Right-posterior face processing anomaly in depression

Evidence of a right-posterior brain anomaly was found in a study of 19 individuals with major depression and 15 controls. Participants performed a recognition-memory task involving positive, neutral, and negative face and word stimuli. Scalp brain wave topography suggested a region-specific anomaly in the depressed group. Individuals with major depression demonstrated a reduction in the N200 component of the event-related brain potential to faces and not words. Furthermore, results indicate that the regional anomaly is specific to positive facial stimuli. Findings are interpreted in light of a model of regional brain specialization in emotion and psychopathology.     

Automatic and effortful processing of self-statements in depression

Clark and Beck (1999) and Williams et al. (1997) have come up with quite different conclusions regarding which cognitive processes are most affected by negative self-schemata and negative knowledge structures. In order to increase the understanding of differences in effortful and automatic processing in depression, we compared never depressed (ND), previously depressed (PD) and clinically depressed (CD) individuals on free recall, recognition and fabrication of positive and negative self-statements. The results showed that: (i) overall NDs and PDs recalled more positive self-statements than CDs, whereas CDs correctly recognized more negative self-statements than NDs and PDs; and (ii) CDs and PDs fabricated more negative than positive self-statements, whereas no difference was obtained for NDs. The results seem to be in line with Clark and Beck's suggestions. However, there are several aspects of the present findings that make the picture more complicated.     

Factors affecting processing mode in visual search

Visual search was studied under a variety of conditions to clarify some differences among the results of previous investigations and to provide a testing ground for models of visual information processing. Display configuration, target and field composition, exposure duration, and display size (up to 16 elements) were among the parameters investigated. In some conditions, mean reaction time was essentially invariant with display size, while in other conditions it increased substantially and linearly with display size. Current models of visual information processing were evaluated in the light of these and previous findings; all were found wanting. The data seem to demand a system subject to flexible cognitive control processes.     

Information processing in patients with first episode major depression

Hammar, Å., Kildal, A. B. & Schmid, M. (2012). Information processing in patients with first episode major depression. Scandinavian Journal of Psychology 53, 445–449. Few studies have investigated cognitive functioning in a group of patients experiencing a first episode of depression. The aim of this study was to investigate how patients diagnosed with a first episode of depression perform in effortful and non‐effortful information processing compared to healthy controls. An experimental paradigm based on a visual search test was applied. Thirty‐one patients and thirty‐one healthy controls were included in the study. All patients experienced a severe level of symptom load at the time of testing. Results showed no significant differences between groups under any of the conditions. Findings in the present study indicate that patients with a first episode of depression perform equally to healthy controls in tasks requiring visual attention in both effortful and non‐effortful information processing.     

Effect of depression on processing interactions in group psychotherapy

Two studies were conducted to investigate the possibility of individual differences in the ability of inpatients to process interactions in group psychotherapy. The first was a pilot study conducted on groups of major depressive patients and matched normal subjects. Subjects were asked to give process comments after viewing simulations of typical group therapy interactions. These comments were later rated on the extent to which they reflected process qualities and accuracy. These data led to a more rigorous and extensive study that included more appropriate control groups as well as measures of potential confounding factors, such as simulation realism, verbal ability, and interaction comprehension. Results indicated that major depressives suffer from deficits in the ability to process group interactions, relative to three types of control groups, including normals. These differences in processing were not significantly positively correlated with any of the potential confounding factors. The implications for understanding interactional processing and group psychotherapy are discussed.     

Mood regulation in depression: Differential effects of distraction and recall of happy memories on sad mood

Recent research suggests that the recall of positive memories plays an important role in mood regulation. In this study, the authors examined the ability of currently depressed, formerly depressed, and never-depressed participants to regulate sad mood through the recall of positive memories or through distraction. Although improvement in mood was found for all participants in response to distraction, under instructions to recall positive memories, never-depressed participants' moods improved, whereas formerly depressed participants' sad moods remained unchanged. It is important to note that depressed participants exhibited a worsening of their sad moods after recalling positive memories. These results suggest both that depression is associated with an impaired ability to use positive recall to regulate a sad mood and that this impairment continues to be evident following recovery.     

