青光眼患者手术应激反应的临床观察

本文用艾森克人格问卷（ＥＰＱ）对５４例青光眼病人进行测验，测验后分成高神经质维度（高Ｎ）和低神经质维度（低Ｎ）两组，各２７人。对其手术前后的焦虑情绪、血皮质醇变化和前房恢复情况进行了观察。结果显示，手术前焦虑自评量表评定（ＳＡＳ）、血皮质醇检验两组无明显差异。手术后ＳＡＳ评定平均分高Ｎ组低于低Ｎ组（Ｐ＜０．０５）；血皮质醇检验高Ｎ组显著高于低Ｎ组（Ｐ＜０．０１；两组前房恢复高Ｎ组平均天数多于低Ｎ组（＜０．０５）。提示不同神经质的病人对应激刺激产生不同强度的焦虑情绪，从而引起内分泌的差异和影响预后。     

生物反馈放松训练和表象训练在飞行训练中的应用研究

本研究试用生物反馈放松训练和表象训练相结合方法,减轻飞行学员的精神紧张及有关的生理反应、２６名２０—２２岁的男性飞行学员,实验、对照组各１３名、实验组学员每次飞行后进行一次肌电生物反馈放松训练和起落航线表象训练,共１６次;对照组学员参加日常飞行训练不加任何干预。实验前后实验组及对照组学员进行黑红数字测试,记录其测试前后的血压、心率;第一次升空及单飞考核飞行后也记录他们的血压和心率。结果表明,实验组学员的单飞考核成绩优于对照组;实验织学员单飞考核后的收缩压及第二次黑红数字测试后的收缩压比实验前显著降低;而对照组的前述生理指标无变化。生物反馈放松训练和表象训练能有效地减轻飞行中的紧张情绪及其生理反应,适于在飞行部队应用。     

儿童青少年大脑认知功能事件相关电位P_（300）的年龄特征

从发展心理学的角度．对幼儿到大学六个年龄组的儿童青少年进行了事件相关电位Ｐ_（３００）测定．结果发现：反映大脑认知功能的事件相关电位Ｐ_（３００）各成分随着年龄增长而发展的趋势十分明显,从而进一步说明了认知发展的特点与大脑高级神经系统活动功能发展特点的密切关系。     

游戏训练提高幼儿自我控制能力:来自ERP的证据

游戏是激发幼儿兴趣的有效载体,已有研究表明游戏可以提高幼儿自我控制的外显行为表现,但未考察是否能够引起幼儿自我控制相关的电生理变化。本研究将幼儿按班级随机分为实验组和对照组,实验组的幼儿接受一学期的游戏训练,对照组不参加训练,进行自由活动,训练前后所有幼儿完成Go/No Go任务的ERP测试,评定自我控制能力。结果发现:实验组后测中No Go任务的N2和P3成分(分别表示为No Go-N2和No Go-P3)平均波幅均显著小于前测,而对照组前后测波幅无变化;同时,后测实验组中No Go-N2平均波幅显著小于对照组。结果表明,游戏训练可促进幼儿自我控制相关大脑系统的发展,为自我控制游戏训练的效果提供了电生理证据。。     

乳头体对海马齿状回习得性长时程突触增强的影响

用高频电脉冲刺激大鼠乳头体（ＭＢ）,可一过性抑制由刺激穿通纤维（ＰＰ）诱发的海马齿状回（ＤＧ）群体锋电位（ＰＳ）。训练作业前先刺激ＭＢ,导致ＤＧ的习得性长时程突触增强（ＬＤＬＴＰ）的形成显著延缓,相应地延缓了条件性饮水反应的建立。电刺激ＭＢ对ＰＰ─ＤＧＰＳ的这种抑制作用在训练所产生的ＰＳ增大达最高水平时显著减弱,刺激ＭＢ对ＬＤＬＴＰ的保持及相应地对条件反应的巩固没有明显影响。结果表明ＭＢ对ＤＧＬＤＬＴＰ的形成有抑制性调制作用。     

