Post-training systemic and intra-amygdala administration of the GABA-B agonist baclofen impairs retention

The effects of the GABA-B receptor agonist baclofen on memory storage were studied in two series of experiments. In the first series, CD-1 mice were trained in two aversively motivated tasks: a one-trial inhibitory avoidance task and a classical conditioning task (conditional emotional response). Immediate post-training ip administration of (+/-)baclofen (10 and 30 mg/kg) impaired retention of animals in both tasks. The effect was time-dependent: Retention was not affected by baclofen administered 120 min after training. In the second series of experiments, which used Sprague-Dawley rats, post-training intra-amygdala administration of baclofen impaired retention of an inhibitory avoidance response. These results support the view that the GABAergic system is involved in the modulation of memory storage and that the amygdaloid complex may be a critical site for effects of drugs affecting the GABAergic system.     

Earwitnesses: effects of speech duration,retention interval and acoustic environment

An experiment was conducted to investigate the reliability of voice lineups. More specifically, the experiment was designed to look into the effects of retention interval (an immediate test or after a week), speech duration (30 or 70 s) and acoustic environment (indoors or indoors and outdoors) on speaker identification accuracy. In addition, the relation between confidence assessments of both participants and test assistant on the one hand and identification accuracy was explored. A total of 361 participants heard the target voice in one of four exposure conditions (short or long text and speech samples recorded only indoors or indoors and outdoors). Half the participants were tested immediately after exposure to the target voice and half 1 week later. The results show that the target was correctly identified in 42% of cases. In the target‐absent condition there were 51% false alarms. Acoustic environment did not affect identification accuracy. There was an interaction between speech duration and retention interval in the target‐absent condition. When listeners were tested after a week, they made fewer false identifications if the speech sample was long. No effects were found when participants were tested immediately. Only the confidence scores of the test assistant had predictive value. Taking the confidence score of the test assistant into account therefore increases the diagnostic value of the identity parade. Copyright © 2004 John Wiley & Sons, Ltd.     

Post-training ethanol disrupts trace conditioned fear in rats: effects of timing of ethanol, dose and trace interval duration

Ethanol has complex effects on memory performance, although hippocampus-dependent memory may be especially vulnerable to disruption by acute ethanol intoxication occurring during or shortly after a training episode. In the present experiments, the effects of post-training ethanol on delay and trace fear conditioning were examined in adolescent rats. In Experiment 1, 30-day-old Sprague-Dawley rats were given delay or trace conditioning trials in which a 10s flashing light CS was paired with a 0.5 mA shock US. For trace groups, the trace interval was 10 s. On days 31-33, animals were administered ethanol once daily (0.0 or 2.5 g/kg via intragastric intubation), and on day 34 animals were tested for CS-elicited freezing. Results showed that post-training ethanol affected the expression of trace, but had no effect on delay conditioned fear. Experiment 2 revealed that this effect was dose-dependent; doses lower than 2.5 g/kg were without effect. Experiment 3 evaluated whether proximity of ethanol to the time of training or testing was critical. Results show that ethanol administration beginning 24h after training was more detrimental to trace conditioned freezing than administration that was delayed by 48 h. Finally, in Experiment 4 animals were trained with one of three different trace intervals: 1, 3 or 10s. Results indicate that post-training administration of 2.5 g/kg ethanol disrupted trace conditioned fear in subjects trained with a 10s, but not with a 1 or 3s, trace interval. Collectively the results suggest that ethanol administration impairs post-acquisition memory processing of hippocampus-dependent trace fear conditioning.     

Trauma and memory: effects of post-event misinformation, retrieval order, and retention interval

The present study concerned effects of misinformation, retrieval order, and retention interval on eyewitness memory for a traumatic event (a vivid murder). Relations between misinformation acceptance and compliance were also examined. The classic three-stage misinformation paradigm (Loftus, 1979) was employed, with a multi-component recognition test added. Either immediately or 2 weeks after viewing a distressing film, 232 adults read a narrative (misleading or control) about the murder and then took a recognition test that tapped memory for central and peripheral details. Test-item order either matched the chronology of the film or was randomly determined. Significant misinformation effects were obtained. Moreover, control participants were more accurate in response to questions about central than peripheral information; however, this was not so for misinformed participants. Sequential but not random retrieval order resulted in a higher proportion of correct responses for central as opposed to peripheral misinformation questions. Compliance was significantly related to misinformation effects. Delay increased participants' suggestibility, impaired memory accuracy, and produced higher confidence ratings for misinformed participants compared to controls. Findings indicate that even for a highly negative event, adults' memory is not immune to inaccuracies and suggestive influences.     

