干预胆碱M受体对药物成瘾的影响及其与多巴胺的关系

药物成瘾是一类精神及行为障碍, 涉及到中枢神经系统的病变。毒蕈碱受体(Muscarinic receptor, M受体)属于胆碱能受体, 分5种亚型。行为学研究表明, 干预M受体能有效影响药物成瘾行为, 但其神经机制还亟待探索。阿片类药物与精神活性药物均能激活中枢多巴胺系统, 而M受体与多巴胺系统在多个脑区产生了交互作用。其中激动M2及M4受体抑制了多巴胺系统功能, 而激动M5受体增强了多巴胺系统功能, 与干预M2、M4、M5受体对药物成瘾行为的影响相对应。以上证据提示, 干预M受体可能通过影响多巴胺系统对药物成瘾起作用。     

The precise time course of lexical activation: MEG measurements of the effects of frequency, probability, and density in lexical decision

Visually presented letter strings consistently yield three MEG response components: the M170, associated with letter-string processing (Tarkiainen, Helenius, Hansen, Cornelissen, & Salmelin, 1999); the M250, affected by phonotactic probability, (Pylkk?nen, Stringfellow, & Marantz, 2002); and the M350, responsive to lexical frequency (Embick, Hackl, Schaeffer, Kelepir, & Marantz, 2001). Pylkk?nen et al. found evidence that the M350 reflects lexical activation prior to competition among phonologically similar words. We investigate the effects of lexical and sublexical frequency and neighborhood density on the M250 and M350 through orthogonal manipulation of phonotactic probability, density, and frequency. The results confirm that probability but not density affects the latency of the M250 and M350; however, an interaction between probability and density on M350 latencies suggests an earlier influence of neighborhoods than previously reported.     

Mental Causation is Not Just Downward Causation

According to a popular model of mental causation, an irreducible mental cause M1 brings about an irreducible mental effect M2 by bringing about M2's supervenience base (ground, realizer, etc.), P2. Call this ‘the Downward Causation View’. This paper raises doubts about the Downward Causation View on grounds that M1 does not cause M2 immediately and there is no causal chain from M1 to M2. Prima facie, then, M1 does not cause M2 on this view. But a theory of mental causation ought to account for how some mental phenomena cause other mental phenomena; so rival theories are to be preferred. After setting out the problem, I consider replies; all fail. 1     

Teacher Versus Peer Models

Female Ss (N=80) observed either a teacher or a peer model (M) demonstrate a motor task with either high or low performance ability. The effects’ of viewing these live performances on S’s subsequent motor performances were examined. After the observation of M, S’s performance in the presence or absence of the observed M was investigated. A Control Group consisting of 20 Ss, viewing no M, was compared to ail other groups for analysis. Results of the M Type × M’s Ability Level × M Presence design indicated that those in the Control Group had significantly lower performances than all other groups on all blocks of trials. In addition, across all trial blocks, S’s performances were enhanced subsequent to having viewed a skillful teacher M. Upon observing M’s demonstration, Ss exhibited increased matching responses and better performances when performing in the presence of M.     

Male/Female Gaze in Same-Sex and Mixed-Sex Dyads Gender-Linked Differences and Mutual Influence

In this study, 108 university students (54 men and 54 women) were each videotaped in two 8-minute problem-solving dyadic interactions: (1) same-sex, and (2) mixed-sex. Trained observers coded the interactions for simultaneous, moment-to-moment gaze and talk behavior of both interactants. MANOVA results for three dyad types (male/male, female/female, and male/female) measured on 10 dyad gaze/talk variables showed that F/F dyads exhibited more mutual gaze/mutual talk and mutual gaze/mutual silence than either M/M or M/F dyads. F/F dyads exhibited less one gazes/same talks and mutual avert/one talks than either M/M or M/F dyads. No differences were found between M/M and M/F dyads on any variable. Analyses of individual change scores from same-sex to mixed-sex dyads indicated that the women in the M/F dyads converged to the male behavior in that dyad condition, whereas the men remained unchanged. The results are discussed in terms of speech accommodation theory.     

