临床肿瘤治疗决策的思考

肿瘤是一种全身性疾病,虽表现为局部的肿块,但其实质是全身免疫功能受损导致某些组织失去控制的异常生长,机体内部由于肿瘤的生长而发生了许多改变.肿瘤治疗的目的在于延长患者生存时间,即与疾病共生存.肿瘤并发症的治疗和术后肿瘤复发或再生的预防在改善生存方面发挥着重要作用.严格的技术准入和规范化治疗是提高治疗效果的保证.     

肿瘤治疗:以人为本,从"过度"到"和谐"

肿瘤的综合治疗,以往过分注重疾病本身,强调彻底杀灭肿瘤的根治性疗法,必然会导致过度治疗.随着对肿瘤演变过程了解程度的提高和临床实践经验的总结,"肿瘤是一种慢性病"成为越来越多的人们的共识.对肿瘤细胞的镇压是必要的,但一定要适可而止,要让健康的细胞、组织、器官修养生息,实现机体与肿瘤的"和平共处",达到长期带瘤生存.     

心理干预在膀胱肿瘤治疗方案中的应用

在临床工作中诊疗膀胱肿瘤时应重视患者的心理状态和精神活动,采取针对性的干预措施,对其躯体疾病的治疗和术后生存质量的提高,有积极的促进作用及良好的辅助治疗效果。本文主要阐述了膀胱肿瘤患者心理因素对膀胱肿瘤的诊疗效果的影响机制,并就如何制定心理干预措施给出了建议。     

肿瘤诊治相关肾损伤的防治决策

肿瘤患者在诊治过程中可能会引起肾脏损伤,如造影剂、化疗和靶向药物的使用等等。如何平衡肿瘤患者在诊治过程中的疗效及安全性,使患者能够接受并完成治疗,延长患者无进展生存和总生存,是肿瘤学界所面临的挑战。     

当前恶性肿瘤治疗存在的问题与失误

恶性肿瘤的临床治疗发展迅速,在取得巨大成绩的同时,也存在着一些失误：其一是广泛存在的过度治疗,由于相当一相分肿瘤患者并不能得益于临床治疗,但几乎所有虱都不倒外地去接治疗,其结果必是这种部分患者受治疗之基。其二是肿瘤治疗目的的不明确,提高肿瘤患者的生存质量并延长生存其工没落到实处,治疗没有长远规划;其三是只注重治疗这一外因,忽视肿瘤因有生物学特性这一内因及肿瘤治疗中的免疫机制;预防是最好的治疗,而目     

肿瘤内科治疗的疗效评价

肿瘤内科治疗是肿瘤综合治疗三大手段之一,在肿瘤治疗中占有举足轻重的地位。肿瘤内科治疗的疗效评价也逐步发展和完善。新的疗效评价指标逐渐被接受,延长生存期和提高肿瘤病人的生存质量已成为肿瘤内科治疗疗效评价的原则,临床肿瘤学工作者应转变观念,以利于更好地开展临床工作。     

上皮起源的惰性病变:概念和临床意义

随着检测手段的不断精确,人们对疾病的认识逐渐加深,现在可以早期检测出一些疾病,使得过度治疗成为普遍现象。有的疾病或者肿瘤并不具有快速生长、恶化及转移的风险,却被早期切除甚至辅以更加侵袭性的治疗,给人们带来精神及心理上新的伤害,如甲状腺癌、前列腺癌、早期肺癌、导管原位癌等等。本文旨在总结常见的几种惰性病变/肿瘤,尤其是上皮起源的惰性病变,对其临床病理特征、病程及预后等方面做一简要归纳,希望能给病理医生的诊断及临床医生的治疗带来一定的提示意义,避免不必要的过度诊断和治疗。     

从自然选择学说看肿瘤免疫

当今人类生存的环境发生了变化,肿瘤的发病率和病死率也越来越高,肿瘤细胞面对强大的免疫系统生存下来,说明肿瘤生存能力增强已经适应了其生存环境,这是环境对肿瘤细胞自然选择的结果。自然选择学说始终贯穿于肿瘤免疫学的免疫监视理论和免疫编辑学说之中,从自然选择的角度看肿瘤免疫学,将为肿瘤治疗策略开创一条新路。     

