Neural correlates of adaptive decision making for risky gains and losses

Do decisions about potential gains and potential losses require different neural structures for advantageous choices? In a lesion study, we used a new measure of adaptive decision making under risk to examine whether damage to neural structures subserving emotion affects an individual's ability to make adaptive decisions differentially for gains and losses. We found that individuals with lesions to the amygdala, an area responsible for processing emotional responses, displayed impaired decision making when considering potential gains, but not when considering potential losses. In contrast, patients with damage to the ventromedial prefrontal cortex, an area responsible for integrating cognitive and emotional information, showed deficits in both domains. We argue that this dissociation provides evidence that adaptive decision making for risks involving potential losses may be more difficult to disrupt than adaptive decision making for risks involving potential gains. This research further demonstrates the role of emotion in decision competence.     

Spiking Phineas Gage: a neurocomputational theory of cognitive-affective integration in decision making

The authors present a neurological theory of how cognitive information and emotional information are integrated in the nucleus accumbens during effective decision making. They describe how the nucleus accumbens acts as a gateway to integrate cognitive information from the ventromedial prefrontal cortex and the hippocampus with emotional information from the amygdala. The authors have modeled this integration by a network of spiking artificial neurons organized into separate areas and used this computational model to simulate 2 kinds of cognitive-affective integration. The model simulates successful performance by people with normal cognitive-affective integration. The model also simulates the historical case of Phineas Gage as well as subsequent patients whose ability to make decisions became impeded by damage to the ventromedial prefrontal cortex.     

主观价值计算与整合的神经机制及其影响因素

决策在人类社会发展的历程中扮演着非常重要的作用,而对其神经机制的探讨才不过几十年的时间。基于价值的决策理论,强调人们首先计算和表征事物的价值,随后比较和决策。在人脑中负责主观价值计算的神经基础有腹内侧前额叶皮层、眶额皮层以及其他脑区,而负责价值整合的脑区有腹内侧前额叶皮层、眶额皮层、背外侧前额叶皮层等。其中时间和风险的价值计算有着相同的神经基础,并且人脑可以将不同属性以及成本进行整合形成主观价值,按照曲线交互作用范式进行。通过自我控制、注意和认知调节等方法,同样可以调制人们的主观价值大小。未来需要继续强调模式分析、个体差异、老龄化和基因对价值计算的影响。     

Individual differences in harm-related moral values are associated with functional integration of large-scale brain networks of emotional regulation

Emotions affects moral judgements, and controlled cognitive processes regulate those emotional responses during moral decision making. However, the neurobiological basis of this interaction is unclear. We used a graph theory measurement called participation coefficient (‘PC’) to quantify the resting-state functional connectivity within and between four meta-analytic groupings (MAGs) associated with emotion generation and regulation, to test whether that measurement predicts individual differences in moral foundations-based values. We found that the PC of one of the MAGs (MAG2) was positively correlated with one of the five recognized moral foundations–the one based on harm avoidance. We also found that increased inter-module connectivity between the ventromedial prefrontal cortex, dorsolateral prefrontal cortex and middle temporal gyrus with other nodes in the four MAGs was likewise associated with higher endorsement of the Harm foundation. These results suggest that individuals' sensitivity to harm is associated with functional integration of large-scale brain networks of emotional regulation. These findings add to our knowledge of how individual variations in our moral values could be reflected by intrinsic brain network organization and deepen our understanding of the relationship between emotion and cognition during evaluations of moral values.     

Adaptive versus veridical decision making and the frontal lobes

Adaptive decision making and veridical decision making are based on different mechanisms. Veridical decision making is based on the identification of the correct response, which is intrinsic to the external situation and is actor-independent. Adaptive decision making is actor-centered and is guided by the actor's priorities. The prefrontal cortex is particularly critical for adaptive decision making and less so for veridical decision making. However, most experimental procedures used in cognitive psychology and neuropsychology focus on veridical decision making and ignore adaptive decision making. Innovative experimental procedures are required to characterize the contribution of the prefrontal cortex to adaptive decision making. We have designed a prototype for such procedures, the Cognitive Bias Task, and present the novel findings generated by this task.     

