Effect of Interleukin-1beta on Pituitary-Adrenal Responses and Body Weight in Neonatal Rats: Interaction with Maternal Deprivation

The hypothalamic-pituitary-adrenal (HPA) axis of the infant rat is normally hyporesponsive during postnatal days (pnd) four to fourteen. This interval is termed the stress hyporesponsive period (SHRP). The HPA axis, however, does respond to selective stimuli, such as interleukin-1beta (IL-1beta) during this period. Furthermore, maternal deprivation has been shown to alter the system so that it is responsive to mild stimuli. The present studies examined the interaction between 24 h of maternal deprivation and intraperitoneal administration of recombinant human (rh) IL-1beta (4 μg/kg) at 3 ages (i.e., pnd 6, 12, 18) during or after the SHRP. The results demonstrate that maternal deprivation modifies the response of the HPA axis induced by IL-1beta in an age-dependent fashion: 1) a greater response at pnd 6; 2) a quicker response at pnd 12; and 3) a suppressed response pattern at pnd 18. Moreover, these responses across ages differ as a function of maternal contact postinjection: 1) deprivation augments the ACTH and CORT response and maternal contact postinjection further augments this response at pnd 6; 2) deprivation increases the ACTH and CORT response to vehicle and the CORT response to IL-1beta in 12 day-old pups and the mother has a modest inhibitory effect; and 3) at pnd 18 deprivation leads to lower ACTH concentrations, but higher overall CORT levels and maternal contact postinjection effectively suppresses both the ACTH and CORT response to IL-1. These differences in the HPA response do not appear to be due to differences in the immune response. Plasma concentrations of endogenous rat IL-1beta determined 1 and 2 h after injection of rhIL-1beta were not modified by deprivation and were reduced at pnd 18 compared to pnd 6 and 12 in NDEP pups. Finally, IL-1beta reduced food intake, as reflected by a decrease in body weight, in deprived pups at all 3 ages. The findings in the present experiments suggest that there are additional pathways through which IL-1beta can act on the CNS to activate the HPA axis besides direct action at the hypothalamus.     

Double Skew-Dual Scaling: A Conjoint Scaling of Two Sets of Objects Related by a Dominance Matrix

Consider two sets of objects, {alpha(1), em leader, alpha(n)} and {beta(1), em leader, beta(m), such as n subjects solving m tasks, or n stimuli presented first and m stimuli presented second in a pairwise comparison experiment. Let any pair (alpha(i), beta(j)) be associated with a real number a(ij), interpreted as the degree of dominance of alpha(i) over beta(j) (e.g., the probability of alpha(i) relating in a certain way to beta(j)). Intuitively, the problem addressed in this paper is how to conjointly, in a "naturally" coordinated fashion, characterize the alpha-objects and beta-objects in terms of their overall tendency to dominate or be dominated. The gist of the solution is as follows. Let A denote the nxm matrix of a(ij) values, and let there be a class of monotonic transformations straight phi with nonnegative codomains. For a given straight phi, a complementary matrix B is defined so that straight phi(a(ij))+straight phi(b(ij))=const, and one computes vectors D(alpha) and D(beta) (the dominance values for alpha-objects and beta-objects) by solving the equations straight phi(A) straight phi(D(beta))/Sigma;straight phi(D(beta))=straight phi(D(alpha)) and straight phi(B(T)) straight phi(D(alpha))/Sigmastraight phi(D(alpha))=straight phi(D(beta)), where (T) is transposition, Sigma is the sum of elements, and straight phi applies elementwise. One also computes vectors S(alpha) and S(beta) (the subdominance values for alpha-objects and beta-objects) by solving the equations straight phi(B) straight phi(S(beta))/Sigmastraight phi(S(beta))=straight phi(S(alpha)) and straight phi(A(T)) straight phi(S(alpha))/Sigmastraight phi(S(alpha))=straight phi(S(beta)). The relationship between S-vectors and D-vectors is complex: intuitively, D(alpha) characterizes the tendency of an alpha-object to dominate beta-objects with large dominance values, whereas S(alpha) characterizes the tendency of an alpha-objects to fail to dominate beta-objects with large subdominance values. For classes containing more than one straight phi-transformation, one can choose an optimal straight phi as the one maximizing some measure of discrimination between individual elements of vectors straight phi(D(alpha)), straight phi(D(beta)), straight phi(S(alpha)), and straight phi(S(beta)), such as the product or minimum of these vectors' variances. The proposed analysis of dominance matrices has only superficial similarities with the classical dual scaling (Nishisato, 1980). Copyright 1999 Academic Press.     

