Direct evidence that an apparent splitting pattern of gamma particles in Ni alloys is a stage of coalescence

High-resolution electron microscopy is used to determine the translation order domains of gamma particles in arrangements formed during Ostwald ripening in the alloy Ni-12at.%Al. Such arrangements have been often identified with the operation of a mechanism of particle splitting in the late stages of the coarsening process, that is when the elastic strain contribution becomes predominant. It is shown that the translation order domains are not identical in such a particle array. This leads to the conclusion that particle splitting is not necessarily the mechanism responsible for the formation of such characteristic particle arrangements. Instead, particle migration can also be considered to be the responsible mechanism for the formation of such a correlated gamma-particle spatial distribution observed in Ni-based alloys.     

Transformationsprozesse in der Traumatherapie und die Technik der Prozessdeutung

This article first describes some of the general principles by which according to the latest concepts mental processing is accomplished: a transformative, self-organizational approach driven by emotion and is intersubjective.From this the basic principles for the treatment technique can be derived, which systematically differentiates between content interpretation and process interpretation. Objects of process interpretation are observable transformation events of the traumatic material during consultations, their success and destruction. Process interpretations restore the blocked processing abilities of the patient and in this way also prepare for the possibility to work with content interpretation.     

第一印象中面孔-人格知觉和语音-人格知觉的异同

人们会根据陌生人的面孔线索或语音线索迅速地对其人格特质进行主观推断而形成第一印象。面孔-人格知觉第一印象和语音-人格知觉第一印象在维度结构和内在机制上具有相似性;在对具体人格特质和维度的敏感性,以及具体的认知机制方面又具有各自的特异性。未来研究可以基于同一批被知觉者开展面孔-人格知觉第一印象和语音-人格知觉第一印象的直接比较,并着力探究二者的过程特点,以及人格知觉第一印象形成时面孔和语音知觉的跨模态整合效应。     

Destruction reconceived: On Winnicott's ‘The Use of an Object and Relating through Identifications’

‘The Use of an Object and Relating through Identifications’ is a landmark contribution that I find very difficult to write about because so much of what lies at its core is merely suggested. It is necessary for the reader not only to read the paper, but also to write it. In my reading/writing of the paper, the mother becomes real for the infant in the process of his actually destroying her as an external object (destroying her sense of herself as an adequate mother), and his perceiving that destruction. She also becomes a real external object for the infant in the process of his experiencing the psychological work involved in surviving destruction, a form of work that does not occur in the world of fantasied objects. The analyst or mother may not be able to survive destruction. It is essential that the analyst be able to acknowledge to himself his inability to survive and, if necessary, to end the analysis because of the very damaging effects for both patient and analyst of prolonged experience of this sort. The author presents clinical discussions of analyses in which the analyst survives destruction and is unable to survive destruction.     

Clinician's comment on the management of pain in arthritis.

The arthritic diseases are major sources of pain or disability, although they differ in etiology and treatment approach. For diseases such as RA, inflammation is the predominant mechanism that leads to systemic complaints such as pain as well as local destruction of cartilage and bone. In contrast, OA is primarily a degenerative process and, although inflammation may occur, it differs in quality and extent from that in the systemic inflammatory arthritidies. For both conditions, psychosocial interventions have significant positive benefits, but their application involves careful consideration of a variety of factors. These factors include the following: diagnosis, disease activity, damage, disease stage, patient age and demographics, presence of comorbidities, and availability of alternative or adjunctive approaches.     

Rebirth fantasy and the psychoanalytic process

In this paper, Jungian and Freudian perspectives on the fantasy of rebirth are explored and a brief review of the literature on the theme is used to show how that the rebirth fantasy seems to be a universal fantasy in the human mind, connected with the experience of both destruction and creation. In the psychoanalytic process the rebirth fantasy is connected with initial hopes for a better life, but is also a vehicle for creating the analytic pair and for separating from the 'totalitarian object'. An account of clinical work with a patient is given to illustrate the mutual and parallel process of rebirth in both the patient and the therapist. For the patient, the therapy was experienced as an awakening or a birth. The therapist was initially doubtful about the patient's capacity to engage in the analytic process but his involvement and interest were 'born' during the early sessions, enabling the patient to rely on him to lead her out of the claustrophobic power of the totalitarian object.     

