PREFRONTAL BRAIN ASYMMETRY:

Abstract— Resting anterior brain electrical activity, self-report measures of Behavioral Approach and Inhibition System (BAS and BIS) strength, and general levels of positive and negative affect (PA and NA) were collected from 46 unselected undergraduates on two separate occasions. Electroencephalogram (EEG) measures of prefrontal asymmetry and the self-report measures showed excellent internal consistency reliability and adequate test-retest stability. Aggregate measures across the two assessments were computed for all indices. Subjects with greater relative left prefrontal activation reported higher levels of BAS strength, whereas those with greater relative right prefrontal activation reported higher levels of BIS strength. Prefrontal EEC asymmetry accounted for more than 25% of the variance in the self-report measure of relative BAS-BIS strength. Prefrontal EEG, however, was not significantly correlated with PA or NA, or the relative strength of PA versus NA Posterior asymmetry was unrelated to the self-report measures.     

Massage and music therapies attenuate frontal EEG asymmetry in depressed adolescents

EEG asymmetry, specifically greater relative right frontal activation, is associated with negative affect. Depressed adults show stable patterns of this asymmetry. The present study assessed the effects of massage therapy and music therapy on frontal EEG asymmetry in depressed adolescents. Thirty adolescents with greater relative right frontal EEG activation and symptoms of depression were given either massage therapy (n = 14) or music therapy (n = 16). EEG was recorded for three-minute periods before, during, and after therapy. Frontal EEG asymmetry was significantly attenuated during and after the massage and music sessions.     

Negative affectivity and EEG asymmetry interact to predict emotional interference on attention in early school-aged children

Negative affectivity (NA) is a broad construct that has been associated with the development of psychopathologies, such as anxiety, and with exaggerated attention to threatening stimuli. EEG asymmetry reflects biological individual differences in emotional reactivity that may underlie the association between NA and attention to threat. The present study included a sample of 31 five-seven year olds (M age in months = 74.39, SD = 6.57) to test the hypothesis that greater NA, combined with greater right anterior and posterior asymmetries, predicts increased attention interference following threat stimuli. Children completed an executive attention task which presented task-irrelevant threat (angry) and non-threat (neutral) faces prior to each trial. EEG asymmetry was measured at baseline for anterior, anterior-temporal and posterior scalp regions and child NA was measured via maternal report. As predicted, children showing greater NA and greater right anterior-temporal asymmetry showed more attention interference following angry faces. Additionally, two trend-level effects emerged: children showing greater NA and greater left anterior-temporal asymmetry showed less attention interference following angry faces, and children showing greater NA and greater left posterior asymmetry showed less attention interference, but only following neutral faces. Discussion focuses on the utility of using EEG asymmetry in the study of temperament, attentional biases, and the biological processes by which temperament confers risk for psychopathology.     

The Affective Temperaments: Differences between Adolescents in the Big Five Model and Cloninger’s Psychobiological Model of Personality

Positive (PA) and negative affect (NA) are indicators or markers of well-being that also reflect stable emotional- temperamental dispositions. In three different studies, self-reported affect was measured by the Positive Affect and Negative Affect Schedule (PANAS). The PANAS measures affect as two separate dimensions and was therefore used to generate four affective temperaments (AFTs): self-actualizing (high PA and Low NA), high affective (high PA and high NA), low affective (low PA and low NA), and self-destructive (low PA and high NA). The present set of studies investigated differences in personality between AFTs in an adolescent sample (N?=?398). Personality was measured by two different models: The Big Five and Cloninger’s psychobiological model. The interaction of PA and NA was expected to reveal differences and similarities in intrapersonal behavior measured by both models of personality. The results show that low NA adolescents reported lower levels of neurotic behavior than high NA adolescents. Nevertheless, despite the experience of high NA respectively, low PA, high and low affective reported higher Self-Directedness than self-destructive adolescents. Implications of the AFTs framework are discussed.     

