工作记忆中央执行功能的脑成像研究

中央执行器是工作记忆模型中的一个独立系统,它在工作记忆中发挥着重要作用。早期的行为实验和近年来的脑成像研究通过不同的任务证实了多种中央执行加工的存在．而脑成像技术在探讨执行加工的神经基础方面以其独特的优势深得认知神经科学的青睐。     

学龄儿童工作记忆结构的验证研究

该研究目标是验证儿童工作记忆是否符合Baddeley提出的由中央执行、情景缓冲区、语音环路及视觉空间模板构成的四成分模型。211名6~9岁小学生完成9个工作记忆任务,这些任务分别测量工作记忆四个子成分的功能。验证性因素分析表明,四因素模型比三因素模型和单因素模型更好地拟合数据。在小学阶段儿童工作记忆不是一个单一的结构,已经分化为四个子成分构成的记忆系统。     

数学学习困难儿童的加工速度与工作记忆

以数学学习困难儿童为研究对象,系统考察了数学学习困难儿童与控制组的加工速度和工作记忆,比较了工作记忆和加工速度对数学学习困难影响的相对贡献.结果发现,与控制组相比,数学学习困难儿童在工作记忆和加工速度方面均存在明显的不足,但加工速度不能解释不同能力组之间的差异,数学学习困难儿童的缺陷在于工作记忆能力的下降.工作记忆缺陷在于数字工作记忆、视空间工作记忆和中央执行功能的整体不足,中央执行功能对数学学习困难儿童影响的解释量最大.     

工作记忆的脑机制研究

在进行学习、记忆、思维及问题解决等高级认知活动时,人们需要一个暂时的信息加工与存储机制,它能够保存被激活的信息表征,以备进一步加工之用,1974年Baddeley等称这种机制为工作记忆(working memory)。工作记忆包括中央执行系统(central executive)、视觉空间存储器(visuoflspatial sketch pad,VSSP)和语音环路(phonological loop)等三部分。中央执行系统负责工作记忆中的注意控制,其功能类似于一个能量有限的注意系统,该系统负责指挥各种次级系统的活动。     

语文学习困难儿童的工作记忆与加工速度

加工速度和工作记忆反应了不同的认知加工过程,在认知发展研究中,加工速度和工作记忆所起的作用仍存在较大的分歧.采用多因素混合实验设计,在严格控制条件下,比较了语文学习困难和控制组儿童的工作记忆和加工速度.结果发现,与控制组相比,语文学习困难儿童在工作记忆和加工速度方面均存在明显的不足,但加工速度不能解释不同能力组之间的差异,语文学习困难儿童的缺陷在于工作记忆能力的下降.工作记忆的缺陷在于言语工作记忆和中央执行功能的不足,与视空间工作记忆能力无关.语文学习困难既存在一般的工作记忆缺陷(中央执行功能)也存在特定的工作记忆(言语工作记忆)能力的不足.     

工作记忆成分在传递性推理中的作用

采用双任务(dual-task)实验范式,探讨工作记忆成分在五项系列问题(five-term task)这种传递性推理中的作用。被试为80名大学生,实验材料为32个空间和时间内容的传递性推理题目。结果发现:(1)空间位置和时间关系的推理结果都支持心理模型理论,而不支持形式规则理论。(2)在推理前提的加工阶段,中央执行系统和视空间模板发挥着关键作用,语音环路没有参与;而在结论的推理阶段,工作记忆的三个成分均发挥了作用。(3)传递性推理在工作记忆系统中采用视空间编码进行表征。     

工作记忆与情景记忆的相互作用

虽然Baddeley的工作记忆模型得到大量实验研究的支持,但是有关工作记忆和长时记忆之间的关系未能得到详细阐述。来自神经心理学的证据表明,工作记忆与情景长时记忆任务均诱发了前额区的激活,但同时发现前额区存在不同的功能分区,可能在工作记忆与情景记忆过程中具有独立的执行功能。工作记忆与情景记忆的相互作用是当前记忆研究关注的问题。已有研究发现,在情景记忆对工作记忆的作用过程中,时间进程与头皮分布均显示了年龄效应与材料加工特点。而工作记忆对情景记忆的作用中,则发现工作记忆早期加工可能对情景记忆的成功形成有更大促进作用。今后的研究应在理论模型支持下,利用多种技术手段探讨两种记忆相互作用的神经加工机制     

