Factors Influencing Clinical Follow-Up for Individuals with a Personal History of Breast and/or Ovarian Cancer and Previous Uninformative <Emphasis Type="Italic">BRCA1</Emphasis> and <Emphasis Type="Italic">BRCA2</Emphasis> Testing

Genetic testing for inherited cancer risk has recently improved through the advent of multi-gene panels and the addition of deletion and duplication analysis of the BRCA genes. The primary aim of this study was to determine which factors influence the intent of individuals with a personal history of breast and/or ovarian cancer and negative or uncertain BRCA1 and BRCA2 testing to return to a hereditary cancer program for additional genetic risk assessment, counseling, and testing. Surveys were sent to 1197 individuals and 257 were returned. Of those participants who were planning to return to clinic, most cited having family members who could benefit from the test result as the primary motivation to return. Many participants who were not planning to return to clinic cited the cost of testing as a barrier to return. Cost of testing and concerns about insurance coverage were the most commonly cited barriers for the group of participants who were undecided about returning to clinic. Results from this study may be used to guide re-contact efforts by clinicians to increase patient uptake to return to clinic for up-to-date genetic risk assessment, counseling, and testing.     

Women with <Emphasis Type="Italic">BRCA1</Emphasis> or <Emphasis Type="Italic">BRCA2</Emphasis> Mutations Renegotiating a Post-Prophylactic Mastectomy Identity: Self-Image and Self-Disclosure.

The Facing Our Risk of Cancer Empowered (FORCE) website is devoted to women at risk for hereditary breast and ovarian cancers. One of the most frequently discussed topics on the archived messaged board has been prophylactic mastectomy (PM) for women with a BRCA1/2 mutation. We reviewed the messages, over a 4 year period, of 21 high risk women and their “conversational” partners who originally posted on a thread about genetic testing, genetic counseling and family history. We used a qualitative research inductive process involving close reading, coding and identification of recurrent patterns, relationships and processes in the data. The women sought emotional support, specific experiential knowledge and information from each other. They frequently found revealing their post PM status problematic because of possible negative reactions and adopted self-protective strategies of evasion and concealment outside of their web-based community. The FORCE message board was considered to be a safe place in which the women could be truthful about their choices and feelings. Results are discussed in terms of Goffman’s concepts “stigma” and “disclosure” and Charmaz’s concepts “interruptions,” “intrusions” and a “dreaded future.”     

Psychological Distress with Direct-to-Consumer Genetic Testing: A Case Report of an Unexpected <Emphasis Type="Italic">BRCA</Emphasis> Positive Test Result

We report a case of a client who discovered she had a BRCA mutation following direct-to-consumer (DTC) genetic testing in the absence of genetic counseling. After testing she presented for genetic counseling with anxiety, distress, and a deficit of knowledge about what the DTC genetic testing revealed. Genetic counseling helped alleviate distress while empowering the client to apply the results of testing to improve medical management. Despite recent studies demonstrating no negative psychological impact of DTC genetic testing on the consumer, this case illustrates that significant psychological distress and confusion can occur as a result of DTC genetic testing for highly penetrant single gene disorders. Pre- and post-test genetic counseling in conjunction with DTC genetic testing may alleviate consumers’ distress and empower clients to proactively utilize their result information.     

Revalidation of the <Emphasis Type="Italic">Sat</Emphasis>-<Emphasis Type="Italic">Chit</Emphasis>-<Emphasis Type="Italic">Ananda</Emphasis> Scale

Sat-Chit-Ananda is an indigenous construct that refers to absolute bliss and consciousness. The present study aimed to strengthen the psychometric properties of the newly developed Sat-Chit-Ananda scale (Singh et al. in Int J Vedic Found Manag 1(2):54–74, 2014). A total of 398 students aged 17–36 years (mean age = 21.33 years, SD = 2.2, 70% males) participated in this study. An exploratory as well as confirmatory factor analysis was computed for the 17-item scale. Its’ concurrent validity was established by assessing its correlation with other well-being measures, namely Flourishing (Diener et al. in Soc Indic Res 97:143–156 2010) and Scale of Positive and Negative Experience (Diener et al. 2010). Satisfactory results were obtained from both exploratory and confirmatory factor analyses. Sat-Chit-Ananda and its factors were found to be significantly positively correlated with Flourishing and Positive Experiences and were negatively correlated with Negative Experiences. Thus, the validity of the Sat-Chit-Ananda (Singh et al. 2014) scale stands further substantiated—offering this scale as a promising new assessment tool.     

