多囊卵巢综合征与代谢综合征

高胰岛素血症和高雄激素血症是多囊卵巢综合征(PCOS)的两大基本特征,共同参与了PCOS的发生与发展,胰岛素抵抗是连接PCOS和MS的纽带.本文阐述了PCOS和MS的相互重叠、PCOS产生胰岛素抵抗的机制、胰岛素抵抗对PCOS的作用.指出早期识别PCOS,有利于及时纠正、阻断其内分泌紊乱,防止MS的发生.提高胰岛素敏感性的治疗措施包括生活方式调整和药物治疗,生活方式的调整主要是控制饮食、运动和改变生活方式,包括戒烟、戒酒;药物治疗主要是使用二甲双胍和噻唑烷二酮类药物,其他药物如右旋肌醇、N-乙酰半胱氨酸、生长抑素类似物、α糖苷酶抑制剂、内腓肽受体抑制剂也具有增强胰岛素敏感性的作用.     

多囊卵巢综合征与代谢综合征

高胰岛素血症和高雄激素血症是多囊卵巢综合征（PCOS）的两大基本特征,共同参与了PCOS的发生与发展,胰岛素抵抗是连接PCOS和MS的纽带。本文阐述了PCOS和MS的相互重叠、PCOS产生胰岛素抵抗的机制、胰岛素抵抗对PCOS的作用。指出早期识别PCOS,有利于及时纠正、阻断其内分泌紊乱,防止MS的发生。提高胰岛素敏感性的治疗措施包括生活方式调整和药物治疗,生活方式的调整主要是控制饮食、运动和改变生活方式,包括戒烟、戒酒;药物治疗主要是使用二甲双胍和噻唑烷二酮类药物,其他药物如右旋肌醇、N-乙酰半胱氨酸、生长抑素类似物、α糖苷酶抑制剂、内腓肽受体抑制剂也具有增强胰岛素敏感性的作用。     

Maternal Attitudes and the Non-Achievement Syndrome

This study investigated the relationship between the mother-child relationship and academic achievement. The population consisted of 45 male achievers and underachievers from a local suburban high school and their mothers. The nature of the mother-child relationship was measured by the Mother—Child Relationship Evaluation. Generally it was found that mothers of achievers were more accepting of their children than were mothers of underachievers. Further, achievers and underachievers differed in the ability to perceive accurately the maternal attitudes. These findings were interpreted in terms of the etiology of underachievement as described by Roth and Meyersburg in the Non-Achievement Syndrome. These dynamics involve maternal rejection and the attempts of the underachiever to maintain a dependent relationship with the parents, and the avoidance of adolescent independence via underachievement.     

Hyperactivity and the Fragile X Syndrome

Workers who have claimed an association between Fragile X [fra(x)] Syndrome and Hyperactivity and aggressive behavior have done so despite the lack of controlled studies using standard diagnostic criteria. Accordingly, we provided a controlled test of the hypothesis that individuals with the fra(x) Syndrome are more hyperactive and have more symptoms of aggression than other mentally retarded individuals. The test formed part of a study to assess autistic behavior in fra(x) individuals. A sample of fra(x) individuals was obtained from the register of a clinical genetics unit and individually matched for age, sex, and IQ with mentally retarded individuals selected from assessment centres. Fortyfive pairs of fra(x) cases and control individuals were compared on criteria which reflected DSM-III concepts of hyperactivity and on criteria reflecting aggressive behavior. The comparison failed to find a higher prevalence of these symptoms in the fra(x) group. An analysis of the study's statistical power suggested that it is unlikely that the investigation failed to detect a large to medium difference between fra(x) individuals and control individuals in the symptoms investigated.     

