Serum creatinphosphokinase (CPK) in endogenic psychoses]

Creatinphosphokinase (CPK) was determined in 141 patients with manic-depressive and schizophrenic psychoses. In general endogenic psychoses of the manic and depressive type as well as chronic schizophrenias show normal CPK values. In acute cases of paranoid-halluzinatory schizophrenias normal values are predominant. In catatonic schizophrenias, as a rule, clearly increased enzyme activities are found. Thise increased values suggest a postulated somatic disease as a cause of the psychosis. Thus, the determination of CPK provides a useful aid in the diagnosis and control of the course of catatonic schizophrenic.     

Determination of creatine kinase activity using bioluminescence

There is given a simple apparatus for monitoring of CK-activities by means of a bioluminescent test. This test makes it possible to determine CK-activities in 1 microliter serum samples as well as in dried blood spots. A good correlation between the bioluminescent test and a standard method was found. The sensitivity of the method is very high and suitable for a screening of affected boys with Duchenne's muscular dystrophy.     

Studies of higher nervous activity in functional psychoses

Psychiatric illnesses can be conceived of as experiments of nature, providing a variety of pathopsychological mechanisms which may elucidate normal psychological processes. Clinically the reactive psychoses are predominantly psychogenic reaction types. They present disturbances of higher nervous activity, similar to those of the neuroses. The unconditional reflex activity is practically as in normal controls, and the most outstanding finding was the large effect of psychodynamic complex structures. This is a physiological parallel to the clinical manifestations with great concern over experienced mental trauma. In the manic-depressive psychoses the most characteristic feature is a marked disturbance of unconditional reflex activity. This factor may be an important physiological mechanism underlying the more biological than psychodynamic reaction type and partly explain the changes of mood and associated interferences with sleep, body weight, sexual activity, aggression and other instinctual and vegetative functions. Schizophrenic psychoses also present changes of unconditional reflex activity, predominantly in the direction of inhibition of response. In addition there are severe dissociations within and between the three levels of unconditional reflexes and the two signaling systems. It is suggested that schizophrenia represents a functional maladaptation, which can be explained from the principles of autokinesis and schizokinesis established by Gantt in animal experiments. Prognostic models based on experimentally established impairment of performances were shown to predict long-term risks of schizophrenic defects just as well as models based on constellations of clinical symptoms. I would predict that psychophysiology and experimental psychology will become increasingly more important for establishing diagnosis and prognosis in the functional psychoses. The data of this article point toward a basis for a prophylactic psychiatry.     

Out-patient treatment of psychoses using depot-fluphenazin]

43 courses of treatment in various psychoses are reported. Peculiarities of dosage and application, and the position of Depot-Fluphenazin as compared to other Depot-neuroliptics are considered in detail.     

Endogenous psychoses in relation to absent phenylalanine hydroxylase activity in thrombocytes

Out of 100 psychotic patients who underwent neurobiochemical examination, in 24 cases activity of phenylalanine hydroxylase in the thrombocytes was found to be absent. 38% of these cases were susceptible to stimulation in vitro by means of folic acid derivative, without actually reaching a normal level of activity. The patients are presented first as a homgeneous group, then in the two major diagnostic divisions, and divided according to the biochemical data. An account is given of early experiences in the treatment of the more intractable cases.     

Studies on protein genetic factors in multiple sclerosis and psychoses]

In more than 200 cases of multiple sclerosis, psychosis and cyclothymia, the Hp types are studied with the help of polyacrylamide gel electrophoresis (Schreyer and Schaible, 1967) and the Gc types wtih agar gel electrophoresis (Schlesinger, Vogt and Prokop, 1963). All Hp and Gc types were found in these diseases, but there was no frequent occurence of any particular type in multiple acleroses of psychoses. According to our results, there is no interdependence between these diseases and the Hp and Gc types.     