晚期消化道肿瘤患者临床治疗的共同决策

胃癌、结直肠癌是临床较常见的消化道肿瘤,其早中期肿瘤手术治疗效果好,但大部分晚期患者已丧失了手术机会,或者手术效果较差,如何让其主动参与进来选择自己的临床治疗方案,从而使自己相对获益最大,具有很重要的临床意义。晚期肿瘤患者临床治疗以提高晚期生活质量、减轻疾病痛苦、延长生存时间为目的,这一过程需要患者的参与,此类患者的每一项临床治疗的决策,应当是在医生指导下,患者主动参与进来,根据自身的实际情况提出治疗方案,临床医生评估其治疗方案可行性之后配合患者完成临床后期治疗,以此来最大限度提高晚期患者的生活水平。     

不同病期肿瘤患者的治疗选择

肿瘤从早期到晚期,需要选择不同的治疗手段来达到不同的治疗目的。从早期的根治性治疗到晚期的支持性治疗,随着肿瘤进展,抗肿瘤治疗强度从弱到强,到晚期又减弱。从能保证病人的生存质量到仅能减轻病人的癌性痛苦。这是肿瘤矛盾转化的必然结果,是抗肿瘤治疗的正确选择。     

Nameless Desire: Alexithymia and the Anorexic Patient

In this article, the author attempts to provide a psychoanalytic understanding of the anorexic patient who is disconnected from her affective experience and is considered to be alexithymic. Through her restrictive food ritual, this type of patient may organize her internal states by repeatedly creating an illusion of what it is that she needs and desires. The author asserts that the task of the therapist working with the anorexic patient with alexithymia is to be aware of his own sensation-based reverie as lived within the intersubjective arena. This will enable the therapist to assist the patient in building an affective vocabulary to accurately identify, differentiate, and label the internal signals of her body. It is suggested that the subjective emotional experience of the patient will continue to be reorganized, expanded, and enriched as the therapist and patient mutually influence one another in this unique relational matrix. A clinical vignette is provided to illustrate intersubjective treatment interventions with a difficult-to-reach anorexic patient.     

Beneficence,Interests, and Wellbeing in Medicine: What It Means to Provide Benefit to Patients

Abstract

Beneficence is a foundational ethical principle in medicine. To provide benefit to a patient is to promote and protect the patient’s wellbeing, to promote the patient’s interests. But there are different conceptions of wellbeing, emphasizing different values. These conceptions of wellbeing are contrary to one another and give rise to dissimilar ideas of what it means to benefit a patient. This makes the concept of beneficence ambiguous: is a benefit related to the patient’s goals and wishes, or is it a matter of objective criteria that constitute wellbeing? This paper suggests a unified conception of wellbeing for use in medicine to determine what counts as a benefit. Two components of wellbeing are identified: (1) objective functioning/health and (2) the patient’s view of her own good. The paper explores how to apply, balance, and weigh these components in clinical situations to determine what counts as a benefit to a patient.     

宁养的概论及实施

宁养为结合团队力量,在患者面临生命末期时,协助其可以面对身、心、灵、社会之整体性的痛苦,关心患者的心声、生命的意义、生活的维持、使患者被治疗、关怀、尊重、倾听、接受及了解,有尊严地面对死亡。照顾者依自己的需要关心、照顾自己,宁养团队成员需装备好自己,了解面对的病患问题,给予全人的照顾,使患者善终,家属善生。     

Here and now: My perspective1

In this paper the author describes her particular perspective in doing analytic work. She stresses working in the here and now. For example, making interpretations that grow out of what the patient says or does in the sessions, keeping the patient’s history in mind, but not letting it lead interpretations. The analysis tries to understand why something is being said now, in this way, and what impact it may have or be designed to have in the analytic relationship. The term ‘here’ refers to what is going on between patient and analyst in the room while not leaving out the patient’s immediate reality in the outside world, his everyday life. The word ‘now’ implies awareness of time that is not just of the past and future but of the patient’s situation at the moment in analysis, which is constantly shifting.The author believes that by working primarily in the present the patient will feel more anchored, both patient and analyst can observe what is going on, for example how anxiety arises or decreases, how defences are mobilised or lessen. Both analyst and patient experience movement and change rather than relying on more theoretical explanations.     

