Pupillary and heart rate reactivity in children with minimal brain dysfunction

This study attempted to replicate and extend previous findings on autonomic arousal and responsivity in children with diagnoses of minimal brain dysfunction (MBD). Pupil size, heart rate, skin conductance, and skin temperature were recorded from 32 MBD and 45 control children during a session that included presentation of visual stimuli, simple reaction time (RT), a cold pressor procedure, and rest periods. The MBD children were tested both off and on clinical dosages of stimulant drugs in a crossover design. Evidence of higher than normal arousal levels in the unmedicated MBD Ss was obtained from resting skin conductance and, more tenuously, from pupil size. Lower phasic responsivity in the MBD children was evidenced by slower RT, less cardiac deceleration to both light and RT stimuli, and smaller pupil dilation to the RT stimuli. Spontaneous pupillary constrictions during rest periods, presumably indicating drowsiness, were observed about equally in MBD and control children. Stimulant drugs raised arousal levels but did not reverse the responsivity deficits. The lower phasic reactivity in the MBD group and the effects of stimulant drugs on arousal indices confirm earlier reports. The finding of higher arousal in drug-free MBD children is incompatible with the low arousal hypothesis of MBD but is consistent with a previous report of the effects of a stimulating environment on these children.This work was supported in part by a grant from the Ittleson Family Foundation. The authors thank Frank Abate for technical assistance.     

Physiologic and motor conditioning and generalization in children with minimal brain dysfunction

Twenty-six children diagnosed as having minimal brain dysfunctions (MBD) were compared with 26 controls in a conditinoing and generalization procedure. Skin resistance, heart rate, and muscle action potentials were monitored throughout. Success involved learning which of two tones signalled the accessibility of a penny. Whereas 92 per cent of controls reached the criterion of five successive correct responses, only 62 per cent of MBD’s did. Further, a third of the MBD’s were so maladaptive as to force procedural variations, while only a few minor irregularities occurred with the controls. Quality of performance was related to age, intelligence, and ability to discriminate and remember tones. Controls were more physiologically reactive than MBD’s, especially in skin resistance. Physiologic differentiation of the two tones was significant in both groups of children and appeared concurrently with motor differentiation. The only evidence of physiologic generalization was in the SR data of controls. The possibility that defective arousal structures, or defective coupling of arousal structures and other perceptual and motor structures, could account for the decreased physiologic reactivity, short attention spans, and poor concentration ofsome MBD’s is discussed. This research, in conformity with other laboratory studies of the brain, indicates that motivational as well as cognitive defects may be organically based.     

Perceptual-motor coordination and style in healthy boys and those with minimal brain dysfunction.

Differences in visual-motor tracking by 8- to 9-yr.-old boys diagnosed with Minimal Brain Dysfunction or healthy have been analyzed. The subject's task was to use two computer keys to control a cursor line within a target which moved horizontally in two directions over the display. Target size and speed were the experimental variables. Off-target incidences and durations were measured and evaluated. The latter were longer and the former were more frequent on small targets for boys with brain dysfunction than for healthy boys. The two measures correlated negatively in most situations. The perceptual-motor style expressed by means of the distribution of coincidences of the two measures being over or under a criterion set equal to the corresponding averages of the healthy boys was different in the two groups. Brain-damaged boys were characterized mostly by the combination of high incidence of low duration misses for small and fast targets and by high incidence of high duration misses for large and slow targets, whereas most healthy boys showed a few misses of low duration for large and slow targets and few misses of high duration for small and fast targets.     