The role of prediction in mental processing: A process approach

Although prediction plays a prominent role in mental processing, we have only limited understanding of how the brain generates and employs predictions. This paper develops a theoretical framework in three steps. First I propose a process model that describes how predictions are produced and are linked to behavior. Subsequently I describe a generative mechanism, consisting of the selective amplification of neural dynamics in the context of boundary conditions. I hypothesize that this mechanism is active as a process engine in every mental process, and that therefore each mental process proceeds in two stages: (i) the formation of process boundary conditions; (ii) the bringing about of the process function by the operation – within the boundary conditions – of a relatively ‘blind’ generative process. Thirdly, from this hypothesis I derive a strategy for describing processes formally. The result is a multilevel framework that may also be useful for studying mental processes in general.     

Synchronization and coupling of phases in periodic processes of conditioning

Locomotor avoidance conditioning and locomotor food conditioning in male albino rats demonstrated that locking of temporary connections is accomplished by coupling of phases of different synchronized periodic neural processes. Phase coupling was verified by the formation of parallel periodic courses of reaction times and motor reaction times in the process of elaboration of conditional avoidance reflexes, and by the curve of the corresponding correlation coefficients, which were calculated from the reaction times and motor reaction times in food conditioning measured every day during the period of stabilization. The authors hold the view that a locking mechanism based on the synchronization of periodic processes in conditioning is most compatible with efficient formation of conditional reflexes and can promote adaptation. Furthermore, it is assumed that information storage, too, occurs periodically, according to the principle of rotary storage.     

视觉搜索中注意模板促进搜索的内在机制

生物的视觉搜索能力对适应外部复杂环境具有非常重要的生存意义。注意模板可以在搜索任务的过程中增强相关信息和抑制无关信息,从而快速找到目标。总结近期研究结果主要有以下发现：在建立注意模板的过程中并不能明确是基于语义信息还是视觉特征信息;注意模板不仅可以存储在工作记忆中,也可以存储在长时记忆中;不同类型注意模板的神经机制存在差异。未来的研究应关注注意模板在建立过程中内部信息如何传递,并关注不同人群注意模板的神经机制,以及解决拒绝模板抑制机制的理论争议。     

建言行为的认知影响因素、理论基础及发生机制

目前关于建言行为的研究大多关注其发生的前因变量, 而探讨其认知发生机制的研究则相对较少。建言行为不论是在行为触发机制、过程决策机制还是建议表达机制等三个方面均与个体的认知活动密切相关。通过梳理影响员工建言行为发生的认知因素, 该文提出员工建言行为认知发生机制全模型, 并对未来的研究方向作出展望。     

Stiff-person syndrome: autoimmunity and the central nervous system

Stiff-person syndrome (SPS) is a rare disease of severe progressive muscle stiffness in the spine and lower extremities with superimposed muscle spasms triggered by external stimuli. Patients with SPS are often referred for psychiatric evaluation and the psychiatrist may be the first to diagnosis SPS. Psychosocial stressors often precede the first manifestations of the disease; depression, anxiety, and alcohol abuse are comorbid illnesses. The identification of an association with antibodies to glutamic acid decarboxylase (GAD) was invaluable for definitively establishing a pathological basis for the disease; antibodies to amphiphysin and gephyrin are also found in cases of SPS but at much lower frequencies. Whether the antibodies inhibit GAD activity in vivo, target GAD-expressing neurons for immune-mediated destruction, are part of a wider immune process, or are merely a marker for destruction of GAD-expressing neurons by an independent neurodegenerative process is not yet clear. Both electromyography and the detection of GAD antibodies are useful in establishing a diagnosis of SPS. Treatment of SPS includes the use of immunomodulating therapies (plasmapheresis and intravenous immunoglobulins) and symptomatic treatment with benzodiazepines and baclofen. The use of tricyclic antidepressants and rapid withdrawal from therapy should be avoided.     

