Recall,recognition, and the hippocampus: Reply to Yonelinas et al. (2004)

Two recent studies disagree about whether recall is more impaired than recognition (and recollection more than familiarity) in patients with damage limited to the hippocampus (Manns, Hopkins, Reed, Kitchener, & Squire, 2003; Yonelinas et al., 2002). Wixted and Squire (2004) pointed out that the disagreement about recall and recognition stems entirely from an outlying recognition score obtained by 1 of 55 control subjects in Yonelinas et al. (2002). In their comment on our paper, Yonelinas et al. (2004) minimize the importance of this result and argue that the role of the hippocampus in recollection and familiarity is best studied using different methods that attempt to measure these processes directly. Here, we argue that the recall versus recognition comparison is the strongest test because it relies on the fewest controversial assumptions, and that the other approaches explored by Yonelinas et al. (2002) rely on questionable, theory-laden assumptions. We also rehearse the reasons for concluding that the patients studied by Manns et al. (2003) have damage limited to the hippocampal region (hippocampus proper, dentate gyrus, and subiculum), and we emphasize that important questions remain about the patients studied by Yonelinas et al. (2002), inasmuch as no neuroanatomical information and minimal neuropsychological information has been provided.     

Recall and recognition are equally impaired in patients with selective hippocampal damage

In two recent studies, the hypothesis that recall is more severely impaired than recognition in patients with damage thought to be limited to the hippocampus was tested. Yonelinas et al. (2002) reported findings that appeared to support this hypothesis, whereas Manns, Hopkins, Reed, Kitchener, and Squire (2003) found that recall and recognition were equally impaired. An analysis of the individual subject data from the two studies revealed that the apparent disagreement stemmed from the inclusion of a single outlying recognition score for 1 of the 55 control subjects in Yonelinas et al. (2002). When that outlier was excluded, the studies were in agreement that recognition and recall are substantially and similarly impaired in these patients. Yonelinas et al. (2002) also analyzed remember/know judgments and ROC data in an effort to show that recollection is selectively impaired in patients, but these analyses also raise problems.     

Recognition memory: Adding a response deadline eliminates recollection but spares familiarity

