Converging evidence of configural processing of faces in high-functioning adults with autism spectrum disorders

There is conflicting evidence about whether individuals with autism spectrum disorder (ASD) demonstrate configural processing of faces. We examined two types of configural processing of unfamiliar faces in high-functioning adults with ASD: Holistic processing (processing a face as a gestalt percept) and processing of second-order relations (the spatial relations among facial features, e.g., distance between two eyes). Compared to age- and IQ-matched typical adults, 17 adults with ASD demonstrated normal holistic processing (as demonstrated by the composite face effect), normal sensitivity to second-order relations in upright faces, and the expected disruption of sensitivity to second-order relations in inverted faces. They were also normal in using the internal features and shape of the external contour to make same/different judgements about facial identity. The results provide converging evidence of configural processing of unfamiliar faces in high-functioning adults with ASD, and bring into question the generalizability of previous reports of abnormal face processing in individuals with ASD.     

Processing of musical structure by high-functioning adolescents with autism spectrum disorders

Enhanced pitch perception and memory have been cited as evidence of a local processing bias in autism spectrum disorders (ASD). This bias is argued to account for enhanced perceptual functioning (Mottron &; Burack, 2001 Mottron, L. and Burack, J. A. 2001. “Enhanced perceptual functioning in the development of autism”. In The development of autism: Perspectives from theory to research, Edited by: Burack, J. A., Charman, T., Yirmiya, N. and Zelazo, P. R. 131–147. Mahwah, NJ: Lawrence Erlbaum.  [Google Scholar]; Mottron, Dawson, Soulières, Hubert, &; Burack, 2006 Mottron, L., Dawson, M., Soulières, I., Hubert, B. and Burack, J. 2006. Enhanced perceptual functioning in autism: An update, and eight principles of autistic perception. Journal of Autism and Developmental Disorders, 36(1): 27–43. doi:10.1007/s10803-005-0040-7[Crossref], [PubMed], [Web of Science ®] , [Google Scholar]) and central coherence theories of ASD (Frith, 1989 Frith, U. 1989. Autism: Explaining the enigma, Oxford: United Kingdom: Blackwell.  [Google Scholar]; Happé &; Frith, 2006 Happé, F. and Frith, U. 2006. The weak coherence account: Detail-focused cognitive style in autism spectrum disorders. Journal of Autism and Developmental Disorders, 36(1): 5–25. doi:10.1007/s10803-005-0039-0[Crossref], [PubMed], [Web of Science ®] , [Google Scholar]). A local processing bias confers a different cognitive style to individuals with ASD (Happé, 1999 Happé, F. 1999. Autism: Cognitive deficit or cognitive style?. Trends in Cognitive Sciences, 3(6): 216–222. doi:10.1016/S1364-6613(99)01318-2[Crossref], [PubMed], [Web of Science ®] , [Google Scholar]), which accounts in part for their good visuospatial and visuoconstructive skills. Here, we present analogues in the auditory domain, audiotemporal or audioconstructive processing, which we assess using a novel experimental task: a musical puzzle. This task evaluates the ability of individuals with ASD to process temporal sequences of musical events as well as various elements of musical structure and thus indexes their ability to employ a global processing style. Musical structures created and replicated by children and adolescents with ASD (10–19 years old) and typically developing children and adolescents (7–17 years old) were found to be similar in global coherence. Presenting a musical template for reference increased accuracy equally for both groups, with performance associated to performance IQ and short-term auditory memory. The overall pattern of performance was similar for both groups; some puzzles were easier than others and this was the case for both groups. Task performance was further found to be correlated with the ability to perceive musical emotions, more so for typically developing participants. Findings are discussed in light of the empathizing-systemizing theory of ASD (Baron-Cohen, 2009 Baron-Cohen, S. 2009. Autism: The Empathizing-Systemizing (E-S) Theory. Annals of the New York Academy of Sciences, 1156: 68–80. doi:10.1111/j.1749-6632.2009.04467.x[Crossref], [PubMed], [Web of Science ®] , [Google Scholar]) and the importance of describing the strengths of individuals with ASD (Happé, 1999 Happé, F. 1999. Autism: Cognitive deficit or cognitive style?. Trends in Cognitive Sciences, 3(6): 216–222. doi:10.1016/S1364-6613(99)01318-2[Crossref], [PubMed], [Web of Science ®] , [Google Scholar]; Heaton, 2009 Heaton, P. 2009. Assessing musical skills in autistic children who are not savants. Philosophical Transactions of the Royal Society Biological Sciences, 364: 1443–1447. doi:10.1098/rstb.2008.0327[Crossref], [PubMed], [Web of Science ®] , [Google Scholar]).     