Self-schemas,depression, and the processing of personal information in children

Recent research in information processing has yielded evidence supporting the self-as-schema model with adults. Further self-schema research with depressed and nondepressed persons has suggested the existence of negative self-schemas in depression, lending support to a content-specificity self-schema model. The present studies were designed to investigate the applicability of the self-as-schema model to children and to examine the extent of negative self-schemas in relatively depressed children. A depth-of-processing incidental recall memory paradigm was employed with two groups of normal third- to sixth-grade children. Results supported the self-as-schema model as applied to children, even the youngest group, by indicating superior recall for words encoded under self-reference instructions, compared to semantic or structural orienting instructions. The content-specificity hypotheses were tested with relatively depressed and nondepressed children, and were supported only for the nondepressed children, who recalled mostly positive content words. The relatively depressed children did not demonstrate content specificity in their recall, showing a more “confused” pattern, and the results were discussed in terms of a developmental model of acquisition of depression vulnerability requiring repeated depressive experiences over time. Although the results were consistent with a self-schema approach, current controversies over the implications of depth-of-processing methods require further research to clarify mechanisms of enhanced self-reference recall.     

Linking major depression and the neural substrates of associative processing

It has been proposed that mood correlates with the breadth of associative thinking. Here we set this hypothesis to the test in healthy and depressed individuals. Generating contextual associations engages a network of cortical regions including the parahippocampal cortex (PHC), retrosplenial complex, and medial prefrontal cortex. The link between mood, associative processing, and its underlying cortical infrastructure provides a promising avenue for elucidating the mechanisms underlying the cognitive impairments in major depressive disorder (MDD). The participants included 15 nonmedicated individuals with acute major depressive episodes and 15 healthy matched controls. In an fMRI experiment, participants viewed images of objects that were either strongly or weakly associated with a specific context (e.g., a beach chair vs. a water bottle) while rating the commonality of each object. Analyses were performed to examine the brain activation and structural differences between the groups. Consistent with our hypothesis, controls showed greater activation of the contextual associations network than did depressed participants. In addition, PHC structural volume was correlated with ruminative tendencies, and the volumes of the hippocampal subfields were significantly smaller in depressed participants. Surprisingly, depressed participants showed increased activity in the entorhinal cortex (ERC), as compared with controls. We integrated these findings within a mechanistic account linking mood and associative thinking and suggest directions for the future.     

Information processing and cognitive organization in unipolar depression: specificity and comorbidity issues

This study investigated information processing and cognitive organization in clinical depression. The specificity of various cognitive mechanisms to depression was also examined. Twenty-six depressed/anxious individuals, 24 pure depressives, 25 never-depressed anxious controls, and 25 nonpsychiatric controls completed a modified Stroop task, the Self-Referent Encoding Task, and two tasks designed to assess cognitive structure. Comorbid depressed/anxious, depressed, and anxious groups performed similarly to one another but differed significantly from nonpsychiatric controls, on the processing and organization of negative content. Specificity to depression was also obtained, as both depressed groups endorsed and recalled less positive information and organized positive self-relevant information with less interconnectedness than anxious individuals and nonpsychiatric controls. These results suggest that depressed individuals have an interconnected negative self-representational system and lack a well-organized positive template of self. These findings are discussed in terms of cognitive models of depression and the tripartite model of depression and anxiety.     

Mood and global-local focus: priming a local focus reverses the link between mood and global-local processing

Positive moods promote a focus on the forest (global focus) and negative moods, a focus on the trees (local focus). Is this well-established link fixed or variable? Does it reflect a direct influence of affect, as usually assumed, or is it frequently observed simply because a global perspective is often dominant? If affect serves as information about the value of currently accessible inclinations, and a global focus is generally the default perspective, then the global focus of positive affect and local focus of negative affect might be variable rather than fixed. Two experiments tested this hypothesis using different mood inductions, different tests of global-local focus, and different methods of inducing global and local perspectives. In each, we discovered that positive affect empowered whatever focus was momentarily dominant. Thus, whether individuals in happy moods saw the forest or the trees depended only on which of the two had been primed.     

Cognitive processing of emotional information in depression, panic, and somatoform disorder

Emotional Stroop tasks (subliminal/supraliminal exposures), implicit memory tasks (tachistoscopic word identification), and explicit memory tasks (free recall after incidental learning) with 4 word types (physical threat, positive, negative, and neutral words) were administered to patients with major depressive disorder (n=30), panic disorder (n=33), somatoform disorder (n=25), and healthy control participants (n=33). On the Stroop task, panic patients showed subliminal interferences for physical threat and negative words, depressive patients showed supraliminal interferences for negative words, and somatoform patients showed supraliminal interferences for physical threat words. No patient groups demonstrated implicit memory biases. On the explicit memory task, depressive and panic patients showed memory biases for negative words; somatoform patients showed biases for physical threat words.     

