审时度势 科学应对——谈新甲型H1N1流感的应对

面对新甲型H1N1的流行,我国在早期采取了严格的防控措施。而随着疫情的不断发展,将其防控策略进行了调整。这在各界引起了诸多的争论。由于流感为呼吸道传染病,完全切断传播途径非常困难。而且新甲型H1N1传播迅速、人群普遍易感、控制传染源困难等原因,无法完全避免新甲型H1N1流感的流行。因此现阶段应将防控目标定位在压峰缓疫,医疗的重点应放在危重患者的救治上,降低病死率,尽可能减少疾病流行对全社会各方面的影响。     

甲型H1N1流感普通型与重症型的处理

本文回顾性总结历史上几次世界性甲型流感流行和2009年H1N1流感流行情况。概述了2009年H1N1流感普通型病例的临床处理。重点阐述2009年H1N1流感重症型病例的高危人群、发生的危险因素以及临床表现。特别强调重症型流感抗病毒治疗的重要性及适应证。同时提醒关注神经氨酸酶抑制剂应用的耐药问题。     

关于甲型H1N1流感未来流行趋势的几点分析

2009年3月以来出现的甲型H1N1流感是一种全新的流感病毒,目前已在全球大流行.从半年的疫情监测结果判断,轻症患者居多,病毒似乎还没有产生明显的变异。但随着北半球冬季的到来,患者数目必然急剧增多。由于现有的疫苗不能充分满足需要,医疗和防疫部门仍需承担相当艰巨的任务。     

甲型H1N1流感大流行2周年记

2009年4月,墨西哥暴发甲型H1N1流感疫情,并迅速蔓延至全球。2009年6月11日,世界卫生组织宣布进入流感大流行,直到2010年8月10日世卫组织宣布世界步入流感大流行后期。自流感暴发已经2年过去了,回顾整个过程我们从中可以学到许多经验和教训,并随时准备应对将来可能发生的新的流感疫情。     

2009年-2011年广州市甲型H1N1流感监测定量研究

本文对广州市2009年7月～2011年1月的发热呼吸道监测数据进行了定量分析,并在此分析的基础上提出了相关政策建议,比如加强人群分类管理、加快疫苗研制、避免抗病毒药物的滥用、重视健康管理和健康教育以及遵循预防控制原则等。     

Sudden Unexpected Versus Violent Death and PTSD Symptom Development

Changes to posttraumatic stress disorder (PTSD) trauma criterion in the 5th edition of the Diagnostic and Statistical Manual of Mental Disorders (DSM–5) have been an area of much scrutiny and debate. One of the proposed changes included removing sudden unexpected death (SUD) from the list of potentially traumatic events. This study tested the extent to which unexpected death differed from violent death and other traumas as measured by PTSD symptoms. Our results indicated a significant difference in symptom development between those experiencing sudden violent death and sudden unexpected, but nonviolent, death. Additional analyses at the DSM–IV symptom cluster level, as well as with Simms, Watson, and Doebbeling’s (2002) factor structure of PTSD symptoms, suggested further distinctions between event types and symptom development. The extent to which SUD should be included in the trauma criterion is considered.     

甲流了解程度、疫苗安全感知、接种行为及其影响机制

采用问卷调查的方法, 对甲流了解程度、疫苗安全感知、接种行为及其影响机制进行了研究, 并运用结构方程对提出的模型进行了验证和调整。结果表明：(1)民众对甲流疫情基本情况、疫苗接种要求和传播途径等方面有较高的了解程度, 但对预防措施和疫苗信息了解较少。(2)交流卷入对了解程度不存在显著影响; 而新闻卷入对了解程度有显著正向影响, 并且新闻卷入对感知疫苗安全程度的正向影响受到了解程度的部分中介。(3)感知甲流疫苗越安全, 越倾向于选择接种疫苗。(4)人格对疫苗的风险认知存在显著影响, 个人随和性(Agreeableness)程度越高, 则感知疫苗的安全程度越高, 而年龄和性别对其均没有显著影响。     

Joint independent random utility models where one of the choice structures satisfies the strict utility model

It is known that one cannot construct an independent joint random utility model for which both the preference and aversion probabilities satisfy the strict utility model. Given this result, it is natural to ask what kind of relations are possible in such contexts. Here, for instance, we demonstrate that if a structure of preference and aversion probabilities are generated by a common independent random utility model, and if the preference probabilities satisfy the strict utility model, then the preference and aversion probabilities are related by what is known as the strong acceptance condition. We also prove an appropriate converse of this result. Finally, an example is given of a process (other than the random utility model) that is compatible with the assumption that a structure of preference and aversion probabilities satisfies a common strict utility model.     

