Catatonic signs in medical and psychiatric catatonias

Patients with psychiatric catatonias vs those with medical catatonias may differ in catatonic phenomenology. To determine if these could be distinguished, the following methods were used: 1) a review of the literature; 2) a chart review; and 3) a prospective series. The literature review of 467 reports of medical catatonias yielded 240 cases that met research criteria. A chart review of 47 episodes of catatonia revealed a higher frequency of negativism in patients with medical catatonias. Prospective data obtained from rating scales revealed an increased frequency of echophenomena in patients with medical catatonias; however, no discriminate pattern of catatonic signs for medical catatonias arose. Overall, catatonic signs appear to share a similar distribution. These findings suggest that psychiatric and medical catatonias are indistinguishable based upon catatonic sign.     

The effect of unilateral stellectomy on the regulation of heart rate during behavioral stress.

Changes in heart rate were examined during classical aversive conditioning before and after either left (n = 10) or right stellectomy (n = 8). Heart rate (HR) significantly (p less than 0.01) increased in response to the conditional stimulus with a further increase noted during the unconditional stimulus. After right stellectomy (RSGx) the aversive stress elicited a significantly (p less than 0.01) smaller increase in heart rate (peak HR change: control 66.8 +/- 6.0; RSGx 36.1 +/- 6.8 beats/min). In contrast left stellectomy did not significantly alter the heart rate conditional response. Cardioselective beta-adrenergic receptor blockade, metoprolol HC1 (BB, 1.0 mg/kg, n = 8), significantly (p less than 0.01) reduced the heart-rate conditional response (peak HR change: control 66.8 +/- 6; BB 25.1 +/- 3.8 beats/min) to the same extent as noted during RSGx. These data suggest that the heart-rate increases elicited by aversive stress are mediated in part by sympathetic nerves that originate or pass through the right stellate ganglion. The residual HR increase noted after RSGx or BB probably results from the withdrawal of cardiac parasympathetic activity.     

Plasma Catecholamine and Performance Associations During Psychological Stress: Evidence for Peripheral Noradrenergic Involvement With an Attention-Demanding Task

The purpose of this investigation was to examine the associations between plasma catecholaminc (CA) response and selected performance measures during psychological stress. Nineteen men (between the ages of 35 and 50) performed a double-conflict (DC) task for 12 min. Self-reported distress resulting from the stress protocol was assessed using the Profile of Mood States and the Spielberger State-Trait Anxiety Inventory. Performance of the DC task was measured by total reaction time (TRT). Cognitive aftereffects were assessed by the time it took to complete three sets of anagrams administered immediately after the DC task. Plasma CA measures were taken at three intervals during the rest period and the DC task. The stress protocol resulted in increased self-reported tension, p ≤ 0.01; confusion, p ≤ 0.01; and anxiety, p ≤ 0.01; with reduced vigor, p less than or equal to 0.01. The men displayed improved TRT, p less than or equal to 0.01, during the DC task, and they had significantly extended performance time, p less than or equal to 0.01, on anagram Set 1 compared to Sets 2 and 3. Although both plasma norepinephrine (NE) and plasma epinephrine (E) increased, only E achieved statistical significance, p less than or equal to 0.05. The only significant correlation between plasma CA and performance occurred with NE and anagram Set 1, p less than or equal to 0.05. The findings arc discussed in terms of a postulated link between circulating NE and cognitive effects of stress.     

Hemispheric dominance in schizophrenics as determined on extrapyramidal side effects of neuroleptics

Phenomena observed during treatment with neuroleptics were clinically measured in an attempt to determine the difference in vulnerability of the two hemispheres and the relation between this difference and schizophrenic diseases. In the group of systematic schizophrenias the increase in tonus was significantly higher in the dominant hemisphere. This finding is considered a verification of the nosological hypothesis of schizophrenias.     

Clinicogenetic studies within the scope of Leonhard taxonomy

Using conventional genealogical methods and genetic correlation analysis, the author investigates Leonhard's classification of schizophrenias and cycloid psychoses. According to the second of these methods, the systematic schizophrenias and cycloid psychoses definitely diverge on account of the phenotypic correlations, whereas the unsystematic group presumably occupies a median genetic position between the two categories first mentioned.     