Temporal Changes in Mood Repair Through Music Consumption: Effects of Mood,Mood Salience,and Individual Differences

Prior research on mood management through media consumption has encountered mixed results. This study seeks to address these discrepancies by incorporating time of measurement into the examination of regulatory outcomes and by identifying trait-like cognitive moderators that presumably are involved in the regulation of negative moods. Results showed that sad mood initially fostered longer listening to mood-compatible music but such preference decreased over time, suggesting the merits of considering temporal changes in the mood-repair process. In addition, ruminative trait was found to be a significant factor in how people cope with their sad moods, whereas mood salience was not.     

Priming the mental time-line: effects of modality and processing mode

The notion of a mental time-line (i.e., past corresponds to left and future corresponds to right) supports the conceptual metaphor view assuming that abstract concepts like “time” are grounded in cognitively more accessible concepts like “space.” In five experiments, we further investigated the relationship between temporal and spatial representations and examined whether or not the spatial correspondents of time are unintentionally activated. We employed a priming paradigm, in which visual or auditory prime words (i.e., temporal adverbs such as yesterday, tomorrow) preceded a colored square. In all experiments, participants discriminated the color of this square by responding with the left or the right hand. Although the temporal reference of the priming adverb was task irrelevant in Experiment 1, visually presented primes facilitated responses to the square in correspondence with the direction of the mental time-line. This priming effect was absent in Experiments 2, 3, and 5, in which the primes were presented auditorily and the temporal reference of the words could be ignored. The effect, however, emerged when attention was oriented to the temporal content of the auditory prime words in Experiment 4. The results suggest that task demands differentially modulate the activation of the mental time-line within the visual and auditory modality and support a flexible association between conceptual codes.     

Biased processing of emotional information in girls at risk for depression

Researchers have documented that children of depressed mothers are at elevated risk for developing a depressive disorder themselves. There is currently little understanding, however, of what factors place these children at elevated risk. In the present study, the authors investigated whether never-disordered daughters whose mothers have experienced recurrent episodes of depression during their daughters' lifetime are characterized by biased processing of emotional information. Following a negative mood induction, participants completed an emotional-faces dot-probe task. Daughters at elevated risk for depression, but not control daughters of never-disordered mothers, selectively attended to negative facial expressions. In contrast, only control daughters selectively attended to positive facial expressions. These results provide support for cognitive vulnerability models of depression.     

Variables influencing the mode of processing of complex stimuli

The present study attempts to specify some of the conditions under which parallel and serial processing may occur. The three variables studied were (1) type of task, (2) relative set for speed vs accuracy, and (3) practice. Pairs of multidimensional, geometric stimuli were presented either simultaneously or successively to S who was required to indicate whether they were the same or different. Each S participated in nine sessions. For half of the Ss speed was emphasized, and for the other half accuracy was emphasized. The results indicated that: (1) responses were faster with successive presentation than with simultaneous presentation; (2) with successive presentation, processing was serial; (3) in the simultaneous presentation condition, a gradual shift from serial to parallel processing occurred with practice; and (4) the speed and accuracy instructions used in this experiment produced no differential effects on latency or errors.     

Facial affect processing and depression susceptibility: cognitive biases and cognitive neuroscience

Facial affect processing is essential to social development and functioning and is particularly relevant to models of depression. Although cognitive and interpersonal theories have long described different pathways to depression, cognitive-interpersonal and evolutionary social risk models of depression focus on the interrelation of interpersonal experience, cognition, and social behavior. We therefore review the burgeoning depressive facial affect processing literature and examine its potential for integrating disciplines, theories, and research. In particular, we evaluate studies in which information processing or cognitive neuroscience paradigms were used to assess facial affect processing in depressed and depression-susceptible populations. Most studies have assessed and supported cognitive models. This research suggests that depressed and depression-vulnerable groups show abnormal facial affect interpretation, attention, and memory, although findings vary based on depression severity, comorbid anxiety, or length of time faces are viewed. Facial affect processing biases appear to correspond with distinct neural activity patterns and increased depressive emotion and thought. Biases typically emerge in depressed moods but are occasionally found in the absence of such moods. Indirect evidence suggests that childhood neglect might cultivate abnormal facial affect processing, which can impede social functioning in ways consistent with cognitive-interpersonal and interpersonal models. However, reviewed studies provide mixed support for the social risk model prediction that depressive states prompt cognitive hypervigilance to social threat information. We recommend prospective interdisciplinary research examining whether facial affect processing abnormalities promote-or are promoted by-depressogenic attachment experiences, negative thinking, and social dysfunction.