Addressing the needs of new mothers in a multi-cultural setting: an evaluation of home visiting support for new mothers – Mom to Mom (Negev)

This study evaluated the Mom to Mom (M2M) program operating in the Negev region of Israel, an area with a high proportion of immigrants. M2M helps women cope with the first year of parenting through home visits of volunteer mothers. Specific objectives were to evaluate (1) Participants’ motivations for joining M2M; (2) Gains from participation; and (3) The effect of participation on post-partum depression (PPD). Three stages included (1) Analysis of demographics of all 440 mothers in M2M; (2) A telephone survey of 51 mothers to assess gains from participation; and (3) 137 mothers filled out the Edinburgh Post-Natal Depression Scale (EPDS) and were followed for one year. Most mothers in M2M were first time mothers, with a high rate of perinatal complications (54.4%) and positive EPDS scores (38.7%). Two major reasons for participation were being an immigrant and having low income. The greatest gains from home visits were increased self-confidence, improved parenting skills and communication with the partner. Seventy-nine percent of mothers with PPD symptoms were functioning at work and at home after a year from joining the program. Our findings suggest that M2M has the capacity to address challenges in the post-natal period among women from diverse cultures.     

Item-specific adaptation and the conflict-monitoring hypothesis: a computational model

M. M. Botvinick, T. S. Braver, D. M. Barch, C. S. Carter, and J. D. Cohen (2001) implemented their conflict-monitoring hypothesis of cognitive control in a series of computational models. The authors of the current article first demonstrate that M. M. Botvinick et al.'s (2001) conflict-monitoring Stroop model fails to simulate L. L. Jacoby, D. S. Lindsay, and S. Hessels's (2003) report of an item-specific proportion-congruent (ISPC) effect in the Stroop task. The authors then implement a variant of M. M. Botvinick et al.'s model based on the assumption that control must be able to operate at the item level. This model successfully simulates the ISPC effect. In addition, the model provides an alternative to M. M. Botvinick et al.'s explanation of the list-level proportion-congruent effect in terms of an ISPC effect. Implications of the present modeling effort are discussed.     

Reviews

F ordham , M ichael . Explorations into the Self
R edpearn , J oseph . My Self, My Many Selves
H obson , R obert F. Forms of Feeling: the Heart of Psychotherapy
C asement , P atricia . On Learning from the Patient
S hepherd , M ichael . Sherlock Holmes and the Case of Dr Freud
A bend , S. M., P order , M. S., W illick , M. S. Borderline Patients: Psychoanalytic Perspectives
V an H erik , J udith . Freud on Femininity and Faith     

Texture-Based Methods for Analyzing Elementary Visual Substances

Human vision is generally assumed to embody a limited number of low-level, spatially parallel image transformations. These transformations define the basic properties vision can sense. Because texture discrimination tasks require rapid, spatially parallel processing, they are ideally suited to investigate these basic transformations. Here it is shown how to use paired comparison texture tasks to functionally analyze such transformations. Tasks are considered in which the observer is presented with two patches of texture, A and B, tiled with micropatterns drawn from a set Omega, and is asked to judge which is greater, M(A) or M(B), for some specific texture property M (e.g., M(A) might be the intensity variance of patch A). Performance is modeled by supposing that the observer approximates M(A) and M(B) by noisy, subjective quantities,;M(A) and;M(B), synthesized from the basic transformations resident in human vision. Psychophysical methods are provided for determining the differential impact on;M of the various micropatterns in Omega. Specifically, an occurrence in patch A (similarly for patch B) of a given micropattern omegainOmega is assumed to contribute an independent, additive random variable X(omega) to;M(A). The mean m(omega) of X(omega) gives the average impact on;M(A) of an occurrence of omega. It is assumed that the observer judges M(A)>M(B) on a given trial if;M(A)-;M(B)+Y>0, for Y a normal random variable with mean zero and unspecified variance. Simple, efficient techniques are provided for accurately estimating the shape of the function m: Omega-->ℝ, which defines the impacts of different micropatterns on M-judgments. These methods yield results that are invariant with respect to all unmeasured model parameters. MATLAB code is supplied for data analysis. Copyright 1999 Academic Press.     

Spatial disinhibition of orientation analyzers

Following the successive presentation of two masking gratings (M1 and M2), subjects were required to detect the presence or absence of a single vertical line (TS). When the orientations of the two masks were optimal, M1 was able to reduce the masking effect of M2 on the TS. For a vertical TS, disinhibition was maximal when the orientations of M1 and M2 were similar and was minimal when the orientational difference was greater than 15 deg. It is suggested that the spatial selectivity of the disinhibition function reflects the activity of neurons tuned to orientation, and that the disinhibition masking paradigm may be a useful psychophysical technique to measure tuning functions of other feature detectors.     

