The behavioral pharmacology of effort-related choice behavior: dopamine, adenosine and beyond

For many years, it has been suggested that drugs that interfere with dopamine (DA) transmission alter the "rewarding" impact of primary reinforcers such as food. Research and theory related to the functions of mesolimbic DA are undergoing a substantial conceptual restructuring, with the traditional emphasis on hedonia and primary reward yielding to other concepts and lines of inquiry. The present review is focused upon the involvement of nucleus accumbens DA in effort-related choice behavior. Viewed from the framework of behavioral economics, the effects of accumbens DA depletions and antagonism on food-reinforced behavior are highly dependent upon the work requirements of the instrumental task, and DA-depleted rats show a heightened sensitivity to response costs, especially ratio requirements. Moreover, interference with accumbens DA transmission exerts a powerful influence over effort-related choice behavior. Rats with accumbens DA depletions or antagonism reallocate their instrumental behavior away from food-reinforced tasks that have high response requirements, and show increased selection of low reinforcement/low cost options. Nucleus accumbens DA and adenosine interact in the regulation of effort-related functions, and other brain structures (anterior cingulate cortex, amygdala, ventral pallidum) also are involved. Studies of the brain systems regulating effort-based processes may have implications for understanding drug abuse, as well as symptoms such as psychomotor slowing, fatigue or anergia in depression and other neurological disorders.     

Opposite actions of dopamine on aversive and appetitive memories in the crab

The understanding of how the reinforcement is represented in the central nervous system during memory formation is a current issue in neurobiology. Several studies in insects provide evidence of the instructive role of biogenic amines during the learning and memory process. In insects it was widely accepted that dopamine (DA) mediates aversive reinforcements. However, the idea of DA being exclusively involved in aversive memory has been challenged in recent studies. Here, we study the involvement of DA during aversive and appetitive memories in the crab Chasmagnathus. We found that DA-receptor antagonists impair aversive memory consolidation, in agreement with previous reports in insects, while administration of DA facilitates memory formation after a weak training protocol. In contrast, DA treatment during appetitive training was found to impair formation of long-term appetitive memory. In addition, as a first step in elucidating the neuroanatomical correlates of DA action on memory, we mapped dopaminergic neurons in the central nervous system of the crab. Results of the current study, together with those obtained in a previous work about the role of octopamine (OA), suggest that both amines (DA and OA) play a dual action in memory processes. On the one hand, DA and OA mediate the aversive and the appetitive signals, respectively, throughout training, while on the other hand, they interfere with the formation of memory of the opposite sign (DA in appetitive and OA in aversive). Our results support a new understanding about the way appetitive and aversive stimuli are processed during memory formation to ensure adaptive behavior.     

A Dilemma for the Doomsday Argument

I present a new case in which the Doomsday Argument (‘DA’) runs afoul of epistemic intuition much more strongly than before. This leads to a dilemma: in the new case either DA is committed to unacceptable counterintuitiveness and belief in miracles, or else it is irrelevant. I then explore under what conditions DA can escape this dilemma. The discussion turns on several issues that have not been much emphasised in previous work on DA: a concern that I label trumping; the degree of uncertainty about relevant probability estimates; and the exact sequence in which we integrate DA and empirical concerns. I conclude that only given a particular configuration of these factors might DA still be of interest.     

A thematic analysis of practitioners' understanding of domestic abuse in terms of post‐traumatic stress disorder (PTSD) and complex‐PTSD (C‐PTSD)

