Neuroplastic Changes Following Social Cognition Training in Schizophrenia: A Systematic Review

Social cognitive impairment is a key feature of schizophrenia and social cognition training (SCT) is a promising tool to address these deficits. Neurobiological dysfunction in schizophrenia has been widely researched, but neuronal changes induced by SCT have been scarcely explored. This review aims to assess the neuroplastic effects of SCT in patients with schizophrenia spectrum disorders. PubMed and Web of Science databases were searched for clinical trials testing the effects of SCT in functional and structural brain measurements of adult patients with schizophrenia or schizoaffective disorders. A total of 11 studies were included: five used fMRI, two used EEG and ERP, one used ERP only, two used MEG and one study used MRI. Data extracting and processing regarding sociodemographic and clinical variables, intervention characteristics, neuroimaging procedures, neuroplastic findings, effect sizes and study quality criteria was completed by two raters. Results indicate a wide range of structural and functional changes in numerous regions and circuits of the social brain, including early perceptual areas, the limbic system and prefrontal regions. Despite the small number of trials currently available, evidence suggests that SCT is associated with neuroplastic changes in the social brain and concomitant improvements in social cognitive performance. There is a lack of extensive knowledge about the neural mechanisms that underlie social cognitive enhancement after treatment, but the reported findings may shed light on the neural substrates of social cognitive impairment in schizophrenia and how improved treatment procedures can be developed and applied.     

On "risk" and reward: investigating state anhedonia in psychometrically defined schizotypy and schizophrenia

Anhedonia, defined as dysfunction in the experience of pleasant emotions, is a hallmark symptom of the schizophrenia spectrum. Of interest, it is well documented that patients with schizophrenia, at least as a group, do not show reductions in their state experience of pleasant stimuli. However, there is emerging evidence to suggest that individuals with schizotypy--defined as the personality organization reflecting the latent vulnerability for schizophrenia--do show these state deficits. This is paradoxical in that schizophrenia reflects a more pathological state in virtually every conceivable domain as compared with schizotypy. The present study examined self-reported affective reactions to neutral-, bad-, and good-valenced stimuli in individuals with psychometrically defined schizotypy and schizophrenia. Two separate control groups were also included, comprising psychometrically defined controls and stable outpatients with affective disorders. With no exceptions, the schizotypy group reported significantly less pleasant affect for each of the three conditions than each of the other groups. Conversely, the schizophrenia group did not statistically differ from the control groups for any of the conditions. Within both the schizotypy and schizophrenia groups, severity of negative symptoms/traits was associated with less pleasant report. We found that individuals with prominent negative symptoms and traits from the schizophrenia and schizotypy groups resembled each other in terms of state anhedonia. The present findings did not appear to reflect comorbid depression or anxiety. Our discussion centers on this apparent paradox in the schizophrenia spectrum--that individuals with schizotypy exhibit state anhedonia, whereas patients with schizophrenia do not.     

Evolutionary developmental psychology: Current status and future directions

The field of developmental psychology is part of a continuum of disciplines, from cell biology to cultural anthropology, that are focused on understanding developing and potentially evolving phenotypes; the reciprocal interactions between genetics and experiences produce variation in developing phenotypes and this variation is the grist for evolutionary selection. The articles in this issue provide cutting edge and multidisciplinary analyses of developing and potentially evolving phenotypes in areas that are of central interest to developmental scientists, including mother–infant attachments, stress responses in children, social cognition, and life span development. The articles and other recent works signal the reemergence of developmental psychology as an evolutionarily informed, multidisciplinary field. In this view, it is not about nature versus nurture or biology versus psychology, it is about tackling difficult problems at multiple levels of analysis, each of which has something to contribute and none of which is sufficient in and of itself.     

Perceptual hysteresis as a marker of perceptual inflexibility in schizophrenia

People with schizophrenia are known to exhibit difficulties in the updating of their current belief states even in the light of disconfirmatory evidence. In the present study we tested the hypothesis that people with schizophrenia could also manifest perceptual inflexibility, or difficulties in the updating of their current sensory states. The presence of perceptual inflexibility might contribute both to the patients’ altered perception of reality and the formation of some delusions as well as to their social cognition deficits. Here, we addressed this issue with a protocol of auditory hysteresis, a direct measure of sensory persistence, on a population of stabilized antipsychotic-treated schizophrenia patients and a sample of control subjects. Trials consisted of emotional signals (i.e., screams) and neutral signals (i.e., spectrally-rotated versions of the emotional stimuli) progressively emerging from white noise – Ascending Sequences – or progressively fading away in white noise – Descending Sequences. Results showed that patients presented significantly stronger hysteresis effects than control subjects, as evidenced by a higher rate of perceptual reports in Descending Sequences. The present study thus provides direct evidence of perceptual inflexibility in schizophrenia.     

