网络相关文字刺激和压力对网络成瘾者线索诱发渴求的影响

渴求感特别是线索诱发渴求是成瘾行为维持和戒断失败的主要原因。本研究通过两个实验分别探讨了网络相关文字刺激和压力对网络成瘾者线索诱发渴求的影响。研究一以25名网络成瘾大学生为被试,以网络相关和中性词语为实验材料,采用线索暴露范式（Cue-reactivity Paradigm）的研究发现,只有网络相关文字刺激能显著诱发网络成瘾者的渴求感。在此基础上,研究二以40名网络成瘾大学生为被试,以公开演讲范式为压力诱发情境,以网络相关词语和中性词语为实验材料,采用线索暴露范式（Cue-reactivity Paradigm）的研究发现,在压力条件下,网络相关文字能诱发网络成瘾者更为强烈的渴求感。本研究深化了对网络成瘾形成维持心理机制的研究,也为网络成瘾的干预矫正提供了思路。     

大学生网络成瘾：背景性渴求与同伴网络过度使用行为及态度的交互作用

基于整体-交互作用模型,选取北京市某高校所有大一学生2511名为被试开展问卷调查,考察了大学生网络使用背景性渴求的特点及其与网络成瘾之间的关系,并就网络使用背景性渴求与同伴网络过度使用行为与态度对网络成瘾的交互作用进行了检验。结果发现:(1)与非网络成瘾大学生相比,网络成瘾大学生的网络使用背景性渴求更高,所感知到的同伴网络过度使用行为更多,同伴对网络过度使用的态度更积极;(2)网络使用背景性渴求各维度、感知到的同伴网络过度使用行为可正向预测大学生的网络成瘾;(3)背景性渴求中的积极结果预期与同伴对网络过度使用的态度对网络成瘾存在显著的交互效应:在低积极结果预期条件下,同伴对网络过度使用的态度可以负向预测网络成瘾程度,而在高积极结果预期条件下,同伴态度对网络成瘾的预测作用不显著。结论:外因在内因比较微弱的条件下发挥更为明显的作用。     

镜像神经在药物心理渴求中的作用及机制

心理渴求是物质依赖者希望重新感受神经活性药物效应的渴望,其神经机制的早期影像研究,主要集中在前额皮质和奖赏中枢.镜像神经是新近发现的位于动作脑区,能理解、分析所观察动作的目的和性质,并通过内隐模拟,产生直接映射式的情绪和认知的神经.最新的研究发现尼古丁成瘾者在相关线索的刺激下,其镜像神经也能被激活.本研究旨在探索镜像神经参与相关线索下心理渴求形成的机制,为发展更可靠的依赖行为的生物学标记提供另一个重要目标,帮助人们更好地理解药物渴求形成的神经生物学基础与过程.     

大学新生网络使用时间与网络成瘾的关系：有中介的调节模型

通过整群取样的方法选取北京市某所高校2250名大一新生为测查对象, 采用问卷方式探讨了大学新生网络使用时间、网络社交使用占网络使用总时间的比重、网络使用的背景性渴求以及网络成瘾程度之间的关系。基于网络使用满足的相关理论以及渴求的条件反射理论, 本研究构建了一个有中介的调节模型, 即网络社交使用比重在网络使用时间与网络成瘾之间起调节作用, 而且这一调节作用通过网络使用的背景性渴求这一中介变量得以实现。结果显示：(1)大学新生每周上网时间为13.58 ± 8.94小时, 网络社交使用占全部上网时间的比重为27.18 ± 18.15%; (2)网络使用时间、网络社交使用比重、网络使用背景性渴求与网络成瘾的五个维度及总分呈显著正相关; (3)网络使用时间以及网络社交使用比重均能够直接正向预测网络成瘾, 同时网络社交比重在网络使用时间预测网络成瘾这一关系中起调节作用, 即相比较少使用网络社交的被试, 较多使用网络社交的群体表现出更高的网络成瘾程度, 且网络使用时间对网络成瘾程度的预测作用相对较低; 而且网络社交比重的调节作用部分通过网络使用的背景性渴求这一中介变量实现。     

大学生压力性生活事件与网络游戏成瘾的关系:一个有调节的中介模型

为探究大学生压力性生活事件与网络游戏成瘾的关系以及基本心理需要满足、领悟社会支持在二者关系中的作用,采用大学生网络游戏成瘾量表、青少年生活事件量表、中文版基本心理需要问卷和领悟社会支持量表,对617名大学生进行调查.结果发现,压力性生活事件与网络游戏成瘾显著正相关.基本心理需要满足在压力性生活事件与网络游戏成瘾之间起部...     

