Differentiating emotional processing and attention in psychopathy with functional neuroimaging

Individuals with psychopathy are often characterized by emotional processing deficits, and recent research has examined the specific contexts and cognitive mechanisms that underlie these abnormalities. Some evidence suggests that abnormal features of attention are fundamental to emotional deficits in persons with psychopathy, but few studies have demonstrated the neural underpinnings responsible for such effects. Here, we use functional neuroimaging to examine attention–emotion interactions among incarcerated individuals (n = 120) evaluated for psychopathic traits using the Hare Psychopathy Checklist–Revised (PCL-R). Using a task designed to manipulate attention to emotional features of visual stimuli, we demonstrate effects representing implicit emotional processing, explicit emotional processing, attention-facilitated emotional processing, and vigilance for emotional content. Results confirm the importance of considering mechanisms of attention when evaluating emotional processing differences related to psychopathic traits. The affective-interpersonal features of psychopathy (PCL-R Factor 1) were associated with relatively lower emotion-dependent augmentation of activity in visual processing areas during implicit emotional processing, while antisocial-lifestyle features (PCL-R Factor 2) were associated with elevated activity in the amygdala and related salience network regions. During explicit emotional processing, psychopathic traits were associated with upregulation in the medial prefrontal cortex, insula, and superior frontal regions. Isolating the impact of explicit attention to emotional content, only Factor 1 was related to upregulation of activity in the visual processing stream, which was accompanied by increased activity in the angular gyrus. These effects highlight some important mechanisms underlying abnormal features of attention and emotional processing that accompany psychopathic traits.     

The Multilevel Modality-Switch Effect: What Happens When We See the Bees Buzzing and Hear the Diamonds Glistening

Previous studies demonstrated that the sequential verification of different sensory modality properties for concepts (e.g., BLENDER-loud; BANANA-yellow) brings about a processing cost, known as the modality-switch effect. We report an experiment designed to assess the influence of the mode of presentation (i.e., visual, aural) of stimuli on the modality-switch effect in a property verification and lexical decision priming paradigm. Participants were required to perform a property verification or a lexical decision task on a target sentence (e.g., “a BEE buzzes”, “a DIAMOND glistens”) presented either visually or aurally after having been presented with a prime sentence (e.g., “the LIGHT is flickering”, “the SOUND is echoing”) that could either share both, one or none of the target’s mode of presentation and content modality. Results show that the mode of presentation of stimuli affects the conceptual modality-switch effect. Furthermore, the depth of processing required by the task modulates the complex interplay of perceptual and semantic information. We conclude that the MSE is a task-related, multilevel effect which can occur on two different levels of information processing (i.e., perceptual and semantic).     

Psychopathic traits associated with abnormal hemodynamic activity in salience and default mode networks during auditory oddball task

Psychopathy is a personality disorder accompanied by abnormalities in emotional processing and attention. Recent theoretical applications of network-based models of cognition have been used to explain the diverse range of abnormalities apparent in psychopathy. Still, the physiological basis for these abnormalities is not well understood. A significant body of work has examined psychopathy-related abnormalities in simple attention-based tasks, but these studies have largely been performed using electrocortical measures, such as event-related potentials (ERPs), and they often have been carried out among individuals with low levels of psychopathic traits. In this study, we examined neural activity during an auditory oddball task using functional magnetic resonance imaging (fMRI) during a simple auditory target detection (oddball) task among 168 incarcerated adult males, with psychopathic traits assessed via the Hare Psychopathy Checklist-Revised (PCL-R). Event-related contrasts demonstrated that the largest psychopathy-related effects were apparent between the frequent standard stimulus condition and a task-off, implicit baseline. Negative correlations with interpersonal-affective dimensions (Factor 1) of the PCL-R were apparent in regions comprising default mode and salience networks. These findings support models of psychopathy describing impaired integration across functional networks. They additionally corroborate reports which have implicated failures of efficient transition between default mode and task-positive networks. Finally, they demonstrate a neurophysiological basis for abnormal mobilization of attention and reduced engagement with stimuli that have little motivational significance among those with high psychopathic traits.     

