学前儿童迷走神经活动与情绪反应、情绪调节及冲动性的关系

Porges的多迷走神经理论提出迷走神经活动(vagal activity)与儿童的情绪及社会行为密切联系,已有研究探讨了儿童迷走神经活动与儿童的情绪反应及调节的关系,但研究结论不够清晰,需要进一步研究澄清。本研究选取93名4-6岁学前儿童被试,运用生理测量手段与呼吸性窦性心律不齐(respiratory sinus arrhythmia,RSA)分析的方法,采用父母报告的学前儿童情绪反应强度、情绪调节能力、冲动性为结果变量,进一步探讨儿童迷走神经活动(以基线RSA、RSA撤出、RSA恢复为指标)与情绪反应、情绪调节及冲动性的关系。研究发现:(1)基线RSA与儿童情绪反应强度显著负相关,与儿童情绪调节能力显著正相关,基线RSA是儿童情绪反应强度显著负向预测因子,是儿童情绪调节能力的显著正向预测因子;(2)RSA撤出、RSA恢复性与儿童冲动性显著负相关,是儿童冲动性显著负向预测因子。研究结果支持了Porges的多迷走神经理论,表明迷走神经活动与儿童情绪反应、情绪调节及冲动性密切联系。     

Individual differences in vagal regulation moderate associations between daily affect and daily couple interactions

Previous research suggests that cardiac vagal regulation (indexed by respiratory sinus arrhythmia, or RSA) provides a physiological substrate for affect regulation, which presumably underlies adaptive interpersonal functioning.The authors tested these associations in the context of daily interactions between 68 cohabiting couples. Participants underwent a laboratory assessment of RSA during rest and also during a series of psychological stressors. Subsequently, they kept daily measures of affect and interaction quality for 21 days. Individual differences in baseline and stress levels of RSA moderated within-person associations between daily affect and the quality of couple interactions. The pattern of results differed for women versus men. Men with lower vagal tone or higher vagal reactivity had stronger associations between daily negative affect and daily negative interactions, and men with higher vagal tone had more positive daily interactions overall. Women with higher vagal tone had stronger associations between daily positive affect and daily positive interactions.     

An initial investigation of baseline respiratory sinus arrhythmia as a moderator of treatment outcome for young children born premature with externalizing behavior problems

The aim of the current study was to examine the moderating effect of baseline respiratory sinus arrhythmia (RSA) on Parent-Child Interaction Therapy (PCIT), a behavioral parent-training intervention, for young children born premature. In this pilot randomized controlled trial, 28 young children (mean age of 37.79 months), who were born <37 weeks gestation and presented with elevated externalizing behavior problems, were randomly assigned to an immediate treatment or waitlist control group. RSA, which provides an approximate marker of individual differences in cardiac vagal tone, was measured during a baseline period. Past research has generally shown that higher levels of baseline RSA correlate with various positive psychological states (e.g., empathy, sustained attention), whereas lower levels of baseline RSA correlate with less optimal psychological states (e.g., higher externalizing behavior problems). Results indicated that baseline RSA significantly interacted with treatment condition in predicting changes in child disruptive behavior. Specifically, low levels of baseline RSA were associated with greater improvements in child disruptive behavior following PCIT. While acknowledging the caveats of measuring and interpreting RSA and the need to include a sympathetic-linked cardiac measure in future research, these findings provide preliminary evidence that children with lower capacity for emotion regulation receive even greater treatment gains. Future research should also examine the moderating effect of RSA in larger samples and explore the potential mediating role of RSA on behavioral parenting interventions.     

Recognition memory and cardiac vagal tone in 6-month-old infants

Individual differences in visual recognition memory and cardiac vagal tone were assessed in 14 6-month-old infants. A multi-dimensional problem was presented with the paired-comparison technique to assess recognition memory. Cardiac vagal tone was evaluated by quantifying the amplitude of respiratory sinus arrhythmia. Individual differences in spontaneous baseline cardiac vagal tone were correlated with two measures of visual recognition memory. Infants characterized by high cardiac vagal tone looked for shorter periods at the standard (i.e., familiar) stimulus during familiarization and looked for longer periods at the novel stimulus during the test trials. In response to the visual stimulus during the familiarization and test trials, heart rate decelerated only for the infants who performed well on the visual recognition memory task (i.e., those who looked longer at the novel stimulus than the familiar stimulus).     