Openness, fluid intelligence, and crystallized intelligence: Toward an integrative model

Many studies are concerned with the bivariate relationships between Openness, fluid intelligence (Gf), and crystallized intelligence (Gc). Results suggest an influence of Gf and Openness on Gc. However, the overlap between Gf and Openness is rarely controlled for. Moreover, interaction effects or longitudinal influences are also often neglected. The present two studies aimed to elucidate exactly these interactions and longitudinal influences. Besides a main effect of Gf on Gc, Study 1 (N = 180) revealed an interaction effect between Openness and Gf. Study 2 utilized longitudinal data (N = 172) and identified an effect of Openness on the development of Gf. Gf and Openness predicted Gc 6 years later. A model integrating the results and providing a theoretical framework and outlook is proposed.     

Serum testosterone determination in the antiandrogen therapy of sexual deviations with cyproterone acetate (preliminary report of experiences)

Total testosterone concentrations in the serum of patients treated with antiandrogens were measured by means of an industrially produced radioimmunological testosterone assay kit (VEB S?chsisches Serumwerk Dresden). Antiandrogen therapy using cyproterone acetate (Androcur) leads to a reduction in serum testosterone concentration which is significant at the p less than 0.01 level. The data suggest that testosterone concentrations vary inversely with increasing Androcur dosage; they are around 7 nmol/l at the doses conventionally administered. The testosterone concentrations obtained under depot-Androcur treatment suggest that intervals between injections should be less than 10 days.     

Caffeine enhances the physiological response to occupational stress in medical students

Caffeine (3.3 mg/kg) was tested against a placebo in 20 male medical students during periods of low (no exams) versus high (final exams) work stress. On each of 8 test days, heart rate and blood pressure were measured at baseline and over a 40-min postdrug interval; immediately afterward, blood was drawn to test plasma cortisol and serum lipid concentrations. Exams increased heart rate (p less than .005) and systolic blood pressure (p less than .02). Caffeine decreased heart rate (p less than .0001) and increased systolic blood pressure (p less than .005), diastolic blood pressure (p less than .0001), plasma cortisol levels (p less than .01), and serum cholesterol levels (p less than .02). Caffeine effects were additive with those of exams, and together they increased the number of men showing systolic blood pressures in the borderline hypertensive range. Thus, caffeine use during periods of increased occupational stress may enhance the cumulative stress response.     

Inspection time and high-speed ball games

It has been suggested that successful batsmen in cricket are not distinguished by their fast speed of visual information intake. A study is presented in which a season's batting averages for twenty regular cricketers, all members of the same local team, were correlated with the cricketers' visual inspection times. The correlation was -0.63 (p less than 0.005), suggesting that the successful batsmen were faster at picking up information from briefly presented visual displays. When the age factor was eliminated, the partial correlation between inspection time and batting average remained significant at -0.52 (p less than 0.01). This finding is discussed with respect to the sources of information available from a ball in flight.     

Does symptomatic schizophrenia exist?

The question if there are "symptomatic schizophrenias" has been discussed since the 20s. Schizophrenic psychoses caused be definable and well known brain diseases are presented. All schizophrenic symptoms and syndromes, the first rank symptoms (K. Schneider) too, occur in somatically founded psychoses. The group of paroxysmal transition syndromes in the sense of aura prolongata (continua) and the episodic schizophrenic psychoses in psychomotor epilepsy may be a model for the schizophrenia research. Vital threatening, so-called pernicious catatonic schizophrenias are found on the basis of infectious brain diseases, sometimes only diagnosed in autopsy. Beside acute and reversible symptomatic schizophrenic psychoses there are, even if rarely, recurrent and chronic courses of symptomatic schizophrenias. That certain conditions for the developing of symptomatic schizophrenias are rarely realised, could be an explanation for their rarity. Some findings indicate that the limbic system is significant for symptomatic (and idiopathic) schizophrenic psychoses and the pre- and postpsychotic basic stages determined by dynamic and cognitive basic symptoms, which are phenomenologically very similar to aura symptoms released by stereoelectroencephalographic depth recordings (Wieser). The characteristic features of marked fluctuation, discontinuity and insteadiness of the cognitive thought, perception, psychomotor and cenesthetic phenomena do not speak against an organic brain disorder provided that the traditional process hypothesis is abandoned in favor of a neurobiochemic disorder, fluctuating on its part depending on endogenous as well as psychic-reactive factors.     

