血脂异常类型与摄食抑制因子-1、脂联素、瘦素的相关性研究

分析不同类型的高脂血症患者血清摄食抑制因子-1(NSF-1)、脂联素(ADP)、瘦素(LEP)水平的变化并探讨它们在脂代谢中的作用。纳入高胆固醇血症组87例,高甘油三酯血症组124例,混合型高脂血症组145例,低高密度脂蛋白血症组29例,健康对照组100例。比较五组临床参数的差异,分析血清NSF-1、ADP、LEP与甘油三酯(TG)、胆固醇(TC)等血脂组分的相关性。结果除低高密度脂蛋白血症组以外血脂异常类型各组的血清NSF-1、LEP水平均显著高于正常对照组;血脂异常各组的血清ADP水平均显著低于健康对照组;NSF-1与TC、TG、低密度脂蛋白胆固醇(LDL-C)呈正相关,与高密度脂蛋白胆固醇(HDL-C)呈负相关;ADP与TG、LDL-C呈负相关,与HDL-C呈正相关。LEP与TC、LDLC呈正相关;TG是NSF-1和ADP的独立影响因素,TC是LEP的独立影响因素。NSF-1、ADP、LEP共同参与脂代谢的调节,在高脂血症的发展进程中起着重要作用。     

正念训练的去自动化效应：Stroop和前瞻记忆任务证据

研究显示正念训练对心理认知和健康有改善作用, 但少有研究用认知实验进行检验并探讨心理机制, 本研究将正常成人分为正念(训练)和对照组(等待)、使用Stroop任务和前瞻记忆任务, 进行前、后测考察。结果发现, 两种任务正念组后测反应时均低于前测, 且不一致条件下更显著, 对照组无差异。对前瞻记忆前后进行中任务的差值进行前、后测比较发现, 对照组后测显著小于前测, 正念组差异不显著。结果表明, 正念训练促进了Stroop和前瞻记忆任务的完成, 起到了抗自动化干扰、及阻止随任务熟悉加工更为自动化的作用。     

缺血性脑血管病患者的记忆障碍与脑脊液(CSF)中三种神经肽关系的研究

本实验对9例缺血性脑血管病(ICVD)患者及9例正常健康对照者及对照者进行了临床记忆量表检查,并测定了患者及对照者的脑脊液(CSF)中P物质(SP)、血管活性肠肽(VIF)及生长抑素(SS)含量。结果:(1)ICVD患者的记忆总分及记忆商(MQ)均显著低于正常健康对照组及对照组;分项测试中亦有降低趋势,且其中联想学习成绩的降低达显著性。(2)ICVD患者CSFSS含量显著低于对照组。(3)ICVD患者CSFSS含量与其MQ是显著正相关。本结果提示ICVD患者有不同程度的记忆障碍,测定CSFSS对患者记忆状况的判断有一定的参考价值。     

BrainHQ视觉训练对脑卒中患者行为记忆功能康复的作用

探讨BrainHQ视觉训练对脑卒中患者记忆功能的康复有效性。选取唐山市康复医疗中心住院脑卒中患者80例,随机分为干预组和对照组各40例。对照组进行常规康复训练,干预组在对照组基础上加用BrainHQ视觉训练,于干预前、后采用行为记忆测验第二版(RBMT-Ⅱ)对两组患者进行测评。干预后干预组在回忆姓名、回忆被藏物品、回忆预约、脸部再认、立即回忆故事、故事延迟回忆、日期、立即回忆路线、路线延迟回忆、信息延迟回忆及总标准分共11项较对照组评分显著提高,有统计学意义(P0.05)。BrainHQ视觉训练可改善脑卒中患者的行为记忆功能。     

左丘脑出血与遗忘

经CT证实的左和右丘脑出血各9例,及18例无脑器质性病灶者,以临床记忆量表、临床失语检查法和视空间功能检查法进行检查。所有被检者均无失语和视空间功能障碍。记忆量表检查结果表明左丘脑出血组记忆量表的各分项值和记忆商明显低于对照组,而右侧丘脑出血组与对照组无显著差异,这提示左丘脑病变可导致和遗留长期遗忘。     