A current controversy in memory research concerns whether recognition is supported by distinct processes of familiarity and recollection, or instead by a single process wherein familiarity and recollection reflect weak and strong memories, respectively. Recent studies using receiver operating characteristic (ROC) analyses in an animal model have shown that manipulations of the memory demands can eliminate the contribution of familiarity while sparing recollection. Here it is shown that a different manipulation, specifically the addition of a response deadline in recognition testing, results in the opposite performance pattern, eliminating the contribution of recollection while sparing that of familiarity. This dissociation, combined with the earlier findings, demonstrates that familiarity and recollection are differentially sensitive to specific memory demands, strongly supporting the dual process view.Receiver operating characteristic (ROC) analysis holds the promise of dissecting the contributions to recognition memory of episodic recollection and familiarity (Yonelinas 2001), and this method can be applied equally well to examine these memory processes in animals as well as humans (Fortin et al. 2004; Sauvage et al. 2008). According to the dual process model, recollection is indexed by the asymmetry of the ROC function whereas familiarity is measured by the degree of curvilinearity of that function, and correspondingly, these two parameters can vary independently (Yonelinas 2001). However, there is controversy about this interpretation of ROC components. Some have argued that the asymmetry and curvilinearity of the ROC function both reflect the strength of memories mediated by a single process (Wixted 2007), and correspondingly, these components of the ROC increase or decrease together in stronger or weaker memories, respectively (Squire et al. 2007).A resolution of this controversy can be advanced by examining whether the ROC asymmetry and curvilinearity are independently influenced by task manipulations that favor either recollection or familiarity, consistent with dual process theory, or instead are similarly influenced by conditions that affect memory strength. Recent data from an animal model of recognition have shown that adding a demand for remembering associations between independent stimuli eliminates the ROC curvilinearity without affecting the asymmetry, consistent with the dual process view (Sauvage et al. 2008; for discussion of associative recognition, see Mayes et al. 2007). However, in order to provide compelling evidence of independence of the two ROC components, it is also critical to show that other memory demands that favor familiarity produce the opposite pattern, elimination of the ROC asymmetry while sparing its curvilinearity. Together these findings would constitute a double dissociation between the two parameters of the ROC function that cannot be explained by a single process theory.As originally conceived in models proposed in the 1970s, familiarity is characterized as a perceptually driven, pattern matching process that is completed rapidly, whereas recollection is characterized as a conceptually driven, organizational process that requires more time (Mandler 1972; Atkinson and Juola 1973, 1974; for reviews, see Yonelinas 2002; Mandler 2008). Consistent with this view, the results of several studies that employ response deadlines in the test phase report that familiarity is more rapid than recollection. For example, forcing people to make speeded recognition responses has little effect on simple yes–no recognition but strikingly reduces performance when subjects must remember where or when an item was studied (Yonelinas and Jacoby 1994; Gronlund et al. 1997; Hintzman et al. 1998). Other studies that require subjects to oppose familiarity and recollection reveal a two-component temporal function that includes a rapidly available familiarity process and a slower recollective process (Dosher 1984; Gronlund and Ratcliff 1989; Hintzman and Curran 1994; McElree et al. 1999). In addition, studies that measure brain evoked response potentials (ERPs) have revealed two distinct ERP modulations commonly observed during recognition: a mid-frontal negativity onsetting about 400 msec after stimulus onset that is associated with familiarity, and a parietally distributed positivity beginning about 500 msec after stimulus onset that is associated with recollection (Smith 1993; Duzel et al. 1997; Curran 2004; Duarte et al. 2006; Woodruff et al. 2006; but see Voss and Paller 2009).Dual process theory predicts that applying an appropriate early response deadline should allow sufficient time for contribution of familiarity but not that of recollection, and so should reduce the ROC asymmetry while sparing its curvilinearity, opposite to the already observed effects of associative memory demands that favor recollection (Sauvage et al. 2008). Confirmation of this prediction combined with the previous findings of the opposite effects in associative recognition would constitute a double dissociation between the features of recollection and familiarity. This result would therefore strongly support the conclusion that the asymmetry and curvilinearity are independent parameters of the ROC function that are differentially linked to features of recollection and familiarity, respectively.     

Response to Algarabel et al., 2012 “Recognition memory deficits in mild cognitive impairment”. Reconsidering claims of familiarity disruptions in mild cognitive impairment

There is some debate over the relative impairment of recollection and familiarity in mild cognitive impairment (MCI). A recent publication by Algarabel et al. (2012, Recognition memory deficits in mild cognitive impairment, Aging, Neuropsychology, and Cognition, 19, 608–619) claims to undermine previous studies reporting preserved familiarity in patients with MCI. Here, we respond to their main criticisms, concluding that they are not sufficiently supported by the data presented. The role of recollection and familiarity in MCI remains unresolved and further work will be required to disentangle the mixed literature.     

The contribution of familiarity to recognition memory is a function of test format when using similar foils

Patient Y.R., who suffered hippocampal damage that disrupted recollection but not familiarity, was impaired on a yes/no (YN) object recognition memory test with similar foils. However, she was not impaired on a forced-choice corresponding (FCC) version of the test that paired targets with corresponding similar foils (Holdstock et al., 2002). This dissociation is explained by the Complementary Learning Systems (CLS) neural-network model (Norman & O'Reilly, 2003) if recollection is impaired but familiarity is preserved. The CLS model also predicts that participants relying exclusively on familiarity should be impaired on forced-choice noncorresponding (FCNC) tests, where targets are presented with foils similar to other targets. The present study tests these predictions for all three test formats (YN, FCC, FCNC) in normal participants using two variants of the remember/know procedure. As predicted, performance using familiarity alone was significantly worse than standard recognition on the YN and FCNC tests, but not on the FCC test. Recollection in the form of recall-to-reject was the major process driving YN recognition. This adds support to the interpretation of patient data, according to which hippocampal damage causes a recollection deficit that leads to poor performance on the YN test relative to FCC.     