吸烟者对香烟相关线索注意偏向的研究述评

吸烟者对香烟相关线索的注意偏向近年来颇受研究界青睐,现有研究大都集中在吸烟者注意偏向的理论解释、研究范式、发生状况以及与吸烟成瘾的关系等方面。其中,在理论解释上形成了诱因敏感、自动行动图式、诱因习惯和目前关注等理论;在研究范式上主要有成瘾stroop任务、点探测任务和线索调控的惊跳测试;在发生状况上涉及发生的被试特征、发生的意识状态、发生的注意阶段、发生的生化基础;在与吸烟成瘾的关系上包括与主观渴求和与觅烟行为的关系。鉴于目前研究所限,未来研究需纳入线索-靶子等研究范式,以深入探讨吸烟者注意偏向的发生阶段及其与吸烟成瘾的关系,进而发现吸烟者注意偏向的特异性之所在。     

冲动性对不同成瘾行为发展的调控及其神经机制

近年来越来越多的研究证据提示, 个体冲动性在成瘾疾患发生发展机制中具有关键作用, 可能成为成瘾行为的潜在易感标记以及早期识别和干预的重要靶点, 但冲动性对不同成瘾行为变化发展的调控机制尚不明确。项目拟综合跨成瘾谱系比较、纵向追踪设计、冲动行为干预等研究途径, 采用人格测量、神经认知、神经影像等技术, 首先比较尼古丁依赖者与网络游戏成瘾者的冲动性结构及其在前额叶–纹状体环路的结构功能改变; 然后采用混合分组设计筛选出具有高低冲动性的非成瘾青少年进行连续追踪研究, 考察冲动性对尼古丁依赖与网络游戏成瘾的预测效力; 并采用认知行为训练, 对吸烟成瘾者与网络游戏成瘾者进行冲动干预, 考察行为干预对冲动性水平及前额叶–纹状体环路功能的改变, 以及对不同成瘾行为发展的抑制后效。旨在探索冲动性作为成瘾的潜在易感标记及干预靶点的效力。     

负性生活事件对大学生抑郁的影响：网络成瘾的中介与5-HTR1A基因rs749098多态性的调节作用

基于抑郁的基因-环境研究范式,以301名大学生为研究对象,探究负性生活事件对大学生抑郁的影响及作用机制。结果表明：(1)负性生活事件、网络成瘾与大学生抑郁两两显著相关;(2)网络成瘾在负性生活事件对大学生抑郁的影响中起部分中介作用;(3) 5-HTR1A基因rs749098多态性在该中介模型的直接路径和中介后半段起调节效应,具体表现为,相比携带C/G和G/G基因型个体,C/C基因型个体负性生活事件对抑郁的负向预测更强,且携带C/C基因型的个体,即使是低水平的网络成瘾的都表现出更高的抑郁情况,而在高水平的网络成瘾的情况下三种基因型都表现出高水平的抑郁。     

模糊决策的认知神经机制

模糊决策是特殊、复杂的风险决策, 还是一种独立的决策类型, 是当前认知神经科学争论的热点问题。一系列的fMRI研究分别得出了不同结论, 但大多数证据支持模糊决策和风险决策之间存在分离, 模糊决策有其独特的决策机制; 模糊决策的认知神经机制也是一个亟待解决的问题。因此本研究拟应用事件相关电位技术、生物反馈技术和基因技术, 采用IGT和GDT任务范式, 通过网络成瘾人群和正常人群的对比研究, 去探索模糊决策和风险决策之间的分离; 应用事件相关电位技术和磁共振技术, 采用IGT范式和选瓶任务范式, 研究模糊决策的认知神经机制; 并从临床角度进一步验证上述结果。该项目的开展, 有助于拓广模糊决策的研究领域和视野, 对理解人类在模糊情境下的决策机制以及模糊决策和风险决策之间的关系, 具有重要的理论意义; 对临床上成瘾人群、脑损伤患者的认知诊断和治疗以及现实中企业和个人的决策, 具有重要的参考价值。     

