我国中西医结合科研工作的回顾与思考

针对我国中西医结合事业现状,通过调研,结合文献,提出中西医结合科研工作的发展对策。试从研究方向、人才队伍、科研交流等方面进行阐述,以期有助于我国中西医结合科研工作的健康发展。     

Ambiguity, trust, and the responsible conduct of research

Ambiguity associated with everyday practice of science has made it difficult to reach a consensus on how to define misconduct in science. This essay outlines some of the important ambiguities of practice such as distinguishing data from noise, deciding whether results falsify a hypothesis, and converting research into research publications. The problem of ambiguity is further compounded by the prior intellectual commitments inherent in choosing problems and in dealing with the skepticism of one's colleagues. In preparing a draft code of ethics for the American Society of Biochemistry and Molecular Biology (ASBMB), an attempt was made to take into account the ambiguities of practice. Also, the draft code adopted trust as its leading principle, specifically the importance of trust as a condition necessary for there to be science. During revision of the code, the focus on trust was changed. The new orientation was on trust as a consequence of carrying out science responsibly. By addressing the obligations necessary to engender trust, the ASBMB ethics code not only sets professional standards, but also makes a clear statement of public accountability.     

The meaning of “significance” for different types of research [translated and annotated by Eric-Jan Wagenmakers,Denny Borsboom,Josine Verhagen,Rogier Kievit,Marjan Bakker,Angelique Cramer,Dora Matzke,Don Mellenbergh,and Han L. J. van der Maas]

Adrianus Dingeman de Groot (1914–2006) was one of the most influential Dutch psychologists. He became famous for his work “Thought and Choice in Chess”, but his main contribution was methodological — De Groot co-founded the Department of Psychological Methods at the University of Amsterdam (together with R. F. van Naerssen), founded one of the leading testing and assessment companies (CITO), and wrote the monograph “Methodology” that centers on the empirical-scientific cycle: observation–induction–deduction–testing–evaluation. Here we translate one of De Groot's early articles, published in 1956 in the Dutch journal Nederlands Tijdschrift voor de Psychologie en Haar Grensgebieden. This article is more topical now than it was almost 60 years ago. De Groot stresses the difference between exploratory and confirmatory (“hypothesis testing”) research and argues that statistical inference is only sensible for the latter: “One ‘is allowed’ to apply statistical tests in exploratory research, just as long as one realizes that they do not have evidential impact”. De Groot may have also been one of the first psychologists to argue explicitly for preregistration of experiments and the associated plan of statistical analysis. The appendix provides annotations that connect De Groot's arguments to the current-day debate on transparency and reproducibility in psychological science.     

Funding,objectivity and the socialization of medical research

There has been a sharp rise in private funding of medical research, especially in relation to patentable products. Several serious problems with this are described. A solution involving the elimination of patents and public funding administered through extended national health care systems is proposed. An earlier version of this paper was presented at an International Conference on “Conflict of Interest and its Significance in Science and Medicine” held in Warsaw, Poland on 5–6 April, 2002.     

The Search for Adam Revisited: Evolution,Biblical Literalism,and the Question of Human Uniqueness

Abstract

This article questions the adequacy of the philosophical category of realism in characterizing Rheticus' endorsement of Copernicus' astronomy. Rheticus and Osiander agree that the human intellect is restricted in its aspirations to truth, resulting in a condition of “causal ignorance” regarding the celestial phenomena on Rheticus' part. Copernicus' pupil advances trust in the most true hypothesis of the motion of the earth without postulating its absolute truth. Causal knowledge waits after Resurrection. In line with Luther's comment on Genesis 1:14, Rheticus ascribes a theological meaningfulness to the pursuit of mathematics, alerting the astronomer to his immortal soul and divine creation.     

Darwin, Social Theory, and the Sociology of Scientific Knowledge

This essay considers ways in which Darwin's account of natural processes was influenced by economic, ethical, and natural-theological theories in his own day. It argues that the Anabaptist concept of "the gospel of all creatures" calls into question alliances between evolutionary theory and social policy that are based on the dominance of conflictual images such as "the survival of the fittest" and questions the negative images of both nature and God that Darwinism has been taken to sponsor. The essay also considers developments in biology that have called into question dualist accounts of human nature as body and soul, thus reminding us that we are fully a part of the natural world and thus contributing, in turn, to a better theological grasp of God's relation to nature.     

Empirical research on the identification of singular,multiple and subordinate argumentation

To examine to what degree argumentation skills are mastered by pupils who attend the vocational, general and academic streams in Dutch secondary education various subtests were constructed. The theoretical study of argumentation as exposed by Van Eemeren and Grootendorst was the basis for this test construction. In this article tests for the identification of singular, multiple and subordinate argumentation are described. Also an account is given of a pretest of these three subtests.     