Current Assessment Practice,Personality Measurement,and Rorschach Usage by Psychologists

The hypothesis under evaluation was that persons giving a larger number of M responses (minimum 5) would show greater ease in expressing themselves creatively than a group of persons giving low M in the Rorschach (0 to 2). Groups were matched on variables of age, education, and socio-economic status. Twenty-two high M and 21 low M persons were tested for creative expression by means of written and verbal TAT, drawings and Lowenfeld Mosaic Designs. Ability to be creatively expressive for high as compared to low M Ss was very great, reaching significance levels beyond .001 on all tests. Flexor and extensor quality of M appeared to be unrelated to ease of creative expression.     

Effects of visual complexity and sublexical information in the occipitotemporal cortex in the reading of Chinese phonograms: a single-trial analysis with MEG

We employ a linear mixed-effects model to estimate the effects of visual form and the linguistic properties of Chinese characters on M100 and M170 MEG responses from single-trial data of Chinese and English speakers in a Chinese lexical decision task. Cortically constrained minimum-norm estimation is used to compute the activation of M100 and M170 responses in functionally defined regions of interest. Both Chinese and English participants’ M100 responses tend to increase in response to characters with a high numbers of strokes. English participants’ M170 responses show a posterior distribution and only reflect the effect of the visual complexity of characters. On the other hand, the Chinese participants’ left hemisphere M170 is increased when reading characters with high number of strokes, and their right hemisphere M170 is increased when reading characters with small combinability of semantic radicals. Our results suggest that expertise with words and the decomposition of word forms underlies processing in the left and right occipitotemporal regions in the reading of Chinese characters by Chinese speakers.     

Can Life Be Evaluated? The Jewish Halachic Approach vs. The Quality of Life Approach in Medical Ethics: A Critical View

In recent years there has been an increase in the number of requests formercy killings by patients and their relatives. Under certain conditions,the patient may prefer death to a life devoid of quality. In contrast to thosewho uphold this quality of life approach, those who hold the sanctity oflife approach claim that life has intrinsic value and must be preservedregardless of its quality. This essay describes these two approaches,examines their flaws, and offers a golden path between the two extremepositions.We discuss the halachic and the secular views, arguing for a balancebetween the sanctity of life and the quality of life. We argue that, indeed,such a balance exists in practice, and that life is important, but it is not sacred. Life can be evaluated, but quality of life is not the solecriterion.     

The effect of adaptation on taste jnds

The jnd for 0.1 M NaCl was measured under two different adapting conditions. Following adaptation to HOH the jnd was 0.009 M and after 0.1 M adaptation it was .018 M. The implications of this change in sensitivity with differing adaptation for Beidler’s theory are discussed.     

Finding locations in the environment: the map as mediator.

When an observer (O) uses a map (M) whose orientation does not correspond to the orientation of the environment (E) in which performance occurs, substantial errors occur: these are called map alignment effects. Much of the prior research on map/environment (M/E) alignment has involved maps of simple paths, although alignment effects have also been demonstrated for you-are-here (YAH) maps. A study is reported in which simple YAH maps were used to test the hypothesis that errors with misaligned maps would fall into categories predictable from the application of inappropriate cognitive operations to the misaligned maps, as demonstrated earlier by Rossano and Warren. Further, performance under conditions of M/E misalignment was compared with performance under map/observer (M/O) misalignment, the situation in which the map is sideways or upside-down with respect to the observer. The major hypothesis was supported: predictable errors occurred under conditions of M/E misalignment. Errors under conditions of M/O misalignment were significantly smaller. Furthermore, when given the choice of using M/E or M/O alignment, each at the expense of the other, the overwhelming choice was to retain M/E rather than M/O alignment. This pattern of results occurred even when environmental features were represented by words rather than by lines and shapes on the map. The results underscore the robustness of map alignment effects.     

Parental correlates of Rorschach human movement responses in children.

The meaning of the human movement response (M) to inkblot stimuli was explored in terms of correlations between children's M productions and the attributes of their parents in 119 familes. M scores were available for the family members; and for each parent there were also measures of personality, values, and childrearing attitudes. A number of the parent-child correlational patterns were congruent with Rorschach's theories concerning the significance of M.     