Effects of age on estimated familiarity in the process dissociation procedure: The role of noncriterial recollection

Research on recognition memory using the process dissociation procedure has suggested that although recollection (R) declines with age, familiarity (F) remains age invariant. However, this research has used relatively broad definitions of R. An important question concerns age-related changes in memory when R is defined in terms of specific event details. Yonelinas and Jacoby (1996a) required young participants to recollect specific, criterial details of a prior event and found evidence that recollection of noncriterial details elevated estimates of F yet still operated automatically. In the present study, the issue of noncriterial recollection was examined in the context of aging. The results replicated the effects of noncriterial recollection for the young, but not for the older adults, who also showed overall reduced levels of familiarity.     

Effects of retention intervals on receiver operating characteristics in artificial grammar learning

Current theories of memory suggest that recognition is composed of separate processes of familiarity and recollection (e.g. [Yonelinas, A. P. (2002). The nature of recollection and familiarity: a review of 30 years of research. Journal of Memory and Language, 46, 441-517]). A key feature of these two processes is that they decay, or are forgotten at different rates. The dual-process model has also been useful in understanding artificial grammar learning. We obtained evidence for recollection and familiarity in artificial grammar learning by analyses of receiver operating characteristics (ROC). Furthermore we found that these were dissociated by retention intervals of 14 days. The slope of the zROC curves deviated reliably from 1 immediately after study and increased towards 1 suggesting that recollection contributed to recognition decisions but declined over the 14-day period leaving familiarity as the only basis for recognition. These data show similar patterns to those observed in word-recognition [Gardiner, J. M., & Java, R. I. (1991). Forgetting in recognition memory with and without recollective experience. Memory &Cognition, 19, 617-623; Tunney, R. J. (submitted for publication). Changes in the subjective experience of recognition over time suggest independent processes] and confirm the view that recollection and familiarity are implicated in artificial grammar learning. Moreover, the data confirm the finding that recollection and familiarity-based memory show different patterns of forgetting.     

Recognition memory and the hippocampus: A test of the hippocampal contribution to recollection and familiarity