Mental illness and the mind-brain problem: Delusion,belief and Searle's theory of intentionality

Until recently there has been little contact between the mind-brain debate in philosophy and the debate in psychiatry about the nature of mental illness. In this paper some of the analogies and disanalogies between the two debates are explored. It is noted in particular that the emphasis in modern philosophy of mind on the importance of the concept of action has been matched by a recent shift in the debate about mental illness from analyses of disease in terms of failure of functioning to analyses of illness in terms of failure of action. The concept of action thus provides a natural conduit for two-way exchanges of ideas between philosophy and psychiatry. The potential fruitfulness of such exchanges is illustrated with an outline of the mutual heuristic significance of psychiatric work on delusions and philosophical accounts of Intentionality.     

Intellectual property and the commercialization of research and development

Concern about the commercialization of research is rising, notably in testing new drugs. The problem involves oversimplified, polarizing assumptions about research and development (R&;D) and intellectual property (IP). To address this problem this paper sets forth a more complex three phase RT&;D process, involving Scientific Research (R), Technological Innovation (T), and Commercial Product Development (D) or the RT&;D process. Scientific research and innovation testing involve costly intellectual work and do not produce free goods, but rather require IP regulation. RT&;D processes involve an unrecognized IP shift from a common IP right in public goods like information and knowledge to private IP in products and other hard assets. The question then is, what kind of IP right: private or common? Since scientific research and innovation testing require openness about adverse findings, and wide, low cost diffusion of results, they require a common, inclusive IP right. Common IP is appropriate to both sharing knowledge goods and recovering the cost of production. Research is furthermore compatible with commercialization and support by other social interests. On the other hand it is incompatible with the exclusionary private IP rights that permit restrictive publication or total suppression of information. Private IP rather than commercialization conflicts with the openness requirements of scientific research and innovation testing. Commercial funding, however, is in principle compatible with research and testing, especially when regulated by a common IP right. This reflects a pragmatic view of the fundamental interconnections of knowledge and other social interests.     

The Body as the Ground of Religion, Science, and Self

The human body is both religious subject and scientific object, the manifest locus of both religious gnosis and secular cognition. Embodiment provides the basis for a rich cross–fertilization between cognitive science and comparative religion, but cognitive studies must return to their empiricist scientific roots by reembodying subjectivity, thus spanning the natural bridge between the two fields. Referencing the ritual centrality and cognitive content of the body, I suggest a materialist but nonreductionist construct of the self as a substantial cognitive embodiment that embraces not just perception and cognition, mind and spirit, but the forceful physicality of the moving body. Proprioception of the body's moving mass constitutes a mode of knowing that resonates strongly with the experience of self, not only across religious traditions but also within the physical sciences. By way of illustration, two directions are suggested in which a construct of the self as a substantial cognitive embodiment might lead us: first, a body–based interpretation of the Islamic myth of Adam and Iblis that reveals an internal substantiality as constitutive of the divinely imaged Self, and second, a new, religious direction for human evolutionary theory based on the implications of an embodied intentionality.     

Future directions in engineering ethics research: microethics, macroethics and the role of professional societies

Three frames of reference for engineering ethics are discussed—individual, professional and social—which can be further broken down into “microethics” concerned with individuals and the internal relations of the engineering profession and “macroethics” referring to the collective social responsibility of the engineering profession and to societal decisions about technology. Few attempts have been made at integrating microethical and macroethical approaches to engineering ethics. The approach suggested here is to focus on the role of professional engineering societies in linking individual and professional ethics and in linking professional and social ethics. A research program is outlined using ethics support as an example of the former, and the issuance of position statements on product liability as an example of the latter. An earlier version of this paper was presented at the International Symposium on Technology and Society 2000 (ISTAS 2000), Rome, Italy, 7 September 2000. Joseph R. Herkert directs a dual-degree program in engineering and humanities/social sciences and is editor of Social, Ethical, and Policy Implications of Engineering (Wiley/IEEE Press).     

The Self, the symbolic and synchronicity: virtual realities and the emergence of the psyche

Jung's theory of synchronicity is seen as a step in the development of a complete theory of the symbol. In so doing, a number of proposals are made for modelling the symbolic process along lines already in use for modelling a variety of other phenomena, ranging from language to the behaviour of earthquakes. These modelling techniques involve processes of self-organization, and raise issues of scaling in systems including symbolic systems. The proposal is made that symbolic systems obey the same rules of scaling that these other systems obey, and that symbolic systems can therefore be understood as exhibiting the characteristics of a power law distribution-a concept that is explained and developed in the paper. It is finally proposed that synchronicity is an aspect of the symbolic that can be characterized as exhibiting a high degree of 'symbolic density'.     

