An attempt to condition components of urine formation in dogs

Previous research on the renal conditional reflex (CR) has resulted in contradictory data. The work of Bykov with dogs and of Hoferet al. with humans indicated that a renal CR is possible, but the experiments of Corsonet al. and Watt and Gantt with dogs having normal or transplanted cervical kidneys showed no clear-cut renal CR’s. The present work supports the latter finding. Three female mongrel dogs were used. One dog (normal) had an externalized ureter; the other two (experimental) had denervated cervical kidneys (autografts). In 155 days of experiments, the investigators found diuresis to occur only on unconditional stimulus,i.e., only when a dog drank diluted milk (one part milk to four parts water)ad lib.; the dogs drank an average of between 500 and 1,100 ml. No diuresis occurred when 30 ml. of the mixture were given (conditional stimulus). Urinalysis indicated a lack of renal conditioning with respect to the excretion rates and the concentrations of creatinine and electrolytes, except for the sodium concentration in the normal dog’s urine, which decreased on bothad lib and test (30 ml) days; the volume was not affected. Conclusion: Drinking a small quantity of diluted milk as a conditional stimulus did not produce a conditional diuretic response either in the normal dog or in the two dogs with transplanted kidneys.     

Effect of dopamine on diuresis and its role in forming a renal CR

Four female mongrel dogs were used. Three had both ureters transplanted to the surface of the abdomen and one had a unilateral nephrectomy on the left and the right ureter transplanted to the abdomen. In dogs with externalized ureters our results with dopamine show changes in cardiac rate and renal secretion. The method used was 1) injection of dopamine, 2) measurement of subsequent changes in renal secretions (unconditional reflex), 3) and heart rate (HR). After 40 daily injections im of 2.5 mg/kg in normal saline the possible production of a diuretic CR was tested by injecting normal saline im and a tone was used as a signal. The control for normal saline showed no change in HR nor any of the constituents measured. The dopamine injection resulted in an increase of epinephrine in the urine of 300–600 per cent for 45 minutes; of norepinephrine of 200–500 per cent for 45 minutes; of an increase of 50 per cent in urine volume for 45 or more minutes; of absolute Na secretion of 49 per cent, of K, 20 per cent; of creatinine, 39 per cent (average in 3 dogs for 45 minutes diuresis). When the conditional stimulus (normal saline and tone) was given after several months training with the conditional signal and the injection of dopamine, there was no significant CR change to the HR nor any of the above components of urine. The conclusion is that in spite of the great increase of urine volume and composition of above substances there was no significant increase to the signals for the im injection of dopamine,i.e., no conditioning to dopamine.     

Immobility experiments with dogs of the Arkansas Line of Nervous Pointers

As demonstrated in four experiments, dogs and pups of the Arkansas Line of Nervous Pointers, in contrast to kennel-mate dogs of the normal line, respond to manual inversion and brief restraint in an open sling with prolonged, mainly hypertonic, immobility. This response is consistent and replicable. At least in 4-month-old pups, the duration of sling immobility is positively correlated with the degree of behavioral pathology as determined by the objective Human Interaction Test. We found no evidence of basic difference between upright freezing and supine immobility.     

Reduction of anxiety in genetically timid dogs

In behavior studies of genetically timid and normal dogs it was possible to focus on nervous non-performing animals in a search for agents which might attenuate the overriding anxiety which causes these animals to become rigid, aversive-avoiding or bizarre in the presence of humans. Of the drugs tested, chlordiazepoxide (Librium, Roche), 75 to 200 mg per dog per day, was most effective in alleviating the anxious condition. Sometimes the drug had the effect of getting the animal over a “threshold” so that he continued to perform (bar-pressing) indefinitely after once started through the aid of chlordiazepoxide. This is considered an example of both schizokinesis and autokinesis which Gantt first described and associated with drug action utilizing conditional response techniques.     

Learning deficits and activity changes: A partial laboratory model in postencephalitic rats for studies of brain damage

Rats ranging from 8–21 days of age were inoculated in the right cerebral hemisphere with St Louis encephalitis virus, Japanese B encephalitis virus, Murray Valley encephalitis virus. Mumps virus however, was injected at age one day. When very young rats were injected with these viral preparations, fatal encephalitis usually developed. Rats injected at ages of more than two weeks showed little or no clinical signs of infection. When inoculated at ages between these extremes, clinical disease developed in most rats but many survived. Physically most of these surviving animals appeared to be normal, but when tested at maturity in a rather complex maze, they showed a marked reduction in learning ability. Tilting-cage-type activity measurements taken overnight with the Murray Valley encephalitis group also indicated that most of the postinfectious rats were hyperactive. These data imply that such a laboratory model might be related to similar hyperactivity and learning disabilities seen in certain types of minimally brain damaged children. A viral-sex interaction often seen in earlier studies is also noted in our animals injected at younger ages.     