A hierarchical bayesian statistical framework for response time distributions

This paper provides a statistical framework for estimating higher-order characteristics of the response time distribution, such as the scale (variability) and shape. Consideration of these higher order characteristics often provides for more rigorous theory development in cognitive and perceptual psychology (e.g., Luce, 1986). RT distribution for a single participant depends on certain participant characteristics, which in turn can be thought of as arising from a distribution of latent variables. The present work focuses on the three-parameter Weibull distribution, with parameters for shape, scale, and shift (initial value). Bayesian estimation in a hierarchical framework is conceptually straightforward. Parameter estimates, both for participant quantities and population parameters, are obtained through Markov Chain Monte Carlo methods. The methods are illustrated with an application to response time data in an absolute identification task. The behavior of the Bayes estimates are compared to maximum likelihood (ML) estimates through Monte Carlo simulations. For small sample size, there is an occasional tendency for the ML estimates to be unreasonably extreme. In contrast, by borrowing strength across participants, Bayes estimation shrinks extreme estimates. The results are that the Bayes estimators are more accurate than the corresponding ML estimators.We are grateful to Michael Stadler who allowed us use of his data. This research is supported by (a) National Science Foundation Grant SES-0095919 to J. Rouder, D. Sun, and P. Speckman, (b) University of Missouri Research Board Grant 00-77 to J. Rouder, (c) National Science Foundation grant DMS-9972598 to Sun and Speckman, and (d) a grant from the Missouri Department of Conservation to D. Sun.     

Exceptions to Hick's law: explorations with a response duration measure

Five experiments used a new response-duration measure in explorations of the conditions necessary for confirmation of Hick's law. Hick's law states that reaction time increases logarithmically with number of choices. Exceptions to the law, venerable as it is, have been reported. They have always included the following conditions: a verbal response; a familiar stimulus with a single dominant name; and a large number of practice trials. These conditions have carried a heavy explanatory burden in accounting for the anamolous results. The present studies use none of these conditions and yet manage to replicate the anamolous result of a very shallow slope across set size, a slope less than one-tenth the usual value. This was accomplished by using a novel task in which the initial component of the response is the same for all stimuli (depression of a single response key) but the termination of the response is different (different durations for each stimulus). Using this task, a slope in the neighborhood of 15 ms per bit of stimulus uncertainty is found, as compared with the usual value of about 150 ms. A number of possible explanations are examined. Among the most important are the possibilities that response overlap is the critical factor (i.e., duration errors overlap); possible stimuli are simply ignored when more than one is involved; and the duration decision is made after the reaction-time interval rather than during it. All three possibilities, as well as some others, are found to be inconsistent with the various experimental outcomes. Instead, a new theory of choice reaction time is presented, which emphasizes the nature of the S-R code that is assumed to represent various reaction-time tasks. This theory leads to a new "law" that is put forward as a replacement for Hick's law. It is RT = a + b(1 - N-1).     

Using logistic regression to estimate delay-discounting functions.

