An electrophysiological study of school-aged children with a history of failure to thrive during infancy

Sixty-five subjects, ages 8 to 12, participated in a visual electrophysiological study. Twenty-two of the subjects had received a diagnosis of nonorganic failure-to-thrive (FTT) before the age of three. The remaining 43 subjects had no history of FTT and served as Controls. IQs were obtained with the abbreviated WISC-III, and the Controls were split into two groups, LO IQ and HI IQ, to provide a LO IQ Control group with an average IQ equivalent to the FTT group. Event-related brain potentials (ERPs) were recorded from five scalp locations during a cued continuous performance task (CPT). Subjects had to press a button every time they saw the letter “X” following the letter “A” (50 targets out of 400 stimuli). During the CPT, the FTT subjects made marginally more errors of omission to targets than the LO IQ Control group and significantly more errors of omission than the HI IQ Control subjects. The groups did not differ significantly on errors of commission (false alarms) or reaction times to targets. ERP averages revealed a group difference in amplitude in a late slow wave for the 50 non-X stimuli (false targets) that followed the letter A. This difference was greatest over frontal sites, where the FTT group had a more negative going slow wave than each control group. Late frontal negativity to No Go stimuli has been linked with post-decisional processing, notably in young children. Thus, the FTT subjects may have less efficient inhibitory processes, reflected by additional late frontal activation. *** DIRECT SUPPORT *** A31BB040 00006     

Infant-mother attachment in children with failure to thrive

This study may represent an advance in the study of failure to thrive (FTT), as (1) it is the first to use the disorganized/disoriented classification of infant-mother attachment (Main & Solomon, 1990) in a study of children with FTT, and (2) it includes measures of social processes associated with individual differences in attachment. Twenty-six children with FTT (10 “organic,” 16 “nonorganic”) and 28 normally growing children, ages 12 to 25 months, were seen in Ainsworth's Strange Situation. The FTT and control groups were equivalent on age of mother (28.0 and 28.6 years, respectively), annual family income ($37,700 and $24,100), and mother's marital status (56% and 52% married). The sample included African-American, Caucasian, and Latino families. In addition, measures of mother-child interaction and mothers' reports of social support and life stress were included. Children with FTT were less likely to show secure and more likely to show anxious, disorganized attachments than normally growing controls: Only 35% of FTTs were secure, whereas 46% showed disorganized attachments. In contrast, 64% of controls were secure and 7% were disorganized. Comparisons between FTTs and controls also revealed differences in maternal sensitivity and stressful social environments. There were no differences in patterns of attachment, level of acute malnutrition, maternal sensitivity, social support, or life stress between organic and nonorganic FTT groups, further discrediting this as a meaningful distinction. The organic and nonorganic groups differed only on a measure of chronicity of malnutrition. These results support the notion that disrupted parent-child relationships and stressful social environments are common in FTT, regardless of the etiology of growth failure. The findings suggest that treatments of FTT must address psychological, as well as medical, problems in these families.     

Psychopathology in mothers of children with failure to thrive

An association between maternal psychopathology and failure to thrive (FTT) has been reported previously, but no prior investigators have used both operationalized diagnostic criteria for psychopathology and a control group in their studies. Twenty-eight mothers of children with FTT and 22 mothers of normally developing control children were assessed for psychopathology by the Structured Clinical Interview for DSM-III-R–Nonpatient Version (SCID-NP) and the Structured Clinical Interview for DSM-III-R–Personality Disorders (SCID-II). Affective disorders, personality disorders, and the COoccurrence in an indvidual of these two types of disorders were found at higher rates in mothers of children with FTT compared to controls. These results clarify prior reports of an association between failure to thrive and maternal psychopathology and may have implications for treatment approaches to FTT.     

Visuospatial working memory in school-aged children exposed in utero to cocaine.