Child and mother cardiac vagal tone: continuity, stability, and concordance across the first 5 years

In this prospective longitudinal study, vagal tone and heart period were measured at 2 months and at 5 years in children and their mothers to evaluate the development of vagal regulation at rest and during an environmental task. Child baseline vagal tone and heart period were discontinuous; mother baseline vagal tone was discontinuous, but heart period was continuous. Group mean baseline-to-task change in vagal tone and heart period were continuous in both children and mothers. Children reached adult levels of baseline vagal tone by 5 years and did not differ from their mothers in baseline-to-task change in vagal tone or heart period. Baseline vagal tone tended to be stable, but baseline heart period and baseline-to-task change in vagal tone and heart period were unstable in children; both were stable in mothers. Baseline-to-task change in vagal tone showed consistent child-mother concordance. These findings contribute to understanding psychophysiological development, especially the ontogenesis of the vagal system and its regulatory capacity.     

Parental drinking problems and children's adjustment: vagal regulation and emotional reactivity as pathways and moderators of risk.

Children's emotional regulation (as indexed by vagal suppression) and children's emotional reactivity during an argument were examined as moderators and mediators of parental problem drinking and children's adjustment in a sample of 6- to 12-year-olds. Cardiac vagal tone was assessed during both a baseline condition and exposure to an audiotaped argument. Vagal suppression was calculated by subtracting vagal tone during the baseline from that recorded during the argument, with a higher number representing increased suppression of vagal tone during the argument. Emotional reactivity was based on both observations of overt behaviors of children and their reported feelings during the argument. A higher level of vagal suppression was a protective factor against children's externalizing, internalizing, and social problems associated with exposure to parental problem drinking. Emotional reactivity was a vulnerability factor, and children's increased anger and fear, and to a lesser degree sadness, each moderated and exacerbated the effects of parental problem drinking on child outcomes.     

父母婚姻质量与儿童内化问题:父母情绪表达的中介作用与儿童迷走神经活动的调节作用

基于家庭系统理论与个体-环境交互理论,研究考察了父母情绪表达在父母婚姻质量与儿童内化问题关系中的中介作用,以及儿童迷走神经活动的调节作用。研究选取155名6~7岁小学儿童为被试,运用便携式生理多道记录仪采集儿童静息与任务状态下的心电（ECG）与呼吸率,换算出基线RSA与RSA反应作为迷走神经活动的指标,采用母亲报告的《婚姻质量问卷》、《家庭情绪表达问卷》和《儿童行为量表》测评父母婚姻质量、父母情绪表达及儿童内化问题。结果发现：（1）父母婚姻质量负向预测小学儿童内化问题;（2）父母消极、积极情绪表达在父母婚姻质量与小学儿童内化问题关系中起中介作用;（3）小学儿童迷走神经张力（基线RSA）调节父母消极情绪表达与儿童内化问题关系。研究结果表明父母婚姻质量不仅直接影响儿童内化问题,同时会通过父母情绪表达间接地影响儿童内化问题。另外,较高迷走神经张力能够缓冲父母消极情绪表达对儿童内化问题的影响。     

2~6岁儿童心迷走紧张的发展

考察2岁、4岁和6岁3个组共104名有效被试,在基线状态下的基线迷走紧张以及与年龄相符的中等压力任务下的迷走抑制的发展。结果发现,基线迷走紧张与迷走抑制有不同的发展模式：4岁组、6岁组儿童的基线迷走紧张显著地高于2岁组,而4岁组与6岁组之间没有显著差异,基线心跳周期随年龄的增长而相应增长;迷走抑制没有年龄差异,6岁组的基线对任务的心跳周期变化显著地大于2岁组的心跳周期变化     

Autonomic reactivity during viewing of an unpleasant film.