Predicting domain‐specific risk taking with the HEXACO personality structure

Although risk taking traditionally has been viewed as a unitary, stable individual difference variable, emerging evidence in behavioral decision‐making research suggests that risk taking is a domain‐specific construct. Utilizing a psychological risk‐return framework that regresses risk taking on the perceived benefits and perceived riskiness of an activity (Weber & Milliman, 1997 ), this study examined the relations between risk attitude and broad personality dimensions using the new HEXACO personality framework (Lee & Ashton, 2004 ) across four risk domains. This personality framework, which has been replicated in lexical studies in over 12 natural languages, assess personality over six broad personality dimensions, as opposed to the traditional Five‐Factor Model, or “Big Five.” Through path analysis, we regressed risk taking in four separate domains on risk perceptions, perceived benefits, and the six HEXACO dimensions. Across all risk domains, we found that the emotionality dimension was associated with heightened risk perceptions and high conscientiousness was associated with less perceived benefits. We also report several unique patterns of domain‐specific relations between the HEXACO dimensions and risk attitude. Specifically, openness was associated with risk taking and perceived benefits for social and recreational risks, whereas lower honesty/humility was associated with greater health/safety and ethical risk taking. These findings extend our understanding of how individuals approach risk across a variety of contexts, and further highlight the utility of honesty/humility, a dimension not recovered in Big Five models, in individual differences research. Copyright © 2010 John Wiley & Sons, Ltd.     

Mother still knows best: Maternal influence uniquely modulates adolescent reward sensitivity during risk taking

Adolescent decision‐making is highly sensitive to input from the social environment. In particular, adult and maternal presence influence adolescents to make safer decisions when encountered with risky scenarios. However, it is currently unknown whether maternal presence confers a greater advantage than mere adult presence in buffering adolescent risk taking. In the current study, 23 adolescents completed a risk‐taking task during an fMRI scan in the presence of their mother and an unknown adult. Results reveal that maternal presence elicits greater activation in reward‐related neural circuits when making safe decisions but decreased activation following risky choices. Moreover, adolescents evidenced a more immature neural phenotype when making risky choices in the presence of an adult compared to mother, as evidenced by positive functional coupling between the ventral striatum and medial prefrontal cortex. Our results underscore the importance of maternal stimuli in bolstering adolescent decision‐making in risky scenarios.     

Developmental changes in decision making under risk: The role of executive functions and reasoning abilities in 8- to 19-year-old decision makers

Previous studies have shown that children and adolescents often tend toward risky decisions despite explicit knowledge about the potential negative consequences. This phenomenon has been suggested to be associated with the immaturity of brain areas involved in cognitive control functions. Particularly, “frontal lobe functions,” such as executive functions and reasoning, mature until young adulthood and are thought to be involved in age-related changes in decision making under explicit risk conditions. We investigated 112 participants, aged 8–19 years, with a frequently used task assessing decisions under risk, the Game of Dice Task (GDT). Additionally, we administered the Modified Card Sorting Test assessing executive functioning (categorization, cognitive flexibility, and strategy maintenance) as well as the Ravens Progressive Matrices assessing reasoning. The results showed that risk taking in the GDT decreased with increasing age and this effect was not moderated by reasoning but by executive functions: Particularly, young persons with weak executive functioning showed very risky decision making. Thus, the individual maturation of executive functions, associated with areas in the prefrontal cortex, seems to be an important factor in young peoples’ behavior in risky decision-making situations.     

The amygdala and ventromedial prefrontal cortex in morality and psychopathy

Recent work has implicated the amygdala and ventromedial prefrontal cortex in morality and, when dysfunctional, psychopathy. This model proposes that the amygdala, through stimulus-reinforcement learning, enables the association of actions that harm others with the aversive reinforcement of the victims' distress. Consequent information on reinforcement expectancy, fed forward to the ventromedial prefrontal cortex, can guide the healthy individual away from moral transgressions. In psychopathy, dysfunction in these structures means that care-based moral reasoning is compromised and the risk that antisocial behavior is used instrumentally to achieve goals is increased.     

Are risk preferences consistent?: The influence of decision domain and personality

This paper examines the consistency of risk preferences across three decision domains important in most people’s lives: work, health and personal finance. We consider the degree to which the five factor model of personality and a range of factors that influence risk-related decision-making (perceived risk, framing, emotions and cost–benefit analysis) impact upon cross-domain consistency. Data were gathered from a sample of participants for whom approaches to risk were likely to vary (academics, chess players, firefighters, mountaineers and City traders). The results showed that participants could be categorised into two groups: those who were consistent in their risk preferences in three decision domains, and those who were inconsistent or domain-specific. The consistent group was significantly lower on neuroticism and higher on agreeableness and conscientiousness with a less variable approach to weighing up the costs and benefits of taking risks than the inconsistent group. The majority of the consistent group was risk averse.When the domain-specific risk preferences of the inconsistent group were examined, data showed that different combinations of personality and decision-making factors predicted risk preferences within each domain.     

