The epidemiology of Wilson's disease in the German Democratic Republic and current problems from the viewpoint of population genetics

Between 1949 and Nov. 30, 1977 a total of 123 cases of Wilson's disease have been registered in the GDR. Using the available statistics the incidence rate of the disease is assumed to be about 2.9/100,000, the gene frequency approx. 0.53 per cent and the heterozygote incidence 1.05 per cent, supposing that the Hardy-Weinberg law applies to a large extent. Conclusions are drawn from the available material with a view to detection of the disease infuture and to genetic family counselling.     

Paraconsistent logic from a modal viewpoint

In this paper we study paraconsistent negation as a modal operator, considering the fact that the classical negation of necessity has a paraconsistent behavior. We examine this operator on the one hand in the modal logic S5 and on the other hand in some new four-valued modal logics.     

Definition of psychotherapy from a methodologic viewpoint

Psychotherapy is the psychological treatment of disturbed person-environment relationships, associations or connections which are learned in a lifelong process of socialization. Accordingly, psychotherapy is a process of learning for the patient and a process of educating for the therapeutist, a process which is controlled by specialists in the case of children as well as adults with serious psychic disorders and which is usually a means of self-education in the case of subjects with slight psychic disorders. The primary objective of psychotherapy is to modify both the attitude and behavior in the sense of improving a subject's ability to fulfill his duties in society.     

Aortic isthmus stenosis from a neurological viewpoint

The etiology, pathogenesis, and clinical treatment of stenoses of the isthmus aortae are outlined. Following this, the particular case of a 41-year-old patient with typical stenosis of the isthmus of the aorta is reported. The course of disease required the need for a surgical operation, which had not initially been taken into consideration, to be reexamined. The patient, after performance on him of vascular restoration, is now on a part-time job. Using age as the sole circumstance indicating the inadvisability of performing a surgical operation in the case of stenosis of the isthmus aortae cannot any longer be considered justifiable.     

Forensic-psychologic-psychiatric assessment from the viewpoint of perpetrators--data from a survey

In this contribution, various aspects of the expert/culprit-relationship and of the communication behavior styles between the included persons within the scope of forensic-psychological-psychiatric expertise, are discussed. A survey is given on results gained with a questionnaire study (n = 93 culprits; Department of Forensic Psychiatry, Charité Berlin) of the most important expectations, of the social-relevant attitudes towards the assessment and physicians before the forensic investigation as well as of the experiences of own feelings, stress and of the culprit's reflections on the physician/proband relationship after the assessment. A good partnership relation between experts and culprits presupposes that the expert not only possesses a high profession but also the necessary interpersonal-social competence.     

On the development of depressive states from a psychodynamic viewpoint

The author analyzes the temporal dimension of depression by making reference to one of the clinical cases he treated and re-examining a clinical case analyzed by Edith Jacobson. According to the result of his observations, the developmental psychodynamics of a depressive state normally appears to take place in two distinct phases: a first narcissistic loss, which gives rise to an integrative conflict and to the formation of a certain identificatory structure, is later followed by a second narcissistic loss, which leads to the real depressive state. The two phases present a specific, intrinsic connection constituted by the implication of the same identificatory element of the self, recognition of which can favour a clinical work that more closely adheres to the deep dynamics of depression.     

Tests of hypothesis in a repeated measures design from a permutation viewpoint

Repeated measures designs have been widely employed in psychological experimentation, however, such designs have rarely been analyzed by means of permutation procedures. In the present paper certain aspects of hypothesis tests ina particular repeated measures design (one non-repeated factor (A) and one repeated factor (B) withK subjects per level ofA) were investigated by means of permutation rather than sampling processes. The empirical size and power of certain normal theoryF-tests obtained under permutation were compared to their nominal normal theory values. Data sets were established in which various combinations of kurtosis of subject means and intra-subject variance heterogeneity existed in order that their effect upon the agreement of these two models could be ascertained. The results indicated that except in cases of high intra-subject variance heterogeneity, the usualF-tests onB andAB exhibited approximately the same size and power characteristics whether based upon a permutation or normal theory sampling basis.This research prepared under Contract No. 2593 from the Cooperative Research Branch of the U. S. Office of Education.