The effects of vicarious experience and stimulus intensity on pain termination and work avoidance

The purpose of the present investigation was to evaluate the role of vicarious experience in the acquisition of pain termination and work avoidance. Fifty-six experimental subjects were randomly assigned to view a film of a model who either terminated exposure to a pain stimulus and work task after 10 sec (high-avoidant) or 70 sec (low-avoidant). Following the film presentation, subjects were exposed to the pain stimulus and work task. Half of the subjects were randomly chosen to perform the task with a low-intensity pain stimulus (LP) and the other half performed the task while exposed to a high-intensity pain stimulus (HP). The results indicated that subjects in the high-avoidant model conditions (HA) did significantly less work and tolerated the pain stimulus for significantly fewer seconds compared to the low-avoidant model groups (LA). Subjects in the LP groups tolerated the pain stimulus significantly longer and did significantly more work compared to subjects in the HP groups. No significant interaction was observed. The results provide support for the hypothesis that behavioral reactions to pain can be acquired by vicarious experience. Implications for future research are discussed.     

An animal analogue to systematic desensitization and elimination of avoidance

Rats first acquired a two-way avoidance response to a discrete warning signal (80 db white noise.) The effects of 3 experimental and 3 control treatments on elimination of the response were evaluated on a nonshock posttreatment extinction test. Group Systematic Desensitization (SD) received graded exposure to the warning signal while they were eating. Rats in Graded Hierarchy (GH) and Extinction (Ext) groups were yoked to Ss in the SD group such that GH and Ext treatment was identical with that of SD except that neither group ate and the Ext group was exposed to the full intensity warning signal (nongraded exposure) on all trials. None of the control groups was exposed to the warning signal between acquisition and the posttreatment test. Results indicated that SD, while interfering with avoidance during treatment, did not differ in effectiveness from control treatment and was significantly less effective than GH and Ext, when avoidance was tested in extinction. It was suggested that the present analogue SD technique impaired S's reception of (exposure to) the warning signal during treatment.     

Perseverative effects of parabrachial lesions: a mechanism of reduced activation?

The acquisition of a spatial reversal task and two reversals of it and the acquisition of an active two-way avoidance task were tested in three groups of male Sprague-Dawley rats: two experimental and one control group. The experimental group received chemical lesions of the parabrachial nuclei (group NPB) or of the dorsal hippocampus (group HC), using ibotenic acid. (Ibotenic acid is a compound which, contrary to kainic acid, fails to produce distant lesions, but, in conformity with kainic acid, spares the majority if not all fibers of passage.) The control group (group CG) received injections of the vehicle solution only. Animals of group NPB, in comparison to those of the other two groups, acquired the reversal task more quickly, but in the acquisition of its two reversals they needed considerably more time and made more perseverative errors. Likewise, only group NPB was significantly impaired in the acquisition of the avoidance task. From these results and from available evidence on connections of the parabrachial neurons with regions specifically involved in variables of the tested tasks (such as the prefrontal cortex), it is concluded that the parabrachial region exerts an activating influence on forebrain areas.     

Pavlovian phenomena in conditioned acceleration—Stimulus summation

Four naive male rats were separately fear-conditioned to two stimuli (light and sound) by pairing these stimuli with shocks. During Sidman avoidance these unreinforced stimuli elicited increases in response rates (conditioned acceleration). In a multiple schedule with light-shock and sound-shock reinforcements in the first component, the rats were tested for summation effects in the second (avoidance) component by presenting the light twice, the sound twice and the compound twice. They were then extinguished by eliminating the shocks in the first component. The effects of compounding were evidenced by: (1) a sizeable and reliable amplitude increase to the compound stimulus during conditioning; (2) a smaller and less consistent decrease in latencies during conditioning in all four subjects; and (3) a greater resistance to extinction for the compound stimulus as measured by mean amplitudes for all four subjects and on six of seven extinction sessions. Latency data during extinction were inconclusive. An additional unexpected finding was what appeared to be a two-factor secondary extinction of the avoidance itself as a result of Pavlovian extinction. The responding in the first four minutes of avoidance was inhibited to such an extent that the number of shocks received during this period increased 700 per cent from the last three conditioning sessions to the first three extinction sessions.     