The frequency of excess success for articles in Psychological Science

Recent controversies have questioned the quality of scientific practice in the field of psychology, but these concerns are often based on anecdotes and seemingly isolated cases. To gain a broader perspective, this article applies an objective test for excess success to a large set of articles published in the journal Psychological Science between 2009 and 2012. When empirical studies succeed at a rate much higher than is appropriate for the estimated effects and sample sizes, readers should suspect that unsuccessful findings have been suppressed, the experiments or analyses were improper, or the theory does not properly account for the data. In total, problems appeared for 82 % (36 out of 44) of the articles in Psychological Science that had four or more experiments and could be analyzed.     

Validity of two measures of anxiety in children

The State-Trait Anxiety Inventory for Children (STAICj and the Children's Manifest Anxiety Scale (CMAS) were administered to 60 emotionally disturbed children and 60 normal children matched on mental age. Emotionally disturbed children obtained significantly higher scores on the A-State and A-Trait portions of the STAIC and the anxiety portion of the CMAS, while normal children obtained significantly higher scores on the Lie scale of the CMAS. Cutoff scores which maximized the discrimination between normal and emotionally disturbed children were established. Results are interpreted as demonstrating the potential usefulness of these measures for screening.     

Exogenous spatial precuing reliably modulates object processing but not object substitution masking

Object substitution masking (OSM) is used in behavioral and imaging studies to investigate processes associated with the formation of a conscious percept. Reportedly, OSM occurs only when visual attention is diffusely spread over a search display or focused away from the target location. Indeed, the presumed role of spatial attention is central to theoretical accounts of OSM and of visual processing more generally (Di Lollo, Enns, & Rensink, Journal of Experimental Psychology: General 129:481–507, 2000). We report a series of five experiments in which valid spatial precuing is shown to enhance the ability of participants to accurately report a target but, in most cases, without affecting OSM. In only one experiment (Experiment 5) was a significant effect of precuing observed on masking. This is in contrast to the reliable effect shown across all five experiments in which precuing improved overall performance. The results are convergent with recent findings from Argyropoulos, Gellatly, and Pilling (Journal of Experimental Psychology: Human Perception and Performance 39:646–661, 2013), which show that OSM is independent of the number of distractor items in a display. Our results demonstrate that OSM can operate independently of focal attention. Previous claims of the strong interrelationship between OSM and spatial attention are likely to have arisen from ceiling or floor artifacts that restricted measurable performance.     

Schilder and Pavlov’s theory of higher nervous activity

In the late 1920s, the Viennese psychoanalyst Paul Schilder, after performing a conditioning experiment with human subjects, criticized I. P. Pavlov’s concept of “experimental neurosis.” Schilder maintained that subjective reports by conditioned human subjects were more informative than the objectively observed behavior of conditioned dogs. In 1932, Pavlov published a rejoinder to Schilder’s critique in theJournal of the American Medical Association. Pavlov maintained that Schilder misunderstood the value and implications of the scientific, objective method in the study of experimental neurosis. In 1934, Schilder subjected Pavlov’s theory of higher nervous activity to an incisive critique in a 1935 article inImago. Schilder objected to Pavlov’s narrow, reductionist conceptualization of the conditional reflex. Schilder reiterated his view that the psychological, subjective explanation of the conditional reflex is preferable to the physiological, objective explanation, and that the inference of cortical phenomena from experimental findings might be improper. Neither Pavlov nor any of his disciples replied to Schilder. The author provides an apology for the Pavlovian position, suggesting that Schilder was unfamiliar with early and late writings of Pavlov.     

Rethinking Medical Humanities

This paper questions different conceptions of Medical Humanities in order to provide a clearer understanding of what they are and why they matter. Building upon former attempts, we defend a conception of Medical Humanities as a humanistic problem-based approach to medicine aiming at influencing its nature and practice. In particular, we discuss three main conceptual issues regarding the overall nature of this discipline: (i) a problem-driven approach to Medical Humanities; (ii) the need for an integration of Medical Humanities into medicine; (iii) the methodological requirements that could render Medical Humanities an effective framework for medical decision-making.     

A cluster-analytically derived typology: Feasible alternative to clinical diagnostic classification of children?