The monetary choice questionnaire (MCQ) and similar computer tasks ask preference questions in order to ascertain indifference, the perceived equivalence of immediate versus larger delayed rewards. Indifference data are then fitted with a hyperbolic function, summarizing the decline in perceived value with delay time. We present a fitting method that estimates the hyperbolic parameter k directly from survey responses. Binary preferences are modeled as a function of time (X2) and a transformed reward ratio (X1), yielding logistic regression coefficients beta 2 and beta 1. The hyperbolic parameter emerges as k = beta 2/beta 1, where the logistic predicted p = .5 (the definition of indifference). The MCQ was administered to 1,073 adolescents and was scored using both standard and logistic methods. The means for In(k) were similar (standard, -4.53; logistic, -4.51), and the results were highly correlated (rho = .973). Simulated MCQ data showed that k was unbiased, except where beta 1 > or = -1, indicating a vague survey response. Jackknife standard errors provided excellent coverage.     

Some effects of interreinforcement time upon choice

Pigeons' responses were reinforced on two identical and concurrently available chain variable-interval-schedules. Unlike the typical concurrent chains procedure, both links were operative throughout, thus producing three types of concurrency: (1) concurrent initial links; (2) concurrent initial and terminal links; (3) concurrent terminal links. Choice proportions in each of these three states suggested that the pigeons were sensitive to momentary likelihoods of reinforcement: choice proportions for a schedule were higher when the schedule had been operative for some time, resulting in a higher probability of reinforcement. The study also showed that the relative rates of responding did not match the relative rates of reinforcement in any of the three states of concurrency. Instead, the choice proportions in both the concurrent initial and in the concurrent terminal links were intermediate between the scheduled and the obtained relative rates of reinforcement, while the choice proportions for a terminal link concurrent with an initial link consistently overmatched the relative interreinforcement times (and were typically 1.00). These data indicate that an accurate characterization of choice may not be obtained by considering only the relative interreinforcement interval where one interreinforcement interval is segmented into a chain. Instead, the organism's choice for a schedule will be substantially lowered by the chaining operation.     

Units of analysis and kinetic structure of behavioral repertoires

It is suggested that molar streams of behavior are constructed of various arrangements of three elementary constituents (elicited, evoked, and emitted response classes). An eight-cell taxonomy is elaborated as a framework for analyzing and synthesizing complex behavioral repertoires based on these functional units. It is proposed that the local force binding functional units into a smoothly articulated kinetic sequence arises from temporally arranged relative response probability relationships. Behavioral integration is thought to reflect the joint influence of the organism's hierarchy of relative response probabilities, fluctuating biological states, and the arrangement of environmental and behavioral events in time.     

Familiarity and organization of category terms in semantic memory

In order to determine production frequencies for various category terms, 219 college students were asked to generate category terms (e.g. Automobiles, Vegetables, Relatives) during a 4-rain period. The production frequency (i.e., the number of subjects who listed a particular term) for a given category term may be considered as reflecting the familiarity or amount of usage of that category term, and, as such, should be of value to memory researchers in designing experiments. Additionally, examination of the order in which terms were produced showed that subjects "clustered" related category terms, (e.g., "Countries" and "States" were often produced successively). This clustering of category terrms is supportive of the hypothesis that categories are organized in semantic memory in some kind of higher order structure.     

Innovation Motivation: The Need to Be Different

All choice points mandate a dichotomous initial decision: whether to attempt to replicate a response previously used in similar situations or to essay a different approach. Individuals are hypothesized to differ in the direction and degree of their relative preference for consistent vs. innovative approaches. According to social learning theory, innovation motivation should be determined by (a) the generalized expectancy that innovation produces reinforcing outcomes and (b) the need value of the opportunity to engage in "different" behaviors. In a series of studies (cumulative N = 397), an inventory measuring the self-attributed value of behavioral variation (the value set on being different, hence, the vDiffer scale) displays adequate internal consistency (mean a =. 79) and independence of social desirability and psychological health-distress. The vDiffer scale correlates strongly (mean r =. 46) with sensation seeking, modestly (r =. 23) with imaginative involvement, and very strongly (r =. 66) with Openness to Experience; predicts divergent production of ideas (r =. 36) on a changes in society test; and correlates quite strongly (mean rs =. 62) with peer nominations.     