Moral judgment in adults with autism spectrum disorders

The ability of a group of adults with high functioning autism (HFA) or Asperger Syndrome (AS) to distinguish moral, conventional and disgust transgressions was investigated using a set of six transgression scenarios, each of which was followed by questions about permissibility, seriousness, authority contingency and justification. The results showed that although individuals with HFA or AS (HFA/AS) were able to distinguish affect-backed norms from conventional affect-neutral norms along the dimensions of permissibility, seriousness and authority-dependence, they failed to distinguish moral and disgust transgressions along the seriousness dimension and were unable to provide appropriate welfare-based moral justifications. Moreover, they judged conventional and disgust transgressions to be more serious than did the comparison group, and the correlation analysis revealed that the seriousness rating was related to their ToM impairment. We concluded that difficulties providing appropriate moral justifications and evaluating the seriousness of transgressions in individuals with HFA/AS may be explained by an impaired cognitive appraisal system that, while responsive to rule violations, fails to use relevant information about the agent’s intentions and the affective impact of the action outcome in conscious moral reasoning.     

Transitive inference in adults with autism spectrum disorders

Individuals with autism spectrum disorders (ASDs) exhibit intact rote learning with impaired generalization. A transitive inference paradigm, involving training on four sequentially presented stimulus pairs containing overlapping items, with subsequent testing on two novel pairs, was used to investigate this pattern of learning in 27 young adults with ASDs and 31 matched neurotypical individuals (TYPs). On the basis of findings about memory and neuropathology, we hypothesized that individuals with ASDs would use a relational flexibility/conjunctive strategy reliant on an intact hippocampus, versus an associative strength/value transfer strategy requiring intact interactions between the prefrontal cortex and the striatum. Hypotheses were largely confirmed. ASDs demonstrated reduced interference from intervening pairs in early training; only TYPs formed a serial position curve by test; and ASDs exhibited impairments on the novel test pair consisting of end items with intact performance on the inner test pair. However, comparable serial position curves formed for both groups by the end of the first block.     

Atypical categorization in children with high-functioning autism spectrum disorder

Children with autism spectrum disorder process many perceptual and social events differently from typically developing children, suggesting that they may also form and recognize categories differently. We used a dot pattern categorization task and prototype comparison modeling to compare categorical processing in children with high-functioning autism spectrum disorder and matched typical controls. We were interested in whether there were differences in how children with autism use average similarity information about a category to make decisions. During testing, the group with autism spectrum disorder endorsed prototypes less and was seemingly less sensitive to differences between to-be-categorized items and the prototype. The findings suggest that individuals with high-functioning autism spectrum disorder are less likely to use overall average similarity when forming categories or making categorical decisions. Such differences in category formation and use may negatively impact processing of socially relevant information, such as facial expressions. A supplemental appendix for this article may be downloaded from http://pbr.psychonomic-journals.org/content/supplemental.     

Diagnosing personality disorders: an examination of the MMPI-2 and MCMI-II

Personality disorders are highly prevalent in clinical populations and affect outcomes across all forms of intervention. This investigation examined the diagnostic efficiency of two widely used, self-report measures of personality disorder (MMPI-2; Butcher, Dahlstrom, Graham, Tellegen, & Kaemmer, 1989; MCMI-II; Millon, 1987), as compared to a structured interview (SCID-II; Spitzer et al., 1987) diagnosis. The measures were administered to 150 residential and outpatient volunteer subjects. Persons with primary organic or psychotic-spectrum disorders were excluded from participation. Results were variable across disorders measured, with low to moderate levels of diagnostic agreement observed. The MCMI-II appears to be a more sensitive measure, whereas the MMPI-2 is more specific. The two self-report measures demonstrated greater convergence with each other than with the interview measure. Both the MMPI-2 and MCMI-II were more accurate at identifying the absence of a given disorder. Although overall diagnostic powers exist at acceptable levels. the results suggest that diagnoses generated by self-report versus interview are not interchangeable.     