The effect of an aversive, high-arousing film on heart rate, respiratory sinus arrhythmia, and electrogastrographic activity (EGG) was investigated. Previous studies have indicated a larger heart-rate deceleration for visual stimuli depicting surgery or blood compared to neutral content, and this phenomenon is similar to the bradycardia observed in animals in response to fear. The heart-rate deceleration is clearly parasympathetically driven, and it is considered a general index of attention. An accurate index of cardiac vagal tone can be obtained by means of quantification of the amplitude of respiratory sinus arrhythmia. The relationship between cardiac vagal tone and EGG is complex, but animal research has shown that suppressing vagal activity dampens gastric motility. We have investigated whether a movie depicting surgery is associated with greater heart-rate deceleration, larger increase in respiratory sinus arrhythmia, and greater increase in EGG activity compared to a neutral movie. In addition, if both respiratory sinus arrhythmia and EGG are indices of vagal tone, a positive correlation between these physiological responses was expected. Analysis indicated an effect of the surgery movie on heart rate and respiratory sinus arrhythmia, but not on EGG activity. Moreover, the expected correlation was not found. Implications for future studies are discussed.     

Developmental trajectories of delinquency symptoms in childhood: the role of marital conflict and autonomic nervous system activity

Trajectories of delinquency symptoms across middle and late childhood were examined through latent growth modeling, with a focus on the role of interactions among parental marital conflict, child sex, and multiple indices (baseline, reactivity) of either parasympathetic nervous system activity, indexed by respiratory sinus arrhythmia (RSA), or sympathetic nervous system activity, indexed by skin conductance level (SCL), as predictors of growth. At Time 1, 128 girls and 123 boys (mean age = 8.23 yrs ± 0.73) and their parents participated. The sample comprised 64% European American and 36% African American children. Families participated in second and third waves of data collection with a 1-year lag between each wave. Interactions among marital conflict, sex, baseline RSA, and RSA reactivity from baseline to a frustrating lab task were significant predictors of growth in delinquent behavior from age 8 to age 10, with overall patterns indicating increasing symptoms for boys who lived in high-conflict homes and had an RSA response profile comprising lower RSA during the baseline and RSA augmentation (increase from baseline to the frustrating task). Furthermore, increases in delinquency symptoms over time were observed for children from high-conflict homes and with an SCL profile characterized by higher baseline levels and lower reactivity (less pronounced SCL increases from baseline) to the frustrating task. Findings highlight the importance of contemporaneous assessments of resting and reactivity levels when examining relations among the environment, physiological functioning, and psychopathology. Results are discussed in the context of interactions between biology and environment as relevant to the development of psychopathology.     

Love alters autonomic reactivity to emotions

Periods of bond formation are accompanied by physiological and emotional changes, yet, little is known about the effects of falling in love on the individual's physiological response to emotions. We examined autonomic reactivity to the presentation of negative and positive films in 112 young adults, including 57 singles and 55 new lovers who began a romantic relationship 2.5 months prior to the experiment Autonomic reactivity was measured by Respiratory Sinus Arrhythmia (RSA) to two baseline emotionally neutral films, two negative films, and two positive films. Results demonstrated that RSA in singles decreased during the presentation of negative emotions, indicating physiological stress response. However, no such decrease was found among new lovers, pointing to more optimal vagal regulation during the period of falling in love. Autonomic reactivity, indexed by RSA decrease from the positive to the negative films, was greater among singles as compared to lovers, suggesting that love buffers against autonomic stress and facilitates emotion regulation. Findings suggest that vagal regulation may be one mechanism through which love and attachment reduce stress and promote well-being and health.     

Parasympathetic Regulation and Inhibitory Control Predict the Development of Externalizing Problems in Early Childhood

The current report examined the longitudinal relations between cognitive self-regulation, physiological self-regulation, and externalizing problems. At age 4 (n = 98; 49 girls) and 6 (n = 87; 42 girls), children completed the Day-Night task, which taps the inhibitory control dimension of executive function. During the task, cardiac activity was measured and respiratory sinus arrhythmia (RSA) was derived as an index of parasympathetic activity. Mothers reported on externalizing problems. A cross-lagged path model was used to estimate longitudinal predictions while controlling for stability in all constructs over time. Earlier inhibitory control negatively predicted later externalizing problems, but not vice versa. However, RSA reactivity moderated this link; better inhibitory control predicted fewer externalizing problems only when reactivity to the Day-Night task ranged from mild RSA suppression to RSA augmentation. Externalizing problems at 6 years were highest among preschoolers who augmented RSA but showed poor inhibitory control performance, suggesting that risk for psychopathology may be better delineated by viewing self-regulation from an integrated, multi-system perspective.     

