激活右腹外侧前额叶提高抑郁症患者对社会疼痛的情绪调节能力：一项TMS研究

负性人际交往经历和负性社会事件是抑郁症的重要诱导因素, 而社会功能受损是抑郁症患者的重要特征之一, 患者通常表现出对社会疼痛的情绪失调。为了提高抑郁症患者在负性社交情境中或面对负性社会事件时的情绪调节能力, 本研究采用经颅磁刺激技术(transcranial magnetic stimulation, TMS), 考察抑郁症患者在腹外侧前额叶(the ventrolateral prefrontal cortex, VLPFC)被激活后其情绪调节能力的改变。结果表明, 当右侧VLPFC被TMS激活且患者采用认知重评策略调节情绪时, 实验组患者(n = 64)比对照组患者(n = 63)在社会排斥情境下报告了更弱的负性情绪体验, 这说明激活右侧VLPFC可以有效提高患者对社会疼痛的外显性情绪调节能力。本研究是采用TMS提高抑郁症患者情绪调节能力的首次尝试, 实验发现不但支持了VLPFC与认知重评策略的因果关系, 还为临床改善抑郁症等社会功能障碍患者的情绪调节能力提供了明确的神经治疗靶点。后续研究还需探讨多疗程TMS刺激方案、改变社会疼痛的诱发方式、对比左右侧VLPFC的治疗效果、尝试使用其他的情绪调节策略, 进一步验证本研究的结论, 优化TMS治疗方案。     

腹内侧前额叶在内隐认知重评中的因果作用

情绪调节对维持个体心理健康、适应社会生活十分重要, 然而以往研究主要关注外显情绪调节, 目前我们对内隐情绪调节的认知神经机制的了解还非常有限。为揭示内隐情绪调节的核心脑区, 本研究使用句子整理任务启动内隐认知重评, 并采用经颅直流电刺激(transcranial direct current stimulation, tDCS)激活内侧前额叶特别是腹内侧前额叶(ventromedial prefrontal cortex, vmPFC), 考察该脑区在内隐情绪调节中的因果作用。结果表明, vmPFC被激活的被试组(实验组, n = 40)在内隐认知重评启动条件下比tDCS伪刺激组(对照组, n = 40), 在观看负性图片时报告了更少的负性情绪, 同时负性图片诱发的晚正成分(late positive potential, LPP)波幅更低(LPP是情绪体验强度的客观指标)。同时, 实验组比对照组在观看负性图片时表现出更低的枕区P1波幅(P1为早期视觉注意程度的客观指标)。以上结果说明, 激活以vmPFC为代表的内侧前额叶不但能增强内隐情绪调节的效果, 还能减少被试对负性刺激的早期注意分配。本研究是采用tDCS技术考察启动引起的内隐情绪调节的首次尝试, 研究结果不但表明了以vmPFC为代表的内侧前额叶在内隐认知重评中的关键作用, 还为临床应用研究指出了增强内隐情绪调节能力的神经调控潜在靶点。     

背外侧前额叶在安慰剂效应中的作用：社会情绪调节研究

为考察安慰剂效应在情绪调节中的脑机制,本研究以社会排斥图片为情绪诱发材料诱发社会疼痛,采用经颅磁刺激技术(transcranialmagneticstimulation,TMS)激活背外侧前额叶(dorsolateralprefrontalcortex,DLPFC),并使用事件相关电位观测TMS对安慰剂下调社会疼痛的影响。实验以“TMS组别”(DLPFC组、控制组)为被试间变量,“安慰剂条件”(安慰剂、非安慰剂)为被试内因素。结果发现, DLPFC组(n=50)比控制组(n=50)在安慰剂条件下报告的负性情绪更弱,反映情绪体验强度的晚正成分的波幅也更低,上述组间差异在非安慰剂条件不显著。结果还表明,DLPFC组比控制组更相信安慰剂的效果,愿意花更多的钱来购买安慰剂。此外相关结果发现,由DLPFC激活导致的安慰剂效应增强可有效降低社交焦虑倾向被试的负性社会情绪。本研究是结合脑调控和脑观测技术探讨安慰剂情绪调节脑机制的首次尝试,研究发现不但揭示了DLPFC在安慰剂调节情绪过程中的重要因果作用,还为临床治疗以情绪失调为主要症状的抑郁焦虑等精神障碍患者提供了脑调控干预的可行性脑靶点。     