论"证"的性质、结构及证研究

证是中医理论中的一个十分重要的概念。在中医现代研究中 ,证的研究乃是最为重要的课题之一。不少学者认为 ,中医的现代化可能会在证实质的研究中得到实现。然而 ,证是什么 ?近年来人们对此问题做过不少讨论 ,见仁见智 ,或说证是证据 ,或说证是症候群 ,或说证是证型 ,或说证是疾病在阶段上的病机 ,或说证是疾病时机体在整体层次上的反应状态 ,或说证是疾病阶段病变在人们认识上的反映。在证实质研究已经经历了相当长时间后的今天 ,我们对证为何物还没一个统一的认识 ,这种状况值得深思。笔者在此就证的性质、证的结构以及证研究问题 ,谈谈自…     

Parental Alienation Syndrome and the Transsexual Parent

ABSTRACT

Transsexual persons are frequently married and are parents prior to the decision for gender transition. Divorce and issues of child custody or child access follow. This typically volatile area is made the more incendiary when one parent is transgendered. Parental Alienation Syndrome is an unique alliance between one parent and child of denigration and hostility to the other parent. When the transgendered parent is the target, Courts may collaborate in destruction of the transsexual parent-child relationship.     

代谢性炎症与代谢综合征

机体对营养物质和病原体在长期的进化过程中形成相同的感应系统.病原体的入侵和营养物质的过剩均可造成免疫系统活化,从而发生代谢性炎症,继而出现代谢综合征,使得以糖尿病为代表的代谢性疾病发病日益增多.代谢性炎症是代谢和免疫相互作用的交叉点,因此阻断代谢性炎症对于预防和控制代谢性疾病具有重要意义.     

代谢性炎症与代谢综合征

机体对营养物质和病原体在长期的进化过程中形成相同的感应系统。病原体的入侵和营养物质的过剩均可造成免疫系统活化,从而发生代谢性炎症,继而出现代谢综合征,使得以糖尿病为代表的代谢性疾病发病日益增多。代谢性炎症是代谢和免疫相互作用的交叉点,因此阻断代谢性炎症对于预防和控制代谢性疾病具有重要意义。     

Adult Asperger Syndrome and the Utility of Cognitive-Behavioral Therapy

Asperger syndrome (AS) is a developmental disorder that was first recognized in the United States in 1994 with the publication of DSM-IV (American Psychiatric Association, Diagnostic and statistical manual of mental disorders, 1994). As a relatively new concept to the United States, both within the professional community and public awareness, the diagnosis has most often applied to children, but there is a large cohort of affected adults who have never been diagnosed or properly treated. Many of these individuals are now seeking treatment for the symptoms of AS and/or comorbid mental health problems (e.g., mood and anxiety disorders). Clinicians are in need of practical and evidence-based interventions to address the problems presented by this growing patient population, but there are few such resources available. This article will present a framework for conceptualizing the mental health needs of adults with AS, using the evidence-based approaches found in the cognitive-behavior therapy (CBT) literature to inform treatment.     

Communal Orientation and the Burnout Syndrome Among Nurses1

In the present study, burnout symptoms (emotional exhaustion, depersonalization, and reduced personal accomplishment) were hypothesized to occur among male and female nurses who are low in communal orientation and feel they invest more in their relationships with patients than they receive in return. Communal orientation refers to the desire to give and receive benefits in response to the needs of and out of concern for others. Furthermore, it was expected that the perception of imbalance would be more strongly related to depersonalization and reduced personal accomplishment among women than among men. The sample consisted of 194 full time working nurses (48.5% males, 51.5% females). Burnout was measured with the Maslach Burnout Inventory (MBI). The results show that the burnout syndrome is more widespread among: (a) subjects, particularly women, who perceive an imbalance in their relationships with patients; (b) subjects low in communal orientation; and (c) subjects who both perceive an imbalance and are low in communal orientation. The results are discussed in the context of theoretical and practical implications.     

代谢综合征与乳腺癌

研究显示,代谢综合征可增加女性乳腺癌的患病风险,在绝经后妇女中表现更明显.这种作用可能通过胰岛素抵抗影响雌激素和性激素结合球蛋白水平、高胰岛素血症的直接或间接作用以及脂肪因子水平异常等机制实现.因此,对于我国乳腺癌发病率可能随代谢综合征人群不断扩大而上升的趋势应予以足够重视.     