It has been suggested that the hippocampus selectively supports recollection and that adjacent cortex in the medial temporal lobe can support familiarity. Alternatively, it has been suggested that the hippocampus supports both recollection and familiarity. We tested these suggestions by assessing the performance of patients with hippocampal lesions on recognition memory tests that differ in the extent to which recollection and familiarity contribute to the recognition decision. When targets and foils are highly similar, prior evidence suggests that, on a forced-choice test in which targets are presented together with highly similar, corresponding foils (the FC-C format), performance is supported primarily by familiarity. By contrast, when targets are presented together with foils that are similar to other targets (the FC-NC format) or when memory is tested in a yes/no (Y/N) format, performance is based much more strongly on recollection. Accordingly, a finding that hippocampal damage impaired both Y/N recognition and FC-NC recognition but spared FC-C recognition would suggest that the hippocampus selectively supports recollection. We administered Y/N, FC-C, and FC-NC tests to five memory-impaired patients with circumscribed hippocampal lesions and 14 controls. The patients were impaired on all three types of recognition test, and there was no indication that the patients were disproportionately benefited or disproportionately impaired on any test. This pattern of performance suggests that the hippocampus supports both recollection and familiarity.The medial temporal lobe (the hippocampus plus the entorhinal, perirhinal, and parahippocampal cortices) is essential for the recognition of past experience. The capacity for recognition is widely thought to depend on two distinct processes, recollection and familiarity (Mandler 1980; Yonelinas et al. 2002; Wixted 2007). Recollection involves remembering specific details about the episode in which an item was encountered. Familiarity involves simply knowing that an item was presented, even when no additional information can be retrieved about the learning episode itself. This distinction has been prominent in recent discussions about memory, particularly in relation to its possible anatomical basis. One proposal is that recollection depends on the hippocampus and that familiarity depends on the adjacent medial temporal lobe cortex (Brown and Aggleton 2001; Mayes et al. 2002; Yonelinas et al. 2002). Alternatively, it has been suggested that the hippocampus is important for both recollection and familiarity and that the distinction between these two processes does not illuminate the functional differences between the hippocampus and adjacent cortex (Rutishauser et al. 2006; Wais et al. 2006; Squire et al. 2007; Wixted 2007).To clarify the role of the hippocampus in recognition memory, the performance of memory-impaired patients with hippocampal damage has often been compared to that of controls on tests that differ in the extent to which recollection and familiarity contribute to the recognition memory decision. One such approach involves the use of highly similar targets and foils tested using a yes/no (Y/N) format and a forced-choice corresponding (FC-C) format (Holdstock et al. 2002; Westerberg et al. 2006; Bayley et al. 2008). In the case of the Y/N format, participants see a list of targets intermixed with foils (each similar to one of the targets) and are asked to respond “yes” to the targets and “no” to the foils. In the FC-C format, participants see a target presented together with its corresponding, similar foil and are asked to identify the target. According to an idea advanced by Norman and O''Reilly (2003), familiarity can support FC-C recognition because one can make effective use of small but consistent differences between the familiarity signals triggered by the target and foil items. That is, when targets and foils are highly similar and are presented together in the FC-C format, familiarity for the target is likely to slightly and reliably exceed that of the similar foil, allowing the target to be correctly chosen on the basis of familiarity. By contrast, in the Y/N format, slight differences between the familiarity signals of target items and their corresponding foils no longer provide useful information, because the targets and their corresponding foils are not presented together at test. Accordingly, good performance with the Y/N format is more dependent on recollection than with the FC-C format.The same explanation may account for why performance on FC-C tests sometimes exceeds performance on forced-choice noncorresponding (FC-NC) tests (e.g., Hintzman 1988). In the FC-NC format, target items are presented together with a noncorresponding foil that is similar to another target item from the study list (Fig. 1). Thus, the FC-C and FC-NC tests differ only in that the similar targets and foils are presented together in the former but not in the latter. When the corresponding targets and foils are presented together (in the FC-C format), participants can make effective use of consistent differences in familiarity values (as discussed above). When the corresponding targets and foils are not presented together, participants cannot make use of the small differences that they might detect through a side-by-side comparison.Open in a separate windowFigure 1.Test format and materials for the three kinds of recognition test. For each test, 12 images, either objects (A) or silhouettes (B), were presented at study, and memory was tested in one of three ways. For the forced-choice corresponding test (FC-C), each target (a studied item) was presented together with a highly similar foil (a new item). For the forced-choice noncorresponding test (FC-NC), each target was presented together with a foil that was highly similar to a different target from the study list. Participants were