Extinction of responding maintained by timeout from avoidance

The resistance to extinction of lever pressing maintained by timeout from avoidance was examined. Rats were trained under a concurrent schedule in which responses on one lever postponed shock on a free-operant avoidance (Sidman) schedule (response-shock interval = 30 s) and responses on another lever produced 2 min of signaled timeout from avoidance on a variable-ratio 15 schedule. Following extended training (106 to 363 2-hr sessions), two experiments were conducted. In Experiment 1 two different methods of extinction were compared. In one session, all shocks were omitted, and there was some weakening of avoidance but little change in timeout responding. In another session, responding on the timeout lever was ineffective, and under these conditions timeout responding showed rapid extinction. The within-session patterns produced by extinction manipulations were different than the effects of drugs such as morphine, which also reduces timeout responding. In Experiment 2 shock was omitted for many consecutive sessions. Response rates on the avoidance lever declined relatively rapidly, with noticeable reductions within 5 to 10 sessions. Extinction of the timeout lever response was much slower than extinction of avoidance in all 4 rats, and 2 rats continued responding at baseline levels for more than 20 extinction sessions. These results show that lever pressing maintained by negative reinforcement can be highly resistant to extinction. The persistence of responding on the timeout lever after avoidance extinction is not readily explained by current theories.     

Covert neuromuscular activity of the dominant forearm during visualization of a motor task

This study evaluated specific covert neuromuscular activity during a silent visualization exercise. 30 subjects participated in a dual-baseline single-subject procedure. The experimental test condition required the subjects to visualize themselves squeezing a hand-size rubber ball as tightly as possible for 1 min. In the comparison test condition, subjects were asked to imagine the 'sun setting on the horizon' for 1 min. Visualization of the motor task brought about significant (p <.05) increases in dominant forearm EMG (microV) and heart-rate activity (bpm) from rest to the experimental test condition. Nondominant forearm activity showed no significant changes from rest to either test condition, and heart-rate activity (bpm) showed no significant change from rest to the comparison visualization task.     

Extinction of avoidance in rats: response availability and stimulus presentation effects

A conditioned a versive stimulus presented in prolonged, continuous fashion is said to be flooded. Using a two-way shuttle avoidance task. Polin (1959) found that animals allowed to respond to flooded stimuli extinguish faster than animals prevented from responding to discrete stimuli of equal total duration. But, as Shearman (1970) noted, the CS presentation and response availability factors were confounded. He arranged them factorially, in a 2 × 2 design, again utilizing two-way avoidance, but found no differences between any of the experimental groups, although all groups extinguished faster than a regular extinction control group, the only group for which CS termination was response-contingent. Since there is evidence from one-way avoidance studies that response prevention facilitates extinction of avoidance with CS exposure held constant (Shipley et al., 1971). we repeated the Shearman design, using a one-way avoidance paradigm, and including a group for whom the aversive CS would be presented in discrete trials at increasing intensities. A separate aspect of the present investigation concerned the measurement of a fear response as well as the avoidance response. Results of several investigations have shown (e.g. Coulter et al. 1969; Linton et al.. 1970) that avoidance behaviour can be extinguished without the extinction of fear. It was thought useful to assess the generality of this result, since in two-factor theory, fear and avoidance are related.Two supplementary experiments replicated important conditions of the initial one, while examining whether response prevention and response non-availability have similar effects (II), and the relation between the fear test and the test for extinction (III).     

Interhemispheric transfer of extinction of the active avoidance reaction in rats.

Cortical spreading depression (CSD) was employed in rats to study the lateralization of extinction of a jumping avoidance reaction. Under unilateral CSD, 181 nonreinforced trials were needed to extinguish the avoidance reaction acquired in three 100-trial sessions of intact-brain training. During a second extinction session, either with the same or with the contralateral hemisphere depressed, the mean number of trials to the extinction criterion (9/10) was 39 (n = 12) or 186 (n = 15), respectively. Five extinction trials performed with the brain intact 1 hr before extinction with contralateral CSD decreased the number of trials to extinction of 98 (n = 11). Thus, extinction of active avoidance can be lateralized and interhemispherically transferred in the same way as acquisition of this habit.     