社交网站成瘾与青少年抑郁的关系:认知负载和核心自我评价的中介作用

为探讨社交网站成瘾对青少年抑郁的影响及其作用机制,在素质-压力模型的视角下,采用社交网站成瘾量表、认知负载量表、核心自我评价量表和流调中心抑郁量表,对武汉市三所全日制中学886名初中生进行调查。结果表明:(1)社交网站成瘾、认知负载、核心自我评价和抑郁两两间存在显著的相关,且社交网站成瘾对抑郁具有显著的正向预测作用;(2)认知负载和核心自我评价能在社交网站成瘾与抑郁的关系中起完全中介作用。具体而言,社交网站成瘾通过三条路径影响抑郁:一是认知负载的单独中介作用;二是核心自我评价的单独中介作用;三是认知负载-核心自我评价的链式中介作用。本研究揭示了社交网站成瘾与抑郁的关系及其作用机制,拓展了社交网站成瘾对个体心理社会适应的研究。     

Life before and after quitting smoking: an electronic diary study

This article describes a multidimensional, multivariate, and multilevel approach to the assessment of nicotine withdrawal. In this prospective study, 70 adult smokers assigned to an active or placebo nicotine patch condition completed multiple daily assessments using an electronic diary. Average and individual growth curves were estimated for affective and nonaffective withdrawal symptoms. All symptoms but hunger increased significantly on the quit day and remained elevated for three weeks. Variability in symptom experiences across individuals increased from pre- to post-quit. Relations between symptom reports (e.g., negative affect or craving) and episodic events (e.g., stressful events or seeing someone smoke) changed from pre-quit to post-quit. Pre-quit increases in negative affect and quit-day increases in craving were inversely related to abstinence three months after the quit day, suggesting that anticipatory and immediate reactions to quitting influence success.     

Effects of nicotine deprivation on craving response covariation in smokers

Most models of craving propose that when cravings are strong, diverse responses--thought to index an underlying craving state--covary. Previous studies provided weak support for this hypothesis. The authors tested whether nicotine deprivation affects degree of covariation across multiple measures related to craving. Heavy and light smokers (N = 127) were exposed to smoking cues while either nicotine deprived or nondeprived. Measures included urge ratings, affective valence, a behavioral choice task assessing perceived reinforcement value of smoking, and smoking-related judgment tasks. Results indicated higher correlations in the nicotine-deprived than in nondeprived group. The measures principally responsible for this effect loaded onto a single common Craving factor for nicotine-deprived but not nondeprived smokers. These findings suggest that, under certain conditions, measures of craving-related processes covary.     

Evidence that episodic memory impairment during tobacco abstinence is independent of attentional mechanisms

Previous studies have demonstrated reductions in episodic memory during nicotine withdrawal. However, these studies have been unable to dissociate memory reductions from losses in attention associated with tobacco abstinence. In the present study, the authors sought to determine whether episodic memory reduction is a primary effect of nicotine withdrawal during tobacco abstinence. Heavy smokers were tested when smoking normally and following 24 hrs of abstinence. Participants were tested with a recognition memory task in which items were studied under full and divided attention conditions. Forward digit span and backward digit span were also included as control measures. Withdrawal was associated with a reduction in memory performance that was independent of attention at encoding. The authors conclude that impairment of episodic memory is a primary effect of nicotine withdrawal during tobacco abstinence. Further research is required to determine if this is associated with continued use of tobacco and cessation failures.     

Evidence That Episodic Memory Impairment During Tobacco Abstinence Is Independent of Attentional Mechanisms

Previous studies have demonstrated reductions in episodic memory during nicotine withdrawal. However, these studies have been unable to dissociate memory reductions from losses in attention associated with tobacco abstinence. In the present study, the authors sought to determine whether episodic memory reduction is a primary effect of nicotine withdrawal during tobacco abstinence. Heavy smokers were tested when smoking normally and following 24 hrs of abstinence. Participants were tested with a recognition memory task in which items were studied under full and divided attention conditions. Forward digit span and backward digit span were also included as control measures. Withdrawal was associated with a reduction in memory performance that was independent of attention at encoding. The authors conclude that impairment of episodic memory is a primary effect of nicotine withdrawal during tobacco abstinence. Further research is required to determine if this is associated with continued use of tobacco and cessation failures.     

Virtual reality cue reactivity assessment in cigarette smokers.

