The deterioration of semantic memory in Alzheimer's disease.

Semantic memory impairment is a common feature of dementia of the Alzheimer type (DAT). Recent research has shown that patients with DAT are more impaired (relative to non-demented controls) in generating exemplars from a particular semantic category (e.g., animals) than words beginning with a particular letter, exhibit an altered temporal dynamic during the production of category exemplars, are impaired on confrontation naming tasks and make predominantly superordinate or semantically related errors, consistently misidentify the same objects across a variety of semantic tasks, and have alterations in multi-dimensional scaling models of their semantic network that are indicative of a loss of concepts and associations. These results are consistent with the view that Alzheimer's disease results in a breakdown in the organization and structure of semantic knowledge as neurodegeneration spreads to the association cortices that presumably store semantic representations.     

Naming consistency in Alzheimer''s disease

Although lexical semantic deficits are postulated to play a prominent role in the anomia of Alzheimer's disease, it is unclear whether the primary disturbance is one of lexical access or one of lexical semantic loss. Response consistency on a naming task is one means of evaluating the underlying source of naming impairment. Access dysfunction usually implies variable word-finding difficulty, while a theory of lexical loss predicts that many word names would be consistently unavailable. Nineteen Alzheimer's disease patients were administered a visual confrontation naming task (the Boston Naming Test) on two occasions 6 months apart. Eighty percent of errors occurred consistently at both times; only 20% of errors occurred on only one occasion. Response consistency occurred significantly more often than expected under the assumption of no response consistency. Findings support the hypothesis that anomia in Alzheimer's disease is in part due to a loss of lexical semantic information.     

The role of semantic knowledge and working memory in everyday tasks

We present a single case study of a patient, HG, who was severely impaired on routine everyday tasks, such as cleaning his teeth and preparing a cup of tea. We used the Action Coding System developed by Schwartz et al. (1991) to provide quantitative and qualitative measures of his performance in a number of experimental manipulations: (a) with task-congruent objects only, (b) with task-congruent objects and semantic distractors, (c) with a set of written commands to follow, (d) when he was given one command at a time, (e) when he was shown how the task should be performed before starting himself, and (f) when the task was divided into smaller subgoals. In general, the majority of HG's errors were step omissions, perseverations, sequence errors, and semantic errors. These semantic errors are particularly interesting since HG was able to name, gesture to, and define all the objects when they were presented in isolation or in task-congruent arrays. We suggest that semantic errors may arise for a number of reasons: (1) impaired access from semantic memory to a network representing action schema, (2) degradation of stored schema, and (3) behavior that is abnormally driven by the goal, by preceding actions, or by salient objects rather than by an appropriate association between these elements in working memory.     

Knowledge and knowledge gaps in semantic memory of technical artifacts

Two hypotheses have been considered regarding the relation between knowledge and semantic knowledge gaps: a “knowledge clash” hypothesis predicting more awareness of knowledge gaps with increasing knowledge, and a “knowledge deficit” hypothesis whereby the relation is the opposite. In order to examine these hypotheses, graduate and undergraduate students were asked to state what they knew and what they did not know about a sample of familiar and unfamiliar artifacts. None of the above hypotheses accounted for the results. Instead, knowledge was found to be differently related to various types of unknown features: increasing knowledge was related to less unknown features of the artifacts' function and to more unknown features about contingency relations. Unknown features of the artifacts’ behaviors were frequently reported in the two knowledge conditions. The results suggest new strands of research on the metacognition of “not knowing.”     

Preservation of categorical knowledge in Alzheimer's disease: A computational account

Abstract

The distinction between knowledge of specific exemplars and knowledge of their general categories is central to much theorising on the nature of semantic memory. The dissociation between exemplar and category knowledge observed in Alzheimer's Disease (AD) would appear to support this distinction, and to suggest that different neural systems are involved in the representation of exemplar and category knowledge. We review the evidence for preserved category knowledge in the semantic memory impairment of AD, and propose an alternative interpretation, according to which category and exemplar knowledge are both represented in the same distributed neural substrate. The relative preservation of category knowledge is a consequence of the greater frequency, and hence greater robustness, of the representation of attributes shared by all or most members of a category, compared to exemplar-unique attributes. We test and confirm the computational adequacy of this hypothesis in two computer simulations.     

