Drugs, Environment, Brain, and Behavior

Abstract— The effects of psychoactive drugs are not just a function of their pharmacological actions, but are due to complex interactions among pharmacological, psychological, and environmental factors. We discuss here how drug-environment interactions determine the likelihood that addictive drugs produce a persistent form of neurobehavioral plasticity (sensitization) thought to be involved in the pathophysiology of addiction and relapse.     

Affect, Social Behavior, and the Brain in Williams Syndrome

ABSTRACT— Williams syndrome (WS) is a rare genetic disorder characterized by intellectual impairment and a distinctive physical and neuropsychological profile. Relative to their level of intellectual functioning, individuals with WS exhibit strengths in language and face recognition, with deficits in visual-spatial cognition. A heightened appetitive drive toward social interaction is a strong behavioral feature. Relative to other neurodevelopmental disorders, WS has a clearly defined genetic basis, together with a consistent neurocognitive profile of strengths and deficits. Thus, this disorder offers unique opportunities for elucidating gene–brain–behavior relationships. We focus on manifestations of the unusual social profile in WS, by examining data within and across levels of cognition, brain, and molecular genetics.     

The Continuity Strategy,Human Behavior,and Behavior Analysis

The Psychological Record - In behavior analysis, continuity refers to the assumption of a similarity of behavioral principles or processes between nonhumans and humans, which is often considered to...     

Imaging the Impact of Prenatal Alcohol Exposure on the Structure of the Developing Human Brain

Prenatal alcohol exposure has numerous effects on the developing brain, including damage to selective brain structure. We review structural magnetic resonance imaging (MRI) studies of brain abnormalities in subjects prenatally exposed to alcohol. The most common findings include reduced brain volume and malformations of the corpus callosum. Advanced methods have been able to detect shape, thickness and displacement changes throughout multiple brain regions. The teratogenic effects of alcohol appear to be widespread, affecting almost the entire brain. The only region that appears to be relatively spared is the occipital lobe. More recent studies have linked cognition to the underlying brain structure in alcohol-exposed subjects, and several report patterns in the severity of brain damage as it relates to facial dysmorphology or to extent of alcohol exposure. Future studies exploring relationships between brain structure, cognitive measures, dysmorphology, age, and other variables will be valuable for further comprehending the vast effects of prenatal alcohol exposure and for evaluating possible interventions.     

Linking Gene, Brain, and Behavior: DRD4, Frontal Asymmetry, and Temperament

ABSTRACT— Gene-environment interactions involving exogenous environmental factors are known to shape behavior and personality development. Although gene-environment interactions involving endogenous environmental factors are hypothesized to play an equally important role, this conceptual approach has not been empirically applied in the study of early-developing temperament in humans. Here we report evidence for a gene- endo environment (i.e., resting frontal brain electroencephalogram, EEG, asymmetry) interaction in predicting child temperament. The dopamine D4 receptor (DRD4) gene (long allele vs. short allele) moderated the relation between resting frontal EEG asymmetry (left vs. right) at 9 months and temperament at 48 months. Children who exhibited left frontal EEG asymmetry at 9 months and who possessed the DRD4 long allele were significantly more soothable at 48 months than other children. Among children with right frontal EEG asymmetry at 9 months, those with the DRD4 long allele had significantly more difficulties focusing and sustaining attention at 48 months than those with the DRD4 short allele. Resting frontal EEG asymmetry did not influence temperament in the absence of the DRD4 long allele. We discuss how the interaction of genetic and endoenvironmental factors may confer risk and protection for different behavioral styles in children.     

Sometimes It Causes Me to Tremble: Fear,Faith, and the Human Brain

This article reviews selected current neuroscientific research on fear and anxiety and sketches three of anxiety’s sources: innate/learned, loss of attachment, and symbolic/narrative construction. The article then explores the role of religious communities and practitioners of pastoral care and counseling in offering both antidotes to destructive anxiety and faithful management of normal or “useful” anxiety.     