Severity of dysfluency correlates with basal ganglia activity in persistent developmental stuttering

Previous studies suggest that anatomical anomalies [Foundas, A. L., Bollich, A. M., Corey, D. M., Hurley, M., & Heilman, K. M. (2001). Anomalous anatomy of speech-language areas in adults with persistent developmental stuttering. Neurology, 57, 207-215; Foundas, A. L., Corey, D. M., Angeles, V., Bollich, A. M., Crabtree-Hartman, E., & Heilman, K. M. (2003). Atypical cerebral laterality in adults with persistent developmental stuttering. Neurology, 61, 1378-1385; Foundas, A. L., Bollich, A. M., Feldman, J., Corey, D. M., Hurley, M., & Lemen, L. C. et al., (2004). Aberrant auditory processing and atypical planum temporale in developmental stuttering. Neurology, 63, 1640-1646; Jancke, L., Hanggi, J., & Steinmetz, H. (2004). Morphological brain differences between adult stutterers and non-stutterers. BMC Neurology, 4, 23], in particular a reduction of the white matter anisotropy underlying the left sensorimotor cortex [Sommer, M., Koch, M. A., Paulus, W., Weiller, C., & Buchel, C. (2002). Disconnection of speech-relevant brain areas in persistent developmental stuttering. Lancet, 360, 380-383] could be at the origin of persistent developmental stuttering (PDS). Because neural connections between the motor cortex and basal ganglia are implicated in speech motor functions, PDS could also be associated with a dysfunction in basal ganglia activity [Alm, P. (2004). Stuttering and the basal ganglia circuits: a critical review of possible relations. Journal of Communication Disorders, 37, 325-369]. This fMRI study reports a correlation between severity of stuttering and activity in the basal ganglia and shows that this activity is modified by fluency shaping therapy through long-term therapy effects that reflect speech production improvement. A model of dysfunction in stuttering and possible repair modes is proposed that accommodates the data presented here and observations previously made by us and by others.     

Child Care in The Netherlands: Trends in Quality Over the Years 1995-2005

The authors assessed the quality of child care in a representative national sample of 42 child-care centers in the Netherlands and compared it with the quality of care that researchers have found using similar samples in 1995 (M. H. van IJzendoorn, L. W. C. Tavecchio, G. J. J. M. Stams, M. J. E. Verhoeven, & E. J. Reiling, 1998) and 2001 (M. J. J. M. Gevers Deynoot-Schaub & J. M. A. Riksen-Walraven, 2005). In the present study, results showed a low level of overall process quality for the 2005 sample, measured by the Infant/Toddler Environment Rating Scale-Revised (T. Harms, D. Cryer, & R. M. Clifford, 2003) and the Early Childhood Environment Rating Scale-Revised (T. Harms, R. M. Clifford, & D. Cryer, 1998). The present authors found a significant decline in process quality in comparison with the 1995 and 2001 findings. They concluded that, from an international perspective, the Netherlands has lost its leading position in child-care quality compared with that from 10 years ago.     

Genetic and environmental influences on individual differences in masculinity, femininity, and gender diagnosticity: analyzing data from a classic twin study

Analyzing data from Loehlin and Nichols's (1976) classic twin study, we computed measures of Masculine Instrumentality (M), Feminine Expressiveness (F), and Gender Diagnosticity (GD). Quantitative genetic modeling analyses of within-sex individual differences in M, F, and GD indicated that: (1) Additive genetic factors contribute significantly to individual differences in M, F, and GD. (2) The environmental effects on M, F, and GD tend to be nonshared. (3) The genetic and environmental components of individual differences in M, F, and GD tend not to show gender differences. Finally, (4) the estimated within-sex heritability of GD (.53) is significantly greater than the estimated within-sex heritabilities of either M (.36) or F (.38).     

BOOK REVIEWS

Women's Ways of Knowing: The Development of Self, Voice, and Mind , M ary F ield B elenky , B lythe M c V icker C linchy , N ancy R ule G oldbercer , and J ill M attuck T arule
Changing Our Minds: Feminist Transformations of Knowledge , S usan H ardy A iken , K aren A nderson , M yra D innerstein , J udy N olte , and P atricia M ac C orquodale (Eds.)
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Love Stories: Women, Men and Romance