MMPI-2 profiles of women with eating disorders in a Dutch day treatment sample

In this study, we examined the MMPI-2 (Butcher, Dahlstrom, Graham, Tellegen, & Kaemmer, 1989) profiles of 324 Dutch patients with eating disorders at an eating disorder day treatment program. We studied the MMPI-2 profiles in 5 diagnostic eating disorder groups. All diagnostic subgroups showed high mean elevations of the T scores on the same 6 or 7 scales. Remarkable similarities existed between the mean profile configurations. The MMPI-2 distinguished especially in that patients with restricting anorexia nervosa scored lower on one Validity scale (F), two Clinical scales (1 and 2) and several Supplementary and Content scales of the MMPI-2 compared to the other groups. Only on the validity Scale L did they score higher. The MMPI-2 also distinguished patients with the bulimia nervosa purging type who scored higher on Scale 9 and different on several Content and Supplementary scales. We discuss results with regard to other studies of MMPI (Hathaway & McKinley, 1983) and MMPI-2 profiles of women with anorexia nervosa, bulimia nervosa, and eating disorder not otherwise specified in inpatient and outpatient settings.     

A connectionist model of category learning by individuals with high-functioning autism spectrum disorder

Individuals with autism spectrum disorder (ASD) show atypical patterns of learning and generalization. We explored the possible impacts of autism-related neural abnormalities on perceptual category learning using a neural network model of visual cortical processing. When applied to experiments in which children or adults were trained to classify complex two-dimensional images, the model can account for atypical patterns of perceptual generalization. This is only possible, however, when individual differences in learning are taken into account. In particular, analyses performed with a self-organizing map suggested that individuals with high-functioning ASD show two distinct generalization patterns: one that is comparable to typical patterns, and a second in which there is almost no generalization. The model leads to novel predictions about how individuals will generalize when trained with simplified input sets and can explain why some researchers have failed to detect learning or generalization deficits in prior studies of category learning by individuals with autism. On the basis of these simulations, we propose that deficits in basic neural plasticity mechanisms may be sufficient to account for the atypical patterns of perceptual category learning and generalization associated with autism, but they do not account for why only a subset of individuals with autism would show such deficits. If variations in performance across subgroups reflect heterogeneous neural abnormalities, then future behavioral and neuroimaging studies of individuals with ASD will need to account for such disparities.     

Genetics of autism spectrum disorders

Characterized by a combination of abnormalities in language, social cognition and mental flexibility, autism is not a single disorder but a neurodevelopmental syndrome commonly referred to as autism spectrum disorder (ASD). Several dozen ASD susceptibility genes have been identified in the past decade, collectively accounting for 10-20% of ASD cases. These findings, although demonstrating that ASD is etiologically heterogeneous, provide important clues about its pathophysiology. Diverse genetic and genomic approaches provide evidence converging on disruption of key biological pathways, many of which are also implicated in other allied neurodevelopmental disorders. Knowing the genes involved in ASD provides us with a crucial tool to probe both the specificity of ASD and the shared neurobiological and cognitive features across what are considered clinically distinct disorders, with the goal of linking gene to brain circuits to cognitive function.     

Assessing psychopathic personality traits with the MMPI-2

In this study, we examined the utility of the MMPI-2 (Butcher et al., 2001) in assessing psychopathic personality traits. We explored whether MMPI-2 scales that measure affective and interpersonal traits add to the instrument's social deviance measures in assessing global psychopathy and its two facets. Our study of 281 male and female college students indicates that the MMPI-2 Social Deviance scales (e.g., Clinical Scales 4 and 9, ASP) predict substantial variance in the social deviance factor and affiliated subscales of the Psychopathic Personality Inventory (PPI; Lilienfeld & Andrews, 1996), whereas MMPI-2 measures of affective and interpersonal functioning predict substantial variance in the affective-interpersonal PPI factor. In addition, the results of two regression models indicate that the Restructured Clinical scales provide the most parsimonious assessment of psychopathic personality traits.     