The categorical structure of semantic memory for famous people: a new approach using release from proactive interference

Memory for familiar people is essential to understand their identity and guide social interaction. Nevertheless, we know surprisingly little about the structure of such memory. Previous research has assumed that semantic memory for people has a categorical structure, but recently it was proposed that memory for people consists only of associations and lacks any categorical structure. Four experiments are reported that use a novel approach by adapting the 'release from proactive interference' (RPI) methodology for use with lists of famous names. Proactive interference occurs when items presented on successive trials are drawn from the same category. Recall can improve following a change to a different category. Sets of names were selected relating to aspects previously demonstrated, on the basis of reaction time data, to form a category (occupation) and a property (nationality) of celebrities (Johnston & Bruce, 1990). RPI was observed for a change at both levels of representation but was only present without explicitly cueing the change of set when the stimuli differed at the category level. At the property level, RPI was only evident when change of set was explicitly cued. RPI was absent at the set change in a novel, ad hoc distinction suggesting that the effect reflected the underlying memory structure.     

Priming and semantic memory loss in Alzheimer's disease

Semantic memory (SM) was investigated in six patients with probable Alzheimer's disease (AD) by on-line measurement of semantic priming in a lexical decision task, and off-line tests of comprehension. Detailed assessment was carried out on naming, name comprehension, and probes of semantic knowledge with a battery of 150 items. The patients performed normally on perceptual tests and displayed an item-specific loss of knowledge on the semantic tests. In a primed lexical decision task, greater semantic priming was found relative to age-matched normals. The priming was substantially greater for items with "degraded" representations as determined by the off-line tests. Lexical decision was also performed more slowly on these items. These unexpected results demand a reevaluation of the concepts of the lexicon and semantic memory structure and their possible alteration in dementia.     

Investigating semantic memory impairments: The contribution of semantic priming

Abstract

The semantic priming task is a valuable tool in the investigation of semantic memory impairments in patients with acquired disorders of language. This is because priming performance reflects automatic or implicit access to semantic information, unlike most other tests of semantic knowledge, which rely on explicit, voluntary access. Priming results are important for two main reasons: First, normal priming results may be observed in patients who perform poorly on other semantic memory tests, enabling us to distinguish between loss of, or damage to, information in semantic memory, and voluntary access to that information. Second, we can investigate the detailed pattern of loss and preservation of different types of semantic information, by charting the priming effects for different kinds of words, and different kinds of semantic relations between primes and targets.

We discuss the use of the priming task in this context, and address some of the theoretical and methodological criticisms that have been raised in connection with use of the priming task to address these issues. We then describe two recent studies in which we have employed semantic priming tasks, along with other more traditional methods, to investigate specific questions about the semantic memory deficits of three patients.     

On the nature of the verbal memory deficit in Alzheimer''s disease

Verbal memory was investigated in patients with Alzheimer's disease (AD) with previously documented deficits in word production and comprehension. Procedures were employed to evaluate word recall and recognition within the context of both "multistore" and "levels of processing" models of memory. In addition, memory abilities were evaluated with respect to performance on measures of verbal fluency and language comprehension. As expected, the AD patients performed significantly worse than normal individuals on all tasks. However, in each experiment their pattern of recall across conditions was found to be qualitatively similar to that produced by normal subjects. It was argued that the memory impairment associated with Alzheimer's disease may be largely due to an inability to encode a sufficient number of stimulus features or attributes. Furthermore, this encoding deficit includes, but is not limited to, semantic attributes. Similarities between the performance of the AD patients and reported findings with Korsakoff patients and normal subjects with "weak" memory were discussed.     