Attentional Biases for Facial Expressions in Social Phobia: The Face-in-the-Crowd Paradigm

The present study examines the attentional bias hypothesis for individuals with generalised social phobia (GSPs). Socially phobic individuals were hypothesised to exhibit attentional bias towards threat stimuli relevant to interpersonal situations. This hypothesis was tested using the face-in-the-crowd paradigm. GSPs and nonanxious controls (NACs) detected an angry, happy, neutral, or disgust target face in a crowd of 12 distracter photographs. Results indicated that, compared to NACs, GSPs exhibited greater attentional biases for angry than for happy faces in a neutral crowd. GSPs were more slowed down in their performance by happy and angry versus neutral distracters; NACs did not exhibit such sensitivity to distracter type. Finally, GSPs were faster in detecting anger than disgust expressions; NACs detected both types of faces equally quickly. Implications of these findings for the maintenance of social phobia are discussed.     

The Biological Basis of Social Interaction

The fact that brain disorder can impair social interactions in different ways suggests that social competence has multiple components that have foundations in brain systems. The physiological basis of one aspect of social cognition, theory of mind, is just beginning to be understood. Brain-imaging studies suggest that a network of areas linking medial prefrontal and temporal cortex forms the neural substrate of mentalizing, that is, representing one's own and other people's mental states. The medial prefrontal areas are prominent also in tasks that involve self-monitoring, whereas the temporal regions are prominent also in tasks that involve the representation of goals of actions. We speculate that the precursors of mentalizing ability derive from a brain system that evolved for representing agents and actions, and the relationships between them.     

Personal and Social Factors in Achievement-Related Cognition: A Study of Attribution,Appraisal, and Emotion among University Students in Delhi

In recent years, achievement-related cognition and emotion have received a lot of attention from all sections of researchers. A number of researchers have tried to empirically study the determinants and consequences of achievement-related cognition. The explanations given range between individualistic explanations and sociocultural explanations. It is believed that both personal and social factors interact together in bringing about variations in achievement-related cognition and emotion. It is widely accepted that there are variations in human behavior, which are generally believed to be the result of generation-old cultural changes. Cultural factors are believed to exert influence on human behavior and psyche. When one talks about culture, it is mostly treated as a homogeneous entity. Variations within cultures and intra-cultural differences due to various social factors are largely ignored. Researchers world over have started believing in the fact that exposure not only to varying cultural conditions but also to different social factors affects individuals’ psychological functioning. Present research is directed towards exploring variations in achievement-related cognition and emotion due to personal and social factors. Eighty students from a university in Delhi participated in the research. The personal factor of self-construal and social factors like gender, social setting, perceived social class, and family were taken into account. Findings of the study corroborated the hypothesis that both personal and social factors have an impact on achievement-related cognition and emotion.     

Unique sets of social and mood characteristics differentiate autistic and negative schizotypy traits in a young adult non-clinical sample

While well-established as distinct disorders, new evidence linking autism and schizophrenia has emerged. One line of evidence is the strong correlation identified between the social traits assessed by the Autism Spectrum Quotient (AQ:Social) and the negative traits of schizotypy. To further explore this association, the current study examined whether these sets of traits are convergent or divergent in the degree to which they relate to specific aspects of socio-emotional functioning. Regression analyses conducted on self-report data collected from 284 undergraduate students showed that the social items from the AQ uniquely relate to levels of social anxiety and social skills, while negative schizotypy traits uniquely relate to social anhedonia and depression. Additionally, AQ:Social and negative schizotypy traits were found to share a significant proportion of variance, independent of each of the socio-emotional variables examined. The results thus provide further evidence of shared atypical social function linked to both autistic-like traits and negative schizotypy traits, but importantly also highlight clear differences in the specific socio-emotional profiles associated with these sets of traits.     

