Psychopharmacological treatment of unipolar depression within the elderly: A discussion paper

Depressive disorders are known to affect all aspects of a person's functioning and are often associated with significant psychosocial impairment. What is unclear is whether these psychosocial issues are consequences or causes of depression; what is known is that these problems do not disappear when the biological symptoms resolve. Existing data on the treatment course and outcome of depression are not generally considered as representative of the older depressed person. Discussion will take place as to whether later life depression should be conceptualized not as a categorical disorder, but as a geriatric syndrome, with multiple aetiologies requiring a combination of treatment interventions. There is general consensus that when intensive psychotherapy is directed towards appropriate patients, geriatric clientele are as able to deal with the viscitudes of intensive therapy as well as any age group. An examination will be undertaken regarding the utilization of psychotherapeutic interventions, namely psychodynamic, interpersonal and cognitive behavioural. Comparative studies have demonstrated all three to be effective, particularly in the treatment of depression. There is a great need for further understanding and research into the appropriateness and efficacy of an integration of psychotherapeutic and pharmacotherapeutic intervention in the treatment of depression, particularly within the elderly. A tantalizing array of research possibilities emerge. If we accept that unipolar depression is a bio-psychosocial phenomena, then we need to understand more about which psychopharmacological treatment paradigms need to be employed, and that perhaps the way forward inclines towards pragmatic integrationism rather than puritanist intervention.     

A new visual illusion: flickering fields are localized in a depth plane behind nonflickering fields

Flickering regions of the visual field are perceived to lie well behind regions which are not flickered. The depth segregation is not due to luminance differences since the average temporal luminance across all the regions was equal. This depth effect produced by flicker is not dependent on the texture of the visual field; nor does it depend on a specific configuration of the flickering and nonflickering areas. It is optimal at a temporal frequency around 6 Hz, which suggests that visual channels responding maximally to high temporal frequencies are involved in the segregation of perceptual regions in depth.     

Correspondence effects with manual gestures and postures: a study of imitation

In this study, the authors applied methods and theories from research of stimulus-response compatibility (SRC) to action imitation. In 6 experiments, they adopted the logic of the Simon paradigm (B. Hommel & W. Prinz, 1996) to explore interference between task-relevant symbolic stimulus features (color) and task-irrelevant iconic stimulus features (2 hand gestures and 2 postures). The same 2 hand gestures served as responses. Pronounced correspondence effects for both gestures and postures showed up throughout. In line with theories of SRC, the authors account for these correspondence effects in terms of overlap arising between stimulus and response features in a common representational domain. As a specific extension of this approach, they propose 2 functionally independent mechanisms: One operates movement-based when dynamic information is provided, and the other operates state-based with static postures as stimuli. Implications for theories of both SRC and action imitation are discussed.     

Constructing a scientific paper: Howell's prothrombin laboratory notebook and paper

Scientists generally record their laboratory activities and experimental results in notebooks, from which they construct scientific papers. The Johns Hopkins physiologist William Henry Howell kept a laboratory notebook from 1913 to 1914, in which he recorded experiments on the blood clotting factor prothrombin. In 1914 he published a paper using this notebook, to justify his theory of prothrombin activation. Howell's paper is reconstructed, in terms of its narrative and argument elements, from the laboratory activities and experimental results recorded in the notebook. This reconstruction reveals an intimate connection between the two texts and the process by which Howell constructed a scientific paper. The generation of scientific knowledge by Howell is then evaluated, especially in terms of theory formation and justification.     

鹖冠子其人与其思想新探

本文认为从现存资料很难证明鹖冠子必定是楚人或是赵人。从《鹖冠子》一书中的相关记载,可见他和赵、楚、秦、齐诸国的思想文化有相当的关系。他的弟子是庞媛,而非庞焕,庞煜与庞焕并非同一人。他的思想虽属于黄老学,但有自己特色的理论：水火相生说、天神地形说、五正说、成鸠氏理想统治说等。有些思想观念有矛盾。     

Evidence from the eyes: Threatening postures hold attention

Efficient detection of threat provides obvious survival advantages and has resulted in a fast and accurate threat-detection system. Although beneficial under normal circumstances, this system may become hypersensitive and cause threat-processing abnormalities. Past research has shown that anxious individuals have difficulty disengaging attention from threatening faces, but it is unknown whether other forms of threatening social stimuli also influence attentional orienting. Much like faces, human body postures are salient social stimuli, because they are informative of one’s emotional state and next likely action. Additionally, postures can convey such information in situations in which another’s facial expression is not easily visible. Here we investigated whether there is a threat-specific effect for high-anxious individuals, by measuring the time that it takes the eyes to leave the attended stimulus, a task-irrelevant body posture. The results showed that relative to nonthreating postures, threat-related postures hold attention in anxious individuals, providing further evidence of an anxiety-related attentional bias for threatening information. This is the first study to demonstrate that attentional disengagement from threatening postures is affected by emotional valence in those reporting anxiety.     

Turning configural processing upside down: part and whole body postures

Like faces, body postures are susceptible to an inversion effect in untrained viewers. The inversion effect may be indicative of configural processing, but what kind of configural processing is used for the recognition of body postures must be specified. The information available in the body stimulus was manipulated. The presence and magnitude of inversion effects were compared for body parts, scrambled bodies, and body halves relative to whole bodies and to corresponding conditions for faces and houses. Results suggest that configural body posture recognition relies on the structural hierarchy of body parts, not the parts themselves or a complete template match. Configural recognition of body postures based on information about the structural hierarchy of parts defines an important point on the configural processing continuum, between recognition based on first-order spatial relations and recognition based on holistic undifferentiated template matching.     

Indian Philosophy and Ethics: Dialogical Method as a Fresh Possibility

This paper discusses the positions held by two opposing camps—the traditionalists and the positivists (to use Pradeep Gokhale’s typology) regarding the presence or absence of ethics in Indian philosophy. It subsequently offers a way ahead of the impasse where I consider some inputs inherent in the method of dialogue in pre-modern Indian philosophy for imagining an ethics of and ethics for plurality. Such an ethics, I argue, cannot be imagined without involving the category of ‘Other,’ which has otherwise remained elusive in the Indian philosophical debates. The diverse nature of Indian societies demands Other-centric ethics to assess and evaluate the enduring moral crisis pervading contemporary times.