Influence of caregiver burden on the association between daily fluctuations in pleasant activities and mood: A daily diary analysis

Much research has focused on behavioral activation and its effect on depression, but less is known about the effects of leisure activities on the two distinct affective domains of depression: positive affect (PA) and negative affect (NA). Furthermore, individual factors (i.e., stress level) may moderate the impact of behavioral activation on affect. The present study utilized a daily diary approach to examine the moderating effect of stress on the relationship between leisure satisfaction and both PA and NA. Twenty-five dementia caregivers completed activity and affect measures four times daily for 14 days. Results were analyzed using multilevel modeling, an approach that considers intra-individual differences in activity and affect over time. Results supported the hypothesis that caregivers with higher burden display a stronger association between leisure satisfaction and affect than caregivers with lower burden. Specifically, caregivers with higher burden had a stronger positive relationship between leisure satisfaction and PA and a stronger negative relationship between leisure satisfaction and NA. These findings suggest that screening caregivers for level of burden may help identify those most likely to benefit from behavioral interventions.     

Retrospective recall of affect in clinically depressed individuals and controls

The current study examined the nature of retrospective recall of affect in depressed participants and nonclinical controls. Utilising the Experience Sampling Method, we compared average momentary affect reports to retrospective summaries of the same period of time. Both groups exhibited exaggerated retrospective summaries of positive affect (PA) and negative affect (NA). Greater bias for PA than NA was found in the controls but not the depressed. Across groups, depressed individuals exhibited more absolute inaccuracy in their recall of NA but not PA. For depressed and nonclinical individuals, retrospective summaries of PA were better predicted by an average of all weekly momentary PA than a combination of the most intense (“peak”) PA and most recent (“end”) PA experiences. For nonclinical participants, retrospective NA was better predicted by an average of all weekly momentary NA. For depressed individuals, however, no clear advantage to predicting retrospective NA by average weekly NA relative to a combination of peak NA and end NA was found. Based on our findings, clinicians should realise that depressive cognition may not lie in recall that is less positive and more negative than “reality” but in retrospective intensifications of all affect that are, compared to normal, relatively greater for negative than for positive affect.     

Does resting electroencephalograph asymmetry reflect a trait? an application of latent state-trait theory

Recent research on brain asymmetry and emotion treated measures of resting electroencephalograph (EEG) asymmetry as genuine trait variables, but inconsistency in reported findings and modest retest correlations of baseline asymmetry are not consistent with this practice. The present study examined the alternative hypothesis that resting EEG asymmetry represents a superimposition of a traitlike activation asymmetry with substantial state-dependent fluctuations. Resting EEG was collected from 59 participants on 4 occasions of measurement, and data were analyzed in terms of latent state-trait theory. For most scalp regions, about 60% of the variance of the asymmetry measure was due to individual differences on a temporally stable latent trait, and 40% of the variance was due to occasion-specific fluctuations, but measurement errors were negligible. Further analyses indicated that these fluctuations might be efficiently reduced by aggregation across several occasions.     

Frontal EEG asymmetry and premenstrual dysphoric symptomatology

Resting frontal electroencephalographic (EEG) asymmetry has been hypothesized to tap a diathesis toward depression or other emotion-related psychopathology. Frontal EEG asymmetry was assessed in college women who reported high (n = 12) or low (n = 11) levels of premenstrual negative affect. Participants were assessed during both the follicular and the late luteal phases of the menstrual cycle. Women reporting low premenstrual dysphoric symptomatology exhibited greater relative left frontal activity at rest than did women high in premenstrual dysphoric symptomatology, an effect that was not qualified by phase of cycle. Although women with extreme levels of symptomatology were assessed, the question of whether such symptoms qualified for premenstrual dysphoric disorder criteria was not assessed. These results are consistent with a diathesis-stress model for premenstrual dysphoric symptomatology.     