Episodic psychoses in epileptic juveniles with reference to electroencephalographic findings]

The present paper describes three juveniles affected with epilepsy, who suffered from episodic psychoses. Such disorders are a very rare occurrence in young persons. The patients had grand mal epilepsy with "secondary temporalization". Clinical and electroencepholographic aspects are discussed by reference to these particular cases. Also, the authors deal with questions of classification and etiopathogenesis. Finally, possible causes producing such psychoses and giving rise to the psychopathological character thereof are pointed out within the framework of a multiconditional approach.     

Pattern of familial psychoses--systematic and unsystematic schizophrenia and cycloid psychoses]

604 cases were examined, 309 of which were systematic schizophrenics, 191 were unsystematic schizophrenics and 104 cycloid psychotics. With the systematic schizophrenics the average period spent in hospital amounted to 16.9 years, with the unsystematic schizophrenics 13.8 years, with the cycloid psychotics 8.2 years. The systematic schizophrenics were discharged from hospital on average 1.5 times, the unsystematic 2.3 times, the cycloid psychotics 4.1 times. Of the systematic schizophrenics, 37.5% were never discharged after their first admittance to hospital, of the unsystematic 25.7%, of the cycloid psychotics 9.6%. Bipolar fluctuations were detected in 1.6% of the systematic schizophrenics, 49.7% of the unsystematic and 78.8% of the cycloid psychotics. 15.9% of the systematic schizophrenics had occurrences of psychoses in their family compared to 50.8% of the unsystematic and 22.1% of the cycloid psychotics. The systematic schizophrenics had 17.5% of their family ill, the unsystematic 69.6%, the cycloid psychotics 25.0%. Of the parents of the systematic schizophrenics 2.3% were ill, of the parents of the unsystematic schizophrenics 11.6%, of the parents of the cycloid psychotics 5.0%. Of the brothers and sisters of the systematic schizophrenics 2.4% were ill, of the unsystematic schizophrenics 10.9%, of the cycloid psychotics 3.0%. These variations in the pattern and occurrence of psychoses in the family seem to prove that the three groups of endogenous psychoses are genetically separable. There are also differentiating features inside the groups. Periodic catatonia in particular is characterized by the great number of psychotics in the family.     

Cognitive disorders in endogenous psychoses

Cognitive disorders of schizophrenics as well as subjects with affective psychosis were studied with the aid of 10 tests. Differences between schizophrenics and patients with affective psychosis could hardly be detected. Subgroup differences within the two broad diagnostic categories are pointing to the importance of the severity of illness. However, some differences between two small samples (N = 9) carefully matched with regard to several relevant aspects - especially concerning the severity of disorder - show that the diagnostic category is not wholly unimportant. Judged on the basis of these differences, there are probably no deficits of a fundamentally different nature; the assumption of divergent cognitive styles or defence mechanisms considering comparable basic deficits seems more plausible.     

Activity of creatine kinase in mice under various “Stress” conditions

“Stress” induced by swimming, immobilization, and fighting in male albino mice results in a significant increase of creatine kinase (CK) activity in blood obtained by decapitation. The increase partially depends on motor activity as shown in fighting animals. Males show higher CK values than females. Isolation and even immobilization also lead to higher CK activity, the latter to a similar extent as swimming and fighting. We believe that CK activity is regulated by processes additional to motor activity.     

Visually controlled space orientation in endogenous psychoses

The visual controlled behaviour in space is measured in 30 psychotic patients. In a room with a row of 8 equal chairs we measured the right-left-choice and the choice of distance. The neglect of the left chairs in patient with "distrust" and "delusion" let us suppose a right hemispherical dysfunction. There is no correlation between psychosis and choice of distance, but a good correlation between disturbed parental home and near distance.     

Multidimensional studies of circadian biorhythm in psychoses

Subject of the report is methodics for a circadian analysis in case of psychotical diseases. Acquisition and filing of psychopathological phenomenona is effected by means of Strukturiertes Psychopathologisches Erfassungssystem (SPES) and other self-or outside-rating-scales. The diurnal variation of body-temperature is taken as physiological reference function. The results of the analysis, which show an internal rhythmic desynchronization in case of phasic as well as in case of non-phasic psychoses, are given by way of exemplary instances.