Perceptual cues used in reproduction of inspired volume

Man is capable of reproducing an inspired lung volume (IV) with relative precision (±3 %–8 %). To investigate the importance of cues which may be used to determine IV, we performed two experiments. In each, the subject inspired a “standard” breath (from resting end~xpired lung volume) corresponding to 25%, 50%, or 75% of inspiratory capacity (IC) and then expired nearly completely. From this expired volume, the subject either tried to reproduce the tidal volume (i.e., volume of air inspired) of the first breath (volume reproduction) or to reproduce the previous end-inspired lung volume (position reproduction). The constant error indicated that subjects overestimated tidal volume by about 200 ml. Despite this overestimation, the variability of reproduction was less for volume reproduction than for position reproduction when IV was small. The JND for volume reproduction increased linearly with increasing IV, whereas the JND for position reproduction was similar at all IVs so that the Weber ratio decreased. These observations suggest that, in the perception of inspired volume, the sensation of end-inspired position is important when the inspired volume is large, but that subjects apparently rely on some other cue to reproduce small lung volumes accurately.     

A preliminary study of the comfort of paced respiration

In order to obtain basal information about what type of externally paced respiration is comfortable, 25 male and 25 female undergraduate students were asked to practice self‐paced respiration. After a 1‐min rehearsal following instructions on comfortable self‐paced respiration, subjects carried out 2 min of self‐paced respiration and rated their level of comfort on a scale of 1–5. This was repeated (up to a maximum of seven times) until the subject recorded a high rating. Results indicated that self‐paced respiration was most comfortable, irrespective of sex, when a respiratory pattern was attained of half the respiratory rate and nearly twice the tidal volume of the trainee's resting condition. Although respiratory sinus arrhythmia and heart rate were indicative of a decrease in cardiac vagal activity and end‐tidal PCO₂ was suggestive of a reduction in anxiety, these effects were small. The results have implications for the utilization of externally paced respiration.     

Cortical control of sinus arrhythmia in man studied by spectral analysis

Eighteen healthy male volunteers, 21–26 years old, participated in a study intended to detect cortical control of beat-to-beat heart rate variability independent of the effects on breathing and mean heart rate. They were tested while seated and standing relaxed (baseline), and while performing tasks requiring concentrated attention while sitting. The mental concentration elicited a typical cardiorespiratory response manifested by moderate acceleration and shallowing of respiration with a small increase of mean heart rate (HR), a pattern already widely acknowledged as typically associated with concentration. With the aid of a variable tone delivered to the ear as a guide, the subjects were trained to breathe at the same rate without concentrating in order to test the influence of respiration on the concentration pattern. ECG, thermistor pneumogram and ear-lobe photo-plethysmogram were recorded and data reduction was performed on 3 minute or 1 minute data sequences selected for the best steady-state. Statistical treatment was limited to a subgroup of 10 subjects in whom there was no overlapping of the spectra of respiratory and Traube-Hering-Mayer sinus arrhythmia (RSA and THM-SA, respectively). Mental concentration elicited significant depression of both RSA and THM-SA even if the respiratory parameters were kept constant.     

Self-esteem and autonomic physiology: parallels between self-esteem and cardiac vagal tone as buffers of threat

In this article a potential physiological connection to self-esteem is suggested: cardiac vagal tone, the degree of influence on the heart by the vagus, a primary nerve of the parasympathetic nervous system. This hypothesis emerges from parallels between the two literatures that suggest both self-esteem and cardiac vagal tone function to provide protection from threat responding. This article reviews these literatures and evidence and preliminary findings that suggest in some contexts self-esteem and cardiac vagal tone may exert an influence on each other. Last, the article discusses theoretical and applied health implications of this potential physiological connection to self-esteem.     

Examining the Prospective Relationship between Pre-Disaster Respiratory Sinus Arrhythmia and Post-Disaster Posttraumatic Stress Disorder Symptoms in Children

