range: 8.9-14.11) during rhyming judgments to visually presented words. More difficult conflicting trials either had similar orthography but different phonology (e.g. pint-mint) or similar phonology but different orthography (e.g. jazz-has). Easier non-conflicting trials had similar orthography and phonology (e.g. dime-lime) or different orthography and phonology (e.g. staff-gain). The modulatory effect from left fusiform gyrus to left inferior parietal lobule was stronger in controls than in children with reading difficulties only for conflicting trials. Modulatory effects from left fusiform gyrus and left inferior parietal lobule to left inferior frontal gyrus were stronger for conflicting trials than for non-conflicting trials only in control children but not in children with reading difficulties. Modulatory effects from left inferior frontal gyrus to inferior parietal lobule, from medial frontal gyrus to left inferior parietal lobule, and from left inferior parietal lobule to medial frontal gyrus were positively correlated with reading skill only in control children. These findings suggest that children with reading difficulties have deficits in integrating orthography and phonology utilizing left inferior parietal lobule, and in engaging phonological rehearsal/segmentation utilizing left inferior frontal gyrus possibly through the indirect pathway connecting posterior to anterior language processing regions, especially when the orthographic and phonological information is conflicting.