糖尿病伴发脑卒中病例临床特点分析

探讨2型糖尿病患者伴发脑卒中的发生率及相关危险因素,采用头CT扫描,化验血糖、胆固醇、甘油三酯、高密度脂蛋白、纤维蛋白原。对我院自2005年7月-2007年7月间收治的2型糖尿病合并脑卒中患者与非糖尿病发生脑卒中患者进行比较分析。200例患者中糖尿病88例,患病率44％,两组患者比较糖尿病并发脑卒中发生多灶性梗死（P〈0．01）,血流变学分析（P〈0．01）其差异有统计学意义。糖尿病合并脑卒中的患者与多种危险因素有关,必须及早控制,防止脑卒中发生、发展,减少致残率。     

Alzheimer病人记忆损害特征的研究

目的了解AD病人记忆损害的特征。方法采用多维记忆评估量表中的12个分测验对30例临床诊断可能的Alzheimer病患者及与病人组相匹配的30例正常受试进行记忆功能的测定。结果AD组几乎在所有的分测验和指数分上均差于对照组。AD轻度组仅在自由组词、残图命名、空间广度、常识记忆等4个分测验及记忆广度、内隐记忆等2个指数分上与对照组之间无明显差异。中重度组则在所有分测验和指数分均差于对照组。经以教育年限为协变量校正后,轻度与中重度组在自由组词、残图命名、经历定向、常识记忆、自由回忆、内隐记忆、日常记忆等分测验和指数分上存在明显差异。12个分测验成绩的比较发现,负荷外显记忆的各个分测验的成绩均较差,负荷内隐记忆的两个分测验的成绩较好。结论轻度AD病人存在着广泛的外显记忆障碍,中重度AD病人除了存在外显记忆障碍外还表现出内隐记忆和日常生括记忆的障碍。这一结果提示人类大脑中存在着多个记忆系统,不同系统受损所导致的记忆障碍不同。     

伴家族史的2型糖尿病危险因素的病例对照研究

为探讨2型糖尿病代谢特征及发病的危险因素,选取大连地区91例有家族史的T2DM患者为病例组,以44例患者的配偶（糖耐量正常）为对照组,进行流行病学问卷调查和体格检查,同时测定空腹血糖、空腹胰岛素、总胆固醇、甘油三酯、高密度脂蛋白、低密度脂蛋白等指标,采用稳态模型法计算两组的胰岛素抵抗指数和β细胞功能指数,并进行多因素非条件Logistic回归分析。结果显示：TG、腰臀比和Ln（HOMAIR）病例组高于对照组,而Ln（HOMAβ）则病例组低于对照组,均具有统计学意义（P〈0．05）。多因素非条件Logistic回归分析结果提示,影响T2DM发病的因素有心血管疾病史、Ln（HOMAIR）及Ln（HOMAβ）。由此可见T2DM患者存在血脂代谢异常;心血管疾病史和Ln（HOMAIR）为发病的危险因素,Ln（HOMAβ）为保护因素。     

家属参与授权教育对老年原发性高血压伴同型半胱氨酸血症患者管理中的应用

探讨家属参与授权教育对老年原发性高血压伴同型半胱氨酸血症患者的干预效果.选取120名老年原发性高血压伴同型半胱氨酸血症患者,随机分成试验组和对照组,每组60名,两组均采取相同的药物治疗,给予常规的授权教育模式.试验组在此基础上给予家属参与授权教育模式,为期6个月.试验组与对照组比较,总胆固醇（TC）、甘油三脂（TG）、高密度脂蛋白胆固醇（HDL-C）、低密度脂蛋白胆固醇（LDL-C）、同型半胱氨酸（Hcy）及血压值低于对照组,差异有统计学意义（P＜0.05）;试验组的生存质量及满意度评分均高于对照组,两组差异有统计学意义（P＜0.05）.经过为期6个月的健康教育干预,这一模式取得了较好的效果.     

中国林县帕金森病患者非运动症状调查

调查中国林县PD患者非运动症状发生状况.对中国林县PD患者和对照人群进行痴呆诊断、运动功能损害评估及其他非运动症状,包括便秘、抑郁、焦虑、睡眠评估.PD患者MMSE平均分为19 (15.00～22.50)分,正常对照人群MMSE平均分21(17.25～24.00)分.两组人群时间定向和MMSE总分两组比较P＜0.05,差异有统计学意义.PD患者抑郁自评分数平均为(39.43士7.95)分,正常对照人群平均分数为(33.34±9.36)分,两组之间有显著差异(P＜0.05).PD患者焦虑患病率(43.3％),与对照人群间差异不显著.38.81％PD患者便秘,与对照组之间差异不显著.PD患者常见非运动症状,以认知功能损害、抑郁、焦虑、便秘为主要表现.     

