Massage and music therapies attenuate frontal EEG asymmetry in depressed adolescents

EEG asymmetry, specifically greater relative right frontal activation, is associated with negative affect. Depressed adults show stable patterns of this asymmetry. The present study assessed the effects of massage therapy and music therapy on frontal EEG asymmetry in depressed adolescents. Thirty adolescents with greater relative right frontal EEG activation and symptoms of depression were given either massage therapy (n = 14) or music therapy (n = 16). EEG was recorded for three-minute periods before, during, and after therapy. Frontal EEG asymmetry was significantly attenuated during and after the massage and music sessions.     

Menstrual cycle, beta-endorphins, and pain sensitivity in premenstrual dysphoric disorder.

This study examined pain sensitivity and pain modularity mechanisms (e.g., beta-endorphin levels, blood pressure) in women with premenstrual dysphoric disorder (PMDD; n = 27) and healthy controls (n = 27) during the follicular and luteal phases of the menstrual cycle. Physiological measures were taken during rest and ischemic pain testing. In both cycle phases, PMDD women (a) displayed lower resting cortisol and beta-endorphin levels and (b) exhibited shorter pain threshold and tolerance times and greater pain unpleasantness ratings during pain. PMDD women also reported greater pain unpleasantness and intensity and had lower beta-endorphin levels in their luteal phase and tended to display higher blood pressure levels at rest and during pain testing. Results suggest that endogenous opioids may be pathophysiologically relevant to PMDD and that the hypothalamic-pituitary-gonadal axis may modulate pain sensitivity in PMDD.     

An Empirical Evaluation of the Diagnostic Criteria for Premenstrual Dysphoric Disorder: Problems with Sex Specificity and Validity

Premenstrual dysphoric disorder is a psychiatric disorder that reportedly affects between 3 to 8% of women. Although not an official diagnosis in the current Diagnostic and Statistical Manual of Mental Disorders, premenstrual dysphoric disorder has received increasing attention in the clinical literature, and considerable debate exists regarding the validity of this proposed condition. This study examined the prevalence of premenstrual dysphoric disorder in a sample of women and men and assessed the construct validity of the disorder. Twenty percent of women met the criteria for provisional diagnosis of premenstrual dysphoric disorder using Diagnostic and Statistical Manual criteria. In addition, 4% of men met these criteria when given sex-neutral assessment forms. Self-reported psychological distress and impaired interpersonal functioning did not predict women's likelihood of meeting the criteria for premenstrual dysphoric disorder. Results cast doubt on the sex-specificity of the diagnostic criteria of premenstrual dysphoric disorder and the construct validity of the disorder. Limitations of this study are discussed.     

Anger style, psychopathology, and regional brain activity

Depression and anxiety often involve high levels of trait anger and disturbances in anger expression. Reported anger experience and outward anger expression have recently been associated with left-biased asymmetry of frontal cortical activity, assumed to reflect approach motivation. However, different styles of anger expression could presumably involve different brain mechanisms and/or interact with psychopathology to produce various patterns of brain asymmetry. The present study explored these issues by comparing resting regional electroencephalographic activity in participants high in trait anger who differed in anger expression style (high anger-in, high anger-out, both) and participants low in trait anger, with depression and anxiety systematically assessed. Trait anger, not anger-in or anger-out, predicted left-biased asymmetry at medial frontal EEG sites. The anger-in group reported higher levels of anxious apprehension than did the anger-out group. Furthermore, anxious apprehension moderated the relationship between trait anger, anger-in, and asymmetry in favor of the left hemisphere. Results suggest that motivational direction is not always the driving force behind the relationship of anger and left frontal asymmetry. Findings also support a distinction between anxious apprehension and anxious arousal.     

IS A LITTLE (PSYCHIATRIC) KNOWLEDGE A DANGEROUS THING?

One hundred thirty-four participants completed a revised Menstrual Distress Questionnaire (MDQ), which included criteria for premenstrual dysphoric disorder (PMDD). Two weeks later the participants again completed the revised MDQ after reading either the Diagnostic and Statistical Manual of Mental Disorders (DSM-IV; American Psychiatric Association, 1994) diagnostic criteria for the PMDD or a copy of the same criteria retitled "Episodic Dysphoric Disorder," with all menstrual cycle references removed. Knowledge of the diagnosis did not affect women's perceptions of their own menstrual cycle-related symptoms, but it increased participants' perceptions of premenstrual changes as a problem for women in general. Chi-square analyses revealed that participants were more willing to attach a psychiatric diagnosis to women they know if they believed the diagnosis was related to the menstrual cycle.     