双通路理论视角下孤独症谱系障碍者的视线加工障碍

临床行为观察发现, 孤独症谱系障碍个体普遍存在不能与他人建立视线接触, 不能追随他人视线看向目标物体等视线加工(gaze processing)障碍。然而已有实验研究发现该群体在实验情境中普遍存在视线接触(eye contact)异常, 但其视线追随行为(gaze following)则存在正常与异常并存的现象。基于视线加工双通路理论的启示, 该障碍可能是由于视线加工皮下通路先天功能异常而皮层通路后天发展异常所致。然而, 该理论尚缺乏皮下通路先天功能异常是视线接触障碍潜在神经机制的直接证据, 还需进一步考察皮下通路先天功能异常对视线追随障碍的影响作用, 以及皮层通路后天发展异常即其补偿机制的神经回路及早期形成过程。     

Visual working memory for dynamic objects: Impaired binding between object feature and location

In daily life, people frequently need to observe dynamic objects and temporarily maintain their representations in visual working memory (VWM). The present study explored the mechanism underlying the binding between perceptual features and locations of dynamic objects in VWM. In three experiments, we measured and compared the memory performance for feature-location binding of multiple dynamic and static objects. The results showed that the feature-location binding was impaired for the dynamic objects compared with the static objects. The impairment persisted when the global spatial configuration of the objects remained intact during the motion, as well as when the binding task was relatively easy, such as binding between single-feature objects and coarse locations. The results indicate that object features and locations are not maintained in VWM as well-integrated object files; rather, the formation of feature-location binding may require additional processes, which are disrupted by the constant change of locations in dynamic circumstances. We propose a consolidation process as possible underlying mechanism, and discuss factors that may influence the strength of feature-location binding in dynamic circumstances.     

地面参照框架形成的连续表面整合加工假说

地面参照框架是空间知觉的重要基础, 连续表面整合加工(SSIP)假说首次对其形成过程做出了推测, 将这一科学问题的研究向纵深推进, 开辟了一个新的研究领域。SSIP假说的核心观点及其相关证据包括地面的表征原理、整合条件和表征结果三个方面, 得到了大量研究的支持。未来研究需结合基于过程检验的技术手段, 直接探查地面参照框架的形成机制, 关注高级认知过程的作用, 并可考虑其在国防上的应用。     

Transfer of control between causal predictive judgments and instrumental responding

Four experiments were conducted to explore outcome-specific transfer from causal predictive judgments to instrumental responding. A video game was designed in which participants had to defend Andalusia from navy and air force attacks. First, they learned the relationship between two instrumental responses (two key on a standard keyboard) and two different outcomes (destruction of the ships or destruction of the planes). Then they learned to predict which of two different stimuli predicted which outcome. Finally, they had the opportunity of making either of the two instrumental responses in the presence of either stimulus. Transfer was shown as a preference for the response that shared an outcome with the current stimulus. The presentation of the stimulus during the test produced a decrease in the overall rate of response. Responding to a neutral stimulus in Experiments 2 and 3 suggested that this overall decrease in responding was due to a combination of the time needed to process the meaning of the stimulus and the activation of the representation of the outcome in the presence of the stimulus during the test. Transfer between predictive judgments and instrumental responding mirrors the outcome-specific Pavlovian instrumental transfer observed in conditioning studies with rats.     