asked to point to exactly the same image they had seen during study. For the yes/no test (Y/N), the 12 targets and the 12 foils (each similar to one of the targets) were intermixed and presented one at a time. Participants were asked to respond “yes” if they had seen exactly the same image before and “no” if they had not. Asterisks identify the target items.A recent study (Migo et al. 2009) provides empirical support for the suggestion that familiarity primarily contributes to the recognition decision in the FC-C format, whereas recollection contributes more strongly in the Y/N format and in the FC-NC format. In the Migo et al. (2009) study, healthy participants received FC-C, FC-NC, and Y/N tests after receiving either standard instructions to make their decisions based on familiarity or recollection or modified instructions to base their decisions on familiarity only. On the FC-NC test and on the Y/N test, performance using familiarity alone was significantly worse than under standard instructions. On the FC-C test, performance using familiarity alone was nearly as good as under standard instructions. This result supports the earlier suggestion that FC-C is primarily supported by familiarity, whereas recollection plays a larger role in FC-NC and Y/N recognition (Norman and O''Reilly 2003).If the hippocampus is critical for recollection but not for familiarity, and if good performance on the FC-C format can be achieved using familiarity alone, then patients with focal hippocampal lesions should be differentially impaired on the Y/N and FC-NC recognition test formats compared with the FC-C format. Three recent studies investigated this issue by assessing the effects of hippocampal damage (or presumed hippocampal damage) on Y/N and FC-C tests that used highly similar targets and foils (the FC-NC format was not used in these earlier studies). All three studies used black-and-white silhouette images of objects, and the FC-C test involved the target item and three similar foils (i.e., multiple-choice with four alternatives). In one study, a single patient with bilateral hippocampal damage (patient Y.R.) was impaired on the test of Y/N recognition but was unimpaired on the test of FC-C recognition (Holdstock et al. 2002). A similar result was reported in patients with a diagnosis of mild cognitive impairment (MCI) (Westerberg et al. 2006). These findings have been taken to support the suggestion that the hippocampus selectively supports recollection. However, the study by Holdstock and colleagues (2002) involved a single patient (Y.R.), and findings from a single patient need not agree with findings obtained from a group of patients (see Discussion). In addition, the Westerberg et al. (2006) study involved individuals with a diagnosis of MCI for whom anatomical data were not available. It is therefore not clear what the status of the hippocampus was in these patients. Moreover, a standard Y/N procedure involving 12 study items and 24 test items (as opposed to the 12 study test items and 60 test items used in previous studies [Holdstock et al. 2002; Westerberg et al. 2006; Bayley et al. 2008]) might be better suited to address the question of whether Y/N recognition is selectively impaired in hippocampal patients. Bayley et al. (2008) tested five patients with circumscribed hippocampal damage using the same test materials and procedure as in Holdstock et al. (2002). When all 60 test items of the Y/N test were scored, the patients were found to be more impaired on the Y/N test than on the FC-C test. However, when only the first 24 test items of the Y/N test were scored (according to the standard Y/N procedure), the patients were found to be impaired on both the Y/N and FC-C tests to a similar degree.The earlier studies (Holdstock et al. 2002; Westerberg et al. 2006; Bayley et al. 2008) compared Y/N recognition to four-alternative FC-C recognition in which each target was presented along with three corresponding foils. None of the earlier studies investigated how patients with hippocampal lesions performed on FC-NC recognition. As Migo et al. (2009) point out, FC-C and FC-NC tests are better matched than the FC-C and Y/N tests because they are both forced-choice tests, and both use the same number of test trials. As such, they argue, it would be more useful to compare FC-C recognition performance to FC-NC recognition performance to determine whether patients with hippocampal lesions are intact or impaired on familiarity-based tests.The present study assessed Y/N, two-alternative FC-C, and two-alternative FC-NC recognition, using highly similar targets and foils. The tests were given to five patients with circumscribed hippocampal damage and 14 matched controls. The Y/N test involved an equal number of targets and foils (unlike the design used in the prior studies), and a two-alternative format was used for the forced-choice tests to make them comparable to the Y/N test (i.e., all three tests involved the same number of targets and foils). The FC-C and FC-NC tests were identical except with respect to how the targets and their corresponding foils were paired on the recognition test.To extend our findings beyond the stimuli used in prior studies, we also used color photographs of objects in addition to black-and-white silhouettes. Using these three test formats, we asked the following questions: (1) Does hippocampal damage impair Y/N recognition memory but spare, or disproportionately benefit, FC-C recognition (as suggested by the view that the hippocampus supports recollection and not familiarity)? Or does hippocampal damage impair Y/N and FC-C recognition similarly (as suggested by the view that the hippocampus supports both recollection and familiarity)? (2) Does hippocampal damage disproportionately benefit FC-C recognition relative to FC-NC recognition, or does hippocampal damage impair FC-C and FC-NC recognition similarly?     