Recognition during recall failure: Semantic feature matching as a mechanism for recognition of semantic cues when recall fails

Research suggests that a feature-matching process underlies cue familiarity-detection when cued recall with graphemic cues fails. When a test cue (e.g., potchbork) overlaps in graphemic features with multiple unrecalled studied items (e.g., patchwork, pitchfork, pocketbook, pullcork), higher cue familiarity ratings are given during recall failure of all of the targets than when the cue overlaps in graphemic features with only one studied target and that target fails to be recalled (e.g., patchwork). The present study used semantic feature production norms (McRae et al., Behavior Research Methods, Instruments, & Computers, 37, 547–559, 2005) to examine whether the same holds true when the cues are semantic in nature (e.g., jaguar is used to cue cheetah). Indeed, test cues (e.g., cedar) that overlapped in semantic features (e.g., a_tree, has_bark, etc.) with four unretrieved studied items (e.g., birch, oak, pine, willow) received higher cue familiarity ratings during recall failure than test cues that overlapped in semantic features with only two (also unretrieved) studied items (e.g., birch, oak), which in turn received higher familiarity ratings during recall failure than cues that did not overlap in semantic features with any studied items. These findings suggest that the feature-matching theory of recognition during recall failure can accommodate recognition of semantic cues during recall failure, providing a potential mechanism for conceptually-based forms of cue recognition during target retrieval failure. They also provide converging evidence for the existence of the semantic features envisaged in feature-based models of semantic knowledge representation and for those more concretely specified by the production norms of McRae et al. (Behavior Research Methods, Instruments, & Computers, 37, 547–559, 2005).     

Antisocial Process Screening Device Subscales Predict Recidivism in an Australian Juvenile Offender Sample

The present study is the first to examine the psychometric properties of the self-report Antisocial Process Screening Device (APSD-SR), and the predictive utility of its subscales for reoffending, among Australian juvenile offenders (N?= 308, M age = 17.00, SD?=?1.49). Exploratory factor analysis supported a modified three-factor structure in which four items loaded differently to prior studies. Total APSD-SR and modified subscale scores were positively associated with criminal history and mental health problems (e.g., internalizing and externalizing problems, alcohol and substance abuse/dependence). Survival analyses indicated that youth scoring high on the APSD-SR total score were faster to reoffend nonviolently (Hazard Ratio [HR]?= 1.31, p?=?.0003) and violently (HR?=?1.42, p?=?.0003) than those scoring low. Whereas the modified grandiose-manipulative subscale predicted faster time to nonviolent recidivism (HR?=?1.18, p?=?.026) as a single predictor, when all subscales were simultaneously entered into the model only callous-unemotional (CU) traits and impulsivity predicted nonviolent recidivism (HR?=?1.19, p?=?.026 and 1.22, p?=?.015, respectively), and only impulsivity predicted violent recidivism (HR?=?1.26, p?=?.014). Findings inform current understanding of the relative contribution of adolescent psychopathy dimensions to designating a particularly high-risk group of Australian youth in custody.     

Changes Over Time in the Comprehension of <Emphasis Type="Italic">He</Emphasis> and <Emphasis Type="Italic">They</Emphasis> as Epicene Pronouns

An epicene pronoun is a gender-neutral singular pronoun used in sentences when the gender of the subject is unknown or unspecified. In English, he and they are commonly-used epicene pronouns. Until recently, he has been widely accepted as being grammatically correct. However, many have argued that he is sexist because it may bias people to think about males. Two experiments were performed using a lexical decision task in which participants reacted to gendered words (e.g., aunt and uncle) after reading sentences using he, they, or unrelated epicene pronouns. We conducted the experiments 15 years apart in order to explore whether change in pronoun usage and the social significance of pronouns would be associated with different priming effects. Both experiments demonstrated that pronouns influence the processing of gendered nouns. However, in Experiment 1 they facilitated the processing of feminine nouns whereas in Experiment 2, he slowed the processing of feminine nouns. We discuss these results with respect to language change and conclude that they is a more effective epicene.     