Drug craving has purportedly been linked to relapse and to substance use. For over two decades, cue reactivity has been a viable method to assess craving and physiological reactions to drug stimuli. However, traditional cue reactivity has faced the following limitations: austere situations or stimuli, lack of complex cues, lack of standardization, and limited generalization outside of the lab setting. In order to improve cue methodologies, a virtual reality (VR) nicotine cue reactivity assessment system (VR-NCRAS) was developed and tested in a controlled experimental trial. Ten nicotine dependent smokers were exposed to VR smoking cues and VR neutral cues in a standardized, timed, computer controlled experiment. Subjective craving and physiological responses were recorded and compared across VR-NCRAS stimuli. Subjective cigarette craving increased significantly and corresponding physiological reactivity was observed in response to VR smoking cues. VR neutral cues did not result in subjective or physiological changes consistent with craving. Implications of these findings on substance abuse research and treatment are discussed.     

纳络酮、地卓西平(MK-801)对大鼠食物渴求的影响

实验以条件性位置偏爱（CPP）的表达为渴求模型观察纳络酮及MK-801对大鼠食物CPP表达,探讨摄食行为调控的心理机制。48只SD大鼠分成食物组（24）与对照组（24）,3轮食物匹配训练后,在CPP表达前分别注射生理盐水、纳络酮（1.0 mg˙kg -1）及MK-801(0.1 mg˙kg -1),观察各组动物在食物匹配训练侧停留时间的变化。结果发现,MK-801促进食物CPP的表达,但纳络酮对食物CPP的表达没有显著影响。以上结果表明MK-801（0.1mg˙kg -1）增强动物的食物渴求至少是其增加摄食量的原因之一,而1.0 mg˙kg -1的纳络酮降低动物的摄食量并不是由于食物渴求的下降导致的。MK-801与纳络酮调节动物摄食行为的心理机制可能不一致。     

Return of experimentally induced chocolate craving after extinction in a different context: divergence between craving for and expecting to eat chocolate

Unlike in fear conditioning, little attention has been devoted to extinction and renewal in appetitive conditioning, despite its relevance for extinction-based addiction treatments. We developed a paradigm, using a specific tray as a conditioned stimulus (CS) for eating chocolate (unconditioned stimulus, US), to investigate the effects of context change on acquisition and extinction of conditioned chocolate craving using an ABA renewal design. In Study 1 (n=32), participants successfully acquired chocolate craving, but unlike what is commonly observed in fear conditioning, craving did not extinguish. In Study 2, we separately assessed craving and US expectancy in a between-subjects design (n=64). US-expectancy data showed acquisition, extinction and renewal in the ABA group. The craving data did not follow this pattern, suggesting different mechanisms for craving and US expectancy. Similarities and differences between craving and US expectancy, as well as practical implications, are discussed.     

Nicotine craving and cue exposure therapy by using virtual environments.

Smokers who are exposed to cues associated with smoking show cardiovascular reactivity and an increase in smoking urges as compared to when they are presented with neutral cues. Cue exposure therapy (CET), which refers to the repeated exposure to drug-related cues in order to extinguish this learned association, has increasingly been proposed as a potential treatment of addictive behaviors, including tobacco smoking. The result of our pilot study suggests that a cue elicited using a virtual environment (VE) is more effective than other cue exposure devices. The VE was composed of craving environments (virtual bar) and objects (an alcoholic drink, a packet of cigarettes, a lighter, an ashtray, a glass of beer, and advertising posters) that are likely to trigger craving, a smoking avatar, and an audio environment that included the noisy sound and music of a restaurant. Sixteen late-adolescent males who smoked at least 10 cigarettes a day were recruited to participate in the VE-CET study. The CET virtual bar program consisted of six sessions, and the participants were exposed repeatedly to each session using different questions and procedures. Although the effects of CET did not yield significant reductions in all of the dependent variables, the craving for cigarettes was gradually decreased during the course of the sessions. This tendency was closely related to the reduction in the smoking count between the morning before the experiment and the start of the experiment. Based on these preliminary results, it appears that VE-CET maybe a useful tool to use in treatment programs to help reduce craving in those who are nicotine dependent.     

相继记忆模式：展现情节记忆形成脑机制的窗口

相继记忆模式在记忆形成的脑认知成像研究领域应用广泛,已成为研究者探究大脑形成记忆时活动的主要窗口。该文在介绍相继记忆模式及记忆形成过程的基础上,分析影响相继记忆效应大小和时空分布的因素,最后讨论内侧颞叶及前额叶神经网络中相关脑区如何分工、协同支持情节记忆形成。情节记忆多维度特性导致该神经网络中有关区域表现出不同形式的相继记忆效应,因此,该文提出有效分离这些脑区在记忆形成中如何分工及交互协同关系进行更为重要