公务员正常高值血压的流行现状及危险因素分析

对吉林省516名公务员的血压及心血管疾病危险因素进行描述性分析,用二分类Logistic回归法筛选危险因素.公务员正常高值血压现患率为34.9%.正常高值血压人群体重指数、腰围、空腹血糖、总胆固醇、低密度脂蛋白胆固醇、甘油三酯、血清肌酐、血尿酸、心-踝血管指数水平以及代谢综合征患病率均高于正常血压组低于高血压组,高密度脂蛋白胆固醇水平低于正常血压组高于高血压组.男性、血脂紊乱会显著增加正常高值血压的患病风险.应加强正常高值血压人群的监测及干预,降低心脑血管疾病发病风险.     

超重/肥胖个体工作记忆的神经机制及干预

全球超重/肥胖人群增长迅猛,1997年世界卫生组织将肥胖认定为全球性流行病。目前,中国成年人的超重/肥胖发生率已超过50%,不健康的饮食行为占肥胖成因的70%。本项目拟从食物特异工作记忆切入,探明超重/肥胖个体食物特异工作记忆的神经机制,以及与一般工作记忆神经机制的差异。再采用前瞻性的研究设计,考察食物特异工作记忆与超重/肥胖发展的渐变关系,探索食物特异工作记忆及其神经活动对个体饮食管理和体质变化的预测作用。最后,采用食物特异抑制控制训练,提升超重/肥胖个体的食物特异工作记忆能力,塑造健康饮食行为。本项目旨在探索塑造健康饮食行为的安全及有效的方法,为超重/肥胖的预防和干预提供理论和实践建议,具有现实性、前沿性和前瞻性。     

公务员正常高值血压的流行现状及危险因素分析

对吉林省516名公务员的血压及心血管疾病危险因素进行描述性分析,用二分类Logistic回归法筛选危险因素。公务员正常高值血压现患率为34．9％。正常高值血压人群体重指数、腰围、空腹血糖、总胆固醇、低密度脂蛋白胆固醇、甘油三酯、血清肌酐、血尿酸、心一踝血管指数水平以及代谢综合征患病率均高于正常血压组低于高血压组,高密度...     

正常高值血压者血压昼夜节律与靶器官损害的相关性研究

探讨正常高值血压昼夜节律与靶器官损害的相关性。入选正常高值血压者150例,其中杓型组72例,非杓型组78例,60例正常血压者为对照组。检测尿白蛋白排泄率（UAE）、颈动脉内膜中层厚度（IMT）和左心室重量指数（LVMI）。杓型组和非杓型组UAE、IMT、LVMI高于对照组（P＜0．01）。非杓型组UAE、IMT、LVMI高于杓型组（P＜0．05）。正常高值血压人群已出现靶器官损害,血压昼夜节律异常与早期靶器官损害密切相关。     

肥胖男性血浆脂联素水平及影响因素

检测正常男性血浆脂联素水平,探讨其与各检测指标之间的相关性。选取正常男性96例,按体重指数（BMI）将上述两组分为2个亚组：肥胖（BMI≥25kg／m^2）组40例及体重正常（BMI〈25kg／m^2）组56例,测定空腹血浆脂联素浓度。肥胖组的血浆脂联素水平[（7．48±3．4）μg／m1]明显低于体重正常组[（10．57±4．73）μg／m1],差异有显著的统计学意义（P〈0．01）。相关分析显示血浆脂联素与体重指数（BMI）、腰围（WC）、血压（BP）、总胆固醇（TC）、血清胰岛素（FINs）、胰岛素抵抗指数（HOMA-IR）之间存在负相关,与高密度脂蛋白胆固醇（HDL-C）正相关。BMI、WC、HOMA-IR为影响血浆脂联素水平的独立因素。男性肥胖者血浆脂联素水平较体重正常者明显降低,血浆脂联素水平可能与肥胖及其相关疾病相关。     