抑郁个体对社会反馈的加工：研究现状及存在问题

抑郁症伴随着严重的社会功能障碍。本文以“社会反馈”这一重要社会性信息为切入点,综述了抑郁症患者及抑郁倾向人群对社会反馈的体验、期待及情绪调节障碍的研究现状,发现抑郁个体对社会奖赏存在快感缺失,对社会排斥、社会拒绝等负性反馈表现出过敏化,对社会奖赏的期待降低,且可能存在情绪调节困难。目前此领域存在社会与非社会反馈神经机制的异同不清楚、异常脑区与社会反馈加工障碍的因果关系难以确定以及无法排除抑郁症患者和抑郁倾向人群存在不同社会反馈加工模式的可能性等问题。     

抑郁症患者认知重评和分心情绪调节的有效性:ERPs研究

使用事件相关电位(ERPs)技术考察抑郁症患者在指导下使用认知重评和分心策略调节负性情绪的有效性。结果发现抑郁症患者可以使用认知重评策略降低负性情绪体验,同时也表现出LPP波幅显著降低,但LPP波幅依然比正常被试大;抑郁症患者使用分心策略后没有降低负性情绪体验,但LPP波幅比正常个体小。结果表明,轻中度抑郁症被试在指导条件下,可以使用认知重评策略并表现出一定程度的有效性,但其认知重评的效果低于正常被试;抑郁症被试使用分心策略的效果好于正常被试。     

抑郁倾向对个体情绪调节目标的影响——来自事件相关电位的证据

目前抑郁症情绪失调的研究主要关注策略的选择和应用, 但是对于情绪调节目标是否异常及其背后的电生理基础尚不清楚。情景选择是成熟的情绪反应产生之前运用的一种调节策略, 可以反映情绪调节目标。本研究要求抑郁倾向被试与控制组被试观看并选择快乐、中性和悲伤场景图片, 同时记录事件相关电位(ERP)和主观情绪偏好。结果发现, 抑郁倾向组悲伤图片的LPP波幅显著小于健康控制组, 并更多地选择再次观看悲伤图片。此外, 抑郁倾向组对于悲伤情绪的偏好显著增加, 对快乐情绪的偏好则显著降低。结果提示抑郁倾向个体对快乐刺激的趋近动机和对悲伤刺激的回避动机都降低, 从而使得抑郁倾向被试的情绪调节目标为更多地体验到悲伤。     

负性情绪调节中认知重评和分心策略的作用:ERPs研究

采用事件相关电位技术,考察了认知重评和分心两种情绪调节策略对负性情绪体验和脑电活动的影响。结果发现,认知重评后被试的负性情绪体验强度和LPP波幅(300~1300ms)比简单注视条件下低;分心后被试的负性情绪体验强度比简单注视条件下低,但LPP波幅显示比简单注视条件下高。这说明认知重评和分心对负性情绪体验和脑电活动的影响不同,负性刺激再次呈现时认知重评优于分心策略的调节。该研究为认知重评和分心的比较研究提供了神经电生理学方面的证据。     

工作记忆刷新训练改善抑郁倾向大学生情绪调节能力的HRV证据

根据流调中心用抑郁量表(CES-D)和贝克抑郁量表(BDI-II-C)的得分情况招募健康被试20例, 抑郁倾向被试40例, 以自愿参加的分组方式将抑郁倾向被试分为工作记忆刷新训练组和对照组, 每组20例。对训练组进行为期20天的工作记忆刷新训练, 对照组不做处理。记录各组被试在前后测的刷新功能以及在情绪调节任务中量表的得分情况, 并收集各组被试在5种实验条件下的心率变异性(HRV)的频域指标值, 结果发现：前测时抑郁倾向个体的HF-HRV显著低于健康个体的平均水平。经过工作记忆训练, 后测的抑郁倾向训练组在情绪调节任务中的HF-HRV水平有显著的提高, 贴近健康对照组的水平, 并与抑郁倾向对照组分离。研究表明, 工作记忆刷新训练能够使抑郁倾向大学生的HRV活动更接近健康被试的HRV活动, 表明抑郁倾向大学生的情绪调节能力得到了改善。     

抑郁症患者工作记忆内情绪刺激加工的特点及其机制

抑郁症患者在工作记忆内情绪刺激加工的特点为倾向于加工与负性心境一致的材料, 被认为是抑郁症认知易感性的核心特征。目前研究者们围绕抑郁症工作记忆中央执行系统三个子功能的情绪刺激加工特点及其作用机制进行了大量研究, 发现在更新功能上, 患者难以移除负性情绪信息, 且在正性信息的加工上存在缺损; 在抑制功能上, 患者难以抑制无关负性情绪信息进入工作记忆; 在转换功能上, 患者情绪材料转换困难的研究证据尚不充分。神经生理与脑成像的研究初步表明, 工作记忆中的情绪刺激加工与抑郁症患者背外侧前额叶和前扣带回的功能激活水平异常有关。未来研究需评估工作记忆三个子功能对抑郁症状的差异性贡献及在情绪刺激加工上的统一性, 并探究其随疾病发生发展变化的轨迹, 谨慎选取并评估不同情绪刺激材料指标的诱发效应及其对工作记忆功能的独特影响。在此基础上, 深入探究工作记忆内情绪刺激加工的神经机制, 为工作记忆偏向矫正干预的临床应用及其预期效果提供理论依据和方向。     