Endogenous attention modulates early selective attention in psychopathy: An ERP investigation

Psychopathic individuals are prone to act on urges without adequate consideration of future consequences or the rights of other individuals. One interpretation of this behavior is that it reflects abnormal selective attention (i.e., a failure to process information that is incongruent with their primary focus of attention; Hiatt, Schmitt, & Newman, Neuropsychology, 18, 50-59, 2004). Unfortunately, it is unclear whether this selective attention abnormality reflects top-down endogenous influences, such as the strength or specificity of attention focus (i.e., top-down set) apart from other, more exogenous (bottom-up), effects on attention. To explore this question, we used an early visual event-related potential (N2pc) in combination with a modified visual search task designed to assess the effect of early endogenous (i.e., top-down) attention on the processing of set-congruent information. The task was administered to a sample of 70 incarcerated adult males, who were assigned to high, intermediate, and low psychopathy groups using Hare’s Psychopathy Checklist-Revised (Hare, 2003). Based on the assumption that their failure to process set-incongruent information reflects the exaggerated effects of endogenous attention, we predicted that participants with high psychopathy scores would show an exaggerated N2pc response to set-congruent information. The results supported the hypothesis and provide novel electrophysiological evidence that psychopathy is associated with exaggerated endogenous attention effects during early stages of processing. Further research is needed to examine the implications of this finding for the well-established failure of psychopathic individuals to process set-incongruent information and inhibit inappropriate responses.     

Does test-enhanced learning transfer for triple associates?

Test-enhanced learning and transfer for triple-associate word stimuli was assessed in three experiments. In each experiment, training and final-test trials involved the presentation of two words per triple associate (triplet), with the third word having to be retrieved. In agreement with the prior literature on different stimuli, training through testing with feedback yielded markedly better final-test performance than did restudy. However, in contrast to the positive transfer reported for paired associate stimuli, minimal or no positive transfer was observed, relative to a restudy control, from a trained cue combination (e.g., A, B, ?) to other cue combinations from the same triplet that required a different response (e.g., B, C, ?). That result also held when two unique cue combinations per triplet were tested during training, and for triplets with low and high average associative strengths. Supplementary analyses provided insight into the overall transfer effect: An incorrect response during training appears to yield positive transfer relative to restudy, whereas a correct response appears to yield no, or even negative, transfer. Cross-experiment analyses indicated that test-enhanced learning is not diminished when two or three cue combinations are presented during training. Thus, even though learning through testing is highly specific, testing on all possible stimulus–response combinations remains the most efficient strategy for the learning of triple associates.     

Unique and Interactive Associations of Callous-Unemotional Traits,Impulsivity and Grandiosity with Child and Adolescent Conduct Disorder Symptoms

The construct of psychopathy remains underrepresented in the clinical diagnosis of Conduct Disorder (CD) as the Diagnostic and Statistical Manual of Mental Disorders 5th edition (DSM-5) only addresses one out of the three dimensions of child psychopathy, Callous Unemotional (CU) traits. This study tests if and to what extent there are unique and interactive associations of CU traits, impulsivity, and grandiosity with child and adolescent CD symptoms. Data were collected from two separate community samples of children (N?=?1599; Mage?=?9.46, SD?=?1.65; 52% female) and adolescents (N?=?2719; Mage?=?16.99, SD?=?0.99; 49% female), who were followed longitudinally after a year. Hierarchical linear regression analyses were conducted, testing cross-sectional and longitudinal associations with CD symptoms, taking into account all three psychopathy dimensions. The cross-sectional findings indicate that only youth presenting a combination of all three psychopathy dimensions scored above the clinical cut-off score for CD. On the other hand, longitudinal findings provided evidence that the combination of high initial levels of CD and CU traits as well as the combination between CD, grandiosity, and impulsivity can lead to clinical levels of future CD symptoms. Findings also indicated that CU traits and impulsivity more strongly predicted adolescent than child CD symptoms, and that CU traits were more strongly associated with boys’ than girls’ CD symptoms. Findings support the inclusion of CU traits as a specifier for the diagnosis of CD, and provide evidence that other psychopathy dimensions can also help clinicians to better understand and treat youth with CD, and should be considered for future revisions of the DSM.     

