错误加工的神经机制

错误加工在认知控制和行为监控中起着关键的作用。监控自己的认知和行为结果,觉察到应该的反应和实际的反应之间的差别（即错误）,纠正这种错误并防止再犯是错误加工的主要内容。错误反应或由代表反应错误等负性反馈刺激诱发的ERP相对于正确反应或由代表反应正确等正性反馈刺激诱发的ERP,表现出一个相对负走向的波形变化,称为错误相关负波（error-related negativity, ERN）和反馈相关负波（feedback-related negativity, FRN）,两者都定位于前扣回附近。错误加工神经机制的研究主要集中于前扣回与ERN、错误意识与错误加工、ERN与FRN的关系。对于前扣带回和ERN的功能意义的解释主要有错误检测理论、冲突监控理论、强化学习理论和预期违反假说。目前错误加工神经机制的研究在研究内容、研究方法和理论观点等方面还存在些问题,这些可能是未来进一步的研究方向     

错误相关负波（ERN）在精神病理学研究中的应用

错误相关负波（error-related negativity, ERN）是由行为错误诱发的一种脑电波成分,最大峰值在错误反应之后的50ms左右,偶极子源定位于前扣带回（anterior cingulate cortex, ACC）附近。错误加工（error processing）的经典研究范式中出现的ERN成分可能反映了ACC具有错误检测、冲突监控、强化学习、情绪动机等功能。大量研究表明过度的和不足的错误相关脑活动（hyperactive and hypoactive error processing）可能分别与精神病理学的内化性和外化性障碍（internalizing and externalizing disorders）相关联。内化性和外化性障碍的内表型（endophenotype）的研究,还存在许多值得进一步探索的问题。     

错误相关负波的神经起源及其影响因素

与个体做出错误反应相伴的错误相关ERP成分叫错误相关负波 (error-related negativity, ERN),当前冲突监控理论、表征失匹配理论和强化学习理论从不同的角度对ERN的神经机制进行解释,各理论间并非完全相互排斥。目前大部分研究认为ERN定位于扣带回,部分研究则出现其它脑区的激活,然而,扣带回与其它脑区存在复杂的神经功能联系,ERN 电位很可能是多个脑区电活动在头颅的综合表现,而非某一脑区的单独表现。ERN的神经机制受到实验任务、被试年龄及其意识水平等因素的影响。未来要推动实验室研究走向临床应用,发现与诊断脑电波异常的病人和毒品易复吸人群。     

错误后减慢理论模型述评

错误后减慢是指错误后正确反应与正确后正确反应相比反应时显著延长的现象.目前研究者已经发现错误后减慢、错误后正确率提高以及错误后干扰效应减少三种错误调控行为,其中错误后减慢是最稳定的错误后行为表现.早期研究主要从冲突监控理论、激活抑制假说、强化学习理论和失匹配理论等角度解释该现象,近年来,研究者又提出了注意朝向理论和评估适应假说.对于该领域未来的研究可以从错误类型、无意识加工、个体差异、新的分析技术的运用方面考虑,以便全面揭示错误后减慢现象的本质.     

错误信息特征对学科领域知识丰富性不同学生学习的错误监控之影响

采用Go/No-Go范式,26名中学生参与实验。考察在基于主体错误反应和基于客体错误信息两类错误监控条件下,学科领域知识教学实验组和对照组对不同类型错误信息监控的脑电成分。结果显示,(1) 错误反应监控条件下,实验组对要义特征的错误反应诱发的ERN较字面特征的更负,而对照组则相反。(2) 错误信息监控条件下,两组学生均表现出监控字面特征错误诱发的ERN波幅较监控要义特征错误的更大。(3) 两种监控条件均表现出实验组产生的ERN波形较对照组的更负。表明：虽然两类监控条件均能诱发明显的ERN,但其影响因素并不相同：基于主体错误反应的监控主要受个体对其错误加工深度的影响;基于客体错误信息的监控则受错误信息的清晰性影响。     