OBJECTIVE: Among the neurocognitive impairments reported as associated with prenatal cocaine exposure, slower response time, and less efficient learning in school-aged children are common to findings from several laboratories. This study presents performance data on a spatial working memory task in 75 prenatally cocaine exposed (CE) and 55 nondrug-exposed (NDE) 8- to 10-year-old children. METHODS: Children were administered a novel neuropsychological measure of immediate- and short-term memory for visuospatial information, the Groton Maze Learning Test (GMLT), a computer-based hidden maze learning test that consists of a "timed chase test" (a simple measure of visuomotor speed), eight learning trials followed by a delayed recall trial after an 8-minute delay and a reverse learning trial. Performance is expressed as correct moves per second and number of errors per trial. RESULTS: Across all trials, the cocaine-exposed group showed significantly slower correct moves per second and made significantly more errors. There were no significant main effects for amounts of alcohol, tobacco, or marijuana exposure. After an 8-minute delay and compared to the eighth trial, cocaine-exposed children showed less consolidation in learning compared to nonexposed children. When asked to complete the maze in reverse, cocaine-exposed children showed a greater decrement in performance (decreased correct moves per second and increased errors) compared to the eighth learning trial. CONCLUSIONS: Children exposed in utero to cocaine exhibit a possible impairment in procedural learning and diminished efficiency in creating and accessing an internal spatial map to master the hidden maze.     

The clinical neuropsychology of attention in school-aged children.

100 children from the north-east of England, aged between 7 and 13 years of age, completed an assessment of intellectual ability and an attention battery based on the work of Mirsky, Anthony, Duncan, Ahearn, & Kellam (1991). Factor analysis was generally supportive of the Mirsky et al. (1991) model. Replication of the adult model produced the same four factors: sustain, encode, focus-execute and shift. Replication of the child model produced a three-factor model in which the encode and focus-execute factors combined. An extended model resulted in the introduction of a new factor labelled errors of processing. The scores on attention factors were found to have a reasonable level of independence from intellectual ability.     

The Bender-Gestalt psychopathology scale: failure to infer validity in a school-aged sample

The concurrent validity of Hutt's (1977) empirical psychopathology scale of the Bender Visual-Motor Gestalt Test was evaluated among three groups of younger school-aged children within the 7-to-10- year age range (M = 109.1): adjustment disordered, conduct disordered, and nonclinical controls (n = 40/group). Excellent interscorer reliability was achieved with approximately 2 hr of self-study of the scoring manual. Although the conduct-disordered group was significantly more immature on Koppitz' Developmental Scoring System, there were no significant differences among groups on the psychopathology scale when visual-motor development was covaried (M = 50.5). This was an unexpected result, given Hutt's initial validation study among school-aged children. The psychopathology scale was not inferred to be valid among adolescents in the only known concurrent validation study. Pending supportive validation research, the psychopathology scale should not be employed in the clinical assessment of younger school-aged children.     

Investigating the neurodevelopmental mediators of aggression in children with a history of child maltreatment:An exploratory field study

Maltreatment of children is a chronic community problem that increases the risk of future aggression. Despite several decades of research highlighting this relationship, few studies have explored the potential neuropsychological deficits that are likely to mediate it. This exploratory study aimed to examine how child maltreatment may be associated with aggression via impairment in the developing prefrontal-limbic-autonomic pathways that are implicated in neuropsychological models of aggression. Furthermore, it aimed to investigate the relationship between child maltreatment and both reactive and proactive aggression subtypes. To investigate this non-invasively in an at-risk population, children with a documented protective care history (n = 20) and a community control group (n = 30), aged between 6 and 12 years, were compared on measures of cardiovascular functioning, affect regulation and cognitive functioning aligned with this neuropsychological model. Whilst no group differences were found on cardiovascular functioning (i.e., resting heart rate, heart rate reactivity, heart rate variability), the protective care group performed significantly worse on measures of affect regulation and cognitive functioning (i.e., global intelligence, executive functioning, smell identification and social cognition). The relationship between child maltreatment and aggression was mediated by executive dysfunction and affect dysregulation but not global IQ, social cognition or olfactory identification. The results suggest that interventions targeting aggression in maltreated children will benefit from clinical assessment and psychological strategies that address the executive dysfunction and affect dysregulation that has been associated with this clinical outcome.     