Frontal brain asymmetry in depression with comorbid anxiety: a neuropsychological investigation

The approach-withdrawal model posits that depression and anxiety are associated with a relative right asymmetry in frontal brain activity. Most studies have tested this model using measures of cortical brain activity such as electroencephalography. However, neuropsychological tasks that differentially use left versus right frontal cortical regions can also be used to test hypotheses from the model. In two independent samples (Study 1 and 2), the present study investigated the performance of currently depressed individuals with or without a comorbid anxiety disorder and healthy controls on neuropsychological tasks tapping primarily left (verbal fluency) or right (design fluency) frontal brain regions. Across both samples, results indicated that comorbid participants performed more poorly than depressed only and control participants on design fluency, while all groups showed equivalent performance on verbal fluency. Moreover, comorbid participants showed "asymmetrical" performance on these two tasks (i.e., poorer design [right frontal] relative to verbal [left frontal] fluency), whereas depressed only and control participants showed approximately symmetrical profiles of performance. Results from these two samples suggest an abnormal frontal asymmetry in neurocognitive performance driven primarily by right frontal dysfunction among anxious-depressed individuals and highlight the importance of considering comorbid anxiety when examining frontal brain functioning in depression.     

Some psychological correlates of generalized and focal epilepsy in children

School-aged children with two types of epilepsy, generalized and focal, were compared with normal children of the same age, sex, and IQ on measures of cognitive style, attention, motor control, and behavioral pathology. Epileptic children were found to employ less efficient cognitive strategies and to have longer reaction times and poorer control of fine motor movements than have normal children. Children with generalized epilepsy were more impaired than were normal children when sustained motor performance was required. Mothers of children with generalized epilepsy reported more behavior problems than did control mothers on an objective checklist. These results suggest special educational methods for the treatment and education of epileptic children.The research reported in this paper was supported by Grant No. MA-45O5 from the Medical Research Council of Canada. Grateful thanks are extended to Dr. Katherine Metrakos, Director of the Convulsive Disorder Clinic, Montreal Children's Hospital, who screened epileptic subjects and gave us her enthusiastic support. The Diagnostic Test Center was most helpful in providing blood serum levels on the clinical sample. We wish to thank the Notre Dame de Grace and Westmount branches of the Y.M.C.A. for access to control subjects.     

Frontal lobe dementia and subcortical vascular dementia: a neuropsychological comparison

We compared the performance of 40 patients with frontal lobe dementia to that of 40 patients with subcortical vascular dementia (80 patients including, 46 men and 34 women) in a set of tasks assessing attentional, executive, and behavioural tasks. The frontal lobe dementia represents an important cause for degenerative disruption and is increasingly recognised as an important form (up to 25%) of degenerative dementia among individuals of late-middle-age. The main involvement is the frontal-subcortical pathway, which is the final target of impairment even in subcortical vascular dementia. A wider involvement of the cortical (decisional) layers in frontal dementia, in contrast with the prominent and widespread involvement of the subcortical pathways (refinement and corrections programs) creates the different profiles of the two groups. Frontal patients have more difficulties in abstract reasoning, focusing attention, and implementing strategies to solve problems. They exhibit more profound behavioural alterations in personality and social conduct and show only moderate depression, and a total lack of insight concerning their dinical condition. In contrast, the patients with subcortical vascular dementia have poor general cognitive functions, high insight, and important depression and apathy as the principal and most salient characteristic of their behavioral conduct.     

MINDS: Toward a computerized test battery for use in health psychological and neuropsychological assessment

MINDS (Mental Information Processing and Neuropsychological Diagnostic System) was developed with the goal of integrating a number of independent and stand-alone test programs that are used in the diagnosis of psychological and neuropsychological health. The system runs under MS-DOS. The shell program integrates subject information with data obtained through the use of the individual test programs. The current test battery comprises tasks on memory, attention, and motor performance; these tasks require the use of additional peripheral response devices, which are controlled via a multiple I/O interface card. Questionnaires are also included; they have been developed with the author language shell program MicroCAT. MINDS is programmed to allow easy integration of new tests. As an example, the Motor Planning Test is described. The equivalence of the computerized questionnaires with existing tests is also discussed.     