Effect of retention interval on the simultaneous cognate-noncognate and remember-know mirror effects

Recognition memory for Spanish-Catalan cognate and noncognate words was tested at retention intervals of 30 minutes, 3 days, and 7 days using a remember/know response procedure. We observed a clear mirror effect for the cognate-noncognate stimulus class and a remember-know response categorisation at the immediate retention interval. However, the cognate and noncognate mirror was still observed at 3 and 7 days, whereas the remember-know mirror disappeared at both retention intervals. Also, we ran a repeated testing condition to be able to carry out a sequential item analysis and observe the fate of the original remember and know responses 3 or 7 days later. The analysis supported the idea that there was a loss of contextual information that was at the root of the disappearance of the remember-know mirror effect. These results provide support to the idea that it is the imbalance between recollection and familiarity that is the most likely cause of the mirror effect.     

Revisiting the rise and fall of false recall: Presentation rate effects depend on retention interval

Leading theories of false memory predict that veridical and false recall of lists of semantically associated words can be dissociated by varying the presentation speed during study. Specifically, as presentation rate increases from milliseconds to seconds, veridical recall is predicted to increase monotonically while false recall is predicted to show a rapid rise and then a slow decrease-a pattern shown by McDermott and Watson (2001) in a study using immediate recall tests. In three experiments we tested the generality of the effects of rapid presentation rates on veridical and false memory. In Experiments 1 and 2 participants exhibited high levels of false recall on a delayed recall test, even for very fast stimulus onset asynchronies (SOA)-contrary to predictions from leading theories of false memory. When we switched to an immediate recall test in Experiment 3 we replicated the pattern predicted by the theories and observed by McDermott and Watson. Follow-up analyses further showed that the relative output position of false recalls is not affected by presentation rate, contrary to predictions from fuzzy trace theory. Implications for theories of false memory, including activation monitoring theory and fuzzy trace theory, are discussed.     

Revisiting the rise and fall of false recall: Presentation rate effects depend on retention interval

Leading theories of false memory predict that veridical and false recall of lists of semantically associated words can be dissociated by varying the presentation speed during study. Specifically, as presentation rate increases from milliseconds to seconds, veridical recall is predicted to increase monotonically while false recall is predicted to show a rapid rise and then a slow decrease—a pattern shown by McDermott and Watson (2001) in a study using immediate recall tests. In three experiments we tested the generality of the effects of rapid presentation rates on veridical and false memory. In Experiments 1 and 2 participants exhibited high levels of false recall on a delayed recall test, even for very fast stimulus onset asynchronies (SOA)—contrary to predictions from leading theories of false memory. When we switched to an immediate recall test in Experiment 3 we replicated the pattern predicted by the theories and observed by McDermott and Watson. Follow-up analyses further showed that the relative output position of false recalls is not affected by presentation rate, contrary to predictions from fuzzy trace theory. Implications for theories of false memory, including activation monitoring theory and fuzzy trace theory, are discussed.     

Comparing techniques for estimating automatic retrieval: effects of retention interval

Results from implicit memory (IM) tasks suggest that automatic retrieval remains stable or decreases over time. In contrast, results from the process dissociation approach (PDA) suggest that automatic retrieval may actually increase over time. One explanation for these discrepant results is that performance on IM tasks is contaminated by controlled retrieval strategies, thereby overestimating automatic retrieval, particularly at short retention intervals, when controlled retrieval strategies are high. An alternative explanation is that automatic and controlled retrieval are positively correlated, rather than independent as assumed by the PDA. If so, the PDA would underestimate automatic retrieval, particularly when controlled retrieval strategies are high. Results from a speeded IM task suggest that a standard IM task provided an accurate estimate of automatic retrieval, whereas the PDA underestimated automatic retrieval at a short retention interval. This pattern of underestimation by the PDA supports the conclusion that automatic and controlled retrieval were positively correlated rather than independent.     

Outcome pre- and postexposure effects: retention interval interacts with primacy and recency

Effects of outcome-alone pretraining and posttraining exposure were investigated in conditioned suppression experiments conducted within a sensory preconditioning preparation with rats. Experiment 1 found that interference by outcome postexposure was stronger than that by outcome preexposure, suggesting a recency effect. Experiment 2 found that after a long retention interval, outcome preexposure produced more interference than outcome postexposure, suggesting a shift from recency to primacy with increasing retention interval. Experiment 3 showed that presentation of a priming stimulus that had been embedded within the earlier phase of treatment also caused a shift from recency to primacy. These results suggest that, at least in a sensory preconditioning paradigm, retrievability of outcome-alone exposure memory is an important determinant of any outcome-alone exposure effect.     