Spatial and ordinal components of form perception and literacy

We suppose that the visual nervous system possesses compensatory rectifying mechanisms by means of which it achieves “constancy” of visual recognition despite variation in physical appearance of the stimulus object. Using geometric rotations, reflections, and other transformations of text as the physical variation, we studied the recognizability of the texts and the influence that practice in reading one type of transformation exerted on the recognition of others. The mathematical structure of the training set was used as a clue to the perceptual mechanisms mediating transfer, isolating perceptual functions involving a geometric transformation and an ordinal operator. The main feature of the theory is its emphasis upon a dialogue or interaction between ongoing problem-solving processes in visual rectification and the sample being recognized. The theory developed is contrasted with other theories of pattern recognition in which concepts such as stimulus generalization, tuned detectors, and preprocessing play major roles. A relation of this theory to problems encountered among disabled readers (“dyslexics”) is also brought out.     

On the choice between eating and aggressive display in the Siamese fighting fish (Betta splendens)

In Expt 1, male Betta splendens were given a choice between food and a mirror image in a T-maze. All fish consistently preferred food. In Expt 2, the choice of fish that lived in the T-maze for the duration of the experiment was compared with the choice of fish that were transferred to the T-maze for each experimental session. Fish that lived in the T-maze consistently preferred food, but fish that were transferred showed a shift in preference toward mirror image. Differential inhibition of hunger and aggression by fear is suggested as the cause of the preference shift.     

我国甲型H1N1流感防控策略的评析及选择

我国目前正处于甲型H1N1流感防控策略重要调整期,在系统梳理和总结我国自甲型H1N1发生以来防控策略基础上,通过对甲型H1N1流感防控引出的哲学命题、防疫体系和国际合作的思考,提出进一步完善我国甲型H1N1防控策略选择的意见和建议。     

Priming effects with food and water reinforcers in hamsters

Hamsters were tested in a square maze with either food or water in each corner compartment. A substantial priming effect (runway times increase as intertrial interval increases) was demonstrated using both food and water reinforcers. A lengthy period of free access to food and water (satiation) immediately abolished the priming effect, although runway times in general remained relatively rapid for some time. Extinction of rapid runway times proceeded more slowly under food than under water deprivation. It is concluded that priming is a widespread phenomenon associated with the presentation of a reinforcing stimulus to an appropriately deprived animal.     

负性生活事件对大学生抑郁的影响：网络成瘾的中介与5-HTR1A基因rs749098多态性的调节作用

基于抑郁的基因-环境研究范式,以301名大学生为研究对象,探究负性生活事件对大学生抑郁的影响及作用机制。结果表明：(1)负性生活事件、网络成瘾与大学生抑郁两两显著相关;(2)网络成瘾在负性生活事件对大学生抑郁的影响中起部分中介作用;(3) 5-HTR1A基因rs749098多态性在该中介模型的直接路径和中介后半段起调节效应,具体表现为,相比携带C/G和G/G基因型个体,C/C基因型个体负性生活事件对抑郁的负向预测更强,且携带C/C基因型的个体,即使是低水平的网络成瘾的都表现出更高的抑郁情况,而在高水平的网络成瘾的情况下三种基因型都表现出高水平的抑郁。     

Pecking and feeding in chicks

Pecking is not controlled by nutritional state in a newly hatched chick, but by 3 days posthatch it normally is. This paper tests the hypothesis that first a chick must learn that pecking leads to ingestion; then, other (nonlearned) processes are automatically responsible for differential pecking rates to nutritive and nonnutritive items. The first experiment shows that experience pecking and ingesting sawdust is sufficient for differential pecking to develop. The second experiment shows that swallowing without pecking (using a force-feeding technique) does not lead to differential pecking. The third experiment shows that pecking without swallowing (using sand glued down to the floor) also does not lead to differential pecking. Finally, the last experiment shows that food deprivation affects pecking rate only after pecking and ingestion have been associated. These results support the above hypothesis that pecking followed by ingestion leads to the “attachment” of the pecking response to the feeding system. Motivational independence of pecking and the hunger system, the association of pecking with ingestion, and the development of behavior systems are discussed. It is concluded that the function of a behavior may not be related to its causes.     