信息保持、短时存贮与执行控制的脑模型

工作记忆的脑机制是认知神经科学研究的重要问题。研究者在分析大量脑成像研究数据的基础上,创建了许多解释工作记忆神经基础的模型。Smith和Jonides发展了工作记忆成分结构模型和贮存与执行加工分离模型。Postle和D’Esposito建构了工作记忆相对表征混合模型,D’Esposito, Postle和Rypma阐述了工作记忆加工阶段动态模型。Fletcher和Henson提出工作记忆额叶分区整合理论。该文通过对上述模型或理论的评价,总结了工作记忆脑成像研究中存在的问题,展望了该研究领域的发展趋势。     

工作记忆训练的研究述评*

以往研究表明,工作记忆是一个资源有限的系统,但近年来大量研究发现工作记忆成绩可以通过训练提高。工作记忆训练是指针对低容量的个体进行针对存储系统或者中央执行系统各成分的训练,以提升个体工作记忆绩效及影响任务相关脑区的活动。来自认知神经科学的证据在评估工作记忆训练的效果上起到了重要作用。虽然目前该领域的研究已经取得一定的成绩,但是利用工作记忆训练来改善个体的工作记忆在具体的方法、训练成效等问题上还存在一定的争议。     

基于手机APP的双维n-back训练的认知与情绪效益

工作记忆训练的训练获益能够迁移至与工作记忆相关的各项基础认知活动中去。基于情绪认知控制与工作记忆之间的密切关联, 本研究设计了一种新型情绪性双维n-back训练, 并且验证利用手机APP搭载训练任务的适用性。结果表明：基于APP的短期双维n-back训练能够使个体在视空间工作记忆任务、活动记忆任务、数字转换任务、Stroop任务上的成绩产生相较控制组更大的进步, 表明训练可以提高个体工作记忆的容量和中央执行功能。然而, 基于不同情绪材料的训练(中性、负性、正性)在各类迁移上差异不大。短期训练无法迁移到情绪Stroop任务中, 即无法产生特异的情绪控制上的效益。双维n-back任务通道单一, 且搭载于手机APP, 拥有较为广阔的应用前景。但将情绪材料单纯地糅合进工作记忆任务中的价值与意义须被进一步考察。     

The episodic buffer: a new component of working memory?

In 1974, Baddeley and Hitch proposed a three-component model of working memory. Over the years, this has been successful in giving an integrated account not only of data from normal adults, but also neuropsychological, developmental and neuroimaging data. There are, however, a number of phenomena that are not readily captured by the original model. These are outlined here and a fourth component to the model, the episodic buffer, is proposed. It comprises a limited capacity system that provides temporary storage of information held in a multimodal code, which is capable of binding information from the subsidiary systems, and from long-term memory, into a unitary episodic representation. Conscious awareness is assumed to be the principal mode of retrieval from the buffer. The revised model differs from the old principally in focussing attention on the processes of integrating information, rather than on the isolation of the subsystems. In doing so, it provides a better basis for tackling the more complex aspects of executive control in working memory.     

The role of the episodic buffer in working memory for language processing

A body of work has accumulated to show that the cognitive process of binding information from different mnemonic and sensory sources as well as in different linguistic modalities can be fractionated from general executive functions in working memory both functionally and neurally. This process has been defined in terms of the episodic buffer (Baddeley in Trends Cogn Sci 4(11):417–423, 2000). This paper considers behavioural, neuropsychological and neuroimaging data that elucidate the role of the episodic buffer in language processing. We argue that the episodic buffer seems to be truly multimodal in function and that while formation of unitary multidimensional representations in the episodic buffer seems to engage posterior neural networks, maintenance of such representations is supported by frontal networks. Although, the episodic buffer is not necessarily supported by executive processes and seems to be supported by different neural networks, it may operate in tandem with the central executive during effortful language processing. There is also evidence to suggest engagement of the phonological loop during buffer processing. The hippocampus seems to play a role in formation but not maintenance of representations in the episodic buffer of working memory.     