There is a growing body of evidence suggesting that domestic abuse (DA) should be conceptualised within the complex post‐traumatic stress disorder (C‐PTSD) model. Recently, in the draft of the International Classification of Diseases, Eleventh Revision, produced by the World Health Organization (WHO), C‐PTSD was included as a separate criterion in which DA is incorporated (ICD‐11, WHO, 2018). In this study, a thematic analysis was used to explore to what extent practitioners working with DA survivors are familiar with PTSD and C‐PTSD. Research into such a prevalent and detrimental problem as DA is important to understand whether the development of theoretical knowledge about DA and C‐PTSD is addressed in practice. In a Women's Centre in South London, six semi‐structured interviews with middle‐aged female practitioners were conducted to investigate each counsellor's experiences, knowledge and reflections. Six final themes were constructed to summarise the main results. The findings demonstrate limited practitioner understanding of DA in terms of C‐PTSD, which seems to impact not only the effectiveness of treatment plans with DA survivors, but also counsellors’ own psychological and physical states. It is also indicated that DA can be conceptualised within the C‐PTSD model that corresponds with previous literature indicating the complex nature of DA. The overall results of the current research acknowledge that DA sectors should not be neglected and better funding and effective psychoeducation in this field are needed.     

participating in a couples therapy outcome study: Participants' views

Discovering that participants who received therapy in a research project and were being debriefed in a therapy outcome study considered those assessment sessions therapeutic, the authors conclude that participants: (a) are aware of the research context, (b) have some idea about how it affected the treatment they got, and (c) see positive outcomes for taking part in the study. Assessment and treatment were not separated in the minds of some participants, as they had been in the mind of the researchers.This study was supported in part by National Institute on Drug Abuse grant #1R 18DA 1069232001.     

Remembered work importance,satisfaction, reminiscence and adjustment in retirement: A case study

Previous research on the relationship between adjustment to retirement and variables related to pre-retirement occupation has been inconclusive with reviewers calling for investigations which take individual dafferences into account, This case study examined the relationship between remembered importance of and satisfaction with occupation, reminiscence about working life and adjustment to retirement in the life of Mr Howard, a 70 year old ex-manager, Quantitative and qualitative analyses attentive to the importance of individual characteristics produced findings consistent with previous research suggesting that intrinsic occupational factors are important earlier on in working life but are replaced by extrinsic factors later in life. Mr Howard reported however, that this change was a reaction to external changes (organizational change due to nationalization) rather than a purely psychological process. He was fairly satisfied with life in general and retirement in particular and reminisced about working life sometimes on his own or with ex-workmates. These findings and the implications of single-case methodology are discussed.     

多巴胺、5-羟色胺通路相关基因及家庭环境对创造力的影响及其作用机制

创造力的遗传基础是近年来创造力研究领域的前沿和热点问题, 但仍尚处于起步阶段, 也未有研究系统探讨遗传与环境因素的交互作用对创造力的影响及其作用机制。本课题拟在中国汉族人群中考察多巴胺(DA)、5-羟色胺(5-HT)神经递质通路上的32个基因约700个多态性位点与创造力的关系, 并首次探讨家庭环境在遗传多态性与创造力关系中的调节作用。研究内容包括：(1)通过单基因、基于通路以及基因—基因交互作用的关联分析, 考察遗传多态性对创造力的影响, 揭示创造力的遗传基础; (2)通过基因—环境交互作用的关联分析, 考察家庭环境在遗传与创造力关系中的调节作用; (3)通过结构方程模型的比较分析, 揭示遗传与家庭环境在创造力两个方面(创造思维与创造人格)共享的与特异的作用机制。该项目成果能够从遗传与环境交互作用的角度阐明创造力个体差异的原因, 有助于构建基于创造力个体差异分析的理论模型, 对创造人才的鉴别和培养具有重要现实意义。     

On the asymptotic distributions of two statistics for two-level covariance structure models within the class of elliptical distributions

Since data in social and behavioral sciences are often hierarchically organized, special statistical procedures for covariance structure models have been developed to reflect such hierarchical structures. Most of these developments are based on a multivariate normality distribution assumption, which may not be realistic for practical data. It is of interest to know whether normal theory-based inference can still be valid with violations of the distribution condition. Various interesting results have been obtained for conventional covariance structure analysis based on the class of elliptical distributions. This paper shows that similar results still hold for 2-level covariance structure models. Specifically, when both the level-1 (within cluster) and level-2 (between cluster) random components follow the same elliptical distribution, the rescaled statistic recently developed by Yuan and Bentler asymptotically follows a chi-square distribution. When level-1 and level-2 have different elliptical distributions, an additional rescaled statistic can be constructed that also asymptotically follows a chi-square distribution. Our results provide a rationale for applying these rescaled statistics to general non-normal distributions, and also provide insight into issues related to level-1 and level-2 sample sizes. The authors thank an associate editor and three referees for their constructive comments, which led to an improved version of the paper. This research was supported by grants DA01070 and DA00017 from the National Institute on Drug Abuse and a University of Notre Dame faculty research grant.     