Prenatal predictors of maternal and newborn EEG

Ninety-two mothers were recruited at a prenatal ultrasound clinic at which time they were given the CES-D for depression and the State-Trait Anxiety Inventory, and their urines were assayed for cortisol, norepinephrine, epinephrine, dopamine, and serotonin. At the neonatal period the mothers and neonates were assessed on frontal EEG asymmetry. Correlation analyses revealed the following: (1) the mothers’ frontal asymmetry was negatively related to prenatal depression (CES-D) symptoms, negatively related to prenatal norepinephrine levels and positively related to prenatal serotonin levels; (2) the frontal asymmetry of the newborn was positively correlated with the mothers’ frontal asymmetry and negatively correlated with the mothers’ prenatal depression (CES-D) symptoms and negatively correlated with the mothers’ prenatal state anxiety scores. The neonates’ EEG frontal asymmetry was also, like the mother's, negatively related to prenatal maternal norepinephrine and positively related to prenatal maternal serotonin.     

Resting frontal brain asymmetry predicts affective responses to films

This article assessed whether resting electroencephalographic (EEG) asymmetry in anterior regions of the brain can predict affective responses to emotion elicitors. Baseline EEG was recorded from 32 female adults, after which Ss viewed film clips preselected to elicit positive or negative affect. Resting alpha power asymmetry in the frontal region significantly predicted self-reported global negative affect in response to clips and predicted the difference between global positive and negative affect. Analyses of discrete emotions revealed a strong relation between frontal asymmetry and fear responses to films. Effects were independent of Ss mood ratings at the time at which baseline EEG was measured. Resting anterior asymmetry may be a state-independent index of the individual's predisposition to respond affectively.     

Premenstrual symptoms: the role of irrational thinking.

104 women, between the ages of 18 and 45 years, were surveyed to investigate the relationship between premenstrual symptomatology, as measured by the Modified Menstrual Distress Questionnaire, and irrational thinking, as measured by the General Attitude and Belief Scale. The women who reported greater premenstrual symptomatology also reported significantly higher scores in the "need for comfort" irrationality subscale. This indicated that these women had particular difficulty dealing with hassles and the resulting feelings of tension and irritability in the premenstruum. It was suggested that the absence of significant effects for other rationality-irrationality subscales could be associated with testing at different times during the menstrual cycle. Irrationality, like other conditions (such as anxiety and depression) prevalent in the premenstruum, could change in intensity across phases of the menstrual cycle.     

Frontal Brain Electrical Activity in Shyness and Sociability

A number of studies have shown that shyness and sociability may be two independent personality traits that are distinguishable across a variety of measures and cultures. Utilizing recent frontal activation–emotion models as a theoretical framework, this study examined the pattern of resting frontal electroencephalographic (EEG) activity in undergraduates who self-reported high and low shyness and sociability. Analyses revealed that shyness was associated with greater relative right frontal EEG activity, whereas sociability was associated with greater relative left frontal EEG activity. Also, different combinations of shyness and sociability were distinguishable on the basis of resting frontal EEG power. Although high-shy/high-social and high-shy/low-social subjects both exhibited greater relative right frontal EEG activity, they differed significantly on EEG power in the left, but not right, frontal lead. High-shy/high-social subjects exhibited significantly less EEG power (i.e., more activity) in the left frontal lead compared with the high-shy/low-social subjects. These findings suggest that in distinguishing individual differences in personality and personality subtypes, it is important to consider not only frontal EEG asymmetry measures, but also the pattern of absolute EEG power in each frontal hemisphere.     

Infant frontal EEG asymmetry moderates the association between maternal behavior and toddler negative affectivity

Relatively little work has examined potential interactions between child intrinsic factors and extrinsic environmental factors in the development of negative affect in early life. This work is important because high levels of early negative affectivity have been associated with difficulties in later childhood adjustment. We examined associations between infant frontal electroencephalogram (EEG), maternal parenting behaviors, and children’s negative affect across the first two years of life. Infant baseline frontal EEG asymmetry was measured at 5 months; maternal sensitivity and intrusiveness were observed during mother-child interaction at 5 and 24 months; and mothers provided reports of toddler negative affect at 24 months. Results indicated that maternal sensitive behaviors at 5 months were associated with less negative affect at 24 months, but only for infants with left frontal EEG asymmetry. Similarly, maternal sensitive behaviors at 24 months were associated with less toddler negative affect at 24 months, but only for infants with left frontal EEG asymmetry. In contrast, maternal intrusive behaviors at 5- and 24-months were associated with greater toddler negative affect, but only for infants with right frontal EEG asymmetry at 5-months. Findings suggest that levels of negative affect in toddlers may be at least partially a result of interactions between children’s own early neurophysiological functioning and maternal behavior during everyday interactions with children in the first two years of life.     