工作记忆与情景记忆中脑区的重合与分离——从脑区定位看两者关系

尽管近期的研究结果认为前额叶在工作记忆和情景记忆任务中均被激活,但是仍然不清楚是否有特定的区域对两种记忆起着不同作用。对于工作记忆和情景记忆在脑区上的重合,研究者们做出了不同的解释。某些研究者认为脑区的重合反映了包含于情景记忆中的工作记忆的作用,另一些研究者则认为这种重合反映的是与工作记忆和情景记忆都有关的反省过程的性质。对此,作者提出了相应的讨论意见。     

工作记忆新探:基于个体差异的研究

近年来对工作记忆的研究开始关注个体差异的理论分析。经典的工作记忆模型得到了发展,引入情境缓冲系统作为多成分模型的一部分,这是对个体经验的重视。传统衡量个体差异的主要指标短时记忆容量(组块)、智力(g)等逐步被工作记忆指标发展替代:如执行性注意控制、工作记忆广度等。工作记忆的个体差异本质上是否与智力的差异具有同构性的焦点引起了广泛关注。在今后的研究中,关于领域一般性与特殊性的及神经生理学等方向可能是厘清工作记忆个体差异的主流趋势。     

The right parahippocampal gyrus contributes to the formation and maintenance of bound information in working memory

Working memory is devoted to the temporary storage and on-line manipulation of information. Recently, an integrative system termed the episodic buffer has been proposed to integrate and hold information being entered or retrieved from episodic memory. Although the brain system supporting such an integrative buffer is still in debate, the medial temporal lobe appears to be a promising candidate for the maintenance of bound information. In the current work, binding was assessed by comparing two conditions in which participants had to retain three letters and three spatial locations presented either bound or separate. At the behavioral level, lower performance was found for bound information than for separate information. When contrasting the two conditions, activation in the right parahippocampal gyrus was greater for the encoding and maintenance of bound information. No activation was observed in the medial temporal lobe during the retrieval of bound information. Together, our results suggest that the parahippocampal gyrus may underlie the integrative and maintenance functions of the episodic buffer.     

Working memory predicts subsequent episodic memory decline during healthy cognitive aging: evidence from a cross-lagged panel design

Aging adults experience declines in working memory and episodic memory, however, it is unclear how these declines operate over time. Decreased working memory may be associated with early changes in episodic memory, by reducing older adults’ ability to meaningfully integrate new information into pre-existing schemas and recall information without the assistance of cues. Given the increased prevalence of Alzheimer’s disease, and concerns based on subjective memory changes, it is important to understand how these processes interact over time. To assess the relationship between working memory and episodic memory during healthy cognitive aging, we performed neuropsychological assessments at multiple time points in a sample of 310 community-dwelling older adults. Using a cross-lagged panel design, we demonstrated that the lagged associations between working memory and later episodic free recall were 50% larger than the lagged associations between episodic recall and later working memory, suggesting working memory may be a useful metric of future episodic memory decline.     

Gender differences in episodic memory and visual working memory including the effects of age

Analysing the relationship between gender and memory, and examining the effects of age on the overall memory-related functioning, are the ongoing goals of psychological research. The present study examined gender and age group differences in episodic memory with respect to the type of task. In addition, these subgroup differences were also analysed in visual working memory. A sample of 366 women and 330 men, aged between 16 and 69 years of age, participated in the current study. Results indicate that women outperformed men on auditory memory tasks, whereas male adolescents and older male adults showed higher level performances on visual episodic and visual working memory measures. However, the size of gender-linked effects varied somewhat across age groups. Furthermore, results partly support a declining performance on episodic memory and visual working memory measures with increasing age. Although age-related losses in episodic memory could not be explained by a decreasing verbal and visuospatial ability with age, women's advantage in auditory episodic memory could be explained by their advantage in verbal ability. Men's higher level visual episodic memory performance was found to result from their advantage in visuospatial ability. Finally, possible methodological, biological, and cognitive explanations for the current findings are discussed.     

Neural Bases of Human Working Memory

Working memory is the memory system that allows us to briefly keep information active, often so we can operate on it. Studies with rhesus monkeys first established that this system is partly mediated by neural mechanisms in the prefrontal cortex. Recently, there has been a substantial effort to study the neural bases of working memory in humans, using neuroimaging techniques such as positron emission tomography and functional magnetic resonance imaging. Some of the initial neuroimaging studies with humans focused on the neural mechanisms that mediate our ability to keep spatial information active. These results indicated that human spatial working memory is partly mediated by regions in parietal and prefrontal cortex. Subsequent research has shown that a different neural system is involved when people store object (rather than spatial) information, a difference similar to that found in monkeys.