应激性生活事件与超重/肥胖青少年内化问题:应对方式的中介作用

通过对广州市1438名中学生进行问卷与体质调查,考察应激性生活事件对超重、肥胖青少年内化问题的影响及作用机制。结果显示:(1)超重、肥胖检出率为17.04%;(2)应激性生活事件能直接预测超重、肥胖青少年的内化问题;(3)消极应对方式在应激性生活事件与超重、肥胖青少年内化问题的关系中起部分中介作用。结果提示应激性生活事件对超重、肥胖青少年内化的影响部分是通过消极应对方式的中介作用实现的。     

体检人员血尿酸与代谢综合征组分的关系

为观察血尿酸与代谢综合征（MS）及其各组分的相关性,随机检测MS,调查人群血尿酸（SUA）水平865份。结果显示：体检的865名人员的高尿酸血症患病率为6．6%,男性为10．4％,女性为3．2％。与正常血尿酸组比较,高血尿酸组的BMI、BP、FPG和血脂谱均升高（P均〈0．05）;研究对象的SUA水平与MS的危险因素呈显著相关,其中与腰围、SBP、DBP、TG、FPG、HOM-IR呈正相关,与HDL-C呈负相关;随着代谢异常数目的增加,SUA水平呈上升趋势;多元Logistic回归高尿酸血症独立相关于超重、高血压和血脂异常。提示SUA水平与MS的危险因素密切相关;高尿酸血症独立相关于超重、高血压和血脂异常。     

急性心理应激对多囊卵巢综合征患者的影响

为了了解PCOS患者易患抑郁症、肥胖、代谢综合征、心血管疾病、糖尿病的原因。通过对28例PCOS患者和28例体重指数、年龄匹配的健康对照组回应公众演讲压力进行分析,在回应公众演讲压力时,PCOS组和对照组均有比较显著的焦虑程度、ACTH、皮质醇、心率和血压升高（P均〈0．01）;但PCOS患者焦虑程度、ACTH、皮质醇...     

Lipo PGE1在肾移植中的应用

为了探讨前列腺素E1的脂微球载体靶向制剂（Lipo PGE1）对肾移植术后移植肾功能恢复和血流动力学的影响,80例肾移植受者在术后被随机分成两组：PGE1组和对照组。PGE1组从手术当天起至术后第14天每天给予静脉注射Lipo PGE1 20μg。比较两组术后尿量、血肌酐、彩色多普勒超声下移植肾收缩期最大血流速度（PSV）和血流阻力指数（RI）以及两组肾功能恢复延迟（DGF）的发生率。应用Lipo PGE1的患者术后尿量明显高于对照组（P〈0．05）,而血肌酐、PSV、RI和肾功能恢复延迟发生率则明显低于对照组（P〈0．05）。因此,前列腺素E1有利于肾移植术后移植肾功能的恢复,对肾移植术后早期肾动脉血流动力学有促进作用。     

大连地区健康人群体重指数分布状况的调查分析

调查分析大连地区健康人群中体重指数(BMI)、腰臀围比(WHR)的分布状况。对630例长期居住大连地区的21岁～60岁汉族健康成人的BMI、WHR进行调查分析,检测受检者身高、体重、腰围、臀围,按不同年龄段、不同性别分析BMI、WHR的性别及年龄分布。大连地区健康人群总体的平均BMI为(23.66±3.12)kg/m~2,其中男性为(24.66±2.88)kg/m~2。女性为(22.41±2.97)kg/m~2,经t检验有显著差异(t=11.85,P＜0.001)。BMI≥25的人群比例为24.1%,BMI≥30的为3.0%。BMI随年龄变化的曲线为斜线,从21岁～60岁,随着年龄的增长而显著升高,51岁～60岁达到最高峰;WHR随年龄变化的曲线为斜线,随着年龄的增长而显著升高,51岁～60岁达到最高峰。随着社会生活水平的提高,人群中BMI、WHR结构发生了明显的变化,肥胖者日趋增多,应重视超重和肥胖的防治工作。     

