Fear Develops to the Conditioned Stimulus and to the Context during Classical Eyeblink Conditioning in Rats

In classical eyeblink conditioning, non-specific emotional responses to the aversive shock unconditioned stimulus (US), which are presumed to coincide with the development of fear, occur early in conditioning and precede the emergence of eyeblink responses. This two-process learning model was examined by concurrently measuring fear and eyeblink conditioning in the freely moving rat. Freezing served as an index of fear in animals and was measured during the inter-trial intervals in the training context and during a tone conditioned stimulus (CS) presented in a novel context. Animals that received CS-US pairings exhibited elevated levels of fear to the context and CS early in training that decreased over sessions, while eyeblink conditioned responses (CRs) developed gradually during acquisition and decreased during extinction. Random CS-US presentations produced a similar pattern of fear responses to the context and CS as paired presentations despite low eyeblink CR percentages, indicating that fear responding was decreased independent of high levels of learned eyeblink responding. The results of paired training were consistent with two-process models of conditioning that postulate that early emotional responding facilitates subsequent motor learning, but measures from random control animals demonstrate that partial CS-US contingencies produce decrements in fear despite low levels of eyeblink CRs. These findings suggest a relationship between CS-US contingency and fear levels during eyeblink conditioning, and may serve to clarify further the role that fear conditioning plays in this simple paradigm.     

Interactions between Callous Unemotional Behaviors and Executive Function in Early Childhood Predict later Aggression and Lower Peer-liking in Late-childhood

Callous unemotional (CU) behaviors are linked to aggression, behavior problems, and difficulties in peer relationships in children and adolescents. However, few studies have examined whether early childhood CU behaviors predict aggression or peer-rejection during late-childhood or potential moderation of this relationship by executive function. The current study examined whether the interaction of CU behaviors and executive function in early childhood predicted different forms of aggression in late-childhood, including proactive, reactive, and relational aggression, as well as how much children were liked by their peers. Data from cross-informant reports and multiple observational tasks were collected from a high-risk sample (N = 240; female = 118) at ages 3 and 10 years old. Parent reports of CU behaviors at age 3 predicted teacher reports of reactive, proactive, and relational aggression, as well as lower peer-liking at age 10. Moderation analysis showed that specifically at high levels of CU behaviors and low levels of observed executive function, children were reported by teachers as showing greater reactive and proactive aggression, and were less-liked by peers. Findings demonstrate that early childhood CU behaviors and executive function have unique main and interactive effects on both later aggression and lower peer-liking even when taking into account stability in behavior problems over time. By elucidating how CU behaviors and deficits in executive function potentiate each other during early childhood, we can better characterize the emergence of severe and persistent behavior and interpersonal difficulties across development.     

Comparison of Single Unit Responses to Tone, Light, and Compound Conditioned Stimuli during Rabbit Classical Eyeblink Conditioning

Unit recordings and lesion studies have implicated the cerebellum as an essential site for the acquisition and maintenance of the conditioned eyeblink response. The current study looked at the neural characteristics of conditioned stimulus (CS) processing in the interpositus nucleus of the cerebellum after training New Zealand white rabbits (Oryctolagus cuniculus) in one of two conditioning paradigms: (a) compound conditioning (CMP), a compound CS consisting of light and tone paired with an air puff unconditioned stimulus (US); or (b) stimulus compounding (ALT), alternating blocks of tone CS and light CS trials paired with the air puff US. Single unit responses were recorded during five sessions after the animals had reached an asymptotic level of responding. Animals were tested for behavioral and neural responses to CS alone trials that included tone alone, light alone, and compound tone-light trials. For the CMP group, the compound CS elicited 80 to 90% conditioned eyeblink responses (CRs), whereas the individual tone and light CSs elicited only 40 to 50% CRs. For the ALT group, all three CSs (tone, light, and compound) elicited very high levels of responding of at least 80% CRs. For the CMP group, there were roughly equal numbers of cells responding to all of the CSs. This includes cells that responded exclusively to one, and only one, of the three stimuli and also those cells that responded to combinations of two or more. Cells from the ALT group were far more likely to respond exclusively to only one of the CSs. Both the behavioral and physiological results suggest that the compound tone-light stimulus was processed as a distinct stimulus, separate from the component tone and light. These results are discussed in the context of multisensory processing.     

Interactions between simultaneous contrast and adaptation to gradual change of luminance

Following adaptation to a field of light which was modulated by a rising ramp so that it repetitively grows gradually brighter, a steady test field of light appears to be gradually growing dimmer. In this study, if a small grey spot of constant luminance was centered in the brightening field, it appeared to be growing gradually dimmer by simultaneous contrast. This apparent dimming led to a brightening aftereffect in the spot. It was shown that this spot aftereffect had two independent components: the apparent dimming of the adapting spot produced its own aftereffect (contrast produced an aftereffect) and also the dimming aftereffect in the surround field spatially induced an aftereffect into the spot during the test period (aftereffect produced simultaneous contrast). Thus simultaneous contrast can both precede and follow successive contrast in the visual system.     