Witnesses stumbling down memory lane: The effects of alcohol intoxication,retention interval,and repeated interviewing

Intoxicated eyewitnesses are often discredited by investigators and in court, but few studies have examined how alcohol affects witnesses’ memory. The primary aim of the present study was to examine how intoxication (alcohol vs. control), retention interval (immediate vs. one week delay), and number of interviews (one vs. two interviews) affect witnesses’ memory. The participants (N?=?99) were randomly assigned to consume either orange juice or alcohol mixed with orange juice, and they all witnessed a filmed mock crime afterwards. The recall took place either (a) immediately and after a one week delay or (b) after a one week delay only. No main effect of alcohol was found on the quantity or quality of the witnesses’ statements. Both intoxicated and sober witnesses recalled more details, and were more accurate, during immediate compared to delayed recall. For witnesses interviewed twice, an average of 30% new details were provided in the second compared to the first interview, and these were highly accurate. In sum, contrary to what one can expect, intoxicated witnesses with a low to moderate blood alcohol concentration (below 0.10%) were reliable witnesses.     

Post-training, but not post-reactivation, administration of amphetamine and anisomycin modulates Pavlovian conditioned approach

The psychostimulant, amphetamine (AMPH), and the protein synthesis inhibitor, anisomycin (ANI), have been shown to modulate the consolidation and reconsolidation of several types of learning. To determine whether Pavlovian conditioned approach (PCA) is modulated in a similar manner, we examined the effects of post-training and post-reactivation administration of both AMPH and ANI on memory for PCA. Male Long-Evans rats received PCA training sessions during which presentations of a CS+ were followed by sucrose delivery. AMPH (1 mg/kg, s.c.) injected immediately but not 6h after the first training session enhanced PCA behavior. ANI (150 mg/kg, s.c.) injected immediately but not 3h after the first training session impaired PCA behavior. This impairment was not due to the development of a conditioned taste aversion. To examine whether PCA can also be modulated by post-reactivation administration of AMPH and ANI, rats were given an injection of AMPH, ANI, or vehicle immediately after a memory reactivation session. Upon testing, the behavior of both the AMPH- and the ANI-treated rats was unaffected. This result remained consistent when the experiment was repeated with changes to various behavioral parameters (i.e., amount of training, length of memory reactivation). These findings indicate that AMPH and ANI act during the post-training but not the post-reactivation period to enhance and impair, respectively, the learning of PCA. This suggests that the consolidation of PCA can be modulated in a manner comparable to other types of learned associations, but once learned, the memory appears to be relatively robust and stable.     

Time and again: effects of repetition and retention interval on 2 year olds' event recall

How and what very young children remember is a central question for understanding the course of memory development. In this research, we examined the effects of two factors on 2-year-old children's ability to recall novel events: repetition of the experience and time since experience. Twenty 24-month-old and twenty 28-month-old children participated in unusual laboratory play events. Half of the children returned after a 2-week delay and again after a 3-month delay (repeated experience condition); the remaining children returned only after 3 months (single experience condition). Memory was assessed by asking children to reenact the events. Recall was generally accurate, and there were no significant effects of age. All children recalled more information about the activities associated with the event than about the objects. Surprisingly, children in the repeated experience condition recalled as much about the events at the 3-month retention interval as at the 2-week retention interval. Further, children in this condition recalled more information at the 3-month retention interval than children in the single experience condition, suggesting that reexperiencing an event may guard against long-term forgetting.     

Classical conditioning and retention of the infant's eyelid response: effects of age and interstimulus interval

Independent groups of 10-,20-, and 30-day-old infants were subjected to a classical eyelid conditioning procedure involving either a 500- or a 1500-msec interstimulus interval (ISI). Ten days later, all received a second conditioning session. A reliable increase in conditioned responding was observed at all ages but only by infants receiving the 1500-msec ISI. Although age was not a significant factor in any conditioning measure except final performance level, which was greater for the oldest than for the youngest group, it did influence long-term retention. A reliable memory component was observed in the Session 2 performance of infants initially trained at 20 and 30 days but not at 10 days. These data demonstrate the importance of temporal parameters in the formation of conditioned associations very early in infancy and provide evidence for the long-term behavioral consequences of those associations.     

Temporal factors influencing the pigeon's successive matching-to-sample performance: sample duration, intertrial interval, and retention interval

A successive matching-to-sample procedure that entails the sequential presentation of sample and test stimuli and the monitoring of response rates in a go/no-go discrimination of matching and nonmatching stimuli was studied as an alternative to the familiar delayed-matching paradigm of animal short-term memory. Three within-subject experiments studied the effects of sample duration (1 to 12 seconds), intertrial interval (5 to 50 seconds), and retention interval (1 to 50 seconds) on the pigeon's successive-matching performance. The results revealed that retention was (a) an increasing function of sample duration and intertrial interval, and (b) a decreasing function of retention interval. These results were in accord with those of more traditional short-term memory paradigms, and reveal the suitability of the successive-matching procedure for studying memory processes.     