Sequential planning in rhesus monkeys (<Emphasis Type="Italic">Macaca mulatta</Emphasis>)

In the current study, we examined the planning abilities of rhesus monkeys (Macaca mulatta) by training them on a five-item list composed of coloured photographs and then testing them on switch and mask trials. In contrast to previous studies where monkeys made responses using a joystick, in the current study, monkeys made responses directly to a touch screen. On switch trials, after a response to the first list item, the on-screen positions of two list items were exchanged. Performance on trials in which the second and third list items were exchanged was poorer compared to normal (non-switch) trials for all subjects. When the third and fourth items were exchanged, however, only one subject continued to show performance deficits. On mask trials, following a response to the first item, the remaining items were covered by opaque white squares. When two items were masked, all four subjects responded to each masked item at a level significantly above chance. When three items were masked, however, only one subjected was able to respond to all three masked items at a level significantly above chance. The results of the present study indicate that three of our four monkeys planned one response ahead while a single monkey planned two responses ahead. The significance of these findings is discussed in relation to previous studies on planning in chimpanzees and monkeys.     

Combinations of <Emphasis Type="Italic">Stit</Emphasis> with <Emphasis Type="Italic">Ought</Emphasis> and <Emphasis Type="Italic">Know</Emphasis>

This paper presents a short survey of recent developments in stit theories, with an emphasis on combinations of stit and deontic logic, and those of stit and epistemic logic.     

Spatial representation of magnitude in humans (<Emphasis Type="Italic">Homo sapiens</Emphasis>), Western lowland gorillas (<Emphasis Type="Italic">Gorilla gorilla gorilla</Emphasis>), and American black bears (<Emphasis Type="Italic">Ursus americanus</Emphasis>)

The spatial-numerical association of response codes (SNARC) effect is the tendency for humans to respond faster to relatively larger numbers on the left or right (or with the left or right hand) and faster to relatively smaller numbers on the other side. This effect seems to occur due to a spatial representation of magnitude either in occurrence with a number line (wherein participants respond to relatively larger numbers faster on the right), other representations such as clock faces (responses are reversed from number lines), or culturally specific reading directions, begging the question as to whether the effect may be limited to humans. Given that a SNARC effect has emerged via a quantity judgement task in Western lowland gorillas and orangutans (Gazes et al., Cog 168:312–319, 2017), we examined patterns of response on a quantity discrimination task in American black bears, Western lowland gorillas, and humans for evidence of a SNARC effect. We found limited evidence for SNARC effect in American black bears and Western lowland gorillas. Furthermore, humans were inconsistent in direction and strength of effects, emphasizing the importance of standardizing methodology and analyses when comparing SNARC effects between species. These data reveal the importance of collecting data with humans in analogous procedures when testing nonhumans for effects assumed to bepresent in humans.     

<Emphasis Type="Italic">Ziran</Emphasis> and <Emphasis Type="Italic">Wuwei</Emphasis> in the <Emphasis Type="Italic">Daodejing</Emphasis>: An Ethical Assessment

In Daoist philosophy, the self is understood as an individual interdependent with others, and situated within a broader environment. Within this framework, the concept ziran is frequently understood in terms of naturalness or nature while wuwei is explained in terms of non-oppressive government. In many existing accounts, little is done to connect these two key Daoist concepts. Here, I suggest that wuwei and ziran are correlated, ethical, concepts. Together, they provide a unifying ethical framework for understanding the philosophy of the Daodejing. I explore the meaning of ziran as self-so-ness or, in human terms, as pertaining to an individual’s spontaneity. The appropriate response to the spontaneity of individuals is to avoid, insofar as possible, imposing or using restrictive norms and methods, that is, wuwei. According to this view, ziran and wuwei offer an account of ethics that attends to core notions of interdependent selfhood, including mutuality, relationality, interdependence, symbiosis, and responsiveness.     