Prior exposure to inescapable electric shock in rats affects extinction behavior after the successful acquisition of an escape response

In Expt 1, rats exposed to 64 inescapable electric shocks in a restrainer or merely restrained were later given either 0, 5, 15 or 30 escape/avoidance training trials with a two-way shuttlebox procedure that does not lead to interference with escape acquisition due to prior exposure to inescapable shock. After escape training all rats were given an escape/avoidance extinction procedure in which shock was inescapable. The rats which had received prior exposure to inescapable shock responded less often and with longer latencies in extinction than did the restrained rats. Experiment 2 demonstrated that this effect is caused by the inescapability of the initial shock treatment. These results were explained in terms of (a) associative interference which minimized the effect of shuttlebox escape training for the preshocked subjects, and (b) a stronger tendency to recognize the presence of an inescapable shock situation during extinction for the preshocked subjects. The relationship between these results and previous work demonstrating that exposure to the escape contingency mitigates the effects of inescapable shock exposure was also discussed.     

Pavlovian processes and response competition as determinants of avoidance response-prevention effects

Two experiments investigated the facilitation of avoidance extinction by exposure to lengthy (5-sec) shock during avoidance response prevention. In Experiment 1, animals exposed to light only or to light-shock pairings during response prevention showed equal facilitation of extinction relative to shock-only animals or to animals receiving no response prevention. Preshock rearing, directly antagonistic to the avoidance response, developed for shocked animals during response prevention and persisted during extinction for light-shock animals. Immediately before extinction, half of each group was permitted a single escape from a light-shock compound by means of the response previously required for avoidance. The only effect was upon the extinction performance of light-shock animals. Rearing was eliminated and extinction responding increased to a level far above that for any of the other animals. Experiment 2 demonstrated that the shock-only treatment affected the extinction performance and rearing of nonescape and escape animals in a manner entirely equivalent to the effects of the light-shock treatment of Experiment 1, provided stimulus conditions (light absent) were the same for all experimental phases. Thus, lengthy shock during avoidance response prevention simultaneously leads to the acquisition of competing behavior and enhances control by a warning signal or contextual stimuli over the avoidance response. Implications for the CS-only response-prevention treatment and the transfer of aversive control are discussed.     

Exploration and avoidance in rats with lesions in amygdala and piriform cortex

Lesions localized to specific areas of the amygdala and overlying cortex in rats produced differential effects in several behavioral tasks. Three different types of lesions were tested: central, basolateral, and cortex lateral to the amygdala. Lesions restricted to the central nucleus produced increased activity on all parameters studied in an open-field test, but the other two groups were not changed. In one-way active avoidance all three groups with lesions showed deficits. The most pronounced change was observed in the central group. All groups showed the same degree of retention loss, but in forced extinction of one-way active avoidance after retraining, the cortical and basolateral groups were most defective. A fear-reduction hypothesis is proposed for the central lesion. The basolateral and cortical areas may be more specifically involved in passive avoidance behavior.     

Nonaware classical conditioning to pictorial facial stimuli in a between-groups paradigm.

The present experiment investigated the effects of aware and nonaware modes of extinction in classical conditioning to facial emotional stimuli. The subjects participated in three different experimental phases. In the first (habituation) phase they were presented with a 500 ms angry face. In the second (acquisition) phase, for half of the subjects the 500 ms face was paired with an aversive noise (experimental group) while for the other half of the subjects the face and the noise presentations were separated by 6-10 s intervals (sensitization control group). In the third (extinction) phase, these two groups were further divided into two subgroups. One subgroup of both the experimental and control group had the face stimulus presented for 30 ms, and immediately masked with a neutral picture. The other two subgroups had the face presented for 500 ms with no mask. The results showed that conditioning only occurred in the experimental subgroups which was indicated by a significant difference between skin conductance responses during habituation and corresponding responses during extinction. Secondly, comparing the experimental and control groups during the extinction phase, a significant conditioning effect was observed for both the aware and nonaware masked modes of extinction for the experimental group. The results suggest that conditioned autonomic responses may be elicited in a nonaware mode.     