Weeds on the Ruins: Agency,Compromise Formation,and the Quest for Intersubjective Truth

Using Kundera's metaphor of “weeds on the ruins” to examine the impact of organized destruction of memory on the survival of a people, this paper explores the role of symptoms in negotiating a relational “compromise formation” by tracing their evolution as signifiers of previously dissociated intersubjective knowledge. It suggests that recent theorizing on the mutual constitution of agency and intersubjectivity creates the possibility of resurrecting the dramatic tension that characterized dual drive theory by relocating that tension between the desire to know (oneself, the Other) and the destruction of that desire. To do so, the paper contemplates an internally consistent lens for reconciling the terrain of deficit and dissociation with that of conflict by offering a process-oriented view of agency as “drive” that is rooted between subjective and material contexts. Finally, the paper explores the quest for intersubjective truth as offering a means of living beyond the ubiquity of compromise formation.     

人类记忆再巩固研究现状及临床应用

巩固的记忆被提取后,进入不稳定状态,再重新稳定下来,这个过程称为记忆再巩固。本文首先阐述人类记忆再巩固主要研究方法和经典范式,梳理记忆再巩固在人类恐惧记忆和情景记忆两个方面的相关研究,并从认知神经科学角度整理记忆再巩固的加工机制。然后总结记忆再巩固应用于创伤性应激障碍和药物成瘾等心理障碍临床治疗的相关文献。最后本文提出未来研究的方向和建议,希冀对人类记忆再巩固的理论研究和临床应用提供新思路。     

A core process in psychoanalytic treatment

A core mechanism of the psychoanalytic process is described. This involves the effects of treatment on an ongoing "unconscious intrapsychic process," which has specific points of vulnerability to pathology. The concept of an intrapsychic process described by the author in previous publications is an expanded formulation of the idea of thought as trial action and of the signal theory of anxiety. The psychoanalytic method alters the functioning of the ego astride this unconscious process, strengthening its control over anxiety, defense, trauma, and symptom formation. This is mutative in the psychoanalytic method.     

Time-window for sensitivity to cooling distinguishes the effects of hypothermia and protein synthesis inhibition on the consolidation of long-term memory

The effects of hypothermia on memory formation have been examined extensively, and while it is clear that post-training cooling interferes with the process of consolidation, the nature of the temperature sensitive processes disrupted in this way remain poorly defined. Post-training manipulations that disrupt consolidation tend to be effective during specific time-windows of sensitivity, the timing and duration of which are directly related to the mechanism through which the treatment induces amnesia. As such, different treatments that target the same basic processes should be associated with similar time-windows of sensitivity. Using this rationale we have investigated the possibility that cooling induced blockade of long-term memory (LTM) stems from the disruption of protein synthesis. By varying the timing of post-training hypothermia we have determined the critical period during which cooling disrupts the consolidation of appetitive long-term memory in the pond snail Lymnaea. Post-training hypothermia was found to disrupt LTM only when applied immediately after conditioning, while delaying the treatment by 10 min left the 24 h memory trace intact. This brief (<10 min) window of sensitivity differs from the time-window we have previously described for the protein synthesis inhibitor anisomycin, which was effective during at least the first 30 min after conditioning [Fulton, D., Kemenes, I., Andrew, R. J., & Benjamin, P. R. (2005). A single time-window for protein synthesis-dependent long-term memory formation after one-trial appetitive conditioning. European Journal of Neuroscience, 21, 1347-1358]. We conclude that hypothermia and protein synthesis inhibition exhibit distinct time-windows of effectiveness in Lymnaea, a fact that is inconsistent with the hypothesis that cooling induced amnesia occurs through the direct disruption of macromolecular synthesis.     

Kinetics of Ostwald ripening in the presence of monomer diffusion along grain boundaries

The kinetics of an Ostwald ripening is studied where the prevailing mechanism of cluster growth is monomer diffusion along grain boundaries. The model describes self-consistently the situation when the delivery of matter to a growing cluster is carried out by monomer diffusion along grain boundaries. An analytical and numerical study of Ostwald ripening kinetics in a homogeneous supersaturated solution is performed. The possible transition modes arising during the Ostwald ripening process are discussed with reference to changes in the dominant monomer delivery mechanism.