Acquiring Explicit Grammatical Knowledge Using the Spanish Verbs <Emphasis Type="Italic">Ser</Emphasis> and <Emphasis Type="Italic">Estar</Emphasis> as Examples

The role of explicit and implicit acquisition of grammatical rules in second language learning was examined by assessing high school students performance after several years of study on the correct use of the Spanish verbs ser and estar. These two verbs are essentially equivalent in use to the English verb “to be,” but there is a complex set of statements that specifies when each is to be used. A 100-item two-choice test in which students from several different high schools receiving instruction in the explicit principles of these two Spanish verbs or receiving immersion training in which no instruction in their grammatical principles was given were examined for the following five factors: (a) general achievement level, (b) comparison of grade level achievement, (c) time allotted to complete the 100-item test, (d) grammatical instruction prior to taking the 100-item test, and (e) comparison of instructional methodology. The results indicated that students receiving explicit instruction in the rules of ser and estar beyond the first year of study achieved slightly higher scores, but that the level of achievement was considered to be poor. Differences between groups for the remaining factors were not significant. It was concluded that successful application of explicitly learned grammatical rules, such as the rules for ser and estar, may not be achievable in the time frame of a two-year high school foreign language course. Considerations regarding implicit and explicit acquisition of grammatical rules in second language learning were presented.     

Psychological Tasks Associated with Divorce: <Emphasis Type="Italic">Eat,Pray, Love</Emphasis> (2010), <Emphasis Type="Italic">An Unmarried Woman</Emphasis> (1978), and <Emphasis Type="Italic">Kramer vs. Kramer</Emphasis> (1979)

The dependency paradox (Feeney) states that independence actually can result from being in a nurturing relationship. Those who divorce often have the opposite notion that independence will occur without a relationship. The movies Eat, Pray, Love, An Unmarried Woman, and Kramer vs. Kramer examine divorce from different angles. The protagonists in all three movies grow through the process of divorce, each achieving a level of autonomy that seemed unattainable within their marriage. This paper aims to explore the concept of divorce in light of the dependency paradox by examining the self-differentiation achieved and the consequences of such independence for both the individual and, in Kramer vs. Kramer, for the child involved.     

Deontological evidentialism and <Emphasis Type="Italic">ought</Emphasis> implies <Emphasis Type="Italic">can</Emphasis>

Deontological evidentialism is the claim that S ought to form or maintain S’s beliefs in accordance with S’s evidence. A promising argument for this view turns on the premise that consideration c is a normative reason for S to form or maintain a belief that p only if c is evidence that p is true. In this paper, I discuss the surprising relation between a recently influential argument for this key premise and the principle that ought implies can. I argue that anyone who antecedently accepts or rejects this principle already has a reason to resist either this argument’s premises or its role in support of deontological evidentialism.     

Association of <Emphasis Type="Italic">ADAM10</Emphasis> and <Emphasis Type="Italic">CAMK2A</Emphasis> Polymorphisms with Conduct Disorder: Evidence from Family-Based Studies

Twin and family studies have shown that genetic factors play a role in the development of conduct disorder (CD). The purpose of this study was to identify genetic variants associated with CD using a family-based association study. We used 4,720 single nucleotide polymorphisms (SNPs) from the Illumina Panel and 11,120 SNPs from the Affymetrix 10K GeneChips genotyped in 155 Caucasian nuclear families from Genetic Analysis Workshop (GAW) 14, a subset from the Collaborative Study on the Genetics of Alcoholism (COGA). 20 SNPs had suggestive associations with CD (p < 10⁻³), nine of which were located in known genes, including ADAM10 (rs383902, p = 0.00036) and CAMK2A (rs2053053, p = 0.00098). Our results were verified using the International Multi-Center ADHD Genetics Project (IMAGE) dataset. In conclusion, we identified several loci associated with CD. Especially, the two genes (ADAM10 and CAMK2A) have been reported to be associated with Alzheimer’s disease, bipolar disorder and depression. These findings may serve as a resource for replication in other populations.     