Serum creatinphosphokinase (CPK) in endogenic psychoses]

Creatinphosphokinase (CPK) was determined in 141 patients with manic-depressive and schizophrenic psychoses. In general endogenic psychoses of the manic and depressive type as well as chronic schizophrenias show normal CPK values. In acute cases of paranoid-halluzinatory schizophrenias normal values are predominant. In catatonic schizophrenias, as a rule, clearly increased enzyme activities are found. Thise increased values suggest a postulated somatic disease as a cause of the psychosis. Thus, the determination of CPK provides a useful aid in the diagnosis and control of the course of catatonic schizophrenic.     

Age, ability, and the role of prior knowledge on the acquisition of new domain knowledge: promising results in a real-world learning environment

Prior knowledge, fluid intelligence (Gf), and crystallized intelligence (Gc) were investigated as predictors of learning new information about cardiovascular disease and xerography with a sample of 199 adults (19 to 68 years). The learning environment included a laboratory multimedia presentation (high-constraint-maximal effort), and a self-directed at-home study component (low-constraint-typical performance). Results indicated that prior knowledge and ability were important predictors of knowledge acquisition for learning. Gc was directly related to learning from the video for both domains. Because the trajectory of Gc stays relatively stable throughout the life span, these findings provide a more optimistic perspective on the relationship between aging and learning than that offered by theories that focus on the role of fluid abilities in learning.     

Psychoses in epilepsy

The heterogenous psychoses in epilepsies, caused by well known conditions, are not rare but associated with regularly a few of seizure-types not with the nature and development of attacks. Polar transitional ranks and converging courses of schizophrenic (accentuated) syndromes in epilepsies and idiopathic schizophrenias are rather frequent. Also (sub-)acute schizophrenic psychoses are corresponding to the complete palette of first and second rank symptoms (K. Schneider) of idiopathic schizophrenias. After manifestations of epilepsy these syndromes can appear at any time. It is given a profile of risks. Progressive avoidance of a. phenylaceturea, b. mixtures of antiepileptics did not put an end to psychotic syndromes: Long-term therapies with 1. Polytherapy, 2. Primidone and Phenytoin (dosedependant) as well as 3. Ethosuximide (-monotherapy) cause a disorder of feed back mechanisms, especially a disturbed regulation of vigilance and sleeping-waking-cycle and their psychological correlates. Carbamazepine and Sodium Valproate are, plasma-level-controlled of preventive antipsychotic effect. Selected neuroleptics of rather slight epileptogenic potency are of going down importance. Benzodiazepines are required mostly in prepsychotic syndromes, Lithium compounds in selected cases. There is no more alternative seizures or psychosis.     

Youth suicides unknown to psychiatric care providers.

Less than 50% of young suicides have consulted psychiatric care providers. Thus the population not found within the psychiatric care sector is described in this paper. Fifty-eight consecutive suicides among adolescents and young adults, studied by psychological autopsies, were classified according to presence or absence of previous psychiatric care. Fifteen of the sixteen subjects without previous care were males, six of these were diagnosed as having an adjustment disorder related to a recent event. Unemployment was less common (p < 0.01), the suicidal processes were shorter (p < 0.001), and previous parasuicide was less frequent (p < 0.001) among nonpatients. Evaluation in accordance with DSM-III-R criteria showed fewer substance abuse disorders (p < 0.01). Open suicidal communication prior to the suicide was less frequent but active methods were used by this population as often as by subjects known to care providers.     

