The involvement of epigenetic defects in mental retardation

Mental retardation is a group of cognitive disorders with a significant worldwide prevalence rate. This high rate, together with the considerable familial and societal burden resulting from these disorders, makes it an important focus for prevention and intervention. While the diseases associated with mental retardation are diverse, a significant number are linked with disruptions in epigenetic mechanisms, mainly due to loss-of-function mutations in genes that are key components of the epigenetic machinery. Additionally, several disorders classed as imprinting syndromes are associated with mental retardation. This review will discuss the epigenetic abnormalities associated with mental retardation, and will highlight their importance for diagnosis, treatment, and prevention of these disorders.     

Brief report: Non-intrusive operant analysis of aggressive behavior in persons with mental retardation

A procedure for operant analysis of aggressive behavior was derived from multi-element assessment methods that have been previously applied to both self-injurious and stereotypic responding. Analog sessions included No Interaction Baseline, Social Disapproval, Demand, Social Reinforcement, and Discriminated Extinction conditions, repeatedly presented within a multi-element design. Three men with differing severity of mental retardation, communicative deficits and aggressive behavior were exposed to multiple brief analog sessions embedded within their normal meal-time routines in group home settings. Mean frequencies of aggressive behavior and concurrent eating indicate that, while aggressive behavior was negatively reinforced in all three participants, both social and non-social contingencies were also prominent. The same contingencies which have been demonstrated to maintain self-injury and stereotypic behavior can therefore also maintain aggression. Results suggest the feasibility of conducting relatively non-intrusive analog assessments in community residences, and support the-extension of functional analysis across differing classes of aberrant behavior.     

EVidence for dorsolateral and orbital prefrontal cortical involvement in the expression of aggressive behavior

Numerous studies have implicated the role of the prefrontal cortex in the expression of aggressive behavior. However, the nature of this relationship remains poorly understood. As such, the purpose of this article is to review both the animal and human literature pertaining to prefrontal cortical functioning and aggression in an attempt to help clarify this relationship. Particular attention is paid to differentiating the functions of the dorsolateral and the orbital regions of the prefrontal cortex in the expression of aggression. Evidence was garnered from four different types of studies: 1) those examining aggressive behavior in animals following ablations to the prefrontal cortex; 2) those examining aggressive behavior in humans following surgical and accidental lesions to the prefrontal cortex; 3) those examining prefrontal cortical functioning in individuals with psychiatric disorders characterized by aggression; and 4) those relating prefrontal cortical functioning to human aggressive behavior in laboratory situations. The general conclusion of this article is that the dorsolateral region of the prefrontal cortex is more likely to be involved in the expression of physical aggression whereas the orbital region is more likely to be involved in the expression of what is termed herein “disinhibited-nonaggressive” behavior. © 1995 Wiley-Liss, Inc.     

Depressive realism and clinical depression

Depressive realism suggests that depressed individuals make more accurate judgments of control than their nondepressed counterparts. However, most studies demonstrating this phenomenon were conducted in nonclinical samples. In this study, psychiatric patients who met criteria for major depressive disorder underestimated control in a contingent situation and were consistently more negative in their judgments than were nondepressed controls. Depressed patients were less likely than their nondepressed counterparts to overestimate control in a noncontingent situation, but largely because they perceived receiving less reinforcement. Depressed patients were no more likely to use the appropriate logical heuristic to generate their judgments of control than their nondepressed counterparts and each appeared to rely on different primitive heuristics. Depressed patients were consistently more negative than their nondepressed counterparts and when they did appear to be more “accurate” in their judgments of control (as in the noncontingent situation) it was largely because they applied the wrong heuristic to less accurate information. These findings do not support the notion of depressive realism and suggest that depressed patients distort their judgments in a characteristically negative fashion.     

Oral Pessimism and Depressive Symptoms

I examined the relation of oral optimistic and oral pessimistic personality traits to depressive symptoms to assess the psychoanalytic claim that fixation at the early phase of the oral stage of psychosexual development is related to depression. College students (N = 140) were administered the Oral Optimism Questionnaire (OOQ; Kline, 1978) and Oral Pessimism Questionnaire (OPQ; Kline, 1978) and the Beck Depression Inventory (BDI; Beck, Ward, Mendelsohn, Mock, & Erbaugh, 1961). Oral pessimism and levels of depressive symptoms were positively correlated, and a subsample of subjects with clinical levels of depressive symptoms also scored significantly higher on the Oral Pessimism Questionnaire than the rest of the sample. For the whole sample, 10 BDI items correlated significantly with the OPQ scores, and 5 OPQ items correlated significantly with the total BDI scores. The psychoanalytic claim relating fixation at the oral pessimism stage to depressive symptoms was supported.     

Biblical Inerrancy and Depressive Symptoms

A number of investigators have studied biblical