Recognition memory deficits in mild cognitive impairment

ABSTRACT There is no agreement on the pattern of recognition memory deficits characteristic of patients diagnosed with mild cognitive impairment (MCI). Whereas lower performance in recollection is the hallmark of MCI, there is a strong controversy about possible deficits in familiarity estimates when using recognition memory tasks. The aim of this research is to shed light on the pattern of responding in recollection and familiarity in MCI. Five groups of participants were tested. The main participant samples were those formed by two MCI groups differing in age and an Alzheimer's disease group (AD), which were compared with two control groups. Whereas one of the control groups served to assess the performance of the MCI and AD people, the other one, composed of young healthy participants, served the purpose of evaluating the adequacy of the experimental tasks used in the evaluation of the different components of recognition memory. We used an associative recognition task as a direct index of recollection and a choice task on a pair of stimuli, one of which was perceptually similar to those studied in the associative recognition phase, as an index of familiarity. Our results indicate that recollection decreases with age and neurological status, and familiarity remains stable in the elderly control sample but it is deficient in MCI. This research shows that a unique encoding situation generated deficits in recollective and familiarity mechanisms in mild cognitive impaired individuals, providing evidence for the existence of deficits in both retrieval processes in recognition memory in a MCI stage.     

Modeling associative recognition: a comparison of two-high-threshold, two-high-threshold signal detection, and mixture distribution models

A 2-high-threshold signal detection (HTSDT) model, a mixture distribution (SON) model, and 2-high-threshold (HT) models with responses distributed over 1 or several response categories were fit to results of 6 experiments from 2 studies on associative recognition: R. Kelley and J. T. Wixted (2001) and A. P. Yonelinas (1997). HTSDT assumes that associative recognition is based on conscious recollection and familiarity assessment, whereas according to SON and HT, associative information results in a shift of familiarity. The modeling results cast doubt on the prominent role of conscious recollection, and as far as models are valid, parameter estimation suggests 2 processes in associative recognition: a shift in familiarity that is due to associative information and the determination of the source of familiarity of pairs.     

Recognition memory deficits in mild cognitive impairment

ABSTRACT

There is no agreement on the pattern of recognition memory deficits characteristic of patients diagnosed with mild cognitive impairment (MCI). Whereas lower performance in recollection is the hallmark of MCI, there is a strong controversy about possible deficits in familiarity estimates when using recognition memory tasks. The aim of this research is to shed light on the pattern of responding in recollection and familiarity in MCI. Five groups of participants were tested. The main participant samples were those formed by two MCI groups differing in age and an Alzheimer's disease group (AD), which were compared with two control groups. Whereas one of the control groups served to assess the performance of the MCI and AD people, the other one, composed of young healthy participants, served the purpose of evaluating the adequacy of the experimental tasks used in the evaluation of the different components of recognition memory. We used an associative recognition task as a direct index of recollection and a choice task on a pair of stimuli, one of which was perceptually similar to those studied in the associative recognition phase, as an index of familiarity. Our results indicate that recollection decreases with age and neurological status, and familiarity remains stable in the elderly control sample but it is deficient in MCI. This research shows that a unique encoding situation generated deficits in recollective and familiarity mechanisms in mild cognitive impaired individuals, providing evidence for the existence of deficits in both retrieval processes in recognition memory in a MCI stage.     

Increasing relational memory in childhood with unitization strategies

Young children often experience relational memory failures, which are thought to result from immaturity of the recollection processes presumed to be required for these tasks. However, research in adults has suggested that relational memory tasks can be accomplished using familiarity, a process thought to be mature by the end of early childhood. The goal of the present study was to determine whether relational memory performance could be improved in childhood by teaching young children memory strategies that have been shown to increase the contribution of familiarity in adults (i.e., unitization). Groups of 6- and 8-year-old children were taught to use visualization strategies that either unitized or did not unitize pictures and colored borders. Estimates of familiarity and recollection were extracted by fitting receiver operator characteristic curves (Yonelinas, Journal of Experimental Psychology: Learning, Memory, and Cognition 20, 1341–1354, 1994, Yonelinas, Memory & Cognition 25, 747–763, 1997) based on dual-process models of recognition. Bayesian analysis revealed that strategies involving unitization improved memory performance and increased the contribution of familiarity in both age groups.     