Neuropsychological functioning among the nonpsychotic relatives of schizophrenic patients: a 4-year follow-up study

In a prior study of 54 relatives of patients with schizophrenia and 72 control participants, 3 neuropsychological functions met the criteria for risk indicators of the schizophrenia genotype: executive functioning, memory, and auditory attention. In an assessment of the stability of these findings, the sample was reexamined 4 years after the initial assessment. Three test scores were found to differ between groups (Immediate Verbal Memory, Delayed Verbal Memory, and Dichotic Listening Digits Detected) or to show a significant Group x Gender interaction (immediate and delayed verbal and visual memories). None of the test scores showed Group x Time interactions, suggesting that the discriminating power of the tests was stable over time. Evidence for deficits in working memory and rule learning on the object alternation test was also found. These results support the idea that neuropsychological dysfunction among relatives of patients with schizophrenia is a stable trait caused by the familial predisposition to schizophrenia.     

Exploratory study of the relations between spatial ability and drawing from memory

Test scores of 119 students, attending either a public four-year college or a technical school, were related to their proportionality and detail drawing scores on the Memory for Designs Test. In regression models, the ETS Maze Tracing, Eliot-Price Mental Rotations, and Bender-Gestalt tests were consistent predictors of proportionality scores, with the latter two tests uniquely related to these. The ETS Shapes Memory Test and the Form Board Test were the strongest predictors for detail accuracy scores. The Shapes test predicted proportionality when the CTY Visual Memory Test BB was excluded. The models then provided support for the hypothesis that drawing designs from memory, a critical skill in drawing, regardless of whether one focuses on accuracy for proportionality scores or for detail scores, is jointly related to the measures of recognition, production, and traditional spatial ability measures. This study identified multifaceted skills in drawing from memory.     

Parallel-form reliability of the Wechsler Memory Scale in a geriatric population with suspected dementia

The present study examined parallel-form reliability of the Wechsler Memory Scale (WMS) in a population where such forms are particularly useful, that is, among patients who are suspected of having some type of dementing illness. Comparative analyses were made for total raw scores. Memory Quotient (MQ) scores, and individual subtest scores. Thirty geriatric patients originally referred for neuropsychological testing because of suspected dementia were given both Forms 1 and 2 of the WMS. The results yielded high overall reliability coefficients for MQ and total raw scores. Individual subtest scores also yielded rather high coefficients, and only one subtest (Associate Learning) had a significant mean difference. Apparently, the two forms have sufficient parallel-form reliability to be considered clinically interchangeable. Thus, the WMS may be a useful tool for repeat evaluations of memory functioning in a demented population.     

Superior implicit memory: a pilot study

In this pilot study, implicit memory was examined in participants selected according to their scores on the Wechsler Memory Scale-Revised. Implicit memory was explored using a word-stem completion test after 24 participants had processed texts to be remembered. Variations in priming were observed among 12 Normal and 12 Good memorizers (Verbal Memory scores >110) following presentation of target words in the context of a coherent text. One intriguing result emerged: the magnitude of the priming effect varied by group, greater among Good memorizers than Normal memorizers.     

Defects of immediate memory related to the cerebral blood flow distribution

Different forms of memory defects were studied in 16 patients with organic dementia. The test performance was related to the regional cerebral blood flow (rCBF) in the left (dominant) hemisphere. Verbal memory (Paired Associates) correlated to the blood flow in temporal and parietal regions. Spatial recognition (Memory for Objects, Memory for Geometrical Design) correlated to the temporal and lower frontal regions. One spatial memory test (Visual Retention test) correlated to the temporal region only. Another spatial memory test (Memory for Design) did not show correlations to any regions of the dominant hemisphere. Finally it was found that the hemisphere mean flow values did not correlate to performance. This emphasizes the main finding—the regional correlations. It is concluded that memory performance involves various extratemporal regions depending upon the specific quality of the memory task to be performed.     

Widening the boundaries of the production effect

Words that are read aloud are more memorable than words that are read silently. The boundaries of this production effect (MacLeod, Gopie, Hourihan, Neary, & Ozubko, Journal of Experimental Psychology: Learning, Memory, and Cognition, 36, 671-685, 2010) have been found to extend beyond speech. MacLeod and colleagues demonstrated that mouthing also facilitates memory, leading them to speculate that any distinct, item-specific response should result in a production effect. In Experiment 1, we found support for this conjecture: Relative to silent reading, three unique productions-spelling, writing, and typing-all boosted explicit memory. In Experiment 2, we tested the sensitivity of the production effect. Although mouthing, writing, and whispering all improved explicit memory when compared to silent reading, these other production modalities were not as beneficial as speech. We argue that the enhanced distinctiveness of speech relative to other productions-and of other productions relative to silent reading-underlies this pattern of results.     