Hypothesis Testing of the <Emphasis Type="Italic">Q</Emphasis>-matrix

The recent surge of interests in cognitive assessment has led to the development of cognitive diagnosis models. Central to many such models is a specification of the Q-matrix, which relates items to latent attributes that have natural interpretations. In practice, the Q-matrix is usually constructed subjectively by the test designers. This could lead to misspecification, which could result in lack of fit of the underlying statistical model. To test possible misspecification of the Q-matrix, traditional goodness of fit tests, such as the Chi-square test and the likelihood ratio test, may not be applied straightforwardly due to the large number of possible response patterns. To address this problem, this paper proposes a new statistical method to test the goodness fit of the Q-matrix, by constructing test statistics that measure the consistency between a provisional Q-matrix and the observed data for a general family of cognitive diagnosis models. Limiting distributions of the test statistics are derived under the null hypothesis that can be used for obtaining the test p-values. Simulation studies as well as a real data example are presented to demonstrate the usefulness of the proposed method.     

Reciprocal recognition of sifaka (<Emphasis Type="Italic">Propithecus verreauxi verreauxi</Emphasis>) and redfronted lemur (<Emphasis Type="Italic">Eulemur fulvus rufus</Emphasis>) alarm calls

Redfronted lemurs (Eulemur fulvus rufus) and Verreaux's sifakas (Propithecus verreauxi verreauxi) occur sympatrically in western Madagascar. Both species exhibit a so-called mixed alarm call system with functionally referential alarm calls for raptors and general alarm calls for carnivores and raptors. General alarm calls also occur in other contexts associated with high arousal, such as inter-group encounters. Field playback experiments were conducted to investigate whether interspecific recognition of alarm calls occurs in both species, even though the two species rarely interact. In a crossed design, redfronted lemur and sifaka alarm calls were broadcast to individuals of both species, using the alarm call of chacma baboons (Papio cynocephalus) as a control. Both species responded with appropriate escape strategies and alarm calls after playbacks of heterospecific aerial alarm calls. Similarly, they reacted appropriately to playbacks of heterospecific general alarm calls. Playbacks of baboon alarm calls elicited no specific responses in either lemur species, indicating that an understanding of interspecific alarm calls caused the responses and not alarm calls in general. Thus, the two lemur species have an understanding of each other's aerial as well as general alarm calls, suggesting that even in species that do not form mutualistic associations and rarely interact, common predator pressure has been sufficient for the development of heterospecific call recognition.     

To <Emphasis Type="Italic">Have</Emphasis> an Ear: Music and the Otological Experience

This essay analyzes the historical development of otology in relation to music. It illustrates the integral role of music perception and appreciation in the study of hearing, where hearing operates not simply as a scientific phenomenon but signifies particular meaningful experiences in society. The four historical moments considered—Helmholtz’s piano-keyed cochlea, the ear phonautograph, the hearing aid, and the cochlear implant—show how the sounds, perceptions, and instruments of music have mediated and continue to mediate our relationships with hearing. To have an ear, one does not just bear a physiological hearing mechanism; one experiences the aesthetics of musical sound.     