The effect of parental modeling of anxious behaviors and cognitions in school-aged children: An experimental pilot study

The current study tested: (1) the impact of parental modeling of anxious behaviors and cognitions on child anxiety level, anxious cognitions, desired avoidance, and objective performance using an experimental paradigm; and (2) whether the impact of parental modeling of anxious behaviors and cognitions differed by parent gender. Twenty-five parents (a random selection of 12 male and 13 female parents) participated with one of their children (ages 8-12 years; 56.0% male; 76.0% Caucasian). All children experienced two test conditions: an anxious condition in which their parent was trained to act anxiously before a planned spelling test and a non-anxious condition in which their parent was trained to act in a relaxed and confident manner before a planned spelling test. Results showed that, regardless of parent gender, children endorsed higher anxiety levels, anxious cognitions, and desired avoidance of the spelling test in the anxious relative to the non-anxious condition. Parental modeling of anxiety did not affect child spelling performance. Significant interaction effects indicated that fathers had a stronger impact on child anxiety level and cognitions than did mothers. Results highlight the importance of parental modeling and the potential role of both mothers and fathers in prevention and treatment for child anxiety.     

Adults with probable developmental coordination disorder selectively process early visual,but not tactile information during action preparation. An electrophysiological study

Developmental coordination disorder (DCD) is a neurodevelopmental condition affecting motor coordination in children and adults. Here, EEG signals elicited by visual and tactile stimuli were recorded while adult participants with and without probable DCD (pDCD) performed a motor task. The task cued reaching movements towards a location in visible peripersonal space as well as an area of unseen personal space. Event-related potentials elicited by visual and tactile stimuli revealed that visual processing was strongly affected by movement preparation in the pDCD group, even more than in controls. However, in contrast to the controls, tactile processing in unseen space was unaffected by movement preparation in the pDCD group. The selective use of sensory information from vision and proprioception is fundamental for the adaptive control of movements, and these findings suggest that this is impaired in DCD. Additionally, the pDCD group showed attenuated motor rhythms (beta: 13–30 Hz) over sensorimotor regions following cues to prepare movements towards unseen personal space. The results reveal that individuals with pDCD exhibit differences in the neural mechanisms of spatial selection and action preparation compared to controls, which may underpin the sustained difficulties they experience. These findings provide new insights into the neural mechanisms potentially disrupted in this highly prevalent disorder.     

An electrophysiological method for the study of binocular rivalry

A technique is described for recording cortical evoked responses from human Ss in binocular rivalry. Each target is illuminated with flickering light at different frequencies upon a steady background. While the S continuously indicates with a response key which target he is seeing, the cortical responses are tape recorded. The tape recording is later analyzed by average response computer separately for each eye, seeing and not seeing. This simultaneous record of the functioning of both eyes eliminates confounding variables found in earlier methods. Controls are included for rivalry changes during a stimulus cycle and for S motor response time.     

An electrophysiological study of the insertion of overt response choice

Using electrophysiological measures, the authors studied changes in prestimulus state, stimulus identification, and response-related processing when, in a go/no-go task, forced choice between 2 overt go responses was inserted. The authors observed decreased prestimulus motor preparation (electromyogram), no change in stimulus identification time (selection negativity), a minor increase in response selection time (lateralized readiness potential), a large increase in response preparation time (lateralized readiness potential), a minor effect on response execution time (electromyogram), and a decrease in the activation of a response-inhibition process on no-go trials (frontal event-related potential). The existence of the response-inhibition process was verified by the presence of inverted lateralized readiness potentials on no-go trials. Pure insertion of response choice in a task seems impossible because the choice between activation and inhibition (go/no-go) always seems already present.     