Psychoanalysis, psychoanalytic science, and psychoanalytic research--1986

The present standing of psychoanalysis as a science and the vitality of psychoanalytic research effort are reviewed. The two are interdependent, since the possibilities for empirical research rest on the necessary assumption that psychoanalysis is indeed enough a science to be susceptible to knowledge advance by the (research) methods of science. Concerning our status as a science, I review attacks on our scientific credentials (both from within our ranks and without) by the logical positivists, by the hermeneuticists (a rubric comprising a variety of hermeneutic, phenomenological, exclusively subjectivistic, and/or linguistically based conceptualizations of our field), and the most recent by the philosopher of science, Adolf Grünbaum. I try to demonstrate what I feel to be the failure of each of these assaults, and why I feel there is no reason to see psychoanalysis as anything other than a scientific psychology and, therefore, in theory amenable to empirical research approaches. I then review the history and the current status of these systematic research efforts in psychoanalysis, and the reasons why these have been far less in scope and in accomplishment than has been possible or than has been needed. Here I have focused especially on research involving technique and our theory of change and cure--i.e., research on the analytic process; on what changes take place (outcome) and how those changes come about or are brought about (process).     

干预胆碱M受体对药物成瘾的影响及其与多巴胺的关系

药物成瘾是一类精神及行为障碍, 涉及到中枢神经系统的病变。毒蕈碱受体(Muscarinic receptor, M受体)属于胆碱能受体, 分5种亚型。行为学研究表明, 干预M受体能有效影响药物成瘾行为, 但其神经机制还亟待探索。阿片类药物与精神活性药物均能激活中枢多巴胺系统, 而M受体与多巴胺系统在多个脑区产生了交互作用。其中激动M2及M4受体抑制了多巴胺系统功能, 而激动M5受体增强了多巴胺系统功能, 与干预M2、M4、M5受体对药物成瘾行为的影响相对应。以上证据提示, 干预M受体可能通过影响多巴胺系统对药物成瘾起作用。     

Multitrait-multimethod model of adolescent deviance,drug use,academic, and sexual behaviors

A multitrait-multimethod design was used to test Jessor and Jessor's (1977) problem behavior theory with a sample of adolescents, their parents, and peers. Behaviors included general deviance, drug use, low academic motivation, and precocious sexual behavior. While research has supported this theory, the reliance on self-report data for the majority of this work may threaten the validity of these findings. Results from hierarchical confirmatory factor analyses indicated that the convergent and discriminant validity of the seven behavior constructs was high and method effects were low. A two-factor second-order model, representing General Drug Use and Other Problem Behavior, accounted for a larger proportion of variance in the lower order factors compared to a single-factor model.This research was supported by Grant DA 03706 from the National Institute on Drug Abuse.     

Does Posttraumatic Growth Buffer the Association Between Death Anxiety and Quality of Life Among People living with HIV/AIDS?