Tripartite model of depression and anxiety in youth psychiatric inpatients: relations with diagnostic status and future symptoms

Examined the relation of the depression aspect of the tripartite model of depression and anxiety to the diagnostic status and future symptoms of two samples that included 74 child and adolescent psychiatric inpatients, ages 7 to 17 years (M = 13.57, SD = 2.39), some with either internalizing or externalizing diagnoses. The tripartite model suggests that anhedonia (low positive affect, or PA) differentiates depression from other conditions, whereas generalized negative affect (NA) also characterizes depression but is not specific to it. In this study, differences among children in PA and NA were associated with depressive versus externalizing diagnostic status and with future symptoms of depression. Depressive disorder diagnoses were associated with the combination of low levels of PA and high levels of NA. Changes over time in depression, but not in anxiety, also were associated with the combination of low PA and high NA. Results provide support for the applicability, clinical utility, and extension of the tripartite model with children.     

Resting frontal brain asymmetry predicts affective responses to films

This article assessed whether resting electroencephalographic (EEG) asymmetry in anterior regions of the brain can predict affective responses to emotion elicitors. Baseline EEG was recorded from 32 female adults, after which Ss viewed film clips preselected to elicit positive or negative affect. Resting alpha power asymmetry in the frontal region significantly predicted self-reported global negative affect in response to clips and predicted the difference between global positive and negative affect. Analyses of discrete emotions revealed a strong relation between frontal asymmetry and fear responses to films. Effects were independent of Ss mood ratings at the time at which baseline EEG was measured. Resting anterior asymmetry may be a state-independent index of the individual's predisposition to respond affectively.     

The Structure of Adolescent Affective Well-Being: The Case of the PANAS Among Serbian Adolescents

The structure of affective well-being and the relationship between positive affect (PA) and negative affect (NA) have rarely been examined among adolescents. The aim of the present research was to investigate the question of bipolarity versus independence of PA and NA as measured by the PANAS across three studies in adolescent samples. The results of Study 1 (N = 1038) showed that a two-factor structure of the PANAS, with correlated PA and NA and allowed correlated errors between similarly worded items provided the best fit to data. Study 2 included three independent samples (total N = 1071), and showed that PA and NA differed in terms of their relationship to various well-being indicators. Study 3 (N = 482) tested the predictive validity of PA and NA in a 5 month follow-up design, and showed that both PA and NA had independent predictive benefits for depression, risky behaviors and life satisfaction, and that PA had no unique role in the prediction of stress and anxiety, while NA had no unique role in the prediction of academic achievement. The results of the present research provided strong support for the relative independence of PA and NA as measured by the PANAS among adolescents.     

Effects of positive and negative affect and emotional suppression on short-term life satisfaction

Relationships between emotional experiences and health and adjustment are influenced by many variables, with emotional suppression (ES) being one of the most influential factors. In the current study, we examined the effects of affect and ES on short-term life satisfaction (LS) measured over the previous week. We also considered the dimension of activation status for both positive affect (PA) and negative affect (NA). The final sample included data collected from 398 undergraduates (184 men and 214 women). Participants answered six questionnaires, two of which were used for another study. All of the tests were of Japanese versions and were answered with regard to the previous week's experiences. Results showed that LS was positively associated with PA and negatively with NA, but that the positive association was stronger for activated PA than deactivated PA, while the negative association was stronger for deactivated NA than activated NA. Furthermore, an interactive effect between deactivated NA and ES on LS was significant in men, where post hoc tests demonstrated that deactivated NA was more negatively associated with LS when ES was higher. This study suggests that activated and deactivated affect differ in their effects on LS. In addition, it is likely that the detrimental effect of deactivated NA on LS is larger when NA is more strongly suppressed. The necessity of interventional research along with the limitations of this study is discussed for future research.     