Structure and process in semantic memory: new evidence based on speed-accuracy decomposition

Reaction-time and accuracy data obtained from studies of sentence verification have not been rich enough to answer certain important theoretical questions about structures and processes in human semantic memory. However, a new technique called speed-accuracy decomposition (Meyer, Irwin, Osman, & Kounios, 1986) may help solve this problem. The technique allows intermediate products of sentence verification to be analyzed more precisely. Three experiments with speed-accuracy decomposition indicate that verification processes produce useful partial information before they are completed. Such information appears to accumulate continuously at a rate whose magnitude depends on the degree of relatedness between semantic categories. This outcome is consistent with continuous computational (e.g., semantic-feature comparison) models of semantic memory. An analysis of reaction-time minima suggests that a discrete all-or-none search process may also contribute at least occasionally to sentence verification. Further details regarding the nature of these processes and the memory structures on which they operate can be inferred from additional results obtained through speed-accuracy decomposition.     

The effect of semantic and syntactic structure on verbal memory in Alzheimer's disease

This study examined the ability of 17 patients with Alzheimer's disease and 17 normal-old subjects to recall short sentences that were normal, or had a disruption in either their semantic structure, their syntactic structure, or both their semantic and syntactic structure. Results showed that sentence recall performance was affected similarly in the demented and normal-old subjects by both the syntactic and semantic structure of the sentences. The presence of either type of language structure appeared to allow both normal and demented subjects to organize strings of words into multiword chunks for more efficient memory encoding.     

The neurobiology of semantic memory

Semantic memory includes all acquired knowledge about the world and is the basis for nearly all human activity, yet its neurobiological foundation is only now becoming clear. Recent neuroimaging studies demonstrate two striking results: the participation of modality-specific sensory, motor, and emotion systems in language comprehension, and the existence of large brain regions that participate in comprehension tasks but are not modality-specific. These latter regions, which include the inferior parietal lobe and much of the temporal lobe, lie at convergences of multiple perceptual processing streams. These convergences enable increasingly abstract, supramodal representations of perceptual experience that support a variety of conceptual functions including object recognition, social cognition, language, and the remarkable human capacity to remember the past and imagine the future.     

Predictors of semantic categorical flexibility in older adults

This study investigated the processes involved in the aging of semantic categorical flexibility. A previous study revealed the effects of aging on the flexible use of taxonomic relations. We aimed to explain our previous results regarding the performance of older adults; we carried out investigations into the respective roles of executive and conceptual factors in semantic categorical flexibility. Fifty older adults carried out a semantic categorical flexibility task alongside conceptual and executive measures. The results replicate our previous findings and indicate that the predictors of the maintenance of the use of taxonomic relations are conceptual and the predictors of the switching from thematic to taxonomic relations are executive.     

Bias in spatial memory: a categorical endorsement

Two experiments investigated how angular estimates reflect bias as a function of response mode, geometric plane of variation, number of implicit categories, memory load and intervening task conditions. In Experiment 1, participants made motor and verbal estimates of incline and azimuth from memory. Estimates in both response modes showed signs of bias predicted by a single-category adaptation of Huttenlocher et al. [Huttenlocher, J., Hedges, L. V., & Duncan, S. (1991). Categories and particulars: Prototype effects in estimating spatial location. Psychological Review, 98, 352-376] category-adjustment model. In Experiment 2, participants made motor estimates of azimuth from memory under a variety of conditions. Stimuli in this experiment were distributed along two contiguous spatial categories. Although increasing levels of cognitive load did not produce a graded effect, participants' estimates were biased and were well described by a multiple-category adaptation of the category-adjustment model. Results from both studies supported an implicit region-based model of bias in spatial memory. These findings were discussed with respect to accounts of spatial memory that propose multiple systems or formats for coding.     