人类颞叶皮层与视,听信息加工:II.左颞叶癫痫病人的脑事件相关电位

记录７名左颞叶癫痫病人和９名正常人在四种实验条件下的事件相关电位：（１）听觉脑干诱发电位,（２）红色闪光刺激,（３）陌生人噪音识别,（４）陌生人面孔识别。实验结果发现,两组被试在视觉信息加工中无差异,在噪音识别中病人的Ｎ１５０和Ｐ３００波潜伏期大于正常人,表明其复杂听觉认知功能受到影响。红色闪光刺激和噪音识别条件下,病人的Ｐ１００波幅大于正常人,说明病人对强刺激的物理强度有较高的反应水平,不易习惯     

简明心境量表(POMS)在中国的试用报告

该研究引进ＰＯＭＳ,采用随机对照的方法将２８９名放化疗病人分成实验组和对照组,分别在治疗前中后测查三次,同时测查３８５名正常人,以验证其在中国大陆的适用情况。研究发现：ＰＯＭＳ各量表同质性信度高,三种方法检验的临床效度均较高,尤其是对心理干预的效果更敏感;但该问卷的区分效度不高,对正常人心境变化的敏感性不如对病人。由此得出,ＰＯＭＳ在中国大陆癌症病人中是可行的、可靠的、有效的和敏感的,可作为心理干预的一个敏感指标。     

半日静坐 半日读书──静坐养生与宋明诸儒的读书治学活动

郭沫若曾说：“静坐这项工夫在宋、明诸儒是很注重的。”（《王阳明和赞》，《郭沫若全集》（历史编），北京，人民出版社１９８４年，第３卷，第３００页）宋明诸儒有一种独特的观点，认为读书学道与静坐养生之间有着内在的联系。所谓“闭门即是深山，读书随处净土。”善养生者，学道读书亦为养生；善治学者，养生静坐均可治学。从根本上说，两者是一回事。所以，理学大师朱熹对学生说：“用半日静坐，半日读书，如此一二年，何忠不进！”（《朱子语类》卷一百一十六）明儒高攀龙《水居》诗云：“兀兀日跌坐，忻忻时读书。”清儒梁章矩更是…     

解决人际问题的认知技能对4—5岁儿童同伴交往行为的影响的实验研究

通过对解决人际问题的认知技能（ＩＣＰＳ）低和高的幼儿同伴交往行为的比较,以及对ＩＣＰＳ低的幼儿进行训练所引起的ＩＣＰＳ变化的比较,发现ＩＣＰＳ高的幼儿同伴交往行为优于ＩＣＰＳ低的幼儿;对ＩＣＰＳ低的幼儿进行训练能改善幼儿的同伴交往行为,增加幼儿的被接受程度,降低幼儿的被拒绝程度;认知在幼儿同伴交往中起着重要作用．     

应对策略和社会支持对提高哮喘患者生活质量的作用

探讨应对策略及社会支持在心理干预对哮喘患者生活质量提高中的作用。采用随机对照的方法,将374名哮喘患者分为实验组（228人）及对照组（146人）,实验组除进行常规的药物治疗外,配合以系统的心理干预方法。选用生活质量问卷、医用应对问卷及社会支持评定量表对治疗前后的生活质量状况、应对策略及社会支持水平进行测量。治疗后,在生活质量总分及各维度、社会支持总分以及对社会支持的利用度上,实验组和对照组得分都有所提高．但实验组提高的分值要显著大于对照组;在回避应对上,实验组和对照组都有所降低,但对照组的降低程度要显著大于实验组,在屈服应对上,实验组和对照组也都有所降低,但实验组的降低程度要显著大于对照组。多元逐步回归分析的结果显示,屈服的降低和对社会支持利用度的提高能够显著预测哮喘患者生活质量的提高。     