Diagnostic differences in social anhedonia: a longitudinal study of schizophrenia and major depressive disorder

This study examined the hypothesis that, in schizophrenia, elevated trait social anhedonia (SA) is a stable individual difference, whereas in depression, increased SA is a reflection of a current clinical state that will diminish with recovery. Differences in trait Negative Affect (NA) and Positive Affect (PA) were also examined. Individuals with schizophrenia (n = 55) and depression (n = 34) were evaluated at baseline during hospitalization and compared with nonpsychiatric control participants (n = 41). Participants were assessed again at a 1-year follow-up. At baseline, compared with control participants, individuals with schizophrenia and depression were both characterized by elevated SA, greater NA, and lower PA. In schizophrenic individuals, elevated SA remained stable over the follow-up. However, in recovered depressed patients, SA declined over the follow-up period. Group differences remained in NA and PA over the 1-year follow-up. These results support the view that elevated SA is enduring in schizophrenia but that elevated SA is transiently related to clinical status in depression.     

Self-ratings of positive and negative affect and retrieval of positive and negative affect memories

Abstract

Based on analysis of self-ratings of mood, positive affect (PA) and negative affect (NA) have been proposed as basic, orthogonal mood dimensions (Watson & Tellegen, 1985). The present study asked subjects (N = 61) to not only provide self-ratings of PA and NA terms but also to retrieve personal memories associated with those terms. Self-rated PA was associated with latency to retrieve PA- but not NA-related memories; self-rated NA was associated with latency to retrieve NA- but not PA-related memories. Self-ratings of PA and NA were not significantly correlated, nor were retrieval latencies for PA and NA memories. Individual item correlations also revealed a strong direct relationship between self-ratings and retrieval latency. The dissociations involving a non-self report measure strengthen the distinction between PA and NA, and the individual item correlations are interpreted as showing that self-ratings of affect are based upon the ease of retrieval of personal memories.     

Reciprocal Prospective Effects of Momentary Cognitions and Affect in Daily Life and Mood Reactivity Toward Daily Events in Remitted Recurrent Depression

Major depressive disorder is a recurrent condition. Potential risk factors for future episodes are maladaptive cognitions, such as rumination and unfavorable reactivity toward negative daily events. Positive thoughts and positive daily events, in contrast, could act as a buffer against mood deterioration. The aim of the present study is to (a) examine differences in daily affect and cognitions in remitted depressed patients with a history of recurrent episodes (rMDD) and healthy controls, (b) analyze reciprocal prospective effects of momentary cognitions and affect, and (c) investigate effects of daily events on affect and cognitions in both groups. A sample of N = 102 participants underwent an ecological momentary assessment (EMA) phase of 5 consecutive days, where rMDD patients (n = 51) and healthy controls (n = 51) indicated their momentary rumination, positive thoughts, affect, and the occurrence of daily events 10 times per day. Via multilevel lag models, we found higher rumination to predict a decrease of positive affect (PA) in the rMDD group, but no effect of rumination on subsequent negative affect (NA) in either group. Higher positive thoughts predicted an increase in PA and a decrease in NA, similarly strong in both groups. Regarding daily events, rMDD patients reported a stronger increase in NA and rumination following negative daily events compared to controls, whereas an observed subsequent decrease of PA and positive thoughts was not moderated by group. Following positive daily events, rMDD patients showed a stronger increase in PA and positive thoughts and a stronger decrease in NA and rumination than controls. For interventions targeting relapse prevention, our results indicate the implementation of strategies fostering the responsiveness to positive events and the up-regulation of positive affect.     

Attachment insecurities,life satisfaction,and relationship satisfaction from a dyadic perspective: The role of positive and negative affect

The purpose of this research is to examine the association between attachment insecurities (anxiety and avoidance) and both subjective well‐being (positive affect [PA] and negative affect [NA] and life satisfaction) and relationship satisfaction. There were 174 Spanish heterosexual couples with a mean length of relationship of 13.9 years who participated in the study. The hypotheses were tested according to the actor–partner interdependence model. We proposed a model in which PA and NA could mediate the association between attachment insecurities and life and relationship satisfaction. Results show that (1) actor effects are more frequent than partner effects; (2) anxious attachment tends to be related to NA and avoidant attachment to PA; (3) avoidance is more detrimental than anxiety for relationship satisfaction at individual and dyadic levels, and (4) there are some mediational effects of NA and PA in the association between attachment insecurities and life and relationship satisfaction.     