The relationship of clinical, cognitive and social measures in schizophrenia: a preliminary finding combining measures in probands and relatives

This study examines performance of schizophrenia patients, unaffected relatives and controls in social cognition, cognitive and psychiatric scales looking for possible markers of vulnerability in schizophrenia. Performance of schizophrenia patients from multiplex families, first-degree relatives, and matched controls was compared and, subsequently, discriminant analysis method was used for identifying the best predictors for group membership. By using Multigroup Discriminant Analyses on the three groups, the best predictors were PANSS, Premorbid Adjustment Scale, Faux Pas test, and a face/emotion categorizing task. This model obtained 82% correct global classification, suggesting that the combination of psychiatric scales and neuropsychological/social cognition tasks are the best approach for characterizing this disease. Although preliminary, our results suggest that social cognition tasks are robust markers of schizophrenia family impairments, and that combining clinical, social and neuropsychological measures is the best approach to asses patients and relatives vulnerability.     

生物运动及其在社会认知障碍研究中的应用

人类对生物运动具有较强的视觉敏感性,即使在视觉线索有限的情况下,仍能提取其中的社会性信息。本研究系统梳理了当前生物运动视知觉实验研究涉及的各类社会性信息,并归纳分析社会认知缺陷与生物运动视知觉加工之间的内在联系,以期促进对生物运动视知觉加工心理机制问题的深入探讨     

Enhanced left frontal involvement during novel metaphor comprehension in schizophrenia: Evidence from functional neuroimaging

The neural basis involved in novel metaphor comprehension in schizophrenia is relatively unknown. Fourteen people with schizophrenia and fourteen controls were scanned while they silently read novel metaphors, conventional metaphors, literal expressions, and meaningless word-pairs. People with schizophrenia showed reduced comprehension of both novel and conventional metaphors. Furthermore, while controls showed enhanced brain activation in right inferior frontal gyrus (IFG) for novel metaphors versus meaningless word-pairs, people with schizophrenia showed an over-activation of left IFG and middle frontal gyrus (MFG). Direct comparison between the groups revealed greater activation in left precuneus for both novel metaphors and literal expressions vs. baseline for individuals with schizophrenia. Direct comparison for novel metaphors vs. literal expressions also revealed increased activation for individuals with schizophrenia in left MFG. These results suggest that the inefficient processing of novel metaphors in schizophrenia involves compensatory recruitment of additional brain regions that include the left MFG and left precuneus.     

Developmental regression in autism spectrum disorders

The occurrence of developmental regression in autism is one of the more puzzling features of this disorder. Although several studies have documented the validity of parental reports of regression using home videos, accumulating data suggest that most children who demonstrate regression also demonstrated previous, subtle, developmental differences. Counter to clinical intuition, the earlier development of social, language, and attachment behaviors followed by regression does not seem to support later recovery of skills or better developmental outcomes compared to children who never had speech or typical social responsivity. In fact, this regressive group may have somewhat greater developmental impairment than the nonregressive group, though the two groups do not appear to present different behavioral phenotypes. Although autism is not the only condition in which regression occurs, it appears to be the most frequent condition. Other disorders that demonstrate an early regression with no known etiology include total blindness from birth and childhood disintegrative disorder, both of which demonstrate behavioral relations to autism. In addition, two biological conditions with known etiologies also involve regression with some behaviors resembling autism behavioral phenotype: Rett syndrome (a genetic disorder; see Glaze, this issue) and Landau-Kleffner syndrome (see McVicar and Shinnar, this issue), which involves a seizure disorder.     

Hints of beauty in social cognition: Broken symmetries in mental dynamics

It is a widely held assumption that social cognition is wholly the result of natural selection and learning, debates arising over how much was naturally selected versus how much is learned. I argue here, however, for there being a third factor, namely physics, specifically symmetries and symmetry breakings in neural dynamics. These symmetries manifest themselves in social judgments in a fairly direct way as descending chains of subgroup types in mental social schemata. These schemata are the four models of Alan Page Fiske's relational-models typology. Descending chains of subgroup types are a phenomenon widely observed in nature; their presence in social cognition is consistent with there being a relevant neural network, the activity of which can undergo symmetry breakings. This would be analogous to the neural activity that has been computer modeled in an attempt to explain animal locomotion. This should encourage work towards specifying the particular symmetry groups in social cognition as a step towards devising computer models of the relevant neural mechanism. Approaches to animal locomotion suggest at least the broad outlines of how to proceed. Evidence of symmetry groups in social schemata also supports the view that the innate aspects of social cognition are at least partly structured by dynamics without being encoded in genes, just as the shape of the protective shell of some viruses results from dynamics without being genetically encoded.     