Overweight and cognition

There is a growing concern among health authorities that an increasing number of people in the Western world become overweight and even obese. It is well known that obesity is related to several diseases (e.g., diabetes, stroke, and high blood pressure) and that such diseases related to obesity lead to early death. It has also been discussed whether overweight and obesity in themselves or in relation to such diseases lead to cognitive decline. On the basis of data from a large, population‐based, prospective study we examined three cognitive domains: episodic memory, semantic memory, and spatial ability. Two body measures were used to define normal weight and overweight, body‐mass index and waist/hip ratio. Although these two body measures reveal quite different prevalence data of overweight, the associations between overweight and cognition are similar. For episodic memory, overweight interacts with age, but when controlling for hypertension, stroke and diabetes, this interaction disappears. For semantic memory, normal weight participants outperform overweight participants even after controlling for these diseases. For spatial ability, the well‐established advantage for men holds for young‐old and old‐old normal‐weight participants. For overweight participants, this advantage holds for middle‐age participants only. We conclude that there is a weight‐cognition relationship even after controlling for obesity‐related diseases. The results are discussed in terms of possible biological mechanisms.     

Lästererfahrungen, Körperbild und Körpergewicht bei jungen Erwachsenen

Background

Negative comments (teasing) on weight and body image in adolescence might predict body dissatisfaction, overweight and eating disorders in adulthood. This study investigated 134 nursing students for a relationship between a history of teasing, body image and weight.

Materials and methods

Subjects with a body mass index (BMI)>?25 kg/m² reported more teasing compared with normal subjects whereas those with a BMI<?20 kg/m² showed lower values compared with normal or overweight subjects. Teasing questionnaire values correlated with aspects of negative body image. The BMI was predicted by factors age (p?=?0.001), sex (p?=?0.016) and teasing subscale weight (p?=?0.001).

Conclusions

It is remarkable that low teasing experience was associated with low weight, which might point to underweight as protective factor against teasing; however, the cross-sectional design of this study precludes direct causal inferences.     

Dysfunctional body investment versus body dissatisfaction: Relations with well-being and controlled motivations for obesity treatment

In this study, we investigated the associations between body image and psychological well-being, exploring the mediating role of controlled regulation for entering obesity treatment. In addition, we analyzed whether investment body image was more strongly associated with controlled regulation (and subsequent well-being) compared to evaluative body image. These analyses were performed controlling for baseline BMI effects. Participants were 139 overweight women (age: 38.0 ± 6.7 year; BMI: 32.0 ± 4.1 kg/m²) entering treatment. Evaluative and investment body image, controlled regulation, and psychological well-being were assessed. Body image investment was positively associated with controlled regulation; evaluative body image was not. Controlled regulation was negatively associated with self-esteem and psychological functioning. Controlled regulation partially mediated the effects of body image investment on self-esteem, but did not mediate its effects on psychological functioning. Results suggest that dysfunctional body image investment might undermine well-being within overweight women, partly by increasing controlled regulation for entering obesity treatment. Discussion focuses on the importance of enhancing body image and autonomy during treatment to improve well-being and weight outcomes.     

Parenting and child body mass index: Longitudinal investigation of maternal and paternal influence

The aim of this study was to investigate the cross‐sectional and longitudinal relationships between general parenting and body mass index (BMI) status of children between the ages of 4 and 7 in Australia. A nationally representative sample of 4,423 children (49% female) and their parents was used for the present study. Measures of parental demandingness and responsiveness were completed by parents at child age 4–5 years. Height and weight measurements of children were taken at child age 4–5, and again at 6–7, from which BMI status was calculated. No influence of mothers' parenting on child BMI status was shown, and fathers' responsiveness was found to be predictive of increased risk for overweight/obesity at 6–7 years. While the present study is complicated by measurement issues, findings suggest that increased risk for overweight in young children may be associated with responsiveness in fathers. Obesity prevention programs involving parents should take into account the influence of fathers' parenting on child BMI status.     