Nonaware classical conditioning to pictorial facial stimuli in a between-groups paradigm

The present experiment investigated the effects of aware and nonaware modes of extinction in classical conditioning to facial emotional stimuli. The subjects participated in three different experimental phases. In the first (habituation) phase they were presented with a 500 ms angry face. In the second (acquisition) phase, for half of the subjects the 500 ms face was paired with an aversive noise (experimental group) while for the other half of the subjects the face and the noise presentations were separated by 6–10 s intervals (sensitization control group). In the third (extinction) phase, these two groups were further divided into two subgroups. One subgroup of both the experimental and control group had the face stimulus presented for 30 ms, and immediately masked with a neutral picture. The other two subgroups had the face presented for 500 ms with no mask. The results showed that conditioning only occurred in the experimental subgroups which was indicated by a significant difference between skin conductance responses during habituation and corresponding responses during extinction. Secondly, comparing the experimental and control groups during the extinction phase, a significant conditioning effect was observed for both the aware and nonaware masked modes of extinction for the experimental group. The results suggest that conditioned autonomic responses may be elicited in a nonaware mode.     

Submovement Organization,Pen Pressure,and Muscle Activity Are Modulated to Precision Demands in 2D Tracking

The authors investigated how tracking performance, submovement organization, pen pressure and muscle activity in forearm and shoulder muscles were affected by target size in a 2D tracking task performed with a pen on a digitizer tablet. Twenty-six subjects took part in an experiment, in which either a small dot or a large dot was tracked, while it moved quasirandomly across a computer screen at a constant velocity of 2 cm/s. The manipulation of precision level was successful, because mean distance to target and the standard deviation of this distance were significantly smaller with the small target than with the large target. With a small target, subjects trailed more behind the center of target and used submovements with larger amplitudes and of shorter duration, resulting in higher tracking accuracy. This change in submovement organization was accompanied by higher pen pressure, while at the same time muscle activity in the forearm extensors and flexors was increased, indicating higher endpoint stability. In conclusion, increased precision demands were accommodated by both a different organization of submovements and higher endpoint stability in a 2D tracking task performed with a pen on a digitizer tablet.     

Using drugs to modify the effect of response prevention on avoidance extinction

Amobarbital and chlordiazepoxide were administered during avoidance response prevention and the effect evaluated in the nondrugged state in a subsequent test for avoidance extinction. It was found that Ss administered 15 mg/kg and 30 mg/kg amobarbital, and 30 mg/kg chlordiazepoxide during response prevention differed significantly from the control Ss in extinction performance. Rather than showing either reduced avoidance performance or no difference with the nondrugged Ss, the Ss drugged during response prevention showed increased avoidance performance in the subsequent test of avoidance extinction. That is, preventing avoidance responding under a drugged (versus nondrugged) state produced increased resistance to extinction of the avoidance response.     

Locus of control and the effects of success and failure in young and community-residing aged women1

A study was conducted to examine reactions to success and failure in young and elderly subjects. Young and aged women, previously classified as internals or externals according to scores on a version of Rotter's (1966) Locus of Control Scale, were asked to work on cognitive problems while listening to bursts of noise. Two experimental conditions were created. One group (perceived success) was led to believe they were successfully avoiding bursts of noise by correctly solving the problems. A second group (perceived failure) believed they were unsuccessful at the problems and not avoiding noises. To test the generality of the effects of the treatments, subsequent performance was assessed on first, a similar task administered by the original experimenter, and secondly, on a dissimilar task given by a different experimenter in another setting. Results on a similar task indicated that subjects showed poor performance following failure regardless of age or locus of control classification. However, internals performed better than externals after both success and failure treatments. Testing the generality of these effects with a dissimilar task, results indicated that externals tended to perform somewhat more poorly after failure and internals somewhat better after failure. However, these I-E differences in reactions to success and failure were largely due to the elderly group, and old-externals showed the poorest performance after failure. The results were interpreted in terms of the particular importance of locus of control as a determinant of adaptability to stress in the elderly.     