Resolutions of control episodes between well and affectively ill mothers and their young children

Control interactions between 87 well and affectively ill mothers and their 15- to 51-month-old children were studied. Spontaneously occurring control interventions (conceptualized as episodes of interaction between mother and child) were coded from 90 minutes of videotaped interactions in a naturalistic laboratory apartment setting. The results suggest developmental changes in mother-child interaction in the 2nd to 4th years of life: the increase of the rate of immediate maternal success (p less than .05) and compromise (p less than .05), on the decrease in maternal use of power (ultimate success by enforcement, p less than .01). Well mothers achieved compromise with their children, particularly daughters, more often than did affectively ill mothers (p less than .05). Affectively ill mothers more often than well mothers avoided confrontation with their children (p less than .05). The impairments in control interventions of affectively ill mothers were exacerbated by the severity of the disorder.     

Favouritism,fairness and joint profit in long-term relationships

This study was designed to test a number of hypotheses about the use of FAV and other strategies as measured by the intergroup ‘matrices’ in four long-term relationships-with spouse, child, friend and workmate. Forty subjects filled in matrices giving three measures of self-favouritism (FAV), and one each of fairness (F) and maximum joint profit (MJP), in relation to the allocation of money and time. It was found that FAV was not used for spouse, and was used less for child than for the non-family relationships (p < 0.01, p < 0.05). There was also an influence of altruism (A) against FAV, when time was distributed between spouse (p < 0.01) or child (p < 0.001) and the self. F was used most for spouse, followed by child, friend and workmate (p < 0.001), and was used more by females in distributing money (p < 0.01). MJP was not used at all for money, but was used to some extent for time.     

Social skills training for young adolescents

A systematic assertiveness training program was developed for adolescents, based on Albert Bandura's social cognitive theory. The program, which focused on peer interactions and social responsibility, consisted of six 40-minute semi-weekly sessions and was presented to a class of 22 sixth-grade social studies students in a middle school. Cognitive acquisition of the information was measured with multiple-choice tests administered immediately after training and at a 6-month follow-up. Trained students performed significantly better than a control group on the posttest (p less than .01) and on the 6-month follow-up (p less than .02), demonstrating that young adolescents can acquire and retain the symbolic information that forms a basis for assertive behavior.     

Diminished weight loss and behavioral compliance during repeated diets in obese patients with type II diabetes.

Compared weight losses during first and second bouts of a very low calorie diet (VLCD) and examined whether decreased compliance might in part explain the decrease in weight loss during the second bout. Forty-five Type II diabetic patients participated in a year-long behavioral weight-reduction program that incorporated a VLCD (400 to 500 kcal/day) during Weeks 1 to 12 and 28 to 40. Weight losses decreased dramatically from the first to the second VLCD (15.54 vs. 1.42 kg, p less than .0001). There was also markedly diminished adherence as assessed by weeks ketonuric, attendance, and completeness of self-monitoring records. The percentage of weeks subjects were in ketosis dropped from 61% during VLCD 1 to 13% during VLCD 2 (p less than .0001). Similarly, subjects attended significantly fewer treatment meetings during VLCD 2 and self-monitored less during VLCD 2 than during VLCD 1. Weeks ketonuric and initial weight accounted for 63% of the variance in weight loss during VLCD 1 (p less than .0001); weeks ketonuric and attendance predicted weight loss during VLCD 2 (p less than .0001), accounting for 54% of the variance. These results suggest the importance of behavioral factors in explaining poorer performance on a repeated diet.     

Studies on protein genetic factors in multiple sclerosis and psychoses]

In more than 200 cases of multiple sclerosis, psychosis and cyclothymia, the Hp types are studied with the help of polyacrylamide gel electrophoresis (Schreyer and Schaible, 1967) and the Gc types wtih agar gel electrophoresis (Schlesinger, Vogt and Prokop, 1963). All Hp and Gc types were found in these diseases, but there was no frequent occurence of any particular type in multiple acleroses of psychoses. According to our results, there is no interdependence between these diseases and the Hp and Gc types.