Enhanced development of auditory change detection in musically trained school‐aged children: a longitudinal event‐related potential study

Adult musicians show superior auditory discrimination skills when compared to non‐musicians. The enhanced auditory skills of musicians are reflected in the augmented amplitudes of their auditory event‐related potential (ERP) responses. In the current study, we investigated longitudinally the development of auditory discrimination skills in musically trained and nontrained individuals. To this end, we recorded the mismatch negativity (MMN) and P3a responses from children who play a musical instrument and age‐matched children with no musical training at ages 7, 9, 11, and 13. Basic auditory processing was investigated by recording ERPs in the Multi‐Feature Paradigm that included frequency, duration, intensity, location, and gap deviants. The detection of musically more relevant sound changes was examined in an oddball paradigm with major chords as standards and minor chords as deviants. The musically trained children showed larger increase in MMN and P3a amplitudes with age for the chord deviants than the control children. There was also a strong trend (p = .054) for larger increase in MMN amplitude in the musically trained children for the location deviant. As no group differences in response amplitudes were evident at the early stages of the training, our results suggest that the superior neural auditory discrimination in adult musicians is due to training and not pre‐existing differences between musicians and non‐musicians.     

The Effect of Language Immersion Education on the Preattentive Perception of Native and Non-native Vowel Contrasts

Proficiency in a second language (L2) may depend upon the age of exposure and the continued use of the mother tongue (L1) during L2 acquisition. The effect of early L2 exposure on the preattentive perception of native and non-native vowel contrasts was studied by measuring the mismatch negativity (MMN) response from 14-year-old children. The test group consisted of six Finnish children who had participated in English immersion education. The control group consisted of eight monolingual Finns. The subjects were presented with Finnish and English synthetic vowel contrasts. The aim was to see whether early exposure had resulted in the development of a new language-specific memory trace for the contrast phonemically irrelevant in L1. The results indicated that only the contrast with the largest acoustic distance elicited an MMN response in the Bilingual group, while the Monolingual group showed a response also to the native contrast. This may suggest that native-like memory traces for prototypical vowels were not formed in early language immersion.     

Duration of auditory sensory memory in parents of children with SLI: a mismatch negativity study

In a previous behavioral study, we showed that parents of children with SLI had a subclinical deficit in phonological short-term memory. Here, we tested the hypothesis that they also have a deficit in nonverbal auditory sensory memory. We measured auditory sensory memory using a paradigm involving an electrophysiological component called the mismatch negativity (MMN). The MMN is a measure of the brain's ability to detect a difference between a frequent standard stimulus (1000 Hz tone) and a rare deviant one (1200 Hz tone). Memory effects were assessed by varying the inter-stimulus interval (ISI) between the standard and deviant. We predicted that parents of children with SLI would have a smaller MMN than parents of typically developing children at a long ISI (3000 ms), but not at a short one (800 ms). This was broadly confirmed. However, individual differences in MMN amplitude did not correlate with measures of phonological short-term memory. Attenuation of MMN amplitude at the longer ISI thus did not provide unambiguous support for the hypothesis of a reduced auditory sensory memory in parents of affected children. We conclude by reviewing possible explanations for the observed group effects.     

Is auditory discrimination mature by middle childhood? A study using time‐frequency analysis of mismatch responses from 7 years to adulthood