Cognitive theories as reinforcement history surrogates: the case of likelihood ratio models of human recognition memory

B. F. Skinner (1977) once argued that cognitive theories are essentially surrogates for the organism's (usually unknown) reinforcement history. In this article, we argue that this notion applies rather directly to a class of likelihood ratio models of human recognition memory. The point is not that such models are fundamentally flawed or that they are not useful and should be abandoned. Instead, the point is that the role of reinforcement history in shaping memory decisions could help to explain what otherwise must be explained by assuming that subjects are inexplicably endowed with the relevant distributional information and computational abilities. To the degree that a role for an organism's reinforcement history is appreciated, the importance of animal memory research in understanding human memory comes into clearer focus. As Skinner was also fond of pointing out, it is only in the animal laboratory that an organism's history of reinforcement can be precisely controlled and its effects on behavior clearly understood.     

Chlordiazepoxide and the moderation of the initial response to reward reduction

The effectiveness of chlordiazepoxide (CDP) in reducing negative contrast on the first day after a shift from 32% to 4% sucrose was investigated in four experiments using rats. Previous studies indicated that CDP was effective on the second, but not on the first postshift day. In Experiments 1 and 1a, neither initial experience (3 or 10 days) with the eventual postshift 4% solution (i.e. 4%, then 32%, then 4%), nor initial experience with alternating 4% and 32% sucrose, led to a reliable contrast-reducing effect of CDP on the first shift day. Evidence from Experiments 2 and 3 suggested that a range of doses of CDP (3, 5, 10, and 15 mg/kg) did not have reliable effects on the first postshift day, although the two lower doses did reduce contrast on the second postshift day (the higher doses were not administered on Day 2). The evidence suggests that the relative ineffectiveness of CDP in moderating the initial response to reward reduction is not related to a problem of recognizing the difference between the postshift solution and the memory of the preshift solution. Alternative interpretations in which CDP's lack of effect on the initial occurrence of contrast is related to an initial stage of unconditioned frustration and/or exploratory behaviour are considered.     

An extended motor network generates beta and gamma oscillatory perturbations during development

This study examines the time course and neural generators of oscillatory beta and gamma motor responses in typically-developing children. Participants completed a unilateral flexion–extension task using each index finger as whole-head magnetoencephalography (MEG) data were acquired. These MEG data were imaged in the frequency-domain using spatial filtering and the resulting event-related synchronizations and desynchronizations (ERS/ERD) were subjected to voxel-wise statistical analyses to illuminate time–frequency specific activation patterns. Consistent with adult data, these children exhibited a pre-movement ERD that was strongest over the contralateral post-central gyrus, and a post-movement ERS response with the most prominent peak being in the contralateral precentral gyrus near premotor cortices. We also observed a high-frequency (∼80 Hz) ERS response that coincided with movement onset and was centered on the contralateral precentral gyrus, slightly superior and posterior to the beta ERS. In addition to pre- and post-central gyri activations, these children exhibited beta and gamma activity in supplementary motor areas (SMA) before and during movement, and beta activation in cerebellar cortices before and after movement. We believe the gamma synchronization may be an excellent candidate signal of basic cortical motor control, as the spatiotemporal dynamics indicate the primary motor cortex generates this response (and not the beta oscillations) which is closely yoked to the initial muscle activation. Lastly, these data suggest several additional neural regions including the SMA and cerebellum are involved in basic movements during development.     