45天-6°头低位卧床对个体额区EEG偏侧化和情绪的影响

考察了16名22~34岁男性被试在45天-6°头低位卧床模拟失重条件下, 在卧床前(第2天)、卧床期(第11, 20, 32, 40天)及卧床后(第8天)的额区EEG偏侧化变化趋势, 并采用贝克焦虑量表(BAI)和贝克抑郁量表(BDI)对主观情绪状态进行评估。研究发现EEG偏侧化指标呈现出明显的线性变化趋势。卧床期间个体的心境状态处于比较低的水平, 报告有较强的躯体焦虑感。在整个卧床期间, 个体为维持稳定的情绪状态而付出比较大的情绪调节努力。     

Children’s Affect Expression and Frontal EEG Asymmetry: Transactional Associations with Mothers’ Depressive Symptoms

Although parents and children are thought to influence one another's affect and behavior, few studies have examined the direction of effects from children to parents, particularly with respect to parental psychopathology. We tested the hypothesis that children's affective characteristics are associated with the course of mothers' depressive symptoms. Children's affect expression was observed during a series of mother-child interaction tasks, and children's resting frontal electroencephalogram (EEG) asymmetry was assessed in a psychophysiology laboratory. Mothers' depressive symptoms were assessed at two time points, approximately one year apart, at the mother-child interaction visits. Depressive symptoms increased over time for mothers with a history of childhood-onset depression whose children exhibited right frontal EEG asymmetry. Depressive symptoms were associated with high child negative affect at both time points for mothers whose children exhibited right frontal EEG asymmetry. Cross-lagged models with a subset of participants provided some evidence of both parent-to-child and child-to-parent directions of effects. Findings suggest that akin to other interpersonal stressors, children's affective characteristics may contribute to maternal depressive symptoms.     

Children’s Depressive Symptoms in Relation to EEG Frontal Asymmetry and Maternal Depression

This study examined the relations of school-age children’s depressive symptoms, frontal EEG asymmetry, and maternal history of childhood-onset depression (COD). Participants were 73 children, 43 of whom had mothers with COD. Children’s EEG was recorded at baseline and while watching happy and sad film clips. Depressive symptoms were measured using parent-report of Children’s Depression Inventory. The key findings are the interaction effects between baseline and film frontal EEG asymmetry on child depressive symptoms. Specifically, relative right frontal EEG asymmetry while watching happy or sad film clip was associated with elevated depressive symptoms for children who also exhibited right frontal EEG asymmetry at baseline. Results suggest that right frontal EEG asymmetry that is consistent across situations may be an marker of depression-prone children.     

The relation between electroencephalogram asymmetry and attention biases to threat at baseline and under stress

Electroencephalogram (EEG) asymmetry in the alpha frequency band has been implicated in emotion processing and broad approach-withdrawal motivation systems. Questions remain regarding the cognitive mechanisms that may help elucidate the observed links between EEG asymmetry and patterns of socioemotional functioning. The current study observed frontal EEG asymmetry patterns at rest and under social threat among young adults (N = 45, M = 21.1 years). Asymmetries were, in turn, associated with performance on an emotion-face dot-probe attention bias task. Attention biases to threat have been implicated as potential causal mechanisms in anxiety and social withdrawal. Frontal EEG asymmetry at baseline did not predict attention bias patterns to angry or happy faces. However, increases in right frontal alpha asymmetry from baseline to the stressful speech condition were associated with vigilance to angry faces and avoidance of happy faces. The findings may reflect individual differences in the pattern of response (approach or withdrawal) with the introduction of a mild stressor. Comparison analyses with frontal beta asymmetry and parietal alpha asymmetry did not find similar patterns. Thus, the data may reflect the unique role of frontal regions, particularly the dorsolateral prefrontal cortex, in cognitive control and threat detection, coupled with ruminative processes associated with alpha activity.     

Putative EEG measures of social anxiety: Comparing frontal alpha asymmetry and delta–beta cross-frequency correlation

The goal of the present study was to examine whether frontal alpha asymmetry and delta–beta cross-frequency correlation during resting state, anticipation, and recovery are electroencephalographic (EEG) measures of social anxiety. For the first time, we jointly examined frontal alpha asymmetry and delta–beta correlation during resting state and during a social performance task in high (HSA) versus low (LSA) socially anxious females. Participants performed a social performance task in which they first watched and evaluated a video of a peer, and then prepared their own speech. They believed that their speech would be videotaped and evaluated by a peer. We found that HSA participants showed significant negative delta–beta correlation as compared to LSA participants during both anticipation of and recovery from the stressful social situation. This negative delta–beta correlation might reflect increased activity in subcortical brain regions and decreased activity in cortical brain regions. As we hypothesized, no group differences in delta–beta correlation were found during the resting state. This could indicate that a certain level of stress is needed to find EEG measures of social anxiety. As for frontal alpha asymmetry, we did not find any group differences. The present frontal alpha asymmetry results are discussed in relation to the evident inconsistencies in the frontal alpha asymmetry literature. Together, our results suggest that delta–beta correlation is a putative EEG measure of social anxiety.     