来源检测对表象引发的错误记忆的影响

采用“学习-再认”模式,考察来源检测对表象引发的错误记忆的影响。结果发现,在再认任务中,正确再认观察项目与想象项目的反应时差异不显著,但在源检测中,正确再认观察项目显著快于正确再认想象项目; 再认时与源检测时的错误再认率差异不显著,但对想象项目的错误再认率显著高于对观察项目。这表明,表象会导致错误记忆发生,提高来源检测操纵并不能够削弱表象引发的错误记忆。根据研究结果提出“表象激活混淆假设”,认为人们虽然使用表象的信息表征方式,却无法获取与之联系的激活路径,容易混淆表象激活的来源。表象激活混淆是表象引发错误记忆的机制。     

外表真实区别、表征变化和错误信念的任务分析

自20世纪80年代以来,“心理理论”已成为发展心理学的研究热点和最活跃、最多产的领域。为了分析和比较“心理理论”的实验任务,该研究以济南市3所幼儿园中的233名3—6岁儿童为有效被试。进行了“意外转移。和“欺骗外表”两种心理理论实验任务。得出如下主要结论：(1)意外转移任务中内隐错误信念显著难于标准错误信念,易化错误信念与标准错误信念的难度不存在显著差异。(2)欺骗外表任务中外表真实区别难度显著低于表征变化和错误信念。(3)意外转移任务的错误信念显著难于欺骗外表任务的错误信念。     

动机在错误加工中的不一致效应：争议与整合

错误加工(errorprocessing)是个体探测错误发生并进行针对性调整的高级认知过程。大量研究表明,动机(如奖励、惩罚等)能够影响错误加工过程,但结果并不一致。本文在梳理和比较以往研究的基础上提出,年龄、性别、实验设计、人格和文化等因素可能影响动机与错误加工的关系。通过进一步整合,提出任务相关性(taskrelevance)可能是潜在的共同作用机制,即在与个体目标高相关的任务中,动机越强则错误加工程度增强(如更大的ERN、Pe波幅);而在低相关任务中,动机对错误加工的影响较弱。在这一理论框架下,上述因素可能通过影响任务相关性进而调节动机与错误加工的关系,新观点的提出有助于解释动机与错误加工关系的矛盾结果。未来一是需要系统验证上述因素及任务相关性的作用,二是关注不同类型错误和错误本身的动机作用,三是进一步探究动机与认知因素如何共同影响错误加工,这些将有助于完善和推进动机取向的错误加工理论。     

婴儿是否拥有错误信念理解能力?

最近10多年,越来越多的婴儿错误信念理解研究不断拓展自发反应任务的范围,发现婴儿的任务表现具有一定的灵活性。对此,有研究者坚持丰富解释,认为婴儿能理解他人的错误信念;也有研究者坚持贫瘠解释,认为婴儿只是借助行为规则等通过任务;近来还有研究者在新的概念框架下做出一种折衷的解释。最终解决婴儿是否拥有错误信念理解能力这个问题,需要研究者们提出一个判定个体拥有错误信念理解能力的明确标准。     

幼儿心理理论水平及其与抑制控制发展的关系

本研究通过经典的错误信念任务首先考察了3与4岁幼儿心理理论的发展水平;然后通过抑制控制任务探讨了幼儿心理理论发展水平与抑制控制能力发展的关系。结果表明,3、4岁在完成错误信念任务时有显著的年龄差异;通过错误信念任务的幼儿在抑制冲突的得分显著地高于没有通过错误信念的幼儿;而且除了他人的错误信念,幼儿在其他错误信念上的水平与抑制冲突成绩有显著的相关。     

Error-related psychophysiology and negative affect

The error-related negativity (ERN/Ne) and error positivity (Pe) have been associated with error detection and response monitoring. More recently, heart rate (HR) and skin conductance (SC) have also been shown to be sensitive to the internal detection of errors. An enhanced ERN has consistently been observed in anxious subjects and there is some suggestion that the ERN is related to general negative affective experience (NA). The ERN has been source localized to the anterior cingulate cortex-a structure implicated in the regulation of affective, response selection, and autonomic resources. Thus, the findings that autonomic measures and affective distress are related to response monitoring are consistent with anterior cingulate cortex function. In the present experiment, we sought to evaluate more comprehensively the relationship between self-reported negative affect and error-related physiology in a between-groups design. Results indicate that high NA was associated with significantly greater ERN and error-related SCR, and smaller Pe. These results are discussed in terms of anterior cingulate cortex function, psychopathology, and response monitoring.     