Using computational neuroscience to investigate the neural correlates of cognitive-affective integration during covert decision making

We presented a proposed neural level mechanism for the integration of cognitive and affective information during covert decision making. The central idea is that the ventromedial prefrontal cortex establishes predicted outcomes of responses through its connections with the amygdala, and that this information is passed through the context-moderated gateway in the nucleus accumbens in order to promote behaviours that are most beneficial to the long term survival of the organism. We then implemented the proposed mechanism in a network of spiking neurons, and tested one of its central claims. Results showed that the model was capable of producing behaviour similar to that observed in normal humans, as well as that exhibited during VMPFC damage.     

Behavioral, but not reward, risk modulates activation of prefrontal, parietal, and insular cortices

Risky decisions may involve uncertainty about possible outcomes (i.e., reward risk) or uncertainty about which action should be taken (i.e., behavioral risk). Determining whether different forms of risk have distinct neural correlates is a central goal of neuroeconomic research. In two functional magnetic resonance imaging experiments, subjects viewed shapes that had well-learned response-reward contingencies. Magnitude of a monetary reward was held constant within one experiment, whereas expected value was held constant within the other. Response selection, in the absence of behavioral risk, evoked activation within a broad set of brain regions, as had been found in prior studies. However, behavioral risk additionally modulated activation in prefrontal, parietal, and insular regions, within which no effect of reward risk was observed. Reward delivery, in comparison with omission, evoked increased activity in the ventromedial prefrontal cortex and the nucleus accumbens. We conclude that distinct brain systems are recruited for the resolution of different forms of risk.     

The contribution of distinct subregions of the ventromedial frontal cortex to emotion,social behavior,and decision making

Damage to the ventromedial frontal cortex (VMFC) in humans is associated with deficits in decision making. Decision making, however, often happens while people are interacting with others, where it is important to take the social consequences of a course of action into account. It is well known that VMFC lesions also lead to marked alterations in patients’ emotions and ability to interact socially; however, it has not been clear which parts of the VMFC are critical for these changes. Recently, there has been considerable interest in the role of the VMFC in choice behavior during interpersonal exchanges. Here, we highlight recent research that suggests that two areas within or adjacent to the VMFC, the orbitofrontal cortex (OFC) and the anterior cingulate cortex (ACC), may play distinct but complementary roles in mediating normal patterns of emotion and social behavior. Converging lines of evidence from human, macaque, and rat studies now suggest that the OFC may be more specialized for simple emotional responses, such as fear and aggression, through its role in representing primary reinforcement or punishment. By contrast, the ACC may play a distinct role in more complex aspects of emotion, such as social interaction, by virtue of its connections with the discrete parts of the temporal lobe and subcortical structures that control autonomic responses.     

Age,executive function,and social decision making: a dorsolateral prefrontal theory of cognitive aging

Current neuropsychological models propose that some age-related cognitive changes are due to frontal-lobe deterioration. However, these models have not considered the possible subdivision of the frontal lobes into the dorsolateral and ventromedial regions. This study assessed the age effects on 3 tasks of executive function and working memory, tasks dependent on dorsolateral prefrontal dysfunction; and 3 tasks of emotion and social decision making, tasks dependent on ventromedial prefrontal dysfunction. Age-related differences in performance were found on all tasks dependent on dorsolateral prefrontal dysfunction. In contrast, age-related differences were not found on the majority of the tasks dependent on ventromedial prefrontal dysfunction. The results support a specific dorsolateral prefrontal theory of cognitive changes with age, rather than a global decline in frontal-lobe function.     

The triadic systems model perspective and adolescent risk taking

In this special issue, Ernst (2014) outlines the triadic systems model, which focuses on the balanced interaction among three functional neural systems: the prefrontal cortex (regulation/control), striatum (motivation/approach), and amygdala (emotion/avoidance). Asynchrony in maturation timelines, coupled with less mature connectivity across brain regions, is thought to result in unique vulnerabilities for risk taking during the adolescent age period. Yet, the research evidence linking the triadic systems model to differences in risk taking across adolescence and adulthood is equivocal, and few studies have examined how neural development is associated with real-world behavior. In this commentary, we outline research on adolescent risk taking which highlights the importance of considering trait level and situational conditions when examining associations between neural systems and behavior, as well as the need to adopt a lifespan perspective.     