Differential roles of hippocampal metabotropic glutamate receptors 1 and 5 in inhibitory avoidance learning

Group I metabotropic glutamate receptors (mGlu1 and 5) have been implicated in synaptic plasticity and learning and memory. However, much of our understanding of how these receptors in different brain regions contribute to distinct memory stages in different learning tasks remains incomplete. The present study investigated the effects of the mGlu5 receptor antagonist, 2-methyl-6-(phenylethynyl)-pyridine (MPEP), and mGlu1 receptor antagonist, (S)-(+)-alpha-amino-4-carboxy-2-methylbenzene-acetic acid (LY 367385) in the dorsal hippocampus on the consolidation and extinction of memory for inhibitory avoidance learning. Male, Sprague-Dawley rats were trained in a single-trial step-down inhibitory avoidance task. MPEP, LY 367385 or saline were infused bilaterally into the CA1 region immediately after training or immediately after the first retention test which was given 24h after training. Rats receiving MPEP (1.5 or 5.0 microg/side) or LY 367385 (0.7 or 2.0 microg/side) infusion exhibited a dose-dependent decrease in retention when tested 24h later. MPEP was ineffective while LY 367385 significantly attenuated extinction when injected after the first retention test using an extinction procedure. These findings indicate a selective participation of hippocampal group I mGlu receptors in memory processing in this task.     

Flexible attention deployment in threatening contexts: An instructed fear conditioning study

Factors leading humans to shift attention away from danger cues remain poorly understood. Two laboratory experiments reported here show that context interacts with learning experiences to shape attention avoidance of mild danger cues. The first experiment exposed 18 participants to contextual threat of electric shock. Attention allocation to mild danger cues was then assessed with the dot-probe task. Results showed that contextual threat caused subjects to avert attention from danger cues. In the second experiment, 36 participants were conditioned to the same contextual threat used in Experiment 1. These subjects then were randomly assigned to either an experimental group, trained to shift attention toward danger cues, or a placebo group exposed to the same stimuli without the training component. As in Experiment 1, contextual threat again caused attention allocation away from danger in the control group. However, this did not occur in the experimental group. These experiments show that acute contextual threat and learning experiences interact to shape the deployment of attention away from danger cues. (PsycINFO Database Record (c) 2012 APA, all rights reserved).     

Inhibitory stimulus control following errorless discrimination learning

Three generalization procedures were used to investigate inhibitory stimulus control following discrimination learning with few errors. Three groups of pigeons acquired a discrimination between a green stimulus (the positive stimulus) and a vertical or horizontal line (the negative stimulus) through differential autoshaping followed by multiple schedule presentation of the two stimuli with gradually increasing stimulus durations. Genereralization testing was along a line-tilt continuum. For one group, the test involved a resistance-to-reinforcement procedure in which responses to all line tilts were reinforced on a variable-interval schedule. For a second group, also tested with the resistance-to-reinforcement procedure, the lines were superimposed on the green field that formerly served as the positive stimulus. A third group was tested in extinction with the combined stimuli. Control groups had no discrimination training but responding to green was nondifferentially reinforced. The control subjects responded more to all line tilts during testing than did the comparable experimental subjects, indicating that the negative stimulus had become an inhibitory stimulus. Both resistance-to-reinforcement groups revealed inhibitory gradients around the negative stimulus, but the gradient for the extinction group was relatively flat. These data are consistent with others that modify Terrace's early conclusion concerning the failure of inhibition to develop during errorless training.     

Relative persistence of avoidance and positively reinforced behavior

In one experiment with rats, and a second with pigeons, subjects were trained on a schedule in which identical response dependencies applied to intermittent receipt of positive reinforcement (PR) for one group and avoidance (AV) of shock for a second group. After obtaining comparable stable training performance for groups PR and AV, persistence tests were conducted with a traditional extinction (EXT) procedure vs. response-independent (FREE) delivery of positive reinforcers or shocks. In both experiments, response elimination was rapid in EXT for groups PR and AV, and responding tended to be maintained in groups PR and AV in the FREE persistence test. These results contradict the widely held assumption that avoidance behavior is unusually resistant to extinction, and they call for a re-examination of elimination of avoidance responding.