Errors are aversive: defensive motivation and the error-related negativity

The error-related negativity (ERN) is a negative deflection in the event-related potential that is maximal approximately 50 ms after the commission of an error. The ERN is generated in the anterior cingulate cortex, a region of the medial prefrontal cortex implicated in both cognitive and emotional processing. Affective and motivational variables influence the magnitude of the ERN, which suggests that the ERN may relate to emotional or motivational aspects of error detection. In the present study, we evaluated the possibility that errors prime defensive motivational responses, and that the ERN may predict the magnitude of defensive reactivity after errors. We found that (a) the defensive startle response was larger following errors than following correct responses, and (b) the magnitude of the ERN predicted the degree of startle potentiation following errors. Thus, response errors prime defensive motivation-and the ERN predicts individual differences in the aversive response to errors.     

An event-related potential study on the observation of erroneous everyday actions

Recent experiments have demonstrated that error-related negativity (ERN) is not only elicited when people commit errors, but also when they observe others committing errors. The present study investigates whether this observed ERN is also present when participants observe execution errors in an everyday context. Participants observed short sequences of pictures showing steps of everyday actions ending either erroneously or correctly. Participants were instructed to indicate by a delayed response whether the observed action was correctly executed or not. The results showed a large P300 for execution errors compared with the observation of correct sequences, but no ERN activity was found. The present experiment indicates that the detection of execution errors in observation does not rely on the error processing mechanism responsible for generating the ERN. The increased P300 amplitudes suggest a more general monitoring process that signals that the occurrence of unexpected events is involved in the detection of execution errors.     

The effects of uncertainty in error monitoring on associated ERPs

A series of experiments were conducted to address the effect of uncertainty regarding performance for predicting the likelihood of a correct-response negativity (CRN) in addition to error-related negativity (ERN). In Study 1, 18 healthy young adults completed letter discrimination tasks during single and dual attention conditions designed to manipulate response certainty. In the second study, the same participants completed easy and difficult tone discrimination tasks designed to influence stimulus certainty. In the third study, task difficulty was manipulated to produce different error rates without altering certainty. Studies 1 and 2 indicated that error and correct responses are processed more similarly when uncertainty is present (i.e., ERN approximately CRN). Furthermore, uncertainty was associated with attenuation of the ERN and enhancement of the CRN, consistent with an error detection hypothesis. Study 3 indicated that task difficulty alone does not influence the ERN or likelihood of a CRN. These results offer support for the error detection account of the ERN and establish the role of uncertainty in predicting the CRN, as postulated by .     

Preverbal error-monitoring in stutterers and fluent speakers

This study was designed to characterize the brain system that monitors speech in people who stutter and matched controls. We measured two electrophysiological peaks associated with action-monitoring: the error-related negativity (ERN) and the error positivity (Pe). Both the ERN and Pe were reliably observed after errors in a rhyming task and a nonverbal flanker task, replicating previous reports of a language-monitoring ERN and demonstrating that the Pe can also be elicited by phonological errors. In the rhyming task, stutterers showed a heightened ERN peak regardless of whether they actually committed an error. Similar results, though only marginally significant, were obtained from the flanker task. These results support the vicious cycle hypothesis, which posits that stuttering results from over-monitoring the speech plan. The elevation of the ERN in stutterers and the similarity of the results between the flanker and rhyming tasks implies that speech-monitoring may rely on the same neural substrate as action-monitoring.     

