On the acceptability of biopharmaceuticals

The issues relating to the licensing of a biopharmaceutical are described. In particular attention is focused on the mind of the regulator who has the responsibility of recommending licensure. There are two key factors which operate on the mind when confronted with such a task: psychology and ethics. The different factors which influence the psychological acceptability of a product for licensure are many and varied; they include perceived need, novelty, education, context and others. Also involved is the regulator’s view of the ethicality of such products and the organisms which make them, with particular reference to those which are genetically engineered. These ethical views are in turn derived by reference to basic systems of ethics which provide guidelines for behavior. It is important for the manufacturers of biopharmaceuticals to be aware of both the psychological and ethical aspects of the regulator’s mind when addressing such individuals with a view to obtaining a license to manufacture a particular biopharmaceutical.     

Ethical considerations in the use of computers in psychological testing and assessment

Ethical considerations in the use of computers in psychological testing and assessment are discussed. Particular attention is given to existing ethics and standards that provide guidance to users of computerized test interpretation and report-writing programs. Issues covering professional accountability and confidentiality are also discussed as they relate to computer-assisted assessment. Areas of appropriate use of computers in testing and assessment are suggested, including test scoring, the analysis of scores, and generating remedial recommendations. Findings are summarized and several guidelines are suggested for users of computers in testing and assessment.     

Ethical questions in the age of the new eugenics

As a result of the publicly funded Human Genome Project (HGP), and an increasing number of private enterprises, a new form of eugenic theory and practice has emerged, differing from previous manifestations. Genetic testing has become a consumer service that may now be purchased at greatly reduced cost. While the old eugenics was pseudoscientific, the new eugenics is firmly based on DNA research. While the old eugenics focused on societal measures against the individual, the new eugenics emphasizes the family as a control agent. Eugenics is now voluntary, with the promise of abortion for those afraid of producing genetically damaged children. The ethical concepts of beneficence, avoidance of maleficence, autonomy, and equity are discussed in terms of aspects of the HGP. One major issue is the need for an ethical system available to health consumers that will empower them and assist in their biogenic decisions. “The concentration on the genes implicated in cancer is only a special case of a general genomania (emphasis added) that surfaces in ... the weekly announcements in The New York Times of the location of yet another gene for another disease. The revealing rhetoric of this publicity is always the same; only the blanks need to be filled in: ‘It was announced today by scientists at [Harvard, Vanderbilt, Stanford] Medical School that a gene responsible for [some, many, a common form of] [schizophrenia, Alzheimer’s, arteriosclerosis, prostate cancer] has been located and its DNA sequence determined. This exciting research, say scientists, is the first step in what may eventually turn out to be a possible cure for this disease.’” Lewontin ¹ Portions of this paper were presented at the Eighth National Conference on Applied Ethics, Long Beach, CA, February 27, 28 and March 1, 1997.     

Ethical considerations in the supervision of applied sport psychology graduate students

Abstract

Some of the most important relationships that a sport psychologist experiences in his or her career are between the supervisor and supervisee in applied practica and internships. These relationships may become models for future professional and ethical behavior with colleagues, students, and clients, and thus deserve careful examination. Ethics form a foundation for practice, and while classroom discussions of ethical issues help educate graduate students, the supervisor-supervisee relationship may provide a hands-on experience of ethical dilemmas and ethical problem solving. Ethics in supervisor-supervisee relationships cover at least two broad areas. First, there is the supervisor's monitoring and mentoring of ethical considerations in the supervisee's relationship with the athlete-client. Second, ethical questions arise in the relationship between the supervisor and the supervisee. The present paper includes discussion of general supervisory issues (e.g., modeling ethical behavior, helping develop counseling skills) and explores the specific ethical problems of referring for counseling, intimacy, and exploitation. Also, three case examples illustrate ethical concerns that may appear in the process of applied sport psychology supervision. Broadening education in ethical issues in supervision for both psychology and exercise science graduate programs may help future practitioners better serve their clients.     

Ethical considerations in the use of nonerotic touch in psychotherapy with children

Although touch frequently occurs in psychotherapy with children, there is little written on the ethical considerations of therapeutic touch. Because physical contact does occur, therapists must consider if, how, and when it is used, for both their clients' safety and their own. In this review, I further develop the issues suggested by Aquino and Lee (2000) in the use of nurturing touch in therapy by considering many types of touch that occur in psychotherapy with children; the possible positive role of touch; clients' perception of touch in therapy; considerations related to the therapist, the child's safety, and any history of abuse in the child's and family's background; and other practical considerations. I list guidelines.     

2008 Revision of the Chinese Code of Ethical Use of Psychological Tests and Its Implementation Status

In response to the rapidly increasing application and abuse of psychological tests in China, the Psychometrics Division of the Chinese Psychological Society published the 2008 revisions of the Chinese Code of Ethical Use of Psychological Tests. We investigated the implementation status of the code 2½ years after its promulgation. Sample included 284 psychological professionals and psychology graduate students. The average accuracy rate for the appropriate use of psychological tests was 67.1% (range = 25.5–97.5%), with 10 items having accuracy rates below 45%. Participants remained uncertain about the clients' rights to information about the purpose, psychometric properties, and scores of the tests. The most frequent violations involved “using psychological tests without psychometric information for entertainment purposes” and “using SCL-90 to measure mental health of normal people.”     