Task-dependent evaluative processing of moral and emotional content during comprehension: An ERP study

Recently, we showed that when participants passively read about moral transgressions (e.g., adultery), they implicitly engage in the evaluative (good–bad) categorization of incoming information, as indicated by a larger event-related brain potential (ERP) positivity to immoral than to moral scenarios (Leuthold, Kunkel, Mackenzie, & Filik in Social, Cognitive, and Affective Neuroscience, 10, 1021–1029, 2015). Behavioral and neuroimaging studies indicated that explicit moral tasks prioritize the semantic-cognitive analysis of incoming information but that implicit tasks, as used in Leuthold et al. (Social, Cognitive, and Affective Neuroscience, 10, 1021–1029, 2015), favor their affective processing. Therefore, it is unclear whether an affective categorization process is also involved when participants perform explicit moral judgments. Thus, in two experiments, we used similarly constructed morality and emotion materials for which their moral and emotional content had to be inferred from the context. Target sentences from negative vs. neutral emotional scenarios and from moral vs. immoral scenarios were presented using rapid serial visual presentation. In Experiment 1, participants made moral judgments for moral materials and emotional judgments for emotion materials. Negative compared to neutral emotional scenarios elicited a larger posterior ERP positivity (LPP) about 200 ms after critical word onset, whereas immoral compared to moral scenarios elicited a larger anterior negativity (500–700 ms). In Experiment 2, where the same emotional judgment to both types of materials was required, a larger LPP was triggered for both types of materials. These results accord with the view that morality scenarios trigger a semantic-cognitive analysis when participants explicitly judge the moral content of incoming linguistic information but an affective evaluation when judging their emotional content.     

A prospective investigation of rumination and executive control in predicting overgeneral autobiographical memory in adolescence

The CaR-FA-X model (Williams et al., 2007), or capture and rumination (CaR), functional avoidance (FA), and impaired executive control (X), is a model of overgeneral autobiographical memory (OGM). Two mechanisms of the model, rumination and executive control, were examined in isolation and in interaction in order to investigate OGM over time. Across two time points, six months apart, a total of 149 adolescents (13–16 years) completed the minimal-instruction autobiographical memory test, a measure of executive control with both emotional and nonemotional stimuli, and measures of brooding rumination and reflective pondering. The results showed that executive control for emotional information was negatively associated with OGM, but only when reflective pondering levels were high. Therefore, in the context of higher levels of reflective pondering, greater switch costs (i.e., lower executive control) when processing emotional information predicted a decrease in OGM over time.     

Sources of Meaning in Life Among Chinese University Students

The current studies were designed to explore the structure of sources of meaning in life among Chinese university students. In Study 1, we content-analyzed 171 students’ answers to the question of what made their lives meaningful and derived 74 frequently mentioned ideas. Then, we composed a questionnaire based on these ideas and administered it to another sample of 523 university students in Study 2. Seven underlying dimensions were identified through exploratory factor analysis: Self-development (i.e., to accomplish one’s aspirations and actualize one’s potential), social commitment (i.e., to contribute to society and to adhere to moral principles), interpersonal relationships (i.e., relationships with family members, friends and others), secular pursuits (i.e., stable jobs, material possessions and social status), experiences in life (i.e., to experience all the joys and sorrows in life), civilization (i.e., reading, thinking, music and arts), and autonomy (i.e., to make decisions freely and take charge of one’s own life). Results are discussed in light of the philosophical influences in Chinese culture, especially those from Confucianism and Taoism.     