Previous studies have examined the concurrent relationship between posttraumatic stress disorder (PTSD) and a range of psychophysiological variables, including respiratory sinus arrhythmia (RSA). However, there is a lack of research examining the prospective development of trauma symptomatology, and the directionality of the association between RSA level and PTSD has yet to be determined. The current study is the first prospective study to examine whether RSA level and RSA reactivity are risk factors for PTSD symptoms in children. Assessments were conducted both prior to (Time 1) and following (Time 2) a natural disaster (i.e., Hurricane Katrina). Participants were 36 children who were 3–6 years-old during the Time 1 assessment. Structured diagnostic interviews were used to assess PTSD symptoms at both Time 1 and Time 2. RSA level during a neutral stimulus, RSA reactivity to emotional video stimuli (distress, joy, and trauma videos) and RSA reactivity to memory stimuli (remote happy memory, trauma memory, mother’s recall of the trauma memory) were also collected at both time points. Time 1 RSA level during a neutral stimulus was a significant predictor of Time 2 PTSD symptoms (controlling for age, Time 1 PTSD symptoms, Time 2 neutral RSA level), such that lower RSA during a neutral condition was related to higher PTSD symptoms. Also, Time 1 RSA reactivity in response to memory (but not video) stimuli, in the form of relatively less vagal withdrawal, was a significant predictor of more Time 2 PTSD symptoms (controlling for age, Time 1 PTSD symptoms, Time 2 RSA reactivity). This unique prospective study provides evidence for level of RSA and RSA reactivity as pre-existing clinical markers of stress sensitivity that predict psychopathology following a trauma.     

Does poor vagal tone exacerbate child maladjustment in the context of parental problem drinking? A longitudinal examination

Children's vagal tone was examined as a vulnerability factor in the longitudinal relation between mothers' (MPD) and fathers' (FPD) problem drinking and children's adjustment. At T1, MPD and FPD were examined, and children's vagal tone was assessed. Two years following initial participation, child adjustment problems were evaluated. A lower level of vagal tone was a vulnerability factor for internalizing problems associated with MPD and FPD and for externalizing difficulties associated with MPD. In the context of a higher level of MPD or FPD, a lower level of vagal tone was a vulnerability factor for increases in externalizing problems over time. Results are supportive of the importance of biopsychosocial perspectives in which child characteristics interact with family risk to predict psychopathology.     

Differential susceptibility and the early development of aggression: interactive effects of respiratory sinus arrhythmia and environmental quality

The purpose of the current study was to predict the development of aggressive behavior from young children's respiratory sinus arrhythmia (RSA) and environmental quality. In a longitudinal sample of 213 children, baseline RSA, RSA suppression in response to a film of crying babies, and a composite measure of environmental quality (incorporating socioeconomic status and marital adjustment) were measured, and parent-reported aggression was assessed from 18 to 54 months of age. Predictions based on biological sensitivity-to-context/differential susceptibility and diathesis-stress models, as well as potential moderation by child sex, were examined. The interaction of baseline RSA with environmental quality predicted the development (slope) and 54-month intercept of mothers' reports of aggression. For girls only, the interaction between baseline RSA and environmental quality predicted the 18-month intercept of fathers' reports. In general, significant negative relations between RSA and aggression were found primarily at high levels of environmental quality. In addition, we found a significant Sex × RSA interaction predicting the slope and 54-month intercept of fathers' reports of aggression, such that RSA was negatively related to aggression for boys but not for girls. Contrary to predictions, no significant main effects or interactions were found for RSA suppression. The results provide mixed but not full support for differential susceptibility theory and provide little support for the diathesis-stress model.     

Individual differences in trajectories of emotion regulation processes: the effects of maternal depressive symptomatology and children's physiological regulation

Trajectories of emotion regulation processes were examined in a community sample of 269 children across the ages of 4 to 7 using hierarchical linear modeling. Maternal depressive symptomatology (Symptom Checklist-90) and children's physiological reactivity (respiratory sinus arrhythmia [RSA]) and vagal regulation (Delta RSA) were explored as predictors of individual differences in trajectories of emotion regulation and negativity (mother-reported Emotion Regulation Checklist; A. M. Shields & D. Cicchetti, 1997). In addition, the authors explored whether children's physiological regulation would moderate the effect of maternal depressive symptomatology on children's emotion regulation trajectories. Results indicated that over time, emotion regulation increased whereas negativity decreased, though considerable individual variability in the pattern of change was observed. Greater maternal depressive symptomatology was associated with less steep emotion regulation trajectories. There was a significant Maternal Depressive Symptomatology x Baseline RSA x Age interaction predicting emotion regulation trajectories. Overall, it appears that the development of emotion regulation over time is compromised when mothers report greater depressive symptomatology. There is also evidence that children's capacity for physiological regulation can buffer some of the adverse consequences associated with maternal depressive symptomatology.