增龄性记忆改变规律及影响因素的研究

本研究用多维记忆量表对280名50～91岁的老年人做了测查,同时收集了一般资料,以探讨增龄性记忆改变的规律和年龄、教育和职业等因素对增龄性记忆改变的影响。结果表明：随年龄增长,各记忆组合分和分测验成绩均呈下降趋势,外显记忆成绩在70岁后呈快速下降,内隐记忆和日常生活记忆在75岁后才有明显下降;记忆总分、外显记忆和日常生活记忆均受年龄和教育的影响,内隐记忆不受教育的影响。结果提示老年人记忆随年龄增长呈渐渐下降,不同记忆功能开始下降的年龄和下降速率不同,教育对增龄性记忆改变有保护作用。     

Beliefs about Memory as a Mediator of Relations between Metacognitive Beliefs and Actual Memory Performance

The goal of the present study was to investigate relationships between personal beliefs about memory, metacognitive beliefs, and actual memory performance. One hundred thirty-seven participants' (aged 20 to 60 years) metacognitive beliefs were measured using the Metacognition Questionnaire (MCQ-30), memory beliefs were measured using the Personal Beliefs about Memory Instrument (PBMI), and an episodic memory task was used to measure actual memory performance, memory predictions, and postdictions. Younger adults had lower scores on the positive beliefs subfactor of the MCQ-30, higher scores on retrospective change and control subfactors of the PBMI, and outperformed middle-aged adults on recall and recall postdiction. Path analysis showed that individuals' beliefs about memory mediate the relationship between metacognitive beliefs and actual memory performance. Specifically, low lack of confidence (or less worry) in one's own memory and attentional capabilities was related to higher memory performance and positive personal beliefs regarding specific memory ability mediated relationship.     

Memory aberrations, transliminality, and delusional ideation

This study investigated the relationships between cognitive-perceptual personality dimensions (transliminality and delusional ideation) and self-report measures of memory error (Oblivion Scale and the Prospective and Retrospective Memory Questionnaire). 100 full- and part-time psychology undergraduate students completed the measures (18 men and 82 women; M = 19.3 yr., SD = 4.4). A positive correlation was found between transliminality and reported memory aberrations (Oblivion Scale scores) and also between transliminality and Prospective and Retrospective Memory Questionnaire scores. Correlations were positive between Peters, et al. Delusions Inventory and the self-report memory measures. Transliminality and Peters, et al. Delusions Inventory scores predicted the number of memory aberrations or slips reported on the Oblivion Scale and Prospective and Retrospective Memory Questionnaire. To explore whether transliminality explained additional variance to that accounted for by the Peters, et al. Delusions Inventory, forward regression was applied and showed aspects of transliminality not accounted for by Peters, et al. Delusions Inventory did not explain additional variance within the self-report memory measures.     

The Development and Validation of the Memory Support Treatment Provider Checklist

Patient memory for the contents of treatment is staggeringly poor, and poor memory for treatment is associated with worse treatment outcome. Accordingly, the Memory Support Intervention was developed to improve patient memory for treatment as an adjunct to treatment as usual. As plans to disseminate the Memory Support Intervention are developed, it is important to have efficient, accurate methods of measuring fidelity to the intervention. However, the existing method of assessing fidelity to the Memory Support Intervention, the Memory Support Rating Scale (MSRS), is burdensome and requires trained independent-raters to spend multiple hours reviewing session recordings, which is not feasible in many routine mental health care settings. Hence, a provider-rated measure of fidelity to the MSI has been developed. The goal of this study is to examine the reliability and validity of scores on this measure—the Memory Support Treatment Provider Checklist. A sample of Memory Support Treatment Provider Checklists (N = 319) were completed by providers (N = 8) treating adults with depression (N = 84). Three metrics of the Memory Support Treatment Provider Checklist were evaluated: (a) the internal consistency and structural validity using confirmatory factor analysis based on prior research on the MSRS and the Memory Support Intervention, (b) construct validity, and (c) predictive validity. Results indicate that the Memory Support Treatment Provider Checklist yields reliable and valid scores of fidelity to the Memory Support Intervention. Overall, this checklist offers a viable, brief method of evaluating fidelity to the Memory Support Intervention.