Men's perception of premenstrual changes on the premenstrual assessment form

Outcome research has shown that partner-spouse support can enhance the therapeutic outcome in a number of clinical problems. In the area of premenstrual tension, studies of treatment have apparently overlooked this issue of partners' support. This study was designed to address how men perceive premenstrual changes. 99 undergraduate men were asked whether they believed that women had premenstrual changes reflected on the 18 unipolar scales of the Premenstrual Assessment Form. Responses suggest that young men acknowledge that some women experience dysphoric features like hostility, mood swings, and low self-esteem as well as physical discomfort and behavioural changes. Clinical implications are outlined.     

Premenstrual tension and personality

The premenstrual symptomalogy (PMT) of 165 students of nursing and midwifery was studied and their personality was assessed using the Eysenck Personality Questionnaire (EPQ). Thirty-four per cent of the Ss showed severe and 42% moderate PMT symptomatology. Ss with severe PMT symptomatology gave significantly higher scores in the neuroticism scale of the EPQ. Abdominal and pelvic pain as well as low back pain, i.e. symptoms of dysmenorrhoea, did not correlate with high neuroticism scores.     

Frontal and parietal EEG asymmetries interact to predict attentional bias to threat

Frontal and parietal electroencephalographic (EEG) asymmetries mark vulnerability to depression and anxiety. Drawing on cognitive theories of vulnerability, we hypothesise that cortical asymmetries predict attention to threat. Participants completed a dot-probe task in which bilateral face displays were followed by lateralised targets at either short (300 ms) or long (1050 ms) SOA. We also measured N2pc to face onset as an index of early attentional capture. At long SOA only, frontal and parietal asymmetry interacted to predict attentional bias to angry faces. Those with leftward frontal asymmetry showed no attentional bias. Among those with rightward frontal asymmetry those with low right parietal activity showed vigilance for threat, and those with high right parietal activity showed avoidance. Asymmetry was not related to the N2pc or to attentional bias at the short SOA. Findings suggest that trait asymmetries reflect function in a fronto-parietal network that controls attention to threat.     

Maternal sensitivity and infant response to frustration: The moderating role of EEG asymmetry

Two hundred and thirty-three 5-month-old infants and their mothers participated in a study designed to examine the influence of maternal sensitivity and infant neurophysiology, as well as interactions between these, on infants’ regulatory behavior and reactivity to emotional challenge. Maternal sensitivity was measured during two mother–child free-play episodes prior to the challenge task. Infant neurophysiology was derived from a measure of resting EEG asymmetry collected during a baseline episode. Infant regulatory behaviors (mother orienting and distraction) and reactivity to challenge (negative affect) were assessed during an arm restraint procedure. Maternal sensitivity predicted mother-orienting behavior for all infants, regardless of baseline EEG asymmetry. Maternal sensitivity also predicted more distraction behaviors for infants with left frontal EEG asymmetry at baseline. In contrast, maternal sensitivity predicted more negative affect for infants with right frontal EEG asymmetry at baseline. These findings lend support for the hypothesis that maternal sensitivity and infant neurophysiological functioning interact to predict regulatory behavior and reactivity and are discussed in terms of the significance for understanding infant regulatory development in the first year of life.     

Linking Gene, Brain, and Behavior: DRD4, Frontal Asymmetry, and Temperament

ABSTRACT— Gene-environment interactions involving exogenous environmental factors are known to shape behavior and personality development. Although gene-environment interactions involving endogenous environmental factors are hypothesized to play an equally important role, this conceptual approach has not been empirically applied in the study of early-developing temperament in humans. Here we report evidence for a gene- endo environment (i.e., resting frontal brain electroencephalogram, EEG, asymmetry) interaction in predicting child temperament. The dopamine D4 receptor (DRD4) gene (long allele vs. short allele) moderated the relation between resting frontal EEG asymmetry (left vs. right) at 9 months and temperament at 48 months. Children who exhibited left frontal EEG asymmetry at 9 months and who possessed the DRD4 long allele were significantly more soothable at 48 months than other children. Among children with right frontal EEG asymmetry at 9 months, those with the DRD4 long allele had significantly more difficulties focusing and sustaining attention at 48 months than those with the DRD4 short allele. Resting frontal EEG asymmetry did not influence temperament in the absence of the DRD4 long allele. We discuss how the interaction of genetic and endoenvironmental factors may confer risk and protection for different behavioral styles in children.