Face engagement during infancy predicts later face recognition ability in younger siblings of children with autism

Face recognition difficulties are frequently documented in children with autism spectrum disorders (ASD). It has been hypothesized that these difficulties result from a reduced interest in faces early in life, leading to decreased cortical specialization and atypical development of the neural circuitry for face processing. However, a recent study by our lab demonstrated that infants at increased familial risk for ASD, irrespective of their diagnostic status at 3 years, exhibit a clear orienting response to faces. The present study was conducted as a follow‐up on the same cohort to investigate how measures of early engagement with faces relate to face‐processing abilities later in life. We also investigated whether face recognition difficulties are specifically related to an ASD diagnosis, or whether they are present at a higher rate in all those at familial risk. At 3 years we found a reduced ability to recognize unfamiliar faces in the high‐risk group that was not specific to those children who received an ASD diagnosis, consistent with face recognition difficulties being an endophenotype of the disorder. Furthermore, we found that longer looking at faces at 7 months was associated with poorer performance on the face recognition task at 3 years in the high‐risk group. These findings suggest that longer looking at faces in infants at risk for ASD might reflect early face‐processing difficulties and predicts difficulties with recognizing faces later in life.     

Sound enhances detection of visual target during infancy: a study using illusory contours

In adults, a salient tone embedded in a sequence of nonsalient tones improves detection of a synchronously and briefly presented visual target in a rapid, visually distracting sequence. This phenomenon indicates that perception from one sensory modality can be influenced by another one even when the latter modality provides no information about the judged property itself. However, no study has revealed the age-related development of this kind of cross-modal enhancement. Here we tested the effect of concurrent and unique sounds on detection of illusory contours during infancy. We used a preferential looking technique to investigate whether audio-visual enhancement of the detection of illusory contours could be observed at 5, 6, and 7 months of age. A significant enhancement, induced by sound, of the preference for illusory contours was observed only in the 7-month-olds. These results suggest that audio-visual enhancement in visual target detection emerges at 7 months of age.     

Group therapy for school-aged children who stutter: a survey of current practices

Although group therapy is recommended for school-aged children who stutter (CWS), it is not widely researched. This study aimed to explore this provision, using a postal survey which investigated the current practices of Speech & Language Therapists (SLTs) in the UK. Seventy percent of SLT services provided some group therapy, but the level of provision was variable. There was a lack of consensus on what the main aims of group therapy should be. Important barriers to group therapy provision were identified, including a perceived lack of clients' interest in group therapy, and insufficient numbers of clients able to travel to group venues. This study enhances the profession's understanding of the provision of group therapy for CWS by identifying patterns of service delivery and highlighting areas of need. EDUCATIONAL OBJECTIVES: Readers should be able to: (1) Provide a rationale for the provision of group therapy for school-aged CWS; (2) Summarize the factors affecting group therapy provision for school-aged CWS; (3) Summarize the aims of therapy identified by the respondents to this survey.     

Attention and reaction to distress in infancy: a longitudinal study

The primary aim of this study was to verify whether early individual differences in look duration are related to general mechanisms of the infant nervous system that draw together attention and emotion. Thirty-one infants were observed at 3, 5, and 11 months of age. Facial expressions of pain and distress were observed by means of C. Izard's (1979) Maximally Discriminative Facial Movement Coding System 90 s after routine pediatric vaccinations. Several measures of visual attention were taken experimentally in a separate testing session. Significant correlations between measures of attention and duration of facial expressions of pain and distress were found at each age level. Infants who showed pain or distress for a shorter time period also paid attention for a shorter time period and vice versa. The main conclusion is that individual differences combining control of both pain and attention can be identified from early infancy.     

The feasibility of a group bender-gestalt test for preschool and primary school-aged children

This study devised and tested a method for group administration of the Bender-Gestalt Test that would be feasible for screening large groups of beginning school-age children. Secondary considerations of the study were the reliability of the group method of administration as well as the predictive validity of test results gathered using the group technique. Students' (N = 144) age range was from five years through nine years. Results indicate that the group method of presentation using Koppitz's DBSS scoring system can yield results as valid and reliable as the traditional individual method of administering the Bender-Gestalt Test.     

Adjustment problems experienced by children during cross-cultural orientation: a pilot study.

A study was undertaken to investigate the adjustment problems of children aged 8-10 years when they relocated from their native countries to Vienna, Austria. There was a moderate correlation between anxiety and adjustment to changes in the physical and material environment and a significant correlation between anxiety and changes in social support systems. Adjustment to changes in parental behavior and changes in language demands both showed a low negative correlation with anxiety. Children who had spent the least time in Vienna showed greater evidence of anxiety and stress than did children who had lived in the city for at least 1 year.