Prejudice Events and Traumatic Stress among Heterosexuals and Lesbians,Gay Men,and Bisexuals

This mixed-methods study examined associations between prejudice events and post-traumatic stress disorder (PTSD) among 382 lesbians, gays, and bisexuals (LGB) and 126 heterosexuals. Using the Composite International Diagnostic Interview, we assessed PTSD with a relaxed Criterion A1; that is, we allowed events that did not involve threat to life or physical integrity to also qualify as traumatic. We first assessed whether exposure to prejudice-related qualifying events differed with respect to participants' sexual orientation and race. We found that White LGBs were more likely than White heterosexuals to encounter a prejudice-related qualifying event, and among LGBs, Black and Latino LGBs were no more likely than White LGBs to experience this type of event. We then used qualitative analysis of participants' brief narratives to examine prejudice events that precipitated Relaxed Criterion A1 PTSD among 8 participants. Two themes emerged: (a) the need to make major changes, and (b) compromised sense of safety and security following exposure to the prejudice event.     

Preexposure to the CS alone,US alone,or CS and US uncorrelated: Latent inhibition,blocking by context or learned irrelevance?

Three experiments on conditioned suppression in rats examined the extent to which preexposure to the CS, the US, or uncorrelated presentations of both interfere with future conditioning. Experiment 1 suggested that the interference caused by preexposure to the US alone may result from blocking by contextual cues: signaling the US during preexposure attenuated the interference. Experiment 2 demonstrated that signaling the US by another stimulus did not attenuate the interference caused by exposure to uncorrelated presentations of CS and US. Experiment 3 replicated the results of Experiments 1 and 2 and directly compared the magnitude of these deficits. The results of these experiments imply that the effects of exposure to uncorrelated presentations of CS and US are not reducible to the sum of the effects of exposure to CS or US alone.     

Origins of a theory of mind

Twenty-two pairs of typically developing toddlers (M = 24.32 months) and their mothers were observed in a play-room solving puzzles during 30 min. The target of the observations was hand-taking gesture. Researchers have thought that this gesture is rare among typically developing children and is more frequent among autistic children. Ten in 22 children showed this gesture in only 30 min. They should know “I can not do it by myself, but my mother can do it.” When we can assume that children know others’ mental mechanism, it might be the origins of a theory of mind.     

Extinction of the context and latent inhibition

The hypothesis that latent inhibition could be reduced by extinguishing the experimental context, that is, exposing the rats to the context between exposure to the conditional stimulus (CS) and conditioning, was tested. All experiments used the conditioned emotional response procedure. In Experiment 1, extinction was not effective when the animals were exposed to the clicker 40 times off the baseline of responding for food and when the clicker CS was partially reinforced with shocks during the test phase. In Experiments 2 and 3, latent inhibition could be reduced by extinction if the animals were exposed to the CS 24 or 16 times on-baseline, and if continuous reinforcement was used during the test. In Experiments 4, 5, and 6, we attempted to determine which variable was responsible for the discrepant results. In Experiment 4, extinction was effective with 20 or 40 on-baseline exposures to the CS, using continuous reinforcement during the test. In Experiment 5, extinction was not effective with exposure on- or off-baseline, using 24 exposures and partial reinforcement. Finally, in Experiment 6, extinction reduced latent inhibition using continuous, but not partial, reinforcement with 40 exposures off-baseline. From these results, we concluded that Wagner's model of habituation was not sufficient to account for latent inhibition and that a hybrid model, using both associative and cognitive representational processes, was necessary.     

Association between the arginine vasopressin receptor 1A (AVPR1A) gene and preschoolers’ executive functioning

Recent evidence implicates the arginine vasopressin (AVP) system in complex neuropsychological disorders which are characterized by deficits in executive functioning (EF). Despite the genetic contribution to EF, little is currently known about its molecular genetic basis. Drawing on research from social neuroscience and the role of related physiological systems in psychopathology, the current study hypothesized that variability in the AVP receptor 1a gene (AVPR1A) would be associated with EF in an epidemiological sample of 323 normally developing preschool-aged children. Using a family-based association design, the current study found that variability in the rs7298346 marker, located in the 5′-flanking region, was significantly related to a composite measure of EF in 4-year-old children after controlling for a variety of covariates and children’s theory of mind. The converse association between AVPR1A and theory of mind (after controlling for EF) was not significant, suggesting a level of specificity in this relationship. The results are discussed in terms of the difficulties faced by genetic association studies in teasing apart the behavioral phenotypes that characterize complex psychological diseases and the involvement of multiple physiological systems in human behavior.