The coupling of short sleep duration and high sleep need predicts riskier decision making

Abstract

Objective: To examine how risk-related decision making might be associated with habitual sleep variables, including sleep variability, sleep duration and perceived sleep need in young adults cross-sectionally and longitudinally.

Design: 166 participants completed a 7-day protocol with sleep and risk-related decision-making measures at baseline (T1) and 12 months later (T2).

Results: Habitual short sleep duration (averaging < 6?h nightly) was identified in 11.0% in our sample. After controlling for baseline demographic factors and risk-taking measures, self-reported sleep need at T1 interacted with habitual short sleep in predicting risk taking at follow-up (F_8,139=9.575, adjusted R²=.431, p<.001). T1 greater perceived sleep need predicted more risk taking among short sleepers, but decreased risk taking among normal sleepers at T2. Variable sleep timing was cross-sectionally correlated with making more Risky choices at baseline and fewer Safe choices after loss at follow up.

Conclusions: Young adults with variable sleep timing and those with short sleep duration coupled with high perceived sleep need were more likely to take risks. The moderating effects of perceived sleep need suggest that individual differences may alter the impact of sleep loss and hence should be measured and accounted for in future studies.     

Anterior insula activity predicts the influence of positively framed messages on decision making

The neural mechanisms underlying the influence of persuasive messages on decision making are largely unknown. We address this issue using event-related fMRI to investigate how informative messages alter risk appraisal during choice. Participants performed the Iowa Gambling Task while viewing a positively framed, negatively framed, or control message about the options. The right anterior insula correlated with improvement in choice behavior due to the positively framed but not the negatively framed message. With the positively framed message, there was increased activation proportional to message effectiveness when less-preferred options were chosen, consistent with a role in the prediction of adverse outcomes. In addition, the dorsomedial and the left dorsolateral prefrontal cortex correlated with overall decision quality, regardless of message type. The dorsomedial region mediated the relationship between the right anterior insula and decision quality with the positively framed messages. These findings suggest a network of frontal brain regions that integrate informative messages into the evaluation of options during decision making. Supplemental procedures and results for this article may be downloaded from http://cabn.psychonomic-journals.org/content/supplemental.     

Both Risk and Reward are Processed Differently in Decisions Made Under Stress

Years of research show that stress influences cognition. Most of this research has focused on how stress affects memory and the hippocampus. However, stress impacts other regions involved in cognitive and emotional processing, including the prefrontal cortex, striatum, and insula. New research examining how stress affects decision processes reveals two consistent findings. First, acute stress enhances selection of previously rewarding outcomes but impairs selection of previously negative outcomes, possibly due to stress-induced changes in dopamine in reward-processing brain regions. Second, stress amplifies gender differences in strategies during risky decisions, with males taking more risk and females less risk under stress. These gender differences in behavior are associated with differences in activity in the insula and dorsal striatum, brain regions involved in computing risk and preparing to take action.     

Neural correlates of emotional intelligence in adolescent children

The somatic marker hypothesis posits a key role for the ventromedial prefrontal cortex, amygdala, and insula in the ability to utilize emotions to guide decision making and behavior. However, the relationship between activity in these brain regions and emotional intelligence (EQ) during adolescence, a time of particular importance for emotional and social development, has not been studied. Using functional magnetic resonance imaging (fMRI), we correlated scores from the Bar-On Emotional Quotient Inventory, Youth Version (EQ-i:YV) with brain activity during perception of fearful faces in 16 healthy children and adolescents. Consistent with the neural efficiency hypothesis, higher EQ correlated negatively with activity in the somatic marker circuitry and other paralimbic regions. Positive correlations were observed between EQ and activity in the cerebellum and visual association cortex. The findings suggest that the construct of self-reported EQ in adolescents is inversely related to the efficiency of neural processing within the somatic marker circuitry during emotional provocation.     

Emotional regulation: implications for the psychobiology of psychotherapy

A range of studies have contributed to understanding the psychobiology of emotional regulation. Functional imaging studies have demonstrated that cortico-limbic circuitry plays an important role in mediating processes such as reappraisal and suppression. Dorsolateral prefrontal cortex may be important in conscious reframing, while ventromedial prefrontal cortex and orbitofrontal cortex may be particularly important in emotion evaluation. Gene variants and early environments impact underlying emotional regulation and its neurobiology. It may be hypothesized that during interventions such as psychotherapy there are improvements in emotional regulation, together with the normalization of related psychobiological mechanisms.