Ethical dilemmas in testing for late onset conditions: reactions to testing and perceived impact on other family members

This paper examines some of the ethical dilemmas that arise when testing for the late onset, untreatable condition of Huntington disease (HD) specifically now that technology allows us to test younger generations of the family for the mutant gene. Drawing on interview data from families with Huntington disease, the reactions to testing and perceived impact on other family members are considered. These are discussed in the light of the possible lowering of the age of test applicants. This potentially raises problems for a younger generation as they are confronted with reproductive decisions that the older generation did not have to face. It also means that individuals have the prospect of living with knowledge of a future illness for much longer.     

Evolutionary autonomous agents and the naturalization of phenomenology

The phenomenological goal of grounding the content of conceptual thought in the background understanding of everyday, skillful coping was approached using evolutionary autonomous agent (EAA) methodology. The behavior of an EAA evolved to perform a specified motor task was identified with skillful coping. Changes in the dynamics of the EAA controller occurred when the EAA encountered an unexpected obstacle with loss of longer time scale components in its hierarchical temporal organization. These temporal changes are consistent with the phenomenological changes which we experience with breakdown during equipment use with our adoption of a more immediate, determinate stance. Since this latter experience is the basis of conceptual thought, the EAA paradigm goes some way in providing a naturalized explanation for the grounding of the content of conceptual thought in everyday, skillful coping in a manner that is physiologically plausible and phenomenologically accurate.     

Robust techniques for testing heterogeneity of variance effects in factorial designs

Several ways of using the traditional analysis of variance to test heterogeneity of spread in factorial designs with equal or unequaln are compared using both theoretical and Monte Carlo results. Two types of spread variables, (1) the jackknife pseudovalues ofs ² and (2) the absolute deviations from the cell median, are shown to be robust and relatively powerful. These variables seem to be generally superior to the Z-variance and Box-Scheffé procedures.This research was sponsored by Public Health Service Training Grant MH-08258 from the National Institute of Mental Health. The author thanks Mark I. Appelbaum, Elliot M. Cramer, and Scott E. Maxwell for their helpful criticisms of this paper. An earlier version of this work was presented at the Annual Meeting of the Psychometric Society, Murray Hill, New Jersey, April, 1976.     

Statistical inference for false positive and false negative error rates in mastery testing

This paper describes an asymptotic inferential procedure for the estimates of the false positive and false negative error rates. Formulas and tables are described for the computations of the standard errors. A simulation study indicates that the asymptotic standard errors may be used even with samples of 25 cases as long as the Kuder-Richardson Formula 21 reliability is reasonably large. Otherwise, a large sample would be required.This work was performed pursuant to Grant No NIE-G-78-0087 with the National Institute of Education, Department of Health, Education and Welfare, Huynh Huynh, Principal Investigator. Points of view or opinions stated do not necessarily reflect NIE position or policy and no official endorsement should be inferred. The editorial assistance of Joseph C. Saunders is gratefully acknowledged.     

A survey of reimbursement for cystic fibrosis carrier testing

To assess the current status of reimbursement for cystic fibrosis (CF) carrier testing, we surveyed individuals tested in the Mid-Atlantic region. Results show that CF testing was covered by insurance in part or in full for greater than 50% of respondents. The test was nearly always covered when performed during pregnancy because of a positive family history, but it was also covered for more than 50% of pregnant respondents with a negative family history. There were no significant differences in coverage by type of insurance. Many respondents needed to supply additional information about the testing to their insurance company before a coverage decision could be made. Before population-based CF screening programs are initiated, more data are needed on insurance reimbursement for testing, especially when performed pre-conceptually.     

Research on familial Creutzfeldt-Jakob disease (FCJD) resulting in presymptomatic testing: Implications for the human genome project

A research study to identify the priori gene mutation in a family with familial Creutzfeldt-Jakob disease (FCJD) evolved into presymptomatic diagnostic testing. Our experience with one case raises concerns regarding similar studies that will ensue as a result of the Human Genome Project. Technological advances in human molecular genetics make it difficult for Institutional Review Boards (IRB) to adequately evaluate proposed studies. Additionally, changes in the implications of the study may occur after initial IRB approval, due to technological progress. While FCJD, like Huntington's disease (HD), has adult onset and causes progressive dementia and ataxia, protocols established for presymptomatic testing of HD were not included in the FCJD study design. It is thus recommended that IRB committees include a genetics professional and that IRB-approved research studies be reevaluated on a regular basis to monitor the impact that technological advances may have on participating human subjects.     

Offering predictive testing for Huntington disease in a medical genetics clinic: Practical applications

Predictive testing for Huntington disease is presently offered in a select few medical genetics centers in the United States. This is in part due to the labor intensive counseling and psychological testing suggested by the research protocols. We discuss some specific suggestions for establishing programs for Huntington disease predictive testing within pre-existing medical genetics clinics to encourage more centers to offer presymptomatic testing. This will allow more at risk individuals the opportunity to consider predictive testing and cut down the expenses of traveling to the few predictive testing centers that currently exist. The counseling principals will remain similar to those discussed here, even following the identification of the Huntington disease mutation.