The structure of semantic person memory: evidence from semantic priming in person recognition

This paper reviews research on the structure of semantic person memory as examined with semantic priming. In this experimental paradigm, a familiarity decision on a target face or written name is usually faster when it is preceded by a related as compared to an unrelated prime. This effect has been shown to be relatively short lived and susceptible to interfering items. Moreover, semantic priming can cross stimulus domains, such that a written name can prime a target face and vice versa. However, it remains controversial whether representations of people are stored in associative networks based on co-occurrence, or in more abstract semantic categories. In line with prominent cognitive models of face recognition, which explain semantic priming by shared semantic information between prime and target, recent research demonstrated that priming could be obtained from purely categorically related, non-associated prime/target pairs. Although strategic processes, such as expectancy and retrospective matching likely contribute, there is also evidence for a non-strategic contribution to priming, presumably related to spreading activation. Finally, a semantic priming effect has been demonstrated in the N400 event-related potential (ERP) component, which may reflect facilitated access to semantic information. It is concluded that categorical relatedness is one organizing principle of semantic person memory.     

Causal conditional reasoning and semantic memory retrieval: a test of the semantic memory framework

This study tested and refined a framework that proposes a mechanism for retrieving alternative causes and disabling conditions (Cummins, 1995) during reasoning. Experiment 1 examined the relation between different factors affecting retrieval. The test revealed high correlations between the number of possible alternative causes or disabling conditions and their strength of association and plausibility. Experiment 2 explored the hypothesis that due to a more extended search process, conditional inferences would last longer when many alternative causes or disabling conditions were available. Affirmation of the consequent (AC) and modus ponens (MP) latencies showed the hypothesized pattern. Denial of the antecedent (DA) and modus tollens (MT) inferences did not show latency effects. The experiment also identified an effect of the number of disabling conditions on AC and DA acceptance. Experiment 3 measured efficiency of disabler retrieval by a limited time, disabler generation task. As predicted, better disabler retrieval was related to lower acceptance of the MP and MT inferences.     

The selective impairment of semantic memory

The selective impairment of semantic memory is described in three patients with diffuse cerebrallesions. These patients, selected on the basis of a failure to recognize or identify common objects (agnosia for objects), were investigated in detail. In particular, their perceptual, language and memory functions were assessed, and the limits and properties of their recognition difficulties explored.

It was found that knowledge of pictorial representations of objects, and of words, was impaired or impoverished, and in both instances knowledge of subordinate categories was more vulnerable than superordinate categories. Evidence is presented that this impairment of semantic memory cannot be accounted for by intellectual impairment, sensory or perceptual deficits, or expressive language disorder. The implications of damage to the semantic memory system for the operation of other cognitive systems, in particular short and long-term memory functions, are considered. Some tentative evidence for the structural basis for a hierarchically organized modality-specific semantic memory system is discussed.     

Episodic and semantic memory influences on picture naming in Alzheimer's disease

This study investigated the relationship between semantic and episodic memory as they support lexical access by healthy younger and older adults and individuals with Alzheimer's disease (AD). In particular, we were interested in examining the pattern of semantic and episodic memory declines in AD (i.e., word-finding difficulty and impaired recent memory) vis-à-vis more preserved remote memories. We administered a picture naming task in which the episodic period of the pictures and whether the pictured items were unique to one period or commonly used across periods were varied. Groups of younger adults (N=40), healthy older adults (N=20) and older adults with AD (N=18) were asked to name drawings of objects in four conditions: dated unique, contemporary unique, dated common, and contemporary common. The results indicated that all participants named items that were common to both episodic periods more successfully than items unique to one period. An interaction was observed such that the healthy older and AD groups were more successful in retrieving names of objects presented in the dated compared to contemporary unique conditions, whereas the younger adults showed the reverse pattern. These results indicate that naming ability is affected both by the cumulative frequency of using an item over a lifetime and by when an item was first acquired. The findings support a theoretical stance which proposes an enduring reciprocal link between semantic and episodic memory. This theoretical relationship has practical implications for the development of intervention strategies when interacting with persons who have AD.