Walk on the bright side: physical activity and affect in major depressive disorder

Although prescribed exercise has been found to improve affect and reduce levels of depression, we do not know how self-initiated everyday physical activity influences levels of positive affect (PA) and negative affect (NA) in depressed persons. Fifty-three individuals diagnosed with Major Depressive Disorder (MDD) and 53 never-depressed controls participated in a seven-day experience sampling study. Participants were prompted randomly eight times per day and answered questions about their physical activity and affective state. Over the week, the two groups of participants did not differ in average level of physical activity. As expected, participants with MDD reported lower average PA and higher average NA than did never-depressed controls. Both participants with MDD and controls reported higher levels of PA at prompts after physical activity than at prompts after inactive periods; moreover, for both groups of participants, PA increased from a prompt after an inactive period to a subsequent prompt at which activity was reported. Depressed participants in particular showed a dose-response effect of physical activity on affect: longer duration and/or higher intensity of physical activity increased their PA significantly more than did short duration and/or lower intensity physical activity. Physical activity did not influence NA in either group. In contrast to previous treatment studies that examined the effects of prescribed structured exercise, this investigation showed that self-initiated physical activity influences PA. These findings also underscore the importance of distinguishing between PA and NA to gain a more comprehensive understanding of the effects of physical activity on affect in MDD.     

EEG correlates of behavioural laterality: right-handedness

Among right-handers, the magnitude of differences in proficiency between the left and right hands varies considerably. Yet significance of the extent of right-handedness is still a controversial issue. To examine whether individual differences in asymmetry of hand skill can partly be attributed to individual differences in asymmetrical hemispheric activation, handedness and electroencephalographic (EEG) laterality were correlated in two large samples (ns = 60 and 128). Analysis indicated that part of the variability in right-handedness may arise from activation asymmetries in the cortex, but whether this relation becomes apparent depends on the cortical area examined and on the experimental condition under which the EEG measures are taken.     

Sylvian fissure and parietal anatomy in children with autism spectrum disorder

Autism spectrum disorder (ASD) is characterized by deficits in social functioning and language and communication, with restricted interests or stereotyped behaviors. Anatomical differences have been found in the parietal cortex in children with ASD, but parietal subregions and associations between Sylvian fissure (SF) and parietal anatomy have not been explored. In this study, SF length and anterior and posterior parietal volumes were measured on MRI in 30 right-handed boys with ASD and 30 right-handed typically developing boys (7-14 years), matched on age and non-verbal IQ. There was leftward SF and anterior parietal asymmetry, and rightward posterior parietal asymmetry, across groups. There were associations between SF and parietal asymmetries, with slight group differences. Typical SF asymmetry was associated with typical anterior and posterior parietal asymmetry, in both groups. In the atypical SF asymmetry group, controls had atypical parietal asymmetry, whereas in ASD there were more equal numbers of individuals with typical as atypical anterior parietal asymmetry. We did not find significant anatomical-behavioral associations. Our findings of more individuals in the ASD group having a dissociation between cortical asymmetries warrants further investigation of these subgroups and emphasizes the importance of investigating anatomical relationships in addition to group differences in individual regions.     

Frontal brain asymmetry predicts infants' response to maternal separation

Examined whether certain features of infant temperament might be related to individual differences in the asymmetry of resting frontal activation. EEG was recorded from the left and right frontal and parietal scalp regions of 13 normal 10-month-old infants. Infant behavior was then observed during a brief period of maternal separation. Those infants who cried in response to maternal separation showed greater right frontal activation during the preceding baseline period compared with infants who did not cry. Frontal activation asymmetry may be a state-independent marker for individual differences in threshold of reactivity to stressful events and vulnerability to particular emotions.