The Ethics of Germline Gene Editing

Germline Gene Editing (GGE) has enormous potential both as a research tool and a therapeutic intervention. While other types of gene editing are relatively uncontroversial, GGE has been strongly resisted. In this article, we analyse the ethical arguments for and against pursuing GGE by allowing and funding its development. We argue there is a strong case for pursuing GGE for the prevention of disease. We then examine objections that have been raised against pursuing GGE and argue that these fail. We conclude that the moral case in favour of pursuing GGE is stronger than the case against. This suggests that pursuing GGE is morally permissible and indeed morally desirable.     

Editing the Reactive Genome: Towards a Postgenomic Ethics of Germline Editing

The reported birth of genetically modified twins in late 2018 has given new fuel to debates about the ethics of germline genome editing (GGE). There is a broad consensus among stakeholders that clinical uses of GGE should be temporarily banned as the technology is not yet deemed safe for use in humans. However, the idea of a complete ban is dismissed by many based on the expectation that more research will eventually allow scientists to make the technology safe without having to put humans at risk first. In this article, I will analyse this assumption and argue that it is undermined by recent developments in the postgenomic life sciences. In particular, I will argue that in a postgenomic view of germline editing a complete ban on specific uses of the technology is warranted, because the research needed to assess the safety of these interventions would not be morally defensible.     

The Wisdom of Caution: Genetic Enhancement and Future Children

Many scholars predict that the technology to modify unborn children genetically is on the horizon. According to supporters of genetic enhancement, allowing parents to select a child’s traits will enable him/her to experience a better life. Following their logic, the technology will not only increase our knowledge base and generate cures for genetic illness, but it may enable us to increase the intelligence, strength, and longevity of future generations as well. Yet it must be examined whether supporters of genetic enhancement, especially libertarians, adequately appreciate the ethical hazards emerging from the technology, including whether its use might violate the harm principle.     

The Effects of Emotional (Non-)Expression in (Chronic) Disease: A Meta-Analytic Review

Research on emotional (non-)expression is characterized by two facets; it has mainly focused on healthy individuals and it has failed to explore the relationships between the different concepts describing expression and non-expression. A meta-analysis was conducted in order to identify the differential effects of emotional expression and non-expression in patient samples. Results showed that neither expression, nor non-expression of emotions was related to perception of disease severity. Psychological distress increased in relation to emotional non-expression, but no effect was shown for emotional expression. Emotional non-expression was also related to adopting a helpless attitude towards the disease. The conceptual and methodological disparities identified in the retrieved studies undermined the validity of the emerged relationships. Reported changes in physical and psychological outcomes were related to the kind of research design, operationalization of (non-)expression and the clinical and psychological condition of the recruited samples. Implications for improving future research are discussed.     

Personal (Non-)Religiosity and Policing

ABSTRACT

In many professions, personal religiosity can have a direct bearing on day-to-day practice and the implementation of policy. This article reviews fieldwork data from interviews with members of the Metropolitan Police Service in London, UK, and identifies the role that personal religiosity, or negative attitudes towards religion, can play in attitudes, practice, and expectations. Reflecting on debates about the nature of religious identity, the authors argue that in an arena where religion is increasingly seen to influence policy and practice, the personal religious or non-religious identity of the individual should not be seen as ‘outside’ the area of work but may require careful negotiation and articulation to avoid normative constructions of religion being applied inappropriately to local communities.     

诚信建设与价值导向

由于社会经济体制的转型 ,传统诚信赖以发挥作用的基础与条件发生了重大变化 ,使“天然性诚信”相应地走向“建构性诚信”。诚信在道德价值体系中属于基础性的规范 ,这种基础性使诚信建设具有优先性。诚信建设既要承接传统、面向现代、与其他社会规范相协调 ,又要充分展现其层次性 ,使之成为攀登更高的道德价值目标的起点。     

生殖细胞基因增强技术的伦理争议与对策

分析生殖细胞基因增强的概念,论述支持和反对生殖细胞基因增强的理由,初步探讨伦理学对策.在人类理性的指引下,生殖细胞基因增强能够成为造福人类的有力武器.     

Raising the Virtuous Bar: The Underlying Issues of Genetic Moral Enhancement

From the perspective of virtue ethics, is it possible and permissible to enhance moral behavior through gene modification? In preparation to answer this question, we must ask five questions: (1) What may we assume regarding genetic inheritance and human nature? (2) Can specific genes predispose behavior related to the moral virtues? (3) What kind of genetic enhancement would be useful for moral enhancement? (4) Should there be a distinction between somatic and germline gene modification? (5) Is genetic modification best approach to moral enhancement? This article concedes that genetic engineering has the capacity to enhance the human disposition to moral behavior, but gene editing cannot create virtue because virtues are stable, habituated dispositions, acquired over time. That being said, gene editing for purposes of enhancing moral behavior is permissible.     

Emotional (Non-)Expression and Health: Data,Questions, and Challenges

The available evidence on the relationship between expression and non-expression of emotions (E/NE) and health is selectively and critically reviewed. It is concluded that research in this field still lacks conceptual lucidity with regard to the many existing E/NE concepts. Despite the fact that few studies adopted appropriate designs for examining causal relationships, some intriguing results have been reported showing promise for the future. These results involve prospective associations between E/NE and chronic disease, such as cardiovascular disease and HIV infection related outcomes. Future studies have to better discriminate between (i) various forms of E/NE, (ii) different (social) contexts of E/NE as well as different cognitive decision processes underlying E/NE, and (iii) individuals for whom different forms of E/NE may be adaptive. We recommend that besides (quasi)experimental studies on the potential mechanisms involved, more prospective studies are conducted in this field in order to allow for causal inferences.     

反社会行为的遗传基础:基因多态性和DNA甲基化

反社会行为是受遗传与环境共同影响的不良行为。分子遗传学和神经生物学的研究发现,基因以基因多态性和DNA甲基化的方式影响脑结构、功能及脑内神经递质的产生和释放,进而影响反社会行为的发生发展。本文从基因多态性和DNA甲基化两方面整理了5-HTT、MAOA、OXTR等8个候选基因与反社会行为的关联。并提出未来研究需进一步探讨基因、脑和神经递质对反社会行为的联合作用。同时,扩展多基因位点、基因多态性与DNA甲基化、积极环境与基因交互作用对反社会行为影响的研究,以全面探索反社会行为发生的遗传基础,进而更加有效的预防反社会行为。     

反社会行为的遗传基础:基因多态性和DNA甲基化

反社会行为是受遗传与环境共同影响的不良行为。分子遗传学和神经生物学的研究发现,基因以基因多态性和DNA甲基化的方式影响脑结构、功能及脑内神经递质的产生和释放,进而影响反社会行为的发生发展。本文从基因多态性和DNA甲基化两方面整理了5-HTT、MAOA、OXTR等8个候选基因与反社会行为的关联。并提出未来研究需进一步探讨基因、脑和神经递质对反社会行为的联合作用。同时,扩展多基因位点、基因多态性与DNA甲基化、积极环境与基因交互作用对反社会行为影响的研究,以全面探索反社会行为发生的遗传基础,进而更加有效的预防反社会行为。     

从多尺度看基因表达调控的稳定性和非稳定性

从系统生物学的角度出发,首次提出了基因表达调控的稳定性和非稳定性问题,并认为可采用多尺度的理论和方法去刻画和分析该问题.从而,更深刻地认识基因表现生命现象的复杂性和多样性.这是一种方法学上的全新尝试,必将为系统生物学的研究增加全新的内容.