People living with HIV (PLWH) may experience death anxiety (DA), which can be detrimental to quality of life. Posttraumatic growth (PTG), however, is antithetical to DA, with its positive attributes at odds with negative psychosocial outcomes. Previous research has not examined the buffering effect of PTG on the association between DA and quality of life. Therefore, in addition to the direct effects of DA and PTG on health-related quality of life (HRQoL), we investigated the moderating role of PTG on the relationship between DA and HRQoL among people living with HIV/AIDS (PLWH) in Nigeria. Using cross-sectional design and availability sampling method, we selected 201 outpatients (men, n?=?63, 31.3%, women, n?=?138, 68.7%, mean age?=?40.1, SD?=?10.5) managed for HIV/AIDS in a Nigerian tertiary healthcare institution. Death Anxiety Inventory-Revised, Posttraumatic Growth Inventory-Short Form, and Patient-Reported Outcome Quality of Life-HIV were used to access DA, PTG and HRQoL, respectively. Results showed that while adjusting for socio-demographic factors (age, gender, time since diagnosis and educational status), DA was associated with physical health, mental health and social relationships domains of HRQoL as well as overall HRQoL. In contrast, PTG did not evidence significant association with HRQoL dimensions and overall HRQoL. The moderation effect of PTG on the association between DA and HRQoL was not supported. Independent of PTG, alleviating DA may be an important target in terms of therapeutic intervention towards improving quality life of PLWH.

     

“Monkeys,babies, idiots” and “primitives”: Nature–nurture debates and philanthropic foundation support for American anthropology in the 1920s and 1930s

There has been a long discussion among historians about the impact that foundation policies had on the development of the social sciences during the interwar era. This discussion has centered on the degree to which foundation officers, particularly from the Rockefeller boards, exercised a hegemonic influence on research. In this essay, I argue that the field of American cultural anthropology has been neglected and must be reconsidered as a window into foundation intervention in nature–nurture debates. Despite foundation efforts to craft an anthropology policy that privileged hereditarian explanations, I contend that cultural anthropologists were committed to proving the primacy of “nurture,” even when that commitment cost them valuable research dollars. It was this commitment that provided an essential bulwark for the discipline. Ironically, it was the need to negotiate with foundations about the purpose of their research that helped cultural anthropologists to articulate their unique, and thus intrinsically valuable, approach to nature–nurture debates. © 2009 Wiley Periodicals, Inc.     

Democracy, Individual Rights and the Regulation of Science

Whether the US Constitution guarantees a right to conduct scientific research is a question that has never been squarely addressed by the United States Supreme Court. Similarly, the extent to which the First Amendment protects the right to communicate the results of scientific research is an issue about which there is scant judicial authority. This article suggests that a crucial guidepost for exploring both these uncharted areas of constitutional law should be whether restrictions on scientific research or communication truly implicate fundamental individual rights or instead primarily concern issues of general social welfare—issues that in a democracy are properly decided by the representative branches of government or their delegates, not by the judiciary.     

组织行为学领域妒忌研究的不同视角、分歧和未来方向

妒忌他人是生活和工作中一种普遍的现象, 虽然宗教学、哲学和历史典籍等领域很久以前就有诸多有关妒忌的记录, 但是, 直到近来妒忌才引起组织行为学研究者的关注。尽管以往多学科和多视角的研究加深了研究者对妒忌的理解, 然而, 在组织行为学领域深入研究妒忌仍面临诸多挑战。为澄清妒忌研究中的挑战、明确分歧、推进妒忌研究, 首先从妒忌特有视角、妒忌分类视角和妒忌整体视角对妒忌研究进行总结分析, 然后重点从妒忌的性质、应对妒忌的策略、解释矛盾结论三方面分析以往三种妒忌研究视角之间的分歧。在此基础上, 建议未来研究可以进一步厘清妒忌内涵和测量、深入研究妒忌者和被妒忌者之间的二元关系、整合不同视角的妒忌研究。     

The effects of divided attention on encoding processes under incidental and intentional learning instructions: Underlying mechanisms?

Divided attention (DA) at encoding has been shown to significantly disrupt later memory for the studied information. However, what type of processing gets disrupted during DA remains unresolved. In this study, we assessed the degree to which strategic effortful processes are affected under DA by comparing the effects of DA at encoding under intentional and pure incidental learning instructions. In three experiments, participants studied list of words or word pairs under either full or divided attention. Results of three experiments, which used different methodologies, converged to show that the effects of DA at encoding reduce memory performance to the same degree under incidental and intentional learning. Secondary task performance indicated that encoding under intentional learning instructions was more effortful than under incidental learning instructions. In addition, the results indicated enhanced attention to the initial appearance of the words under both types of learning instructions. Results are interpreted to imply that other processes, rather than only strategic effortful ones, might be affected by DA at encoding.     