Are affective events richly recollected or simply familiar? The experience and process of recognizing feelings past

The author used the remember/know paradigm and the dual process recognition model of A. P. Yonelinas, N. E. A. Kroll, I. Dobbins, M. Lazzara, and R. T. Knight (1998) to study the states of awareness accompanying recognition of affective images and the processes of recollection and familiarity that may underlie them. Results from all experiments showed that (a) negative stimuli tended to be remembered, whereas positive stimuli tended to be known; (b) recollection, but not familiarity, was boosted for negative or highly arousing and, to a lesser extent, positive stimuli; and (c) across experiments, variations in depth of encoding did not influence these patterns. These data suggest that greater recollection for affective events leads them to be more richly experienced in memory, and they are consistent with the idea that the states of remembering and knowing are experientially exclusive, whereas the processes underlying them are functionally independent.     

The Effects of Healthy Aging,Amnestic Mild Cognitive Impairment,and Alzheimer’s Disease on Recollection and Familiarity: A Meta-Analytic Review

It is well established that healthy aging, amnestic Mild Cognitive Impairment (aMCI), and Alzheimer’s Disease (AD) are associated with substantial declines in episodic memory. However, there is still debate as to how two forms of episodic memory – recollection and familiarity – are affected by healthy and pathological aging. To address this issue we conducted a meta-analytic review of the effect sizes reported in studies using remember/know (RK), receiver operating characteristic (ROC) and process dissociation (PD) methods to examine recollection and familiarity in healthy aging (25 published reports), aMCI (9 published reports), and AD (5 published reports). The results from the meta-analysis revealed that healthy aging is associated with moderate-to-large recollection impairments. Familiarity was not impaired in studies using ROC or PD methods but was impaired in studies that used the RK procedure. aMCI was associated with large decreases in recollection whereas familiarity only tended to show a decrease in studies with a patient sample comprised of both single-domain and multiple-domain aMCI patients. Lastly, AD was associated with large decreases in both recollection and familiarity. The results are consistent with neuroimaging evidence suggesting that the hippocampus is critical for recollection whereas familiarity is dependent on the integrity of the surrounding perirhinal cortex. Moreover, the results highlight the relevance of method selection when examining aging, and suggest that familiarity deficits might be a useful behavioral marker for identifying individuals that will develop dementia.     

Recognition,recollection, familiarity and executive function in medicated patients with moderate Parkinson's disease

There is conflicting evidence about whether Parkinson's disease (PD) is associated with deficiencies in recognition memory (RM) and the processes which underlie it, namely recollection (a form of recall) and familiarity (a feeling of memory in the absence of recall). The aims of the current study were to examine forced‐choice verbal RM (assessed with the Warrington Recognition memory Test), yes‐no RM, recollection, familiarity and executive functioning in 17 patients with moderate PD and 17 healthy volunteers matched for age and premorbid intelligence. We predicted that patients with moderate PD would display a significant recollection deficit on the yes‐no RM test, because their strategic memory processing that depends on executive functioning and is necessary for efficient encoding and/or retrieval, was disrupted. In contrast, familiarity memory, which is not dependent on these processes, and forced‐choice RM (which is largely dependent on familiarity) should show higher levels of preservation. We also predicted that recollection should be correlated with severity of executive dysfunction. Our findings revealed that the PD patients were as likely to accurately discriminate between targets and distractors as the healthy volunteers on both RM tests. However, the PD patients were significantly less reliant on recollection‐driven recognition decisions on the yes‐no RM test when compared with the healthy control group. The patients also displayed executive function deficits, but these were not correlated with recollection. The extent to which the PD patients' reliance on familiarity at the expense of recollection is explained by impairments in strategic memory processes/executive function and/or medial temporal lobe retrieval processes needs further exploration.     

The<Emphasis Type="Italic">remember</Emphasis> response: Subject to bias,graded, and not a process-pure indicator of recollection

Recognition memory judgments have long been assumed to depend on the contributions of two underlying processes: recollection and familiarity. We measured recollection with receiver-operating characteristic (ROC) data and remember-know judgments. Under standard remember-know instructions, the two estimates of recollection diverged. When subjects were told they might need to justify theirremember responses to the experimenter, the two estimates were more likely to agree. The data support the conclusion thatremember responses are generally based on a continuous underlying process but that specific task instructions can produce data that appear consistent with a high-threshold recollective process. Models based on signal detection theory provide a better account of these data than does the dual-process model (Yonelinas, 1994) or process-pure interpretations.     