Ten years of longitudinal research on U.S. adolescent sexual behavior: Developmental correlates of sexual intercourse,and the importance of age,gender and ethnic background

We integrated findings from 35 recent, longitudinal studies of the onset of heterosexual intercourse. Correlates of adolescent sexual intercourse onset, whether in early (before age 16) or middle (ages 16–18) adolescence, included living with other than two biological parents, being less monitored by parents, having more advanced physical maturity and more involvement in dating behavior, and having more permissive attitudes toward sex. When studies were organized by age of participants, the onset of intercourse was more strongly associated with alcohol use, delinquency, school problems and (for girls) depressive symptoms in Early studies (sexual intercourse by age 15 or before only) than was found in studies classified as Middle (assessment of sexual intercourse up to age 18) or Late (knowledge of those who delayed until after age 18). Although more research is needed, additional factors were associated with delaying first sexual intercourse until after age 18, including religious attitudes and anxiety, with some factors more relevant for girls and some more applicable to boys. In total, the evidence suggests there are many similarities, but also some important differences, in the correlates associated with early versus middle versus later onset of sexual intercourse. This seems to signify more than one pathway (set of distal and proximal correlates) associated with sexual behavior during adolescence that should be tested in future research. Throughout the review, we highlight differences in the correlates of girls’ versus boys’ sexual intercourse and how race/ethnicity moderates associations. These gender and racial/ethnic differences were found largely in analyses of family processes, school and religion, and parent education. We end by summarizing several priority areas for future research.     

Individual,Community, and National Resilience in Peace Time and in the Face of Terror: A Longitudinal Study

The present paper is based on thrice-repeated measures. The sample constituted 561 Jewish Israeli adults who experienced these terror attacks. The study examined individual, community and national resilience and their associations with resilience-promoting factors (sense of coherence, social support, and self-efficacy); as well as resilience-suppressing factors (distress symptoms, sense of danger, and exposure). Results indicated that resilience scores were quite stable across the three repeated measures, whereas sense of coherence, distress symptoms, sense of danger, and exposure significantly changed across the three repeated measures. Sense of coherence was the best predictor for individual, community, and national resilience.     

Animals,humans and x-men: Human uniqueness and the meaning of personhood

Research in animal intelligence suggests to some that humans are different only in degree from animals, possibly eroding the traditional theological doctrine of the imago dei. In this paper, several critical boundary areas between humans and animals are examined for scientific evidence about human distinctiveness. These include communication and language capacity, cultural creativity, spirituality, and ethical capacity. Chimpanzee language studies and research in Neanderthal mentality are examined as the closest known natural approximations to human communication and intelligence. The implications of the findings are explored in relation to human culture, ethics, and spirituality in a context consistent with evolutionary continuity. Aspects of human uniqueness are apparent, can be fruitfully encompassed in the idea of personhood, and are coherent with Trinitarian theology's anthropological focus.     

How to study the ‘quality of psychoanalytic treatments’ and their long‐term effects on patients' well‐being: A representative,multi‐perspective follow‐up study3

How can we study the ‘quality of psychoanalytic treatments’? The authors attempt to answer this question by discussing a naturalistic, multi‐perspective and representative follow‐up study of psychoanalyses and long‐term psychoanalytic psychotherapies. We studied a representative sample (n = 401) of all the patients who had terminated their psychoanalytic treatments with members of the German Psychoanalytical Association (DPV) between 1990 and 1993. Between 70 and 80 per cent of the patients achieved (average 6.5 years after the end of treatment) good and stable psychic changes according to the evaluations of the patients themselves, their analysts, independent psychoanalytic and non‐psychoanalytic experts, and questionnaires commonly applied in psychotherapy research. The evaluation of mental health costs showed a cost reduction through fewer days of sick leave during the seven years following the end of long‐term psychoanalytic treatments. The results achieved using non‐psychoanalytical instruments are complemented by the richness of the idiosyncratic findings, gained by the psychoanalytic research instruments.     

Using the Theory of Gender and Power to Examine Experiences of Partner Violence,Sexual Negotiation,and Risk of HIV/AIDS Among Economically Disadvantaged Women in Southern India

This article uses the Theory of Gender and Power to examine women's vulnerability to HIV/AIDS in order to: understand the vulnerability of female sex workers/poor women due to poverty and lack of educational resources; explore women's vulnerability in the context of client/partner violence, alcohol use, male partner's high-risk behaviors, and women's lack of control in their intimate relationships; and explore the role of traditional heterosexual gender norms in the outcomes of sexual negotiation. Ethnographic data were collected from 32 women and 38 men in India as part of an ongoing National Institute of Mental Health study. Results highlighted women's vulnerability to HIV/AIDS stemming from partner violence, alcohol use, poverty, dangers of sex work environments, and tacit acceptance of cultural/gender norms.