Impairment of gaze-directed spatial coding in recent-onset schizophrenia

Patients with schizophrenia show deficits in core cognitive functions as well as in social cognition. The aim of the present study was to test whether deficits in social cognition influence nonsocial, “cold”, cognition. Thirty-five patients with recent-onset schizophrenia (SC) and 30 healthy controls (HC) performed a Simon task with social and simple geometric stimuli. We investigated whether the Simon effect, the slowing of reaction times produced by stimulus incongruities in the task-irrelevant spatial domain, differs between patients and healthy participants as a function of the social nature of the cues. The Simon effect was generated by a schematic drawing of human eyes (social cues) or rectangles (nonsocial cues). Overall, patients had longer reaction times than HC. In the eye-like condition, the Simon effect was significantly stronger for HC than for SC. In HC the Simon effect was significantly stronger in the eye-like than in the rectangle condition. In patients, the Simon effect did not differ significantly between both conditions. Thus, the influence of social cues was greatly reduced in the patient group. Current psychopathology or antipsychotic treatment did not influence results. The present study supports earlier findings of altered processing of schematic social cues in patients with schizophrenia, especially when gaze is task-irrelevant.     

A systematic review of the association between attributional bias/interpersonal style,and violence in schizophrenia/psychosis

Despite the widely recognized link between schizophrenia and violence, the illness-specific factors underlying that association remain unclear. A body of work has implicated deficits in social cognition, consistently seen in schizophrenia, that may mediate the risk of violence. Two specific areas of interest are attributional bias and interpersonal style. We conducted a systematic literature search using EMBASE, Scopus, Ovid Medline, PsycINFO and Science Direct databases with search terms relating to attributional bias, interpersonal style and violence/aggression in schizophrenia. Eleven studies were identified, six related specifically to attributional bias and five to interpersonal style. Results suggest an association between hostile and externalizing attribution biases, and violence in schizophrenia. Furthermore, hostile, dominant, and coercive interpersonal styles are also frequently associated with violence in schizophrenia. An interaction between cognitive impairments and underlying personality traits, as well as other co-morbid or illness factors, is proposed to likely underpin associations with violence in schizophrenia. Conclusions are limited by methodological constraints. The field would benefit from consistent definitions of violence, and a more systematic approach to cognitive assessment. Furthermore, studies with more homogeneous samples; and longitudinal designs are warranted in order to gain a better understanding of causation with regard to illness factors specific to schizophrenia.     

Some markers of mirroring appear intact in schizophrenia: evidence from mu suppression

Although schizophrenia is associated with impairments in social cognition, the scope and neural correlates of these disturbances are largely unknown. In this study, we investigated whether schizophrenia patients show impaired functioning of the mirror neuron system (MNS), as indexed by electroencephalographic (EEG) mu (8–13 Hz) suppression, a hypothesized biomarker of MNS activity that is sensitive to the degree of social interaction depicted in visual stimuli. A total of 32 outpatients and 26 healthy controls completed an EEG paradigm that included six action observation or execution conditions that differed in their degrees of social interaction. Participants also completed a validated empathy questionnaire. Across both groups, we found a significant linear increase in mu suppression across the conditions involving greater levels of social engagement and interaction, but no significant group or interaction effects. Patients self-reported diminished empathic concern and perspective taking, which showed some moderate relations to mu suppression levels. Thus, the schizophrenia group showed generally intact modulation of MNS functioning at the electrophysiological level, despite self-reporting empathic disturbances. The disturbances commonly seen on self-report, performance, and neuroimaging measures of mentalizing in schizophrenia may largely reflect difficulties with higher-level inferential processes about others’ emotions, rather than a basic incapacity to share in these experiences.     