Orientation in the cuttlefish <Emphasis Type="Italic">Sepia officinalis</Emphasis>: response <Emphasis Type="Italic">versus</Emphasis> place learning

Several studies have demonstrated that mammals, birds and fish use comparable spatial learning strategies. Unfortunately, except in insects, few studies have investigated spatial learning mechanisms in invertebrates. Our study aimed to identify the strategies used by cuttlefish (Sepia officinalis) to solve a spatial task commonly used with vertebrates. A new spatial learning procedure using a T-maze was designed. In this maze, the cuttlefish learned how to enter a dark and sandy compartment. A preliminary test confirmed that individual cuttlefish showed an untrained side-turning preference (preference for turning right or left) in the T-maze. This preference could be reliably detected in a single probe trial. In the following two experiments, each individual was trained to enter the compartment opposite to its side-turning preference. In Experiment 1, distal visual cues were provided around the maze. In Experiment 2, the T-maze was surrounded by curtains and two proximal visual cues were provided above the apparatus. In both experiments, after acquisition, strategies used by cuttlefish to orient in the T-maze were tested by creating a conflict between the formerly rewarded algorithmic behaviour (turn, response learning) and the visual cues identifying the goal (place learning). Most cuttlefish relied on response learning in Experiment 1; the two strategies were used equally often in Experiment 2. In these experiments, the salience of cues provided during the experiment determined whether cuttlefish used response or place learning to solve this spatial task. Our study demonstrates for the first time the presence of multiple spatial strategies in cuttlefish that appear to closely parallel those described in vertebrates.     

A Unified Nonparametric IRT Model for <Emphasis Type="Italic">d</Emphasis>-Dimensional Psychological Test Data (<Emphasis Type="Italic">d</Emphasis>-ISOP)

The (univariate) isotonic psychometric (ISOP) model (Scheiblechner, 1995) is a nonparametric IRT model for dichotomous and polytomous (rating scale) psychological test data. A weak subject independence axiom W1 postulates that the subjects are ordered in the same way except for ties (i.e., similarly or isotonically) by all items of a psychological test. A weak item independence axiom W2 postulates that the order of the items is similar for all subjects. Local independence (LI or W3) is assumed in all models. With these axioms, sample-free unidimensional ordinal measurements of items and subjects become feasible. A cancellation axiom (Co) gives, as a result, the additive isotonic psychometric (ADISOP) model and interval scales for subjects and items, and an independence axiom (W4) gives the completely additive isotonic psychometric (CADISOP) model with an interval scale for the response variable (Scheiblechner, 1999). The d-ISOP, d-ADISOP, and d-CADISOP models are generalizations to d-dimensional dependent variables (e.g., speed and accuracy of response). The author would like to thank an Associate Editor and two anonymous referees and also Professor H.H. Schulze for their very valuable suggestions and corrections.     

Predispositions to Lymphoma: <Emphasis Type="Italic">A Practical Review for Genetic Counselors</Emphasis>

This review provides a synopsis for genetic counselors of the major concepts of lymphoma predisposition: genomic instability, immune deficiency, inappropriate lymphoproliferation, and chronic antigen stimulation. We discuss syndromes typifying each of these mechanisms. Importantly, our review of the genetic counseling literature reveals sparse discussion of genetically-based immune-mediated lymphoma predisposition, which we address in depth here. We aim to increase awareness among genetic counselors and colleagues in oncology about familial susceptibility and facilitate critical thinking about lymphoma risk assessment. Clinical application of this knowledge is aided by recommendations for collection of personal and family history to guide risk assessment and testing. Lastly, we include a special discussion of genetic counseling issues including perceptions of the context, nature, and magnitude of lymphoma risk, as well as coping with awareness of susceptibility to lymphoma.     

<Emphasis Type="Italic">Ceteris</Emphasis>-<Emphasis Type="Italic">Paribus</Emphasis> Qualifiers

Antecedent-strengthening, a trivially valid inference of classical logic of the form: P → Q ? (P & R) → Q, has a counterpart in everyday reasoning that often fails. A plausible solution to the problem involves assuming an implicit ceteris paribus (CP) qualifier that can be explicated as an additional conjunct in the antecedent of the premise. The qualifier can be explicated as ‘everything else relevant remains unchanged’ or alternatively as ‘nothing interferes’. The qualifier appears most prominently in the context of the discussion of laws in the sciences, where these laws are often expressed with a CP qualifier. From an analysis of the qualifier’s role in the problem of antecedent-strengthening, we can learn more about CP qualifiers in general and in their application to the laws used in the sciences.