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To examine the role of ventilatory response in nocturnal panic, subjects experiencing nocturnal panic were compared with those who experienced daytime panic attacks only. In particular, measures of chronic hyperventilation (baseline pCO2) and CO2 hypersensitivity (response to ventilatory challenges) were assessed. Subjective and psychophysiological measures were obtained during baseline, forced hyperventilation, and carbon dioxide inhalation phases of a standardized laboratory-based assessment. The groups did not differ with respect to subjective or physiological measures or to the frequency with which panic occurred during the assessment. The results do not lend support to models that emphasize central CO2 hypersensitivity and chronic hyperventilation as primary mechanisms underlying nocturnal panic.  相似文献   

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In Phases 1 and 3, two Japanese monkeys responded on a multiple variable-ratio 80 variable-interval X schedule, where the value of X was adjusted to ensure equal between-schedule reinforcement rates. Components strictly alternated following the delivery of a food pellet, and each session ended following 50 components. Phase 2 differed from the others only in that the 50 pellets previously earned during the session were delivered together at session's end. Variable-ratio response rates did not decrease across phases, but variable-interval response rates decreased substantially during the Phase 2 procedure. This rate decrease was attributed to the food-at-session's-end manipulation removing the greater immediacy of reinforcement provided by short interresponse times relative to long interresponse times. Without this time preference for short interresponse times, the variable-interval interresponse-time reinforcement feedback function largely controlled response emission, dictating a response-rate reduction. This result was explained in terms of the economic notion of “maximizing present value.”  相似文献   

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Cortisol is elevated during severe depression. However, some studies of outpatients suggest reduced cortisol levels, either basal or poststress. More definite evidence of this phenomenon is needed, and correlates that may explain the disparate findings should be identified. Women from the community (37 depressed and 36 nondepressed) completed electronic diaries in order to help researchers assess the cortisol awakening response (CAR), sleep, and social contacts. Depressed women had a blunted CAR compared with nondepressed women. Among the nondepressed but not among depressed women, time of waking, and number of social contacts (especially positive ones) were independently associated with CAR. These psychosocial factors may contribute to a normal CAR, but their regulatory influence may become disrupted during mild to moderate clinical depression.  相似文献   

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《Developmental Review》2006,26(2):138-174
The stress response systems of the human child are highly sensitive to social challenges. Because stress hormones can have negative developmental and health consequences, this presents an evolutionary paradox: Why would natural selection have favored mechanisms that elevate stress hormone levels in response to psychosocial stimuli? Two complementary hypotheses are considered: (a) maladaptation to the novelty of chronic stress in social environments, and (b) adaptive neural reorganization that facilitates the ontogeny of social competencies. Data on salivary cortisol, morbidity, and social environment from an 18 year study of child health in a rural community on the island of Dominica are examined from the perspective of these alternative hypotheses. Results indicate that difficult family environments and traumatic events are associated with elevated cortisol levels and higher morbidity. The long-term effects of traumatic early experiences on cortisol profiles are complex and indicate domain-specific effects, with normal recovery from physical stressors, but heightened response to negative-affect social challenges.  相似文献   

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The study examines whether anxiety or chronic relationship stress alter the way that couple conflict affects cortisol levels for women and men during the transition to parenthood. Saliva samples, assayed for cortisol, were collected before and after couple interaction from 128 heterosexual couples expecting their first child. Confirming prior research, expectant mothers had higher cortisol levels than their spouses, and gestational age was linked to women's cortisol level. Negativity during couple interaction was associated with greater cortisol reactivity for men, but not women. Tests of moderation indicated little relation between negativity and cortisol recovery for individuals with a low level of anxiety or little history of chronic arguing with the partner. However, among individuals with elevated levels of either of these two factors, negativity was linked to less cortisol recovery for men, but more cortisol recovery for women. Consistent results were also found for the relation between low warmth in the couple interaction and both reactivity and recovery for men and women high in anxiety. Future research should examine whether pregnancy is responsible for these different gender patterns, or whether the inhibition of negativity is stressful for women with high levels of risk.  相似文献   

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Bion's basic theory of transformations includes the concept of invariances: those aspects that are kept unchanged in the transformation. Translations are considered transformations that include invariances that allow for the recognition of the transformation. Psychoanalytic interpretations are seen by the author of this paper as a special case of such transformations. From Borges's radically open perspective on translation, psychoanalytic interpretations can be characterized as pertaining to one of three categories: (1) interpretations that change the unfamiliar to the familiar, (2) rigid motion transformations, or (3) interpretations that are transformations towards O. These ideas are dramatized in the reading of two of Borges's fictional stories that present two different approaches to translation, Averroes' search and Pierre Menard, author of the Quixote. These stories exemplify transformations in –K and + K. Finally, Cervantes' intuition of a hybrid language that approaches O and allows for a peaceful and multilayered interpretation of reality (transformation towards O) is discussed.  相似文献   

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In his book, Being‐in‐the‐World: A Commentary on Heidegger's Being and Time, Division I, Hubert Dreyfus argues that Heidegger's concept of authenticity is incomprehensible. He maintains that there are two conflicting accounts of inauthenticity in Being and Time. He elucidates what he calls the ‘structural account’ of inauthenticity and being‐in‐the‐world in the main body of his work, and then criticizes what he calls the ‘motivational account’ in an Appendix. Because he overlooks certain textual evidence and underemphasizes fleeing and the role of choice, his interpretation is neither complete nor compelling. I offer an alternative interpretation of authenticity. While Heidegger's notion of authenticity may still be weakened by other flaws, it is not incomprehensible in the sense that Dreyfus contends.  相似文献   

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