Is pressure stressful? The impact of pressure on the stress response and category learning

We examined the basic question of whether pressure is stressful. We proposed that when examining the role of stress or pressure in cognitive performance, it is important to consider the type of pressure, the stress response, and the aspect of cognition assessed. In Experiment 1, outcome pressure was not experienced as stressful but did lead to impaired performance on a rule-based (RB) category-learning task, but not on a more procedural information-integration (II) task. In Experiment 2, the addition of monitoring pressure resulted in a modest stress response to combined pressure and impairment on both tasks. Across experiments, higher stress appraisals were associated with decreased performance on the RB, but not on the II, task. In turn, higher stress reactivity (i.e., heart rate) was associated with enhanced performance on the II, but not on the RB, task. This work represents an initial step toward integrating the stress cognition and pressure cognition literatures and suggests that integrating these fields may require consideration of the type of pressure, the stress response, and the cognitive system mediating performance.     

Resistance to change of forgetting functions and response rates

This experiment examined the effects of reinforcement probability on resistance to change of remembering and response rate. Pigeons responded on a two-component multiple schedule in which completion of a variable-interval 20-s schedule produced delayed matching-to-sample trials in both components. Each session included four delays (0.1 s, 2 s, 4 s, and 8 s) between sample termination and presentation of comparison stimuli in both components. The two components differed in the probability of reinforcement arranged for correct matches (i.e., rich, p = .9; lean, p = .1). Response rates during the variable-interval portion of the procedure were higher in the rich component during baseline and more resistant to the disruptive effects of intercomponent food and extinction. Forgetting functions were constructed by examining matching accuracy as a function of delay duration. Baseline accuracy was higher in the rich component than in the lean component as measured by differences in the gamma-intercept of the forgetting functions (i.e., initial discrimination), rather than from differences in the slope of the forgetting function (i.e., rate of forgetting). Intercomponent food increased the rate of forgetting relatively more in the lean component than in the rich component, but initial discrimination was not systematically affected. Extinction reduced initial discrimination relatively more in the lean component than in the rich component, but did not systematically affect rate of forgetting. These results are consistent with our previous data suggesting that, as for response rate, accuracy and resistance to change of discriminating are positively related to rate of reinforcement. These data also suggest that the disruptability of remembering depends on the conditions of reinforcement, but the way in which remembering is disrupted depends on the nature of the disruptor.     

Observing videos of a baby crying or smiling induces similar,but not identical,electroencephalographic responses in biological and adoptive mothers

It is well-known that adoptive mothers respond to cues from their babies in similar ways to biological mothers, and that cortical processing is critical for adequate motive–emotional maternal responses. This study used electroencephalographic activity (EEG) to characterize prefrontal, parietal and temporal functioning in biological mothers (BM), adoptive mothers (AM), and non-mothers (NM), while viewing videos of a baby smiling or crying. The BM presented higher absolute power (AP) in the delta and theta bands (associated with pleasant, positive emotional experiences) in the frontal and parietal areas under all conditions. In response to the smiling video, both types of mothers presented a lower AP in alpha1 in the three cortices (indicative of increased attention) and, mainly in temporal areas, a higher AP in the fast frequencies (beta and gamma, reflecting increased alertness to sensory stimuli and cognitive processing). This EEG pattern in the BM and AM could reflect the greater attention and, probably, the positive mood caused by the smiling video, showing that both are sensitive to these pleasant stimuli. When viewing the video of a baby crying, the AM had higher AP in the fast frequencies (temporal and parietal areas), indicating that they were more reactive to this unpleasant video, while the NM presented only a lower AP in alpha1 in all cortices, a finding that could be associated with the general activation induced by these unpleasant stimuli as a consequence of their lack of maternal experience. These findings should help improve our understanding of the neural mechanisms involved in the processing of sensorial stimuli that establish affective-emotional links during motherhood.     

Effect of Pain on the Heart Rate of Normal and Schizophrenic Individuals

Wilder's Law of Initial Values (LIV) is described and carried through to Pavlov's theory of excitation-inhibition of the CNS, then to Eysenck's personality theory of introversion-extraversion. LIV-derived inferences of two-whiskered curvilinearity are developed with respect to measurement of introversion-extraversion and adjustment.     