Behavioural and electrophysiological studies give differing impressions of when auditory discrimination is mature. Ability to discriminate frequency and speech contrasts reaches adult levels only around 12 years of age, yet an electrophysiological index of auditory discrimination, the mismatch negativity (MMN), is reported to be as large in children as in adults. Auditory ERPs were measured in 30 children (7 to 12 years), 23 teenagers (13 to 16 years) and 32 adults (35 to 56 years) in an oddball paradigm with tone or syllable stimuli. For each stimulus type, a standard stimulus (1000 Hz tone or syllable [ba]) occurred on 70% of trials, and one of two deviants (1030 or 1200 Hz tone, or syllables [da] or [bi]) equiprobably on the remaining trials. For the traditional MMN interval of 100–250 ms post-onset, size of mismatch responses increased with age, whereas the opposite trend was seen for an interval from 300 to 550 ms post-onset, corresponding to the late discriminative negativity (LDN). Time-frequency analysis of single trials revealed that the MMN resulted from phase-synchronization of oscillations in the theta (4–7 Hz) range, with greater synchronization in adults than children. Furthermore, the amount of synchronization was significantly correlated with frequency discrimination threshold. These results show that neurophysiological processes underlying auditory discrimination continue to develop through childhood and adolescence. Previous reports of adult-like MMN amplitudes in children may be artefactual results of using peak measurements when comparing groups that differ in variance.     

学习困难的ERP研究

事件相关脑电位（Event—related potentials,ERPs）是研究心理学和认知神经科学的重要技术手段,将该技术用于学习困难的脑机制的研究,有助于发现学习困难的神经机制。研究表明,学习困难者的P300波幅较小,潜伏期较长。学习困难者的MMN波幅比控制组小,在信息的自动加工方面存在缺陷。在单词命名任务中,学习困难者的N400较小,而且不同类型学习困难者的波幅和潜伏期存在明显差异。     

Atypical central auditory speech-sound discrimination in children who stutter as indexed by the mismatch negativity

PurposeRecent theoretical conceptualizations suggest that disfluencies in stuttering may arise from several factors, one of them being atypical auditory processing. The main purpose of the present study was to investigate whether speech sound encoding and central auditory discrimination, are affected in children who stutter (CWS).MethodsParticipants were 10 CWS, and 12 typically developing children with fluent speech (TDC). Event-related potentials (ERPs) for syllables and syllable changes [consonant, vowel, vowel-duration, frequency (F0), and intensity changes], critical in speech perception and language development of CWS were compared to those of TDC.ResultsThere were no significant group differences in the amplitudes or latencies of the P1 or N2 responses elicited by the standard stimuli. However, the Mismatch Negativity (MMN) amplitude was significantly smaller in CWS than in TDC. For TDC all deviants of the linguistic multifeature paradigm elicited significant MMN amplitudes, comparable with the results found earlier with the same paradigm in 6-year-old children. In contrast, only the duration change elicited a significant MMN in CWS.ConclusionsThe results showed that central auditory speech-sound processing was typical at the level of sound encoding in CWS. In contrast, central speech-sound discrimination, as indexed by the MMN for multiple sound features (both phonetic and prosodic), was atypical in the group of CWS. Findings were linked to existing conceptualizations on stuttering etiology.Educational objectives: The reader will be able (a) to describe recent findings on central auditory speech-sound processing in individuals who stutter, (b) to describe the measurement of auditory reception and central auditory speech-sound discrimination, (c) to describe the findings of central auditory speech-sound discrimination, as indexed by the mismatch negativity (MMN), in children who stutter.     

Psychophysiological and cognitive responses to stressful stimuli in subjects practicing progressive relaxation and clinically standardized meditation

Thirty-six volunteer subjects were assigned to one of three conditions: progressive relaxation, clinically standardized meditation, or a waiting list control group asked to relax daily (without specific instruction). Subjects were given paper and pencil tests two times, separated by 5 weeks during which time the two treatment groups received 4 weekly sessions of group training. All subjects were tested in the psychophysiology laboratory at the end of the 5-week period, during which time they were exposed to 5 very loud tones. While relaxing as deeply as possible using the techniques they had learned and anticipating the loud tones, the meditation group exhibited higher heart rates and higher integrated frontalis EMG activity, but they also showed greater cardiac decelerations following each tone, more frontal alpha, and fewer symptoms of cognitive anxiety than the other two groups. The relaxation group reported more sensations of muscular relaxation than the other groups, but also some symptoms of hyperventilation. The results are generally consistent with Davidson and Schwartz's (1976) categorization of meditation as a ‘cognitive’ technique, and suggest that frontal EEG alpha may be a physiological marker for the absence of cognitive anxiety. Physiological findings also support Goleman and Schwartz's (1976) suggestion that meditation prepares people to cope with stress.     