Auditory preference of children with autism spectrum disorders

Research on children with autism spectrum disorders suggests differences from neurotypical children in the preference for ‘social’ versus ‘nonsocial’ sounds. Conclusions have been based largely on the use of head-turn methodology which has various limitations as a means of establishing auditory preference. In the present study, preference was assessed by measuring the frequency with which children pressed a button to hear different sounds using an interactive toy. Contrary to prior results, both groups displayed a strong preference for the highly social sounds. These findings have implications for approaches to language intervention and for theoretical debates regarding social motivation.     

自闭症谱系障碍的生物基础

自闭症谱系障碍是一组发病于生命早期, 由一系列生理、心理因素引起的神经发育障碍。遗传、脑神经结构、营养素等是自闭症谱系障碍的生物基础的重要来源。个体在孕育早期形成的大脑和机体异常可能是导致自闭症谱系障碍的关键。这种异常在出生后的发育中具体作用于神经活动、脑发育、免疫系统等生理途径。研究者们今后可以尝试横跨不同自闭症谱系障碍亚型、年龄和发育阶段, 开展横向与纵向相结合的大范围研究, 以进一步明确自闭症谱系障碍的生物基础。     

Developmental regression in autism spectrum disorders

The occurrence of developmental regression in autism is one of the more puzzling features of this disorder. Although several studies have documented the validity of parental reports of regression using home videos, accumulating data suggest that most children who demonstrate regression also demonstrated previous, subtle, developmental differences. Counter to clinical intuition, the earlier development of social, language, and attachment behaviors followed by regression does not seem to support later recovery of skills or better developmental outcomes compared to children who never had speech or typical social responsivity. In fact, this regressive group may have somewhat greater developmental impairment than the nonregressive group, though the two groups do not appear to present different behavioral phenotypes. Although autism is not the only condition in which regression occurs, it appears to be the most frequent condition. Other disorders that demonstrate an early regression with no known etiology include total blindness from birth and childhood disintegrative disorder, both of which demonstrate behavioral relations to autism. In addition, two biological conditions with known etiologies also involve regression with some behaviors resembling autism behavioral phenotype: Rett syndrome (a genetic disorder; see Glaze, this issue) and Landau-Kleffner syndrome (see McVicar and Shinnar, this issue), which involves a seizure disorder.     

自闭症谱系障碍个体的注意解离

注意解离是注意定向网络的重要组成部分, 指在注意转移过程中对原来刺激进行注意分离的过程。自闭症个体注意解离的早期受损会直接影响其它重要功能的发展, 尤其是唤醒调节和共同注意发展。采用间隙重叠范式的研究发现, 自闭症个体注意解离能力是否异常还存在争议, 被试年龄及取样、测量指标和刺激特征可能是影响的因素; 其神经机制可能涉及额叶、顶叶、小脑和胼胝体等脑区。未来应从脑机制研究入手, 综合考虑被试特征、研究方法和刺激特征对注意解离结果的影响, 明确其在自闭症早期预测和识别中的作用。     

自闭症谱系障碍个体的社会动机缺陷

自闭症谱系障碍(ASD)是一种源于儿童期的神经发育障碍, 社会交往障碍是其核心特征, 与社会动机缺陷密切相关。社会动机是引导个体社会行为的强大动力, 主要表现为社会定向、社会奖赏和社会维持。现有研究表明, ASD个体的社会动机发展存在缺陷, 他们对社会刺激的注意偏向减少, 不能主动寻求和体会社会互动带来的快乐, 且缺乏维持社会关系的行为策略等。然而, 相关研究结果受到个体特征、环境和实验设计等因素的影响。研究者未来应综合考虑这些影响因素, 加强对ASD个体社会动机理论的整合研究, 以便全面系统地了解ASD个体的社会动机缺陷。     