Disrupting reconsolidation: pharmacological and behavioral manipulations

We previously demonstrated that disrupting reconsolidation by pharmacological manipulations "deleted" the emotional expression of a fear memory in humans. If we are to target reconsolidation in patients with anxiety disorders, the disruption of reconsolidation should produce content-limited modifications. At the same time, the fear-erasing effects should not be restricted to the feared cue itself considering that fear generalization is a main characteristic of anxiety disorders. In Experiment I and Experiment I(b), we addressed these issues using a within-subject differential startle fear conditioning paradigm and a test of fear generalization. In Experiment II, we tested whether a behavioral approach targeting the reconsolidation through extinction learning was also effective in weakening the original fear memory. A behavioral procedure is evidently preferred over drug manipulations provided that similar effects can be obtained. Here, the extinction procedure subsequent to retrieval did not "erase" the emotional expression of the fear memory as the retrieval techniques (i.e., reminder shocks and reacquisition) unveiled a return of the startle fear response to the fear-relevant stimuli. In contrast, β-adrenergic receptor blockade during reconsolidation selectively deleted the fear-arousing aspects of the memory (i.e., startle fear response) along with its category-related information. The pharmacological manipulation rendered the core memory trace too weak to observe fear generalization after successful reacquisition. Hence, relearning following the disruption of reconsolidation seems to be qualitatively different from initial learning. Our findings demonstrate that disrupting reconsolidation by pharmacological manipulations, although selective, undermines the generalization of fear, a key feature of anxiety disorders.     

The segment as the minimal planning unit in speech production: Evidence based on absolute response latencies

A minimal amount of information about a word must be phonologically and phonetically encoded before a person can begin to utter that word. Most researchers assume that the minimum is the complete word or possibly the initial syllable. However, there is some evidence that the initial segment is sufficient based on longer durations when the initial segment is primed. In two experiments in which the initial segment of a monosyllabic word is primed or not primed, we present additional evidence based on very short absolute response times determined on the basis of acoustic and articulatory onset relative to presentation of the complete target. We argue that the previous failures to find very short absolute response times when the initial segment is primed are due in part to the exclusive use of acoustic onset as a measure of response latency, the exclusion of responses with very short acoustic latencies, the manner of articulation of the initial segment (i.e., plosive vs. nonplosive), and individual differences. Theoretical implications of the segment as the minimal planning unit are considered.     

Generation of hypotheses in Wason's 2-4-6 task: an information theory approach.

We explored the "context of discovery" in Wason's 2-4-6 task, focusing on how the first hypothesis is generated. According to Oaksford and Chater (1994a) people generate hypotheses extracting "common features", or regularities, from the available triples, but their model does not explain why some regularities contribute to the hypothesis more than do other regularities. Our conjecture is that some regularities contribute to the hypothesis more than do other regularities because people estimate the amount of information in the perceived regularities and try to preserve as much information as possible in their initial hypotheses. Experiment 1, which used two initial triples, showed that the presence of high-information relational regularities in the initial triples affected the information in the initial hypotheses more than did the presence of low-information object regularities. Experiment 2 extended the results to the classic situation in which only one initial triple is given. It also suggested that amount of information is the only aspect of the structure of the triple that affects hypotheses generation. Experiment 3 confirmed the latter finding: Although relations are commonly distinguished between first-order and higher order relations, the latter being most important for generating hypotheses (Gentner, 1983), higher order relations do have an effect on Wason's 2-4-6 task only if their presence incre ases information. In the conclusion we discuss the statistical soundness of human hypotheses generation processes, and we ask an unanswered question: Amount of information explains why some regularities are preferred to others, but only within a set of "nonarbitrary" regularities; there are object regularities that are rich in information content, but are considered "arbitrary", and are not used in generating hypotheses. Which formal property can distinguish between these two sets of regularities?