Sensitivity to viewpoint in children's drawings of objects and relations between objects.

Previous literature suggests that young children are relatively insensitive to viewpoint, only showing their view when the task is manipulated to provoke it. In contrast, older children appear to become more sensitive to viewpoint and it has been claimed that there is a developmental progression toward use of linear perspective as a means of drawing a view-specific scene. This study investigates sensitivity to viewpoint by manipulating it directly. Children between the ages of 6 and 14 years were asked to draw an L-shaped array of three cubes from one of three views: frontal eye level, frontal looking down, and corner looking down. At every age children showed sensitivity to their view in the sense that there were consistent differences between the drawings produced in the three viewing conditions. In the case of younger children this did not lead to an accurate portrayal of either their view or the array relations. Older children portrayed their view and the array relations more accurately, and viewpoint had a strong effect on the choice of projection system both within and between objects. There was no evidence of a general progression toward use of linear perspective.     

Sensitivity to triadic attention between 6 weeks and 3 months of age

In Study 1, 6-week- and 3-month-old infants gazed more to an adult when she alternated attention between an object and the infant versus when attention was directed only to the object. In Study 2, 6-week-olds did not discriminate between triadic situations with face-to-face interaction controlled.     

Interactions between encoding and retrieval in the domain of sequence-learning

In this article, the authors propose to characterize sequence learning in terms of automatic versus non-automatic processing and to apply this contrast independently to knowledge acquisition and retrieval. In several experiments of sequence learning, automaticity of both the acquisition and retrieval of the acquired knowledge was independently assessed. It was found that the sequence learning order can be demonstrated under all combinations of knowledge acquisition and retrieval. In particular, at least in the simple sequences the authors used, this applies in cases in which both the acquisition and the retrieval of knowledge are strictly automatic--that is, when neither is required for the task nor beneficial to deliberate behavior. The proposed framework has implications for the notion of sequence learning and the investigation of learning in general.     

Subcellular interactions between parallel fibre and climbing fibre signals in purkinje cells predict sensitivity of classical conditioning to interstimulus interval

Classical conditioning of the nictitating membrane response requires a specific temporal interval between conditioned stimulus and unconditioned stimulus, and produces an incrase in Protein Kinase C (PKC) activation in Purkinje cells. To evaluate whether biochemical interactions within the Purkinje cell may explain the temporal sensitivity, a model of PKC activation byCa ²⁺, diacylglycerol (DAG), and arachidonic acid (AA) is developed.Ca ²⁺ elevation is due to CF stimulation and IP3 inducedCa ²⁺ release (IICR). DAG andIP ₃ result from PF stimulation, while AA results from phospholipase A2 (PLA ₂). Simulations predict increased PKC activation when PF stimulation precedes CF stimulation by 0.1 to 3 s. The sensitivity of IICR to the temporal relation between PF and CF stimulation, together with the buffering system of Purkinje cells, significantly contribute to the temporal sensitivity.     

Parallel between antianxiety and cardiovascular effects of chlordiazepoxide in genetically nervous dogs

There is evidence that cardiac arrhythmias are partially of CNS origin, and that certain drugs affect arrhythmia, both positively and negatively, through CNS action. We hypothesized and confirmed that chlordiazepoxide diminished the well-established incidence of arrhythmias (A-V blocks and nodal escapes) in five nervous pointer dogs. It is known that this drug normalizes behavior and aids in the bar-pressing performance of nervous dogs. Nervous dogs tend to have low heart rates (HRs) while normals have higher HRs. Chlordiazepoxide increased HRs in our five nervous dogs, and we postulated that HR increase would be less or none in normals. This was confirmed in a later study of five normals. A further study of eight normal dogs and eight nervous dogs essentially reproduced these findings, suggesting the possibility that the slow heart rates and the behavioral abnormality have a common basis, expected to be some CNS biochemical lesion.     

经验信息与共变信息对判断两原因共同作用的影响

本研究考察了被试在使用经验信息和共变信息进行两原因共同作用因果判断时所具有的特点。研究结果表明:(1)两原因的性质对于被试的选择有着显著影响。当两原因的可信度相等时,更多被试认为两原因都可以引起结果。(2)两原因都不出现时结果出现的概率P(e/~i~j)对于被试的选择没有显著影响。(3)两原因单独出现时结果出现的概率对于被试的选择有着显著的影响,但是这一变量是与两原因的可信程度共同产生影响的。     

Sensitivity to differences between enjoyment and non‐enjoyment smiles in children with autism spectrum disorder

The sensitivity of male children (5–15 years) with and without autism spectrum disorder (ASD) to the affective state of others was tested using an emotion recognition task. Only children without ASD could reliably differentiate between enjoyment and non‐enjoyment smiles. Results are considered in terms of the social impairments of children with ASD.     