熟悉性与回想分离的新证据

人们常常发现自己对某一情景有些熟悉, 但又想不起以前有关的经历。对这种熟悉感的理论解释, 一种观点认为熟悉感来自一种较弱的记忆形式, 与有回忆情况下的再认属于同一加工过程(single-process models, SPM)。另一种观点则认为, 熟悉感来自一种基于熟悉性的再认, 与基于回想的再认相互独立(dual-process theories, DPT)。在实验室, 评估熟悉性与回想是否相互独立的基本方法是寻找两者分离的证据。本文尝试梳理无线索回忆再认(recognition without cued recall, RWCR)范式的研究, 结果显示：熟悉性对某种特殊的概念加工和整体特征的知觉加工要比回想更加敏感, 并没有支持SPM关于回想和熟悉性各自对意义加工和局部特征的知觉加工更加敏感的推断。而且RWCR研究还观测到熟悉性与回想在行为和神经成像方面的实验性分离, 支持了DPT关于熟悉性与回想相互独立的推断。最后, 本文从熟悉性的深层机制和中英文材料对RWCR的不同影响出发, 对未来研究提出展望。     

Recollection and familiarity in recognition memory: adult age differences and neuropsychological test correlates

Dual process theories account for age-related changes in memory by proposing that old age is associated with deficits in recollection together with invariance in familiarity. The authors evaluated this proposal in recognition by examining recollection and familiarity estimates in young and older adults across 3 process estimation methods: inclusion/exclusion, remember/know, and receiver operating characteristics (ROC). Consistent with a previous literature review (Light, Prull, LaVoie, & Healy, 2000), the authors found age invariance in familiarity when process estimates were derived from the inclusion/exclusion method, but the authors found age differences favoring the young when familiarity estimates were derived from the remember/know and ROC methods. Recollection estimates were lower for older adults in all 3 methods. Recollection and familiarity had variable relationships with frontal- and temporal-lobe measures of neuropsychological functioning in older adults, depending on which method was used to generate process estimates. These data suggest that although recollection deficits appear to be the rule in aging, not all estimates of familiarity show age invariance.     

Production benefits both recollection and familiarity

In three experiments, we investigated the roles of recollection and familiarity in the production effect—the finding that words read aloud are remembered better than words read silently. Experiment 1, using the remember/know procedure, and Experiment 2, using the receiver operating characteristic procedure, converged in demonstrating that production enhanced both recollection and familiarity. Experiment 3 supported the role of recollection by demonstrating that specific episodic information—that is, whether a word had been studied aloud or silently—was stronger for items studied aloud. These findings fit with an explanation of the production effect as hinging on two factors: greater recollection of distinctive information from the study episode, and more familiarity due to greater attention allocated to the material studied aloud.     

An evaluation of recollection and familiarity in Alzheimer’s disease and mild cognitive impairment using receiver operating characteristics

There is a need to investigate exactly how memory breaks down in the course of Alzheimer’s disease (AD). Examining what aspects of memorial processing remain relatively intact early in the disease process will allow us to develop behavioral interventions and possible drug therapies focused on these intact processes. Several recent studies have worked to understand the processes of recollection and familiarity in patients with mild cognitive impairment (MCI) and very mild AD. Although there is general agreement that these patient groups are relatively unable to use recollection to support veridical recognition decisions, there has been some question as to how well these patients can use familiarity. The current study used receiver operating characteristic (ROC) curves and a depth of processing manipulation to understand the effect of MCI and AD on the estimates of recollection and familiarity. Results showed that patients with MCI and AD were impaired in both recollection and familiarity, regardless of the depth of encoding. These results are discussed in relation to disease pathology and in the context of recent conflicting evidence as to whether familiarity remains intact in patients with MCI. The authors highlight differences in stimuli type and task difficulty as possibly modulating the ability of these patients to successfully use familiarity in support of memorial decisions.