Despite numerous studies of the relationships among symptoms manifested by children and adolescents, there have been few systematic attempts to group individuals on the basis of the syndromes identified. In the course of a treatment evaluation project requiring classification of both child patients and untreated controls, the present study was conducted to determine whether replicable types of children and adolescents could be identified by the cluster analysis of their IJR Behavior Checklist profiles. One clinical sample (N=185) and two mixed clinical and normal subsamples (Ns of 358 and 373) were cluster-analyzed separately. Seven types that replicated across at least two subsamples were identified: (1) High Assets, Flat Symptom Profile; (2) Sociopathic, Academic Problems; (3) Moderate Assets, Egocentric, Incontinent; (4) Insecure, Somaticizing, Underachieving; (5) Aggressive, Overreactive; (6) Schizoid, Withdrawn, Anxious, Bizarre; and (7) Diffuse, Mixed Pathology. The issue posed by the title of the article was explored in the light of the findings.     

A Cross-Sectional and Longitudinal Investigation of the External Correlates of Sluggish Cognitive Tempo and ADHD-Inattention Symptoms Dimensions

The objective was to determine if the external correlates of sluggish cognitive tempo (SCT) and ADHD-inattention (IN) dimensions were the same in cross-sectional and longitudinal analyses. Teachers and aides rated SCT, ADHD-IN, ADHD-hyperactivity/impulsivity (HI), oppositional defiant disorder (ODD), and depression along with academic impairment in 758 Spanish children (55 % boys) on three occasions (twice at the end of the first grade year [6-week separation] and then again 12-months later at the end of the second grade year). Three of eight SCT symptoms showed substantial loadings on the SCT factor and substantially higher loadings on the SCT factor than the ADHD-IN factor for teachers and aides at each assessment (seems drowsy, thinking is slow, and slow moving). Cross-sectional and longitudinal analyses yielded similar results with SCT and ADHD-IN factors having different and unique external correlates (higher scores on SCT predicted lower scores on ADHD-HI and ODD while higher scores on ADHD-IN predicted higher scores on ADHD-HI and ODD with SCT and ADHD-IN both uniquely predicting academic impairment and depression). Developmental and methodological reasons are discussed for the failure to find an inconsistent alertness SCT factor (daydreams, alertness fluctuates, absent-minded, loses train of though, and confused).     

Commentary on Wolford,Taylor, and Beck: The conjunction fallacy?

AlthoughP(A&B|X) can never exceedP(A|X) (the conjunction rule), it is possible forP(X|A&B) to exceedP(X|A). Hence, people who rankA&B as more probable thanA are not necessarily violating any normative rule if the ranking is done in terms of the probability of these events to yield an eventX. Wolford, Taylor, and Beck (1990) have argued that this indeed is what happens in some problems (e.g. Tversky& Kahneman’s [1983] Linda problem). The claim made here is that the Linda problem is hard to reconcile with this interpretation; that there is little if any evidence that subjects utilize this interpretation; and that in any case, representativeness can account for all Linda problem results.     

Seeing two faces together: preference formation in humans and rhesus macaques

Humans, great apes and old world monkeys show selective attention to faces depending on conspecificity, familiarity, and social status supporting the view that primates share similar face processing mechanisms. Although many studies have been done on face scanning strategy in monkeys and humans, the mechanisms influencing viewing preference have received little attention. To determine how face categories influence viewing preference in humans and rhesus macaques (Macaca mulatta), we performed two eye-tracking experiments using a visual preference task whereby pairs of faces from different species were presented simultaneously. The results indicated that viewing time was significantly influenced by the pairing of the face categories. Humans showed a strong bias towards an own-race face in an Asian–Caucasian condition. Rhesus macaques directed more attention towards non-human primate faces when they were paired with human faces, regardless of the species. When rhesus faces were paired with faces from Barbary macaques (Macaca sylvanus) or chimpanzees (Pan troglodytes), the novel species’ faces attracted more attention. These results indicate that monkeys’ viewing preferences, as assessed by a visual preference task, are modulated by several factors, species and dominance being the most influential.     

Poor communication in psycholinguistics: Review of four new textbooks

Four new textbooks on psycholinguistics are reviewed:Psycholinguistics: A Cognitive View of Language by H. S. Cairns and C. E. Cairns;Experimental Psycholinguistics by S. Glucksberg and J. H. Danks;Psycholinguistics: Introductory Perspectives by J. F. Kess, andIntroduction to Psycholinguistics by I. Taylor. Three general issues about psycholinguistics are considered in detail: (1) Psycholinguists should attempt to provide psychological tests of competing linguistic theories. (2) More attention should be given by psycholinguists to the work done in the field of human information processing. (3) There is evidence for the Whorfian hypothesis, even in its strong version, at the phonetic level of language. It is concluded that improvement is needed in the communication between psycholinguistics and related disciplines and among the subdivisions of psycholinguistics.     