Detecting phonemes and letters in text: Interactions between different types and levels of processes

In six experiments, subjects detected phonemes or letters in text presented auditorily or visually. Experiments 1 and 2 provided support for the hypothesis that a mismatch between the phoneme and letter representations of a target leads to detection errors. In addition, visual word unitization processes were implicated. Experiments 3 and 4 provided support for the hypothesis that the Gestalt goodness of pattern affected detection errors when subjects searched for letters. Experiments 5 and 6 demonstrated that the effects of unitization on the detection of letters in common words were decreased by altering the familiar configuration of the test words. The combined results of all six experiments lead to the conclusion that both visual and phonetic processes influence letter detection, that these processes communicate through a type of cross-checking, and that there are at least two levels of visual (and perhaps of phonetic) processing involved in the letter detection task.     

Increasing Ethical Sensitivity to Racial and Gender Intolerance in Schools: Development of the Racial Ethical Sensitivity Test

We analyzed a sample of 356 forms containing information that Colorado law legally requires both licensed and unlicensed therapists to disclose to clients. The majority of forms contained the legally mandated information; fewer forms contained ethically desirable information. The average readability grade level was 15.74, corresponding to upper-level college, and 63.9% of the forms reached the highest (most difficult) readability grade of 17 +. Therapists are obeying the law, but do not appear to be taking advantage of the opportunity to provide their clients useful information in an accessible way.     

Interactions between intrinsic principles of similarity and proximity and extrinsic principle of common region in visual perception

The interactions between intrinsic grouping principles (by proximity or by similarity in shape or luminance) and extrinsic grouping by common region were examined by presenting both principles acting alone or conjoined with another principle in visual patterns. The procedure used in our study closely mirrored that of Quinlan and Wilton (1998 Perception 27 417-430). However, in the present experiment, the intrinsic and extrinsic grouping principles involved had similar relative salience in order to avoid their possible effects on interactions. The results showed that the grouping effect of conjoined cooperating principles was greater than that of either principle acting alone, and the grouping effect of conjoined competing principles was lower than that of either principle operating alone. Compatibility of data with additive effects of grouping principles has been examined.     

How to turn a hawk into a dove and vice versa: Interactions between emotions and goals in a give-some dilemma game

The present study investigated emotional influences on behavior in a one-shot, simultaneous, give-some dilemma game. In accordance with functional perspectives on the role of discrete emotions, we found fear to reduce, and guilt to increase levels of cooperation. Moreover, we showed individual differences in the effect of induced emotional states. Specifically, results indicated that inducing fear reduced cooperation only for individuals with a pro-social value orientation, and that guilt induction increased cooperation only for individuals with a pro-self value orientation. We also established that both social value orientations could be adequately described in terms of differences in chronically accessible goals (as assessed by value-importance ratings). These results, therefore, seem to support our hypothesis that individual differences in the behavioral consequences of induced emotional states are related to variation in chronic accessibility of general goals associated with a particular emotional state.     

Child and Adult Sensitivity to Gender Information in Patterns of Facial Motion

Sixty 5-year-olds and 120 adults participated in research that examined the development of sensitivity to gender information in patterns of facial motion. Subjects were asked to identify the gender of static or dynamic versions of point-light stimulus faces. The dynamic facial displays were filmed either while the stimulus recited the alphabet or while they were engaged in an interaction. Although adults' levels of identification accuracy were greater than those obtained by children, both age groups were able to identify the gender of dynamic facial displays at greater than chance levels. However, adults were able to identify the gender of both reciting and interacting faces, whereas children could only discriminate sex at greater than chance levels when observing interacting faces.     

Sensitivity to the displacement of facial features in negative and inverted images

Subjects have previously been reported to show difficulties in recognising faces which are either inverted or in photographic negative. Experiments are reported in which a two-alternative forced-choice technique was used to measure sensitivity for distinguishing faces which have been modified by having the eyes moved vertically or horizontally. Subjects were less sensitive to such changes for inverted faces or negative faces, and were even less sensitive for faces that were both inverted and negative. No such effects were found for a control stimulus consisting simply of three solid circles in the same positions as the eyes and mouth of a face. When the stimuli consisted of eyes, nose, and mouth, but without a surround, no evidence of inversion or negation effects was found, which suggests that a facial surround is necessary. When the stimulus consisted of a facial surround with the eyes, nose, and mouth replaced by solid circles, effects of negation were found, but no effects of inversion. This dissociation of the effects of negation and inversion may suggest that they are the result of different underlying mechanisms.     

Sensitivity of 4-year-olds to featural and second-order relational changes in face distinctiveness

Sensitivity to adult ratings of facial distinctiveness (how much an individual stands out in a crowd) has been demonstrated previously in children age 5 years or older. Experiment 1 extended this result to 4-year-olds using a "choose the more distinctive face" task. Children's patterns of choice across item pairs also correlated well with those of adults. In Experiment 2, original faces were made more distinctive via local feature changes (e.g., bushier eyebrows) or via relational changes (spacing changes, e.g., eyes closer together). Some previous findings suggest that children's sensitivity develops more slowly to relational changes than to featural changes. However, when we matched featural and relational changes for effects on distinctiveness in adult participants, 4-year-olds were equally sensitive to both. Our results suggest that (a) 4-year-olds' face space has important aspects of structure in common with that of adults and that (b) there is no specific developmental delay for a second-order relational component of configural/holistic processing.