A comparison of cognitive/neuropsychological impairments of nonretarded autistic and schizophrenic children

The performance of children meeting DSM-III criteria for schizophrenic disorder and infantile autism and of normal children (ages 7 years 10 months to 14 years 4 months) was compared on the Wisconsin Card Sorting Test, Rey's Tangled Line Test, Benton Judgment of Line Orientation, Digit Symbol Substitution Test, and Peabody Picture Vocabulary Test. The mean performance IQ of the schizophrenic and autistic children was equal and in the normal range. The normal children were of average intelligence as estimated by the PPVT. As compared to normal children, both autistic and schizophrenic children were impaired on the DSST and RTLT. The autistic children had significantly lower scores on the PPVT than schizophrenic and normal children. The schizophrenic children made significantly more perseverative responses on the WCST than did normal children. They significantly increased their nonperseverative errors on the second half of the WCST, after having been taught the correct sorting principles. It is argued that in schizophrenia a core deficit in momentary processing capacity underlies the above performance pattern. In contrast, in autism the core cognitive deficit involves an inability to use language to regulate and control ongoing behavior.Preparation of this article was supported in part by a John D. and Catherine T. MacArthur Foundation Grant to Robert Asarnow, and NIMH Grant MH 30897 to the UCLA Clinical Research Center for the Study of Childhood Psychoses. We gratefully acknowledge the assistance of Michael J. Goldstein, Ph.D., who acted as reseach advisor to the first author over the course of this study; Delores Adams, who assisted us in data analysis; and Sara Lerner, who enthusiastically helped us in data collection. We also acknowledge the assistance of the staff of the Clinical Research Center for the Study of Childhood Psychosis at UCLA, as well as the many children who participated in this study, and their parents.     

The sexual and mental health problems of street children: a transcultural preventative approach in counselling psychology

Sexual and mental health problems are on the increase world-wide especially among street children. A high proportion of vulnerable children who live in the street suffer exploitation, poor quality of life that often lead to sexual and mental health problems. Evidence is needed on the theoretical perspectives taken to address the existing gaps in counselling psychology research and practice on the plight of street children. It is also important to identify interventions that could be implemented to prevent the expansion of sexual and mental health problems among street children. Because of paucity of evidence in counselling psychology, an attempt has been made to highlight the risks factors associated with street children such as sexual exploitation, engaging in unsafe sex at an early age, promiscuity, unplanned pregnancy which tend to lead to mental health problems. Case studies are presented that illustrate the importance of a preventative transcultural approach in counselling psychology.     

Sleep disturbance and neuropsychological function in young children with ADHD

Sleep disturbance, common among children with ADHD, can contribute to cognitive and behavioral dysfunction. It is therefore challenging to determine whether neurobehavioral dysfunction should be attributed to ADHD symptoms, sleep disturbance, or both. The present study examined parent-reported sleep problems (Children’s Sleep Habits Questionnaire) and their relationship to neuropsychological function in 64 children, aged 4–7 years, with and without ADHD. Compared to typically developing controls, children with ADHD were reported by parents to have significantly greater sleep disturbance—including sleep onset delay, sleep anxiety, night awakenings, and daytime sleepiness—(all p ≤ .01), and significantly poorer performance on tasks of attention, executive control, processing speed, and working memory (all p < .01). Within the ADHD group, total parent-reported sleep disturbance was significantly associated with deficits in attention and executive control skills (all p ≤ .01); however, significant group differences (relative to controls) on these measures remained (p < .01) even after controlling for total sleep disturbance. While sleep problems are common among young children with ADHD, these findings suggest that inattention and executive dysfunction appear to be attributable to symptoms of ADHD rather than to sleep disturbance. The relationships among sleep, ADHD symptoms, and neurobehavioral function in older children may show different patterns as a function of the chronicity of disordered sleep.     

A controlled clinical comparison of attention performance in children with ADHD in a virtual reality classroom compared to standard neuropsychological methods.