Relations among regular and irregular morphologically related words in the lexicon as revealed by repetition priming

Several experiments examined repetition priming among morphologically related words as a tool to study lexical organization. The first experiment replicated a finding by Stanners, Neiser, Hernon, and Hall (Journal of Verbal Learning and Verbal Behavior, 1979,18, 399-412), that whereas inflected words prime their unaffixed morphological relatives as effectively as do the unaffixed forms themselves, derived words are effective, but weaker, primes. The experiment also suggested, however, that this difference in priming may have an episodic origin relating to the less formal similarity of derived than of inflected words to unaffixed morphological relatives. A second experiment reduced episodic contributions to priming and found equally effective priming of unaffixed words by themselves, by inflected relatives, and by derived relatives. Two additional experiments found strong priming among relatives sharing the spelling and pronunciation of the unaffixed stem morpheme, sharing spelling alone, or sharing neither formal property exactly. Overall, results with auditory and visual presentations were similar. Interpretations that repetition priming reflects either repeated access to a common lexical entry or associative semantic priming are both rejected in favor of a lexical organization in which components of a word (e.g., a stem morpheme) may be shared among distinct words without the words themselves, in any sense, sharing a “lexical entry.”     

Causal Decision Theory and EPR correlations

The paper argues that on three out of eight possible hypotheses about the EPR experiment we can construct novel and realistic decision problems on which (a) Causal Decision Theory and Evidential Decision Theory conflict (b) Causal Decision Theory and the EPR statistics conflict. We infer that anyone who fully accepts any of these three hypotheses has strong reasons to reject Causal Decision Theory. Finally, we extend the original construction to show that anyone who gives any of the three hypotheses any non-zero credence has strong reasons to reject Causal Decision Theory. However, we concede that no version of the Many Worlds Interpretation (Vaidman, in Zalta, E.N. (ed.), Stanford Encyclopaedia of Philosophy 2014) gives rise to the conflicts that we point out.     

Generality of a congruity effect in judgements of relative order

The judgement of relative order (JOR) procedure is used to investigate serial-order memory. Measuring response times, the wording of the instructions (whether the earlier or the later item was designated as the target) reversed the direction of search in subspan lists (Chan, Ross, Earle, & Caplan Psychonomic Bulletin & Review, 16(5), 945–951, 2009). If a similar congruity effect applied to above-span lists and, furthermore, with error rate as the measure, this could suggest how to model order memory across scales. Participants performed JORs on lists of nouns (Experiment 1: list lengths = 4, 6, 8, 10) or consonants (Experiment 2: list lengths = 4, 8). In addition to the usual distance, primacy, and recency effects, instructions interacted with serial position of the later probe in both experiments, not only in response time, but also in error rate, suggesting that availability, not just accessibility, is affected by instructions. The congruity effect challenges current memory models. We fitted Hacker’s (Journal of Experimental Psychology: Human Learning and Memory, 6(6), 651–675, 1980) self-terminating search model to our data and found that a switch in search direction could explain the congruity effect for short lists, but not longer lists. This suggests that JORs may need to be understood via direct-access models, adapted to produce a congruity effect, or a mix of mechanisms.     

General and Domain-Specific Effectiveness of Cognitive Remediation after Stroke: Systematic Literature Review and Meta-Analysis

Cognitive remediation (CR) has been shown to improve cognitive abilities following a stroke. However, an updated quantitative literature review is needed to synthesize recent research and build understanding of factors that may optimize training parameters and treatment effects. Randomized controlled trials of CR were retrieved from seven electronic databases. Studies specific to adult stroke populations were included. Treatment effects were estimated using a random effects model, with immediate and longer-term follow-up outcomes, and moderator effects, examined for both overall and domain-specific functioning. Twenty-two studies were identified yielding 1098 patients (583 in CR groups). CR produced a small overall effect (g?=?0.48, 95% CI 0.35–0.60, p?<?0.01) compared with control conditions. This effect was moderated by recovery stage (p?<?0.01), study quality (p?=?0.04), and dose (p?=?0.04), but not CR approach (p?=?0.63). Significant small to medium (g?=?0.25–0.75) post-intervention gains were evident within each individual outcome domain examined. A small overall effect (g?=?0.27, 95% CI 0.04–0.51, p?=?0.02) of CR persisted at follow-up (range 2–52 weeks). CR is effective and efficient at improving cognitive performance after stroke. The degree of efficacy varies across cognitive domains, and further high-quality research is required to enhance and sustain the immediate effects. Increased emphasis on early intervention approaches, brain-behavior relationships, and evaluation of activity and participation outcomes is also recommended.