An inquiry into the problem of evil

Paper presented as the invited keynote address at the Society of Clinical Psychologists of Chile Annual Conference, Santiago, Chile, November, 1992.     

An inquiry into the process of temporal orientation.

A recent study (Koriat and Fischhoff 1974) in which subjects were asked to respond to the question ‘What day is today?’ revealed ease of day retrieval to be a curvilinear function of the day of the week, with greatest difficulty being encountered in midweek. Data suggested a twostage model for the day retrieval process, with the weekend serving as a facilitating ‘landmark.’ It was unclear whether these results were due to the day on which the subject was questioned or to the day label which he was requested to produce, the two being completely confounded. In the present experiment, subjects at each of the six working days of two weeks were presented with questions of the form ‘Is today …?’ until 12 correct RT's were obtained for each Actual Day—Proposed Day combination. Major results include significant quadratic effects for Actual Day, Proposed Day and Actual Day—Proposed Day temporal distance; greater latencies for acceptance (‘yes, today is…’) than rejection responses; and details of the weekend effect. The nature of temporal orientation and the role of landmarks are discussed as well as the specifics of the day label retrieval and day label evaluation processes.     

Social isolation stress-induced aggression in mice: a model to study the pharmacology of neurosteroidogenesis

Long-term social isolation of laboratory animals is a model to study the behavioral and neurochemical consequences of the absence of social interaction in rodents. Many of the symptoms induced by isolation resemble depression and anxiety disorder symptomatology. Our studies have revealed that male mice socially isolated for more than 4 weeks, exhibit increased aggressiveness, a reduced responsiveness to GABA(A) receptor acting drugs, and a downregulation of brain levels of 3alpha,5alpha-tetrahydroprogesterone (allopregnanolone: 3alpha,5alpha-THP), a neurosteroid endowed with potent positive allosteric modulatory activity of the action of GABA at various GABA(A) receptor subtypes. This downregulation of 3alpha,5alpha-THP appeared to be associated with the reduction of brain type I 5alpha-reductase mRNA and protein expression. Systemic administration of the selective serotonin reuptake inhibitor fluoxetine and its metabolite norfluoxetine normalized brain 3alpha,5alpha-THP content and reduced responsiveness to GABA(A) mimetic drugs in a stereospecific manner. These drugs in nanomolar doses also reduced social isolation-induced aggressiveness with the same stereospecificity as detected in their action on 3alpha,5alpha-THP brain content, while their ex vivo inhibition of serotonin reuptake occurred at high micromolar doses and lacked stereospecificity. From these results we infer that the brain 3alpha,5alpha-THP content physiologically upregulates GABA(A) receptor responsiveness to GABA and that social isolation induces a reduction of brain 3alpha,5alpha-THP content that is probably causally related to the onset of aggression.     

An experimental inquiry into transference roles and age

In this psychotherapy analogue investigation, the effects of client age and therapist age on transference-like projections onto therapists were examined. Young (25-35) and older (60-70) pseudoclients compared paraprofessional therapists to significant figures in their own lives after a dyadic "helping" interview. The results provide empirical support for the phenomenon of reverse transference in therapy with older patients. Older clients were more inclined than young clients to view therapists, particularly younger therapists, as similar to their children. Young clients more willingly attributed parental qualities to older therapists. Both old and young clients may see therapists more as peers or friends than as family members.     

Pain‐induced aggression and changes in social behavior in mice

The effects of neuropathic, formalin, and acetic acid‐induced visceral pain were investigated on the social and aggressive behaviors in the Swiss male mice. Neuropathic pain was induced by tibial nerve transection (TNT). Also, somatic and visceral pain was conducted by intraplantar injection of diluted formalin (1%, 20 μl) and intraperitoneal administration of acetic acid (0.6%, 200 μl), respectively. Fourteen and twenty one days after the TNT surgery, and also, 1 and 7 days following formalin and acetic acid administration, the three‐chambered test was used to determine sociability and preference for social novelty and resident/intruder test was used for the evaluation of the aggressive behaviors. In the sociability phase of the three‐chambered test, all the three models of pain did not change the animal's sociability. However, in the social novelty preference phase, the animals in pain showed deficits in social novelty preference by a significant increase in the time spent with the familiar mice compared to the control groups. Also, animals in pain significantly showed more aggressive behaviors like biting and clinching and have much less attack latency in comparison to the control groups. Pain‐induced changes in the social novelty preference and aggressive behaviors continued in the neuropathic group until the end of the experiment. However, 7 days following the induction of both formalin and visceral pain, animals' social memory, and aggression almost returned to the standard value. These results suggest that long‐lasting pain could lead to social memory impairment and increase aggressive behaviors in mice.     

An empirically derived scoring system for intermale aggression in mice

Scoring systems used to assess intermale aggression have been characterized by arbitrary scales and wide variability in the behaviors selected for measurement. The use of such different systems severely limits the ability of investigators to make meaningful comparisons among studies and indicates that there is a need for a common, statistically derived evaluative system for intermale aggression. We measured the frequency and duration of five major components of agonistic behavior exhibited by intact males toward olfactory bulbectomized stimulus males and then analyzed the data using a number of univariate and multivariate procedures. The results were used to generate two statistically based scoring systems, one a short-form index and the other a composite index for more detailed studies of aggression. It is hoped that these statistically derived systems will be adopted by other investigators to increase methodological congruence in the field.     

An inquiry into the construct validity of the Vividness of Visual Imagery Questionnaire

The construct validity of the Vividness of Visual Imagery Questionnaire (VVIQ) was investigated using a series of visual memory tasks. Subjects were shown a picture after completing the questionnaire. Their ability to recall that picture was probed through a free-recall procedure, drawing, two spatial-recall tasks, and a multiple-choice questionnaire. Scores on the VVIQ were statistically unrelated to performance on any of the memory tasks demonstrating a lack of support for construct validity as a measure of visual memory imagery.     

Abduction and metaphor: An inquiry into common cognitive mechanism

Abduction and metaphor are two significant concepts in cognitive science. It is found that the both mental processes are on the basis of certain similarity. The similarity inspires us to seek the answers to the following two questions: (1) Whether there is a common cognitive mechanism behind abduction and metaphor? And (2) if there is, whether this common mechanism could be interpreted within the unified frame of modern intelligence theory? Centering on these two issues, the paper attempts to characterize and interpret the generation and evolution of scientific metaphors from the perspective of the cognitive mechanism of abductive inference. Then it interprets the common cognitive mechanism behind abduction and metaphor within Hawkins’ frame of intelligence theory. The commonality between abduction and metaphor indicates the potential to further explore human intelligence.     

Predatory aggression in lines of wild mice selected for interfemale aggression

Mice descending from lines previously selected for high and low levels of interfemale aggression and from a nonselected control line were exposed to live crickets on two consecutive test days. Latencies both to attack and to eat the cricket were recorded. No line or sex differences in attacking were found, although latency to attack decreased over test days. Control line mice were more likely to engage in the eating of the cricket than either the high or low selected lines, suggesting that the selection procedure may have dissociated attacking and eating components of predatory behavior.