Personality Traits Elucidate Sex Differences in Attention-Deficit/Hyperactivity Disorder Comorbidity During Early Childhood

Attention-Deficit/Hyperactivity Disorder (ADHD) is highly comorbid with other childhood disorders, and there are striking sex differences in this comorbidity, particularly during early childhood. For example, boys with ADHD are more likely to exhibit comorbid disruptive behavior and neurodevelopmental disorders, compared to girls, during early childhood. Yet, explanations for these well-established sex differences remain in short supply. The current study evaluated the novel hypothesis that personality traits may serve as intermediate phenotypes that help explain sex differences in common ADHD comorbidity profiles during early childhood. Study participants were 109 children between the ages of 3 and 6 and their primary caregivers and teachers/daycare providers, recruited from the community and over-recruited for ADHD-related problems. Primary caregivers completed the Child Behavior Checklist, and teachers/daycare providers completed the Teacher Report Form as a measure of child behavior problems. Examiners completed the California Q-Sort as a measure of child personality traits. Moderated mediation analyses suggested that personality traits explain associations between ADHD and oppositional-defiance, aggression, and language problems in a sex-specific manner. While high neuroticism mediated associations between ADHD and oppositional-defiance in girls, disagreeableness mediated associations between ADHD and aggression and low conscientiousness mediated associations between ADHD and neurodevelopmental language problems in boys. Sex differences in trait-psychopathology associations may help explain sex differences in comorbidity profiles with possible implications for child assessment and personalized early intervention.     

Looming Threats and Animacy: Reduced Responsiveness in Youth with Disrupted Behavior Disorders

Theoretical models have implicated amygdala dysfunction in the development of Disruptive Behavior Disorders (DBDs; Conduct Disorder/Oppositional Defiant Disorder). Amygdala dysfunction impacts valence evaluation/response selection and emotion attention in youth with DBDs, particularly in those with elevated callous-unemotional (CU) traits. However, amygdala responsiveness during social cognition and the responsiveness of the acute threat circuitry (amygdala/periaqueductal gray) in youth with DBDs have been less well-examined, particularly with reference to CU traits. 31 youth with DBDs and 27 typically developing youth (IQ, age and gender-matched) completed a threat paradigm during fMRI where animate and inanimate, threatening and neutral stimuli appeared to loom towards or recede from participants. Reduced responsiveness to threat variables, including visual threats and encroaching stimuli, was observed within acute threat circuitry and temporal, lateral frontal and parietal cortices in youth with DBDs. This reduced responsiveness, at least with respect to the looming variable, was modulated by CU traits. Reduced responsiveness to animacy information was also observed within temporal, lateral frontal and parietal cortices, but not within amygdala. Reduced responsiveness to animacy information as a function of CU traits was observed in PCC, though not within the amygdala. Reduced threat responsiveness may contribute to risk taking and impulsivity in youth with DBDs, particularly those with high levels of CU traits. Future work will need to examine the degree to which this reduced response to animacy is independent of amygdala dysfunction in youth with DBDs and what role PCC might play in the dysfunctional social cognition observed in youth with high levels of CU traits.     

Generalist genes: implications for the cognitive sciences

In the 'generalist genes' hypothesis, it is suggested that the same genes affect most cognitive abilities and disabilities. This recently proposed hypothesis is based on considerable multivariate genetic research showing that there is substantial genetic overlap between such broad areas of cognition as language, reading, mathematics and general cognitive ability. We assume that the hypothesis is correct and consider here its implications for cognitive neuroscience. In our opinion, the two key genetic concepts of pleiotropy (in which one gene affects many traits) and polygenicity (in which many genes affect a trait) that underlie the generalist genes hypothesis imply a 'generalist brain'. That is, the genetic input into brain structure and function is general not specific.     

“凭感觉”的热情与能力：社会认知内容的生理线索

热情与能力是解析社会认知的普适性框架,同现实情境中诸多要素存在着关联。与众多明显带有社会属性的要素相比,源自面孔或者颜色的视觉、声音的听觉、身体姿态的动觉、温度变化的肤觉等生理线索,也可以跟热情与能力的社会知觉产生关联,这个过程可能基于生理–社会的知觉联结假设或者知觉启动假设而发生。以生理–社会的知觉关系为切入点,热情与能力更能发挥解析具体情境的灵活性。侧重典型生理线索的挖掘、建立生理线索同热情与能力的组态关系,以及这种关系对社会性偏向的影响,将有助于推进热情与能力融入更为广泛的社会应用之中。