脆弱儿童综合症研究

脆弱儿童综合症是指父母不管儿童实际健康状况而认定孩子死亡风险增加以及由此导致的儿童的行为问题.影响该病症发展的主要因素很多,但其可变性仍未详述.从Calkins的观点来分析脆弱儿童综合症的发展状况,可以详解其可变性及实行预先干预治疗.认识到父母的过度敏感对脆弱儿童综合症发展的危险后,一般应采取集体干预的治疗措施来预防和减轻行为障碍的后遗症.     

代谢综合征与乳腺癌

研究显示,代谢综合征可增加女性乳腺癌的患病风险,在绝经后妇女中表现更明显。这种作用可能通过胰岛素抵抗影响雌激素和性激素结合球蛋白水平、高胰岛素血症的直接或间接作用以及脂肪因子水平异常等机制实现。因此,对于我国乳腺癌发病率可能随代谢综合征人群不断扩大而上升的趋势应予以足够重视。     

A Case of Triple X Syndrome Manifesting with the Syndrome of Nonverbal Learning Disabilities

There has been a relative absence of studies that have examined comprehensively the neuropsychological profiles of females with Triple X Syndrome across a battery of tests and measures. A case is reported of a 9 1/2-year-old female with Triple X Syndrome whose neuropsychological test results were suggestive of greater right- versus left-cerebral hemisphere dysfunction. Overall, the patient's neuropsychological profile was indicative of the syndrome of Nonverbal Learning Disabilities (NLD) as proposed by Rourke (Rourke 1987, 1988, 1995; Rourke & Tsatsanis, 1996). The results are discussed in light of Rourke's NLD Syndrome and the related white matter model.     

Cowden Syndrome

Cowden syndrome is an autosomal dominant inherited cancer syndrome characterized by multiple hamartomas which may develop in any organ. Mucocutaneous papillomas and trichilemmomas are hallmarks of the syndrome. Affected individuals are at high risk of developing both benign and malignant disease of the thyroid and breast. Epithelial thyroid carcinoma occurs in 3–10% of affected individuals while women have a 25–50% lifetime risk of developing adenocarcinoma of the breast. Because of the cancer risk, it is imperative that health care providers recognize Cowden syndrome. The susceptibility gene has been localized to 10q22-23 and preliminary studies demonstrate no genetic heterogeneity.     

从中医症、证、病的概念谈辨证与辨病的关系

中医学中的症、证、病是三个不同的概念,症是人体在疾病状态下发出的每一个信息;证是疾病在瞬间的症状总和,是信息群;而病是症状和证候的主体,是一种状态,也是一个过程.只有辨证是不够的,辨证的同时应追求辨病,将辨证与辨病结合起来,在明确疾病诊断的前提下,辨证才是比较准确的.     

神经内分泌系统与多囊卵巢综合征

精神、心理因素会引起神经递质的改变,神经递质的变化又能引起促性腺激素的分泌异常,以神经递质作为桥梁,研究精神、心理因素与多囊卵巢综合征(PCOS)的关系。精神、心理因素使体内多巴胺、去甲肾上腺素、β-内啡肽及5-羟色胺的含量变化,从而影响促性腺激素释放激素及黄体生成素的水平。因此,精神、心理因素是PCOS的重要诱因,而PCOS又加重心理障碍。     

神经内分泌系统与多囊卵巢综合征

精神、心理因素会引起神经递质的改变,神经递质的变化又能引起促性腺激素的分泌异常,以神经递质作为桥梁,研究精神、心理因素与多囊卵巢综合征(PCOS)的关系.精神、心理因素使体内多巴胺、去甲肾上腺素、β-内啡肽及5-羟色胺的含量变化,从而影响促性腺激素释放激素及黄体生成素的水平.因此,精神、心理因素是PCOS的重要诱因,而PCOS又加重心理障碍.