情绪调节灵活性对负性情绪的影响：来自经验取样的证据

情绪调节灵活性是指个体根据不断变化的情境需求灵活部署情绪调节策略的能力。本研究采用经验取样方法,通过拟合个体在日常生活事件(如,未通过考试)和突发公共卫生事件(COVID-19)中的策略使用剖面结构和情境负性程度与策略使用程度的共变关系测量个体的情绪调节灵活性水平,并探讨其对个体后续负性情绪(抑郁和焦虑)的影响。两个独立样本结果表明：单一策略使用偏好(如沉浸偏好和表达抑制偏好)的个体在负性生活事件中和疫情期间经历了更高水平的抑郁和焦虑情绪。此外,当个体随情境负性程度提高使用更多分心策略,而随情境负性程度降低使用更多认知重评策略(意味较高的情绪调节灵活性),其抑郁和焦虑情绪水平更低。以上结果共同证实了情绪调节灵活性有利于减少个体的负性情绪体验。     

Cerebellum and processing of negative facial emotions: cerebellar transcranial DC stimulation specifically enhances the emotional recognition of facial anger and sadness

Some evidence suggests that the cerebellum participates in the complex network processing emotional facial expression. To evaluate the role of the cerebellum in recognising facial expressions we delivered transcranial direct current stimulation (tDCS) over the cerebellum and prefrontal cortex. A facial emotion recognition task was administered to 21 healthy subjects before and after cerebellar tDCS; we also tested subjects with a visual attention task and a visual analogue scale (VAS) for mood. Anodal and cathodal cerebellar tDCS both significantly enhanced sensory processing in response to negative facial expressions (anodal tDCS, p=.0021; cathodal tDCS, p=.018), but left positive emotion and neutral facial expressions unchanged (p>.05). tDCS over the right prefrontal cortex left facial expressions of both negative and positive emotion unchanged. These findings suggest that the cerebellum is specifically involved in processing facial expressions of negative emotion.     

Cerebellum and processing of negative facial emotions: Cerebellar transcranial DC stimulation specifically enhances the emotional recognition of facial anger and sadness

Some evidence suggests that the cerebellum participates in the complex network processing emotional facial expression. To evaluate the role of the cerebellum in recognising facial expressions we delivered transcranial direct current stimulation (tDCS) over the cerebellum and prefrontal cortex. A facial emotion recognition task was administered to 21 healthy subjects before and after cerebellar tDCS; we also tested subjects with a visual attention task and a visual analogue scale (VAS) for mood. Anodal and cathodal cerebellar tDCS both significantly enhanced sensory processing in response to negative facial expressions (anodal tDCS, p=.0021; cathodal tDCS, p=.018), but left positive emotion and neutral facial expressions unchanged (p>.05). tDCS over the right prefrontal cortex left facial expressions of both negative and positive emotion unchanged. These findings suggest that the cerebellum is specifically involved in processing facial expressions of negative emotion.     

The influence of emotion regulation on social interactive decision-making

Although adequate emotion regulation is considered to be essential in every day life, it is especially important in social interactions. However, the question as to what extent two different regulation strategies are effective in changing decision-making in a consequential socially interactive context remains unanswered. We investigated the effect of expressive suppression and emotional reappraisal on strategic decision-making in a social interactive task, that is, the Ultimatum Game. As hypothesized, participants in the emotional reappraisal condition accepted unfair offers more often than participants in the suppression and no-regulation condition. Additionally, the effect of emotional reappraisal influenced the amount of money participants proposed during a second interaction with partners that had treated them unfairly in a previous interaction. These results support and extend previous findings that emotional reappraisal as compared to expressive suppression, is a powerful regulation strategy that influences and changes how we interact with others even in the face of inequity.     

Effects of tDCS over the right DLPFC on attentional disengagement from positive and negative faces: An eye-tracking study

The aim of this study was to increase insight in the neural substrates of attention processes involved in emotion regulation. The effects of right dorsolateral prefrontal cortex (i.e., DLPFC) stimulation on attentional processing of emotional information were evaluated. A novel attention task allowing a straightforward measurement of attentional engagement toward, and attentional disengagement away from emotional faces was used. A sample of healthy participants received 20 minutes of active and sham anodal transcranial direct current stimulation (i.e., tDCS) applied over the right DLPFC on 2 separate days and completed the attention task after receiving real or sham stimulation. Compared to sham stimulation, tDCS over the right DLPFC led to impairments in attentional disengagement from both positive and negative faces. Findings demonstrate a causal role of right DLPFC activity in the generation of attentional impairments that are implicated in emotional disturbances such as depression and anxiety.     