神经影像视角下的肥胖脑机制研究

肥胖作为一种全球性流行病,与许多慢性非传染性疾病密切相关。本文主要从脑功能和脑结构层面对现有肥胖研究做系统梳理。脑功能上,个体在加工食物线索时奖赏环路的过度激活、认知控制环路的活动缺失构成了肥胖的易感因子。脑结构上,全脑灰质体积、白质纤维束完整性和整体弥散水平的降低,从不同的影像层面提供了肥胖的神经解剖证据。未来研究可以从纵向研究的开展、干预措施的扩展和多模态脑成像数据的整合等方面展开。     

Behaviour change among overweight and socially disadvantaged adults: a longitudinal study of the NHS Health Trainer Service

Social disadvantage is associated with being overweight, a poor diet and physical inactivity. The NHS Health Trainer Service (HTS) is a national initiative designed to promote behaviour change among socially disadvantaged people in England and Wales. This study reports pre-post changes in body mass index (BMI), associated behaviours and cognitions among service users who set dietary or physical activity goals during a 12-month period (2008-2009; N?=?4418). Sixty-nine percent of clients were from the two most deprived population quintiles and 94.7% were overweight or obese. Mean BMI decreased from 34.03 to 32.26, with overweight/obesity prevalence decreasing by 3.7%. There were increases in fruit and vegetable consumption, reductions in fried snack consumption, increases in frequency of moderate or intensive activity and gains in self-efficacy and perceived health and wellbeing. Clients with higher BMI, poorer diet or less activity at baseline achieved greater change. Findings suggest that the NHS HTS has the potential to improve population health and reduce health inequalities through behaviour change.     

Problematic eating behaviors and nutritional status in 7 to 12 year-old Chilean children

Overweight and obesity are medical conditions that require a multidisciplinary analysis of their causes and treatment. In Chile a sustained increase in the presence of obesity and excess weight has been observed in children. However, the amount and the dynamics of the aforementioned problematic eating behaviours in Chilean children are unknown. The aim of this study was to assess the relationship between restrained, external, and emotional eating, and variations in body mass index (BMI) in Chilean children. Consequently, 453 children from 7 to 12 years of age responded to the Children's Dutch Eating Behaviour Questionnaire, Spanish version. In addition, their anthropometric data were obtained. A positive association was found between restrained eating and BMI, and a negative correlation between external eating and BMI. Emotional eating demonstrated a modest inverse relationship with BMI. A significant interaction between problematic behaviour and nutritional status (normal-weight, overweight, obese) was revealed. Restrained eating was characteristic of obese children whereas external eating of normal-weight children. These results suggest that problematic eating behaviours and their relationship with body weight are similar to those described in studies in Europe.     

Childhood Overweight and Obesity: Maternal and Family Factors

Treatment programs for childhood overweight and obesity have highlighted the importance of the family in treatment. Considering this, it is surprising that few studies have examined the role of family factors in the development of childhood overweight and obesity. The objective of this study was to examine which family and maternal factors predict increases in weight in boys and girls during middle to late childhood. This study used longitudinal data from the childhood growth and development (GAD) Study. The GAD Study involved 286 healthy weight, overweight and obese children, aged 6–13 years at baseline, who completed baseline, 1-year follow-up and 2-year follow-up assessments. Overweight/obese children were recruited from clinical and community settings. A broad range of maternal and family factors were assessed. Linear mixed models were used to identify which factors predicted child Body Mass Index (BMI) z-scores over time. For community-based children, maternal BMI and single-parent family structure were significant longitudinal predictors of child BMI z-scores. For the clinical participants, low family income was the only significant multivariate predictor of child BMI z-scores. The strong association between child BMI, maternal BMI and family structure confirms the need to target prevention and intervention efforts for childhood overweight and obesity towards families with overweight parents, particularly single-parent families.