Seek first to understand

A recent study suggests that doctors often diminish effective time with patients by talking about themselves in a manner that does not improve the patient visit and is sometimes disruptive to it. Good care requires hearing what the patient has to say, as the doctor cannot set proper goals for a visit without knowing the patient's agenda. Listening to the patient is the key both to good patient care and to caring for the patient.     

Medicine as a trade

The doctor-patient relationship is usually seen and accepted as a giving-taking association, in which the doctor is a giver and the patient is a taker. The paper challenges such a one-way relationship, and stresses the patient as a giver and the doctor as a receiver. The patient is described as a source for the emotional development of the doctor, and as a source of knowledge. He is also a source for what could be called ‘life experience’. By serving as a source for these three elements, the patient is also seen as a source for reward. There is a danger of under-utilisation of this reward by the doctor, when (1) he is engaged only in giving, (2) he wilfully obstructs the channel of information, and (3) he feels ‘saturation’ called by the doctor ‘experience’. This under-utilisation will ultimately lead to ‘medical parasitism’. This parasitism is seldom recognised by the patient, because the arrest of development of a doctor is usually hardly noticed, and this will lead to neglect of the patient, so that the ‘trade’ between doctor and patient becomes unfair, as the long-term investment which the patient has placed in the doctor, does not pay off any longer.     

The clinical notion of working within

Clinical material is used to illustrate the Modern Kleinian approach to and within a patient’s defensive system and their particular transference profile. Rather than embrace the traditional concept of the working-through (WT) process, the author focuses on the analytic here-and-now of working within a patient’s unconscious phantasy world, the transference, and any pathological organizations that are relied upon. This is a more holistic and comprehensive method of working analytically, based on working within a patient’s internal object relational experience, which hopefully leads to growth and transformation. A summary of the first two analytic sessions with one patient, material from a psychotic patient in treatment for 6 months, and a higher functioning patient seen for more than a year are presented to show the utility of working in this manner with all patients regardless of their level of psychic organization.     

Truth as a way of developing and preserving the space for thinking in the minds of the patient and the analyst

Clinical material from the analysis of a young patient diagnosed with borderline personality disorder and heavily dependent on drugs was examined to identify changes in setting that may be necessary to enable the psychoanalytical treatment of this type of patient. The article describes a lack of truth in the patient's life and the absence of a good enough space for thinking in her mind. In order to enhance the development of the capacity for symbolization in the patient's mind, the analyst had to become an object the patient needed. In order to do this the analyst had to manage setting alteration. Theoretical frameworks proposed by Ferenczi, Winnicott and Bion were used to guide the psychoanalyst's approach to this patient. The survival of the capacity for thinking psychoanalytically inside the analyst's mind when the setting has been significantly distorted by the disruptive behavior of the patient is guaranteed by the trueness of their link. It is suggested that maybe this is decisive for a successful psychoanalytical treatment of this type of patient.     

论医疗权及其实践

患者的医疗权可以表现为宪法上的应然权利和实践中的实然权利.在具体医疗实践中,患者获得公正、必须和费用节省的医疗服务的权利,是以患者支付医疗费用为前提的.在特定情况下,虽然患者无支付能力,也可以享有医疗权.患者有拒绝医疗的权利.     

The Role of Regret in Medical Decision-making

In this paper, I explore the role that regret does and should play in medical decision-making. Specifically, I consider whether the possibility of a patient experiencing post-treatment regret is a good reason for a clinician to counsel against that treatment or to withhold it. Currently, the belief that a patient may experience post-treatment regret is sometimes taken as a sufficiently strong reason to withhold it, even when the patient makes an explicit, informed request. Relatedly, medical researchers and practitioners often understand a patient’s post-treatment regret to be a significant problem, one that reveals a mistake or flaw in the decision-making process. Contrary to these views, I argue that the possibility of post-treatment regret is not necessarily a good reason for withholding the treatment. This claim is justified by appealing to respect for patient autonomy. Furthermore, there are occasions when the very reference to post-treatment regret during medical decision-making is inappropriate. This, I suggest, is the case when the decision concerns a “personally transformative treatment”. This is a treatment that alters a person’s identity. Because the treatment is transformative, neither clinicians nor the patient him/herself can ascertain whether post-treatment regret will occur. Consequently, I suggest, what matters in determining whether to offer a personally transformative treatment is whether the patient has sufficiently good reasons for wanting the treatment at the time the decision is made. What does not matter is how the patient may subsequently be changed by undergoing the treatment.