The Undiscovered Mind: How the Human Brain Defies Replication, Medication, and Explanation

In The End of Science, I argued that particle physics, cosmology, evolutionary biology, and other fields of pure science have entered an era of diminishing returns (Horgan, 1997). Although scientists will continue refining and extending current theories and applying their knowledge in the realms of technology and medicine, they may never again achieve insights into nature as profound as quantum mechanics, relativity theory, the big bang theory, natural selection, and DNA-based genetics. One reasonable objection to the book was that mind-related research, of all current scientific enterprises, has the most revolutionary potential, and it deserves a more thorough treatment than it received in The End of Science. I responded to this objection by writing a book that focused on "mind-science"(Horgan, 1999). The Undiscovered Mind considered not only the debate over consciousness, which was the primary focus of The End of Science; it also reviewed the record of fields such as clinical psychology, psychiatry, behavioral genetics, evolutionary psychology, artificial intelligence, and neuroscience. I contended that there has been little progress in understanding the mind, replicating its properties, or treating its disorders—especially compared with the extravagant claims made by proponents of certain approaches. In this article, I summarize some of my book's main points.     

12 Brain/Mind Learning Principles in Action: The Fieldbook for Making Connections,Teaching, and the Human Brain – Renate Nummela Caine,Geoffrey Caine,Carol McClintic,and Karl Klimek

Books reviewed: 12 Brain/Mind Learning Principles in Action: The Fieldbook for Making Connections, Teaching, and the Human Brain. By Renate Nummela Caine, Geoffrey Caine, Carol McClintic, and Karl Klimek. Thousand Oaks, Calif.: Corwin Press, 2005. xvi + 263 pages. ISBN 1‐4129‐0984‐8.     

Olfaction,Emotion and Associative Learning: Effects on Motivated Behavior

Two experiments were conducted to investigate emotional associative learning to odors and subsequent behavioral effects. In Experiment 1, participants experienced a frustration mood induction in the presence of an unfamiliar ambient odor and later worked on puzzle tests in a room scented with either the same-odor, a different-odor, or no-odor. Participants in the same-odor condition spent significantly less time working on the tests than participants in the other conditions; however, test accuracy did not vary. To clarify the findings, Experiment 2 included a test-only control and an emotionally neutral same-odor conditions. Results were compatible with the conclusion that decreased time spent by participants in the negative-same-odor condition was due to emotions elicited by associative learning to the ambient odor, although alternative interpretations remain possible. These data extend our previous results with children and suggest that odors readily become associated to emotions and can thereby influence behavior.     

Developing a Learning Progression for Curriculum,Instruction, and Student Learning: An Example from Mathematics Education

Learning progressions have been demarcated by some for science education, or only concerned with levels of sophistication in student thinking as determined by logical analyses of the discipline. We take the stance that learning progressions can be leveraged in mathematics education as a form of curriculum research that advances a linked understanding of students learning over time through careful articulation of a curricular framework and progression, instructional sequence, assessments, and levels of sophistication in student learning. Under this broadened conceptualization, we advance a methodology for developing and validating learning progressions, and advance several design considerations that can guide research concerned with engendering forms of mathematics learning, and curricular and instructional support for that learning. We advance a two-phase methodology of (a) research and development, and (b) testing and revision. Each phase involves iterative cycles of design and experimentation with the aim of developing a validated learning progression. In particular, we gathered empirical data to revise our hypothesized curricular framework and progression and to measure change in students. thinking over time as a means to validate both the effectiveness of our instructional sequence and of the assessments designed to capture learning. We use the context of early algebra to exemplify our approach to learning progressions in mathematics education with a focus on the concept of mathematical equivalence across Grades 3-5. The domain of work on research on learning over time is evolving; our work contributes a broadened role for learning progressions work in mathematics education research and practice.     

Relationships,Environment, and the Brain: How Emerging Research is Changing What We Know about the Impact of Families on Human Development

Recent research is providing family therapists with new information about the complex interaction between an individual's biological makeup and his/her social and physical environment. Family and social relationships, particularly during sensitive periods early in life, can affect a child's biological foundation. Additionally, stress during the early years can have a lasting effect on an individual's physical and mental health and contribute to the onset of severe mental illness. Community programs have been developed to intervene early with families who have an at‐risk child to prevent or minimize the onset of mental illness including providing partnerships with at‐risk mothers of infants to shape attachment relationships. Programs are also developing individual and family interventions to prevent the onset of psychosis. Practicing family therapists can incorporate emerging neuroscience and early intervention research and leverage the growing base of community programs to enhance the effectiveness and sustainability of mental health outcomes for clients. Additionally, family therapy education programs should broaden student training to incorporate the growing body of information about how family relationships affect individual mental health development.