Look before you regulate: differential perceptual strategies underlying expressive suppression and cognitive reappraisal

Successful emotion regulation is important for maintaining psychological well-being. Although it is known that emotion regulation strategies, such as cognitive reappraisal and expressive suppression, may have divergent consequences for emotional responses, the cognitive processes underlying these differences remain unclear. Here we used eye-tracking to investigate the role of attentional deployment in emotion regulation success. We hypothesized that differences in the deployment of attention to emotional areas of complex visual scenes may be a contributing factor to the differential effects of these two strategies on emotional experience. Eye-movements, pupil size, and self-reported negative emotional experience were measured while healthy young adult participants viewed negative IAPS images and regulated their emotional responses using either cognitive reappraisal or expressive suppression. Consistent with prior work, reappraisers reported feeling significantly less negative than suppressers when regulating emotion as compared to a baseline condition. Across both groups, participants looked away from emotional areas during emotion regulation, an effect that was more pronounced for suppressers. Critically, irrespective of emotion regulation strategy, participants who looked toward emotional areas of a complex visual scene were more likely to experience emotion regulation success. Taken together, these results demonstrate that attentional deployment varies across emotion regulation strategies and that successful emotion regulation depends on the extent to which people look toward emotional content in complex visual scenes.     

不同抑郁症状青少年调节不同强度情绪时策略选择的差异

最新研究发现,情绪强度会影响健康个体的情绪调节策略选择。然而,至今尚未有研究考察情绪强度对不同抑郁症状青少年策略选择的影响。对此,本研究通过流调中心用抑郁量表划分出无抑郁、阈下抑郁和抑郁症青少年,进而考察其在面对高-低强度积极-消极日常情绪事件时选择认知重评和认知沉浸的差异。结果发现：当面对高强度积极情绪、低强度积极情绪和低强度消极情绪时,三组被试的策略选择均无显著差异;当面对高强度消极情绪时,无抑郁青少年比阈下抑郁和抑郁症青少年更多选择认知重评而更少选择认知沉浸,但阈下抑郁和抑郁症青少年之间无显著差异。结果表明：不同抑郁症状青少年在面对不同强度和效价情绪时的情绪调节策略选择存在差异,表现为高强度消极情绪下抑郁症状越多的青少年越少选择认知重评而越多选择认知沉浸。这一发现有助于识别和干预青少年的抑郁症状。     

第三方惩罚的神经机制：来自经颅直流电刺激的证据

第三方惩罚既是社会规范在群体得以维系的基石, 也是个体维护社会规范的体现。当前关注社会规范的神经研究大多基于第二方惩罚的独裁者或最后通牒实验框架, 缺乏对第三方维护社会规范过程中相关脑区活动的探索, 对这一过程的内在神经机制也不清楚。本文基于第三方惩罚的独裁者博弈框架, 对右侧背外侧前额叶区域(DLPFC)进行不同极性的经颅直流电刺激(tDCS), 同时依据第三方是否需要为其惩罚付出成本设计了零成本和有成本两个实验任务。结果发现, 第三方在零成本任务的情绪反应和惩罚显著受到tDCS设置的影响, 且阴极刺激显著提升了第三方的惩罚值, 这表明情绪机制对第三方惩罚有着重要影响。另外, 第三方在零成本和有成本任务中的惩罚差异在不同tDCS设置之间也存在显著差异, 这与第三方惩罚还受到自利机制影响的观点相符。本文率先为右侧DLPFC活动影响第三方惩罚提供了神经层面的证据, 且支持了第三方对社会规范的遵从与其负性情绪反应和自利加工密切相关的机制解释。     

Differences in emotion modulation using cognitive reappraisal in individuals with and without suicidal ideation: An ERP study

Difficulties in emotion regulation have been associated with increased suicidal thoughts and behaviours. The majority of studies have examined self-reported use of emotion regulation strategies. In contrast, the current study focused on a direct measure of individuals’ ability to use a specific emotion regulation strategy, cognitive reappraisal, using the late positive potential (LPP), an event-related potential component that reflects attention to emotional stimuli. Specifically, the cognitive reappraisal ability of 33 undergraduate students was assessed via an image-viewing task during which the participants had to passively view, increase or reduce their emotions in response to looking at neutral, positive or dysphoric images. We found that participants with a history of suicidal ideation (SI) had significantly higher LPP when asked to reduce negative emotion in response to dysphoric images, compared to individuals with no history of SI. These findings suggest that difficulties with using cognitive reappraisal, specifically to decrease negative affect, might be linked to suicide risk.