Some detrimental effects of using extra stimuli to guide learning in normal and autistic children

This study was designed to assess the effectiveness of using prompts (extra "guiding" stimuli) for teaching normal and autistic children. One group of normal children was pretrained on a color discrimination. Later, the colors were used as prompts (presented simultaneously with new training stimuli) to teach four new discriminations. Another group of normal children was trained on the same discriminations with a trial-and-error procedure (i.e., no prompting). A third group consisted of autistic children who were trained on these discriminations using the prompt procedure. Analyses of the results showed the following. (1) The trial-and-error group of normal children acquired more discriminations than the prompt group of normal children. (2) A comparison of the two prompt groups showed that the autistics failed to transfer from the prompt cue to the training cue more often than the normal children; rather, the autistics generally continued responding to the faded color cue. (3) Autistic and normal children who failed to acquire the discriminations when trained with a prompt procedure did acquire these discriminations when no prompt was used. That is, the results suggest that the presentation of an extra guiding stimulus was detrimental to the acquisition of training discriminations for all subjects, and particularly so far autistic children. Therefore, the common practice of providing extra guiding stimuli in proportion to the severity of the learning disorder may actually be harmful to the learning of new skills. Implications of these results for future research are discussed.     

The chronometry of mental ability: An event-related potential analysis of an auditory oddball discrimination task

The relation between intelligence and speed of auditory discrimination was investigated during an auditory oddball task with backward masking. In target discrimination conditions that varied in the interval between the target and the masking stimuli and in the tonal frequency of the target and masking stimuli, higher ability participants (HA) displayed more accurate discriminations, faster response time, larger P300 amplitude, and shorter P300 and mismatch negativity (MMN) latency than lower ability participants (LA). Task difficulty effects demonstrated with variation in mask type indicate that the mask does not interfere with the detection of the deviant target stimulus, but rather that the target and mask are integrated as a single compound stimulus. The temporal effects suggest that the speed of accessing short-term memory is faster for HA than LA and, on the basis of the MMN latency, the effect is accomplished automatically, without focused attention. Moreover, the pattern of results obtained with these data support the view that the accuracy effects are determined by processing speed rather than discrimination ability. Comparator models that accommodate these effects are discussed.     

The processing of rhythmic structures in music and prosody by children with developmental dyslexia and developmental language disorder

Rhythm perception seems to be crucial to language development. Many studies have shown that children with developmental dyslexia and developmental language disorder have difficulties in processing rhythmic structures. In this study, we investigated the relationships between prosody and musical processing in Italian children with typical and atypical development. The tasks aimed to reproduce linguistic prosodic structures through musical sequences, offering a direct comparison between the two domains without violating the specificities of each one. About 16 Typically Developing children, 16 children with a diagnosis of Developmental Dyslexia, and 16 with a diagnosis of developmental language disorder (age 10–13 years) participated in the experimental study. Three tasks were administered: an association task between a sentence and its humming version, a stress discrimination task (between couples of sounds reproducing the intonation of Italian trisyllabic words), and an association task between trisyllabic nonwords with different stress position and three‐notes musical sequences with different musical stress. Children with developmental language disorder perform significantly lower than Typically Developing children on the humming test. By contrast, children with developmental dyslexia are significantly slower than TD in associating nonwords with musical sequences. Accuracy and speed in the experimental tests correlate with metaphonological, language, and word reading scores. Theoretical and clinical implications are discussed within a multidimensional model of neurodevelopmental disorders including prosodic and rhythmic skills at word and sentence level.