Electrophysiological analysis of error monitoring in schizophrenia

In this study, the authors sought to determine whether abnormalities exhibited by schizophrenia patients in event-related potentials associated with self-monitoring--the error-related negativity (ERN) and the correct response negativity (CRN)--persist under conditions that maximize ERN amplitude and to examine relationships between the ERN and behavior in schizophrenia. Participants performed a flanker task under 2 contingencies: one encouraging accuracy and another emphasizing speed. Compared with healthy participants, in schizophrenia patients the ERN was reduced in the accuracy condition, and the CRN was enhanced in the speed condition. The amplitude of a later ERP component, the error positivity, did not differ between groups in either task condition. Reduced self-correction and increased accuracy following errors were associated with larger ERNs in both groups. Thus, ERN generation appears to be abnormal in schizophrenia patients even under conditions demonstrated to maximize ERN amplitude; however, functional characteristics of the ERN appear to be intact.     

Stress regulation and cognitive control: evidence relating cortisol reactivity and neural responses to errors

In this study, we tested the relationship between error-related signals of cognitive control and cortisol reactivity, investigating the hypothesis of common systems for cognitive and emotional self-regulation. Eighty-three participants completed a Stroop task while electroencephalography (EEG) was recorded. Three error-related indices were derived from the EEG: the error-related negativity (ERN), error positivity (Pe), and error-related alpha suppression (ERAS). Pre- and posttask salivary samples were assayed for cortisol, and cortisol change scores were correlated with the EEG variables. Better error–correct differentiation in the ERN predicted less cortisol increase during the task, whereas greater ERAS predicted greater cortisol increase during the task; the Pe was not correlated with cortisol changes. We concluded that an enhanced ERN, part of an adaptive cognitive control system, predicts successful stress regulation. In contrast, an enhanced ERAS response may reflect error-related arousal that is not adaptive. The results support the concept of overlapping systems for cognitive and emotional self-regulation.     

An Experimental Therapeutics Approach to the Development of a Novel Computerized Treatment Targeting Error-Related Brain Activity in Young Children

In the current study, we utilize an experimental medicine approach to examine the extent to which a single-session, computerized intervention impacts a transdiagnostic neural marker of risk (i.e., the error-related negativity [ERN]) in 70 children between the ages of 6 and 9 years. The ERN is a deflection in the event-related potential occurring after an individual makes a mistake on a lab-based task and has been shown to be transdiagnostically associated with a variety of anxiety disorders (e.g., social anxiety, generalized anxiety), obsessive-compulsive disorder, and depressive disorders in over 60 studies to date. Building on these findings, work has been done to link an increased ERN to negative reactions to, and avoidance of, making mistakes (i.e., error sensitivity). In the current study, we capitalize on this previous work by examining the extent to which a single-session, computerized intervention may engage the target of “error sensitivity” (measured by the ERN, as well as self-report of error sensitivity). We examine the convergence of multiple measures of the construct of “error sensitivity” (i.e., child self-report, parent report on child, and child electroencephalogram [EEG]). We also examine relationships between these three measures of “error sensitivity” and child anxiety symptoms. Overall, results suggested that treatment condition predicted changes in self-reported error sensitivity but not changes in ERN. Based on the lack of previous work in this area, we view this study as a novel, preliminary, first step toward using an experimental medicine approach to examine our ability to engage the target of the ERN (i.e., error sensitivity) early in development.     

Maturation of action monitoring from adolescence to adulthood: an ERP study

This study investigated the development of the frontal lobe action-monitoring system from late childhood and adolescence to early adulthood using ERP markers of error processing. Error negativity (ERN) and correct response negativity (CRN) potentials were recorded while adolescents and adults (aged 12-22 years, n = 23) performed two forced-choice visual reaction time tasks of differing complexity. Significant age differences were seen for behavioural and ERP responses to complex (infrequent, incompatible) trials: adolescents elicited an error negativity of reduced magnitude compared with adults. Furthermore, in contrast to adults, adolescents showed a non-significant differentiation between response-locked ERP components elicited by correct (CRN) and error responses (ERN). Behaviourally, adolescents corrected fewer errors in incompatible trials, and with increasing age there was greater post-error slowing. In conclusion, the neural systems underlying action-monitoring continue to mature throughout the second decade of life, and are associated with increased efficiency for fast error detection and correction during complex tasks.