Echoic memory in the rat: effects of inspection time, retention interval, and the spectral composition of masking noise.

Memory for tones (1100 vs. 2330 Hz) was studied in 4 rats (Rattus norvegicus), as affected by the durations of both target tones (30 to 620 ms) and noise-filled retention intervals (0 to 480 ms). With a 0-ms delay, performance was near asymptotic with the 30-ms tone, but the memory of this brief tone suffered a massive decrement at retention intervals as brief as 60 ms; in contrast, memory for the 340-ms tone was stable for at least 240 ms. If the retention interval was filled by band-stop noise (with targets presented in the spectral gap), then the rat's memory for brief tones was superior to that obtained with the standard broad-band noise filler, and band-stop noise was better than a band-pass noise that had the tones embedded in the region of its spectral energy. These findings are consistent with the hypotheses that auditory memory in the rat consists of a transient sensorylike echoic store and a short-term store more resistant to the effects of retroactive interference.     

The length of the retention interval,forgetting, and subjective similarity

A long retention interval tends to result in the poor retention known as forgetting. A high subjective similarity between stimuli frequently produces their poor retention. Thus, a long retention interval may increase the subjective similarity between stimuli (the RIISS hypothesis), and this increase may produce forgetting. To examine this hypothesis, college students made speeded same-different discriminations between two lines or tones of different lengths or frequencies that were 400 ms or 3,300 ms apart, and they rated the similarity of these stimuli. The long interval produced poorer overall performance as expected, but also produced poorer performance on different than same stimuli, implying that it increased the subjective similarity between the initial and subsequent stimuli, and it also increased rated similarity, in support of the RIISS hypothesis. The position that stored stimuli lose less common information than distinctive information explains RIISS evidence better than does perturbation theory.     

Assessing human reorientation ability inside virtual reality environments: the effects of retention interval and landmark characteristics

The purpose of the present study was to assess the navigational behaviour of adult humans following a disorientation procedure that perturbed their egocentric frame of reference. The assessment was carried out in a virtual reality (VR) environment by manipulating the disorientation procedure, the retention interval, the relative positions of target and landmark. The results of experiment I demonstrated that adding a physical rotation to a virtual disorientation procedure did not yield an additional decrease in searching performance. The results of experiment II showed that shortening the delay between study and test phase decreased the errors more markedly for geometric than landmark ones. An orientation specificity effect due to the manipulation of the relative position between target and landmark was discussed across the experiments. In conclusion, VR seemed to be a valuable method for studying human reorientation. Moreover, the virtual experimental setting involved here promoted knowledge of the relationship between working memory and spatial reorientation paradigm.     

The effect of cue-familiarity, cue-distinctiveness, and retention interval on prospective remembering

Five experiments investigated the effects of cue familiarity, cue distinctiveness, and retention interval on prospective remembering. Results showed that (1) performance in a prospective memory task is facilitated when the cue is unfamiliar and/or distinctive; and (2) it is impaired by 3-minutes' delay between the instructions and the task (Experiment 1). A beneficial effect of distinctiveness was also found when perceptual rather than semantic distinctiveness was tested (Experiment 2). Experiments 3 and 4 ruled out the hypotheses that “unfulfilled expectancy” of an event (i.e. non-appearance of the cue during training) (Experiment 3), or some sort of “habituation” in the target context (Experiment 4), may have caused the low performance observed in the delayed conditions. Finally, results from Experiment 5 showed that delay negatively affected prospective remembering when it was filled with either a demanding interpolated activity (practice in a STM task) or an undemanding motoric activity (repetitive hands movements). Unfilled delay and an undemanding verbal activity (counting) were found not to affect prospective memory. Implications for the mechanisms underlying prospective remembering are discussed.     

Age-related differences in the impact of spacing, lag, and retention interval

An experiment is reported that examines age-related differences in the lag effect and its relation to retention interval. A total of 30 young and 30 older adults received both once-presented pairs and twice-presented pairs that were tested in a continuous cued-recall paradigm either after a short retention interval (2 pairs intervening between the last presentation of a pair and its test) or a long retention interval (20 pairs intervening between the last presentation of a pair and its test). In addition, the twice-presented pairs were separated by either 0, 1, 4, 8, or 20 intervening pairs. The results replicated the interaction between retention interval and lag that has been reported by Glenberg (1976, Journal of Verbal Learning and Verbal Behavior, 15, 1-16). Furthermore, although the older adults performed considerably lower than the younger adults in overall recall performance, their data were remarkably similar to the younger adults in the patterning of means. A mathematical modeling procedure was used to fit the data to Estes' stimulus fluctuation model. The results of this modeling procedure suggest that, compared with younger adults, older adults (a) encode less contextual information at a given point in time and (b) have a slower rate of contextual fluctuation across time.