Verbal reaction times to hues vs hue names and forms vs form names

Iwo choice reaction time (RI) studies were carried out in which different classes of stimuli—hues vs hue names in one study and forms vs form names in the other—occurred in independent lists of2, 4, and6 equally probable alternatives. Mean choice RIs were faster for hue names and form names than for hues and forms with4 and6 alternatives, but no significant differences were found in the2-stimulus lists. In both studies, significant list length by stimulus type (e.g., hues vs hue names) interactions indicated greater increase in mean RI with increases in list length for forms and hues than for form names and hue names. It was concluded that differential amounts of generalization of interference aceounted for the interactions. Effects of experimental variables on inferred components of RI were also examined.     

Amorality

Actions are usually grouped into one of several moral categories. Familiar ones include the morally required, the morally permitted, and the morally prohibited. These categories have been expanded and/or refined to include the supererogatory and the “suberogatory”. Some eschew deontic categories such as the above, but nevertheless allow the existence of two comparative moral categories, i.e., the morally better or morally worse. At the risk of adding to the clutter, I want to explore the possibility of yet a further category, viz., amoral action, or actions that, strictly speaking, lack any moral status whatsoever. I think admitting the existence of amoral actions is not only plausible in its own right, but has consequences for our understanding the nature of moral obligation.     

Further Evidence for Reliability and Validity of the Triarchic Psychopathy Measure in a Forensic Sample and a Community Sample

Psychopathy is often described as a constellation of personality characteristics encompassing features such as impulsivity and antisociality, and a lack of empathy and guilt. Although the use of self-reports to assess psychopathy is still debated, there are distinct advantages to such measures and recent research suggests that they may not be as problematic as previously thought. This study further examined the reliability and validity of the Triarchic Psychopathy Measure (TriPM) in a community sample (N = 496) and forensic psychiatric patient sample (N = 217). Results indicated excellent internal consistencies. Additionally, the TriPM total and subscale scores related as expected to different subscales of the Psychopathic Personality Inventory –Revised (PPI-R) and to the Reactive and Proactive Aggression Questionnaire, reflecting good construct validity. Most importantly, ROC curve analyses showed that the TriPM evidenced better discrimination between the community sample and forensic psychiatric patients than the PPI-R. The current study extends the existent evidence demonstrating that the TriPM can be used as an efficient self-report instrument.     

One Thought Too Few: Where <Emphasis Type="Italic">De Dicto</Emphasis> Moral Motivation is Necessary

De dicto moral motivation is typically characterized by the agent’s conceiving of her goal in thin normative terms such as to do what is right. I argue that lacking an effective de dicto moral motivation (at least in a certain broad sense of this term) would put the agent in a bad position for responding in the morally-best manner (relative to her epistemic state) in a certain type of situations. Two central features of the relevant type of situations are (1) the appropriateness of the agent’s uncertainty concerning her underived moral values, and (2) the practical, moral importance of resolving this uncertainty. I argue that in some situations that are marked by these two features the most virtuous response is deciding to conduct a deep moral inquiry for a de dicto moral purpose. In such situations lacking an effective de dicto moral motivation would amount to a moral shortcoming. I show the implications for Michael Smith’s (1994) argument against Motivational Judgment Externalism and for Brian Weatherson’s (2014) argument against avoiding moral recklessness: both arguments rely on a depreciating view of de dicto moral motivation, and both fail; or so I argue.     

Measuring discriminability when there are multiple sources of bias

Performance measures such as log d and d′?aim to measure stimulus discriminability independently of response bias in conditional discrimination tasks, including the yes/no signal-detection procedure. However, they assume only one dimension of bias (e.g., response color) and do not account for bias on additional dimensions (e.g., response side). Such bias reduces log d, thus violating the statistical independence of discriminability and bias measurements. We modified log d to account for side bias and reanalyzed previous side-biased data. With strong side bias, the modified log d differed enough from the standard log d to potentially alter the conclusions of an experiment. Simulations showed that the modified log d produces discriminability estimates that are more accurate and bias-independent than the standard log d calculation.     