Irritability as a Transdiagnostic Vulnerability Trait:Current Issues and Future Directions

In recent years, irritability has received increasing attention among mental health professionals given its transdiagnostic associations with diverse forms of psychopathology. In contrast to other emotional states and traits, however, literature addressing associations between irritability and related temperament and personality constructs is limited. In addition, those who study irritability have diverse perspectives on its neurobiological substrates. In this comment, we situate irritability in the literatures on child temperament and adult personality, and describe a model in which irritability derives from low tonic dopamine (DA) levels and low phasic DA reactivity in subcortical neural structures implicated in appetitive responding. We note that different findings often emerge in neuroimaging studies when irritability is assessed in circumscribed diagnostic groups versus representative samples. We conclude with directions for future research, and propose that more authors use hierarchical Bayesian modeling, which captures functional dependencies between irritability and other dispositional traits (e.g., trait anxiety) that standard regression models are insensitive too. Treatment implications are also considered.     

Disfluencies, language comprehension, and Tree Adjoining Grammars

Disfluencies include editing terms such as uh and um as well as repeats and revisions. Little is known about how disfluencies are processed, and there has been next to no research focused on the way that disfluencies affect structure-building operations during comprehension. We review major findings from both computational linguistics and psycholinguistics, and then we summarize the results of our own work which centers on how the parser behaves when it encounters a disfluency. We describe some new research showing that information associated with misarticulated verbs lingers, and which adds to the large body of data on the critical influence of verb argument structures on sentence comprehension. The paper also presents a model of disfluency processing. The parser uses a Tree Adjoining Grammar to build phrase structure. In this approach, filled and unfilled pauses affect the timing of Substitution operations. Repairs and corrections are handled by a mechanism we term “Overlay,” which allows the parser to overwrite an undesired tree with the appropriate, correct tree. This model of disfluency processing highlights the need for the parser to sometimes coordinate the mechanisms that perform garden-path reanalysis with those that do disfluency repair. The research program as a whole demonstrates that it is possible to study disfluencies systematically and to learn how the parser handles filler material and mistakes. It also showcases the power of Tree Adjoining Grammars, a formalism developed by Aravind Joshi which has yielded results in many different areas of linguistics and cognitive science.     

Role of dopamine,the frontal cortex and memory circuits in drug addiction: insight from imaging studies

Drug addiction is characterized by a set of recurring processes (intoxication, withdrawal, craving) that lead to the relapsing nature of the disorder. We have used positron emission tomography to investigate in humans the role of dopamine (DA) and the brain circuits it regulates in these processes. We have shown that increases in DA are associated with the subjective reports of drug reinforcement corroborating the relevance of drug-induced DA increases in the rewarding effects of drugs in humans. During withdrawal we have shown in drug abusers significant reductions in DA D2 receptors and in DA release. We postulate that this hypodopaminergic state would result in a decreased sensitivity to natural reinforcers perpetuating the use of the drug as a means to compensate for this deficit and contributing to the anhedonia and dysphoria seen during withdrawal. Because the D2 reductions are associated with decreased activity in the anterior cingulate gyrus and in the orbitofrontal cortex we postulate that this is one of the mechanisms by which DA disruption leads to compulsive drug administration and the lack of control over drug intake in the drug-addicted individual. This is supported by studies showing that during craving these frontal regions become hyperactive in proportion to the intensity of the craving. Craving is also associated with activation of memory circuits including the amygdala (implicated in conditioned learning), hippocampus (implicated in declarative learning), and dorsal striatum (implicated in habit learning) all of which receive DA innervation. We therefore postulate that dopamine contributes to addiction by disrupting the frontal cortical circuits that regulate motivation, drive, and self-control and by memory circuits that increase the motivational salience of the drug and drug-associated stimuli.