In this initial pilot study, a controlled clinical comparison was made of attention perforance in children with attention deficit-hyperactivity disorder (ADHD) in a virtual reality (VR) classroom. Ten boys diagnosed with ADHD and ten normal control boys participated in the study. Groups did not significantly differ in mean age, grade level, ethnicity, or handedness. No participants reported simulator sickness following VR exposure. Children with ADHD exhibited more omission errors, commission errors, and overall body movement than normal control children in the VR classroom. Children with ADHD were more impacted by distraction in the VR classroom. VR classroom measures were correlated with traditional ADHD assessment tools and the flatscreen CPT. Of note, the small sample size incorporated in each group and higher WISC-III scores of normal controls might have some bearing on the overall interpretation of results. These data suggested that the Virtual Classroom had good potential for controlled performance assessment within an ecologically valid environment and appeared to parse out significant effects due to the presence of distraction stimuli.     

Deficit in phonological processes: a characteristic of the neuropsychological profile of children with NF1

Learning disabilities are one of the most frequent complications of neurofibromatosis type 1 (NF1) in children. Studies of the effects of the neurocognitive deficit on academic performance are relatively rare, owing to the small size of the populations concerned. However, research is needed to develop effective rehabilitation programs. In the present study, we explored the impact of a possible phonological deficit on the reading abilities of children with NF1. A multicenter, cross-sectional study was conducted in France on two groups of 75 children with or without NF1 aged 8–12 years, matched for age, sex, handedness, and reading level. All participants underwent a neuropsychological evaluation to assess their general cognitive level, reading skills, phonological processes, visuoperceptual abilities, and attentional capacity. Phonological skills were assessed by means of two phonological awareness tasks and one short-term memory task. In the group of children with NF1, 41% had reading difficulties. Phonological processes were impaired in this group, compared with the children without NF1. Similar differences were found for a phoneme deletion task after adjustment for reading difficulties, IQ level, and visuoperceptual abilities. Phonological awareness, but not phonological short-term memory, was impaired in children with NF1, and not just those whose reading was impaired. Results suggest that children with NF1 have a phonological awareness deficit, whatever their reading level. Identification of reduced phonological skills may warrant the implementation of a specific rehabilitation program before early reading difficulties emerge.     

The phenomenological underpinning of the notion of a minimal core self: a psychological perspective

The paper argues that Zahavi's defence of the self as an experiential dimension, i.e. "identified with the first-person givenness of experiential phenomena", and of the notion of a pre-reflective minimal core self relies on an unwarranted assumption. It is assumed that awareness of the phenomenal mode of experiences of objects, i.e. what the object "feels" like for the experiencer, is comparable with, indeed entails, first-person givenness of experience. In consequence both the arguments concerning the foundational role of the pre-reflective minimal core self and the explanation of the unity and identity of the self through time give rise to intractable problems.     

Categorization and abstraction abilities in 3-year-old children: a comparison with monkey data

Three-year-old children were tested on three categorization tasks of increasing levels of abstraction (used with adult baboons in an earlier study): the first was a conceptual categorization task (food vs toys), the second a perceptual matching task (same vs different objects), and the third a relational matching task in which the children had to sort pairs according to whether or not the two items belonged to the same or different categories. The children were tested using two different procedures, the first a replication of the procedure used with the baboons (pulling one rope for a category or a relationship between two objects, and another rope for the other category or relationship), the second a task based upon childrens prior experiences with sorting objects (putting in the same box objects belonging to the same category or a pair of objects exemplifying the same relation). The children were able to solve the first task (conceptual categorization) when tested with the sorting into boxes procedure, and the second task (perceptual matching) when tested with both procedures. The children were able to master the third task (relational matching) only when the rules were clearly explained to them, but not when they could only watch sorting examples. In fact, the relational matching task without explanation requires analogy abilities that do not seem to be fully developed at 3 years of age. The discrepancies in performances between children tested with the two procedures, with the task explained or not, and the discrepancies observed between children and baboons are discussed in relation to differences between species and/or problem-solving strategies.