Natural,Artifactual, and Moral Goodness

In Natural Goodness, Philippa Foot (2001) aims to provide an account of moral evaluation that is both naturalistic and cognitivist. She argues that moral evaluation is a variety of natural evaluation in the sense that moral judgments of human action and character have the same “grammar” or “conceptual structure” as natural judgments of the goodness (e.g., health) of plants and animals. We argue that Foot’s naturalist project can succeed, but not in the way she envisions, because her central thesis that moral evaluation is a variety of natural evaluation is not entirely correct. We show that both moral and natural evaluation are species of kind evaluation, which encompasses moral, natural, and artifact evaluation. Kind evaluation is a form of evaluation, according to which things are evaluated qua members of a kind, in such a way that the kind into which something is classified informs the standards of evaluation (or norms) for things of that kind. Because the source of the normative standards for moral evaluation is different from the source of the normative standards for natural evaluation, moral evaluation is not a species of natural evaluation. However, both are varieties of kind evaluation. This account of moral evaluation as a variety of kind evaluation is still an effective response to non-naturalism and to non-cognitivism.     

Irrational Beliefs and Attention Bias Towards Symptoms-Related Stimuli in Maintaining Gastrointestinal Symptoms: Results from a Pilot Study

Recent etiopathogenic theories of gastrointestinal conditions state that information processing biases can be a possible major factor involved in the aetiology and maintenance of these conditions. This exploratory study investigated the role of attention biases (AB) towards symptoms-related cues in gastrointestinal patients with respect to symptom maintenance, simultaneously taking into consideration the role of irrational beliefs. We included 32 patients diagnosed with gastrointestinal conditions. Patients completed a battery of psychological tests and an experimental task aimed to measure the preferential attention processing of linguistic stimuli related to gastrointestinal symptoms when they compete for attention resources with neutral stimuli. AB was positively related to irrational beliefs [r(31) = .376, p = .037] and analgesics use [r(32) = .518, p = .002], but not to self-report gastrointestinal symptoms [r(30) = ?.165, p = .382]. Irrational beliefs correlated with pain catastrophizing [r(31) = .373, p = .039], but not to gastrointestinal symptoms, pain intensity, visceral sensitivity or negative emotions; however, pain catastrophizing correlated with all of these. Taken together, our results suggest that core irrational beliefs action as general vulnerability factors that trigger specific implicit and explicit cognitive mechanisms (i.e., AB, pain catastrophizing) involved in the onset and maintenance of symptoms. Future experimental studies should test the robustness of these results in larger samples and aim to further advance our understanding of how cognitive factors interact and potentiate each other in generating and maintaining debilitating suffering.     

An examination of social and psychological influences on academic learning: a focus on self-esteem,social relationships,and personal interest

The present study focused on an examination of both global and domain-specific self-esteems in secondary mathematics learning. The extent to which self-esteem, in general, would account and explain educational success through social relationships with teachers and peers, and personal interest in learning tasks is the main inquiry of this correlational investigation. Two hundred and eighty-three year 10 students (128 girls, 155 boys) were asked to respond to a number of Likert-scale inventories. Causal modeling procedures, aided by the statistical software MPlus 7.3, were used to analyze the data and to test the hypothesized model. A series of a posteriori analyses yielded a modified model for discussion, producing a number of key findings, namely: (a) the differential influences of both global (e.g., →relationship with teachers) and domain-specific (e.g., →relationship with peers) self-esteems, (b) the positive influences of social relation with teachers (e.g., →exam result) and interest in learning tasks (e.g., →end-of-school term grade), and (c) the mediating functioning of relationship with peers and interest in learning tasks. This evidence, overall, provides additional theoretical insights into the operational nature and trajectories of effective learning.