Reduced chromatic discrimination in children with autism spectrum disorders

Atypical perception in Autism Spectrum Disorders (ASD) is well documented ( Dakin & Frith, 2005 ). However, relatively little is known about colour perception in ASD. Less accurate performance on certain colour tasks has led some to argue that chromatic discrimination is reduced in ASD relative to typical development ( Franklin, Sowden, Burley, Notman & Alder, 2008 ). The current investigation assessed chromatic discrimination in children with high-functioning autism (HFA) and typically developing (TD) children matched on age and non-verbal cognitive ability, using the Farnsworth-Munsell 100 hue test (Experiment 1) and a threshold discrimination task (Experiment 2). In Experiment 1, more errors on the chromatic discrimination task were made by the HFA than the TD group. Comparison with test norms revealed that performance for the HFA group was at a similar level to typically developing children around 3 years younger. In Experiment 2, chromatic thresholds were elevated for the HFA group relative to the TD group. For both experiments, reduced chromatic discrimination in ASD was due to a general reduction in chromatic sensitivity rather than a specific difficulty with either red–green or blue–yellow subsystems of colour vision. The absence of group differences on control tasks ruled out an explanation in terms of general task ability rather than chromatic sensitivity. Theories to account for the reduction in chromatic discrimination in HFA are discussed, and findings are related to cortical models of perceptual processing in ASD.     

A threat-detection advantage in those with autism spectrum disorders

Identifying threatening expressions is a significant social perceptual skill. Individuals with autism spectrum disorders (ASD) are impaired in social interaction, show deficits in face and emotion processing, show amygdala abnormalities and display a disadvantage in the perception of social threat. According to the anger superiority hypothesis, angry faces capture attention faster than happy faces in individuals with a history of typical development [Hansen, C. H., & Hansen, R. D. (1988). Finding the face in the crowd: An anger superiority effect. Journal of Personality and Social Psychology, 54(6), 917–924]. We tested threat detection abilities in ASD using a facial visual search paradigm. Participants were asked to detect an angry or happy face image in an array of distracter faces. A threat-detection advantage was apparent in both groups: participants showed faster and more accurate detection of threatening over friendly faces. Participants with ASD showed similar reaction time, but decreased overall accuracy compared to controls. This provides evidence for less robust, but intact or learned implicit processing of basic emotions in ASD.     

Specific and general autobiographical knowledge in adults with autism spectrum disorders: The role of personal goals

Autobiographical knowledge is stored hierarchically, at both specific and general levels of representation. It has also been proposed that the self is the structure around which autobiographical memories are organised. The current series of studies assessed whether the autobiographical memory difficulties observed in adults with autism spectrum disorders (ASD) could be due to problems in using the self as an effective memory cue. A series of cueing paradigms were used to assess the accessibility of both specific and general autobiographical knowledge relating to (i) currently pursued goals (either high or low in self–concordance) and (ii) goals that participants were not currently pursuing. Results demonstrated that while event-specific knowledge was impaired in the ASD group, general event knowledge appeared relatively intact. Moreover, while both event-specific and general event knowledge were organised around goals of the self in control participants, a corresponding relationship was only observed for general event knowledge in the ASD group.     

Attenuation of change blindness in children with autism spectrum disorders

Change blindness refers to the difficulty most people find in detecting a difference between two pictures when these are presented successively, with a brief interruption between. Attention at the site of the change is required for detection. A number of studies have investigated change blindness in adults and children with autism spectrum disorders (ASD). Some have produced evidence that people with ASD find changes to social stimuli harder to detect and changes to non‐social stimuli easier to detect, relative to comparison participants. However, other studies have produced entirely contradictory findings. There is a need for consistency in methodology to aid understanding of change blindness and attentional processes in ASD. Here, we replicate a change blindness study previously carried out with typically developing (TD) children and adults and with adults with ASD. Results reveal attenuated change blindness for non‐social stimuli in children with ASD relative to TD norms. Our results are interpreted, alongside others' findings, as potentially indicative of a complex relationship between different influences on attention over time.     

Detecting fake-good and fake-bad MMPI-2 profiles

This study examined the extent to which the validity scales of the Minnesota Multiphasic Personality Inventory-2 (MMPI-2) could identify subjects who were faking bad or faking good and differentiate between psychiatric patients and normal subjects who were faking bad. Subjects were 106 undergraduate college students and 50 psychiatric patients. Results indicate that the mean profiles and optimal cutoff scores resembled those previously reported for the original MMPI. Accurate identification of persons who were faking bad or faking good was achieved. It was possible to differentiate between the psychiatric patients and normal persons who were faking bad, but different cutoff scores were needed to differentiate between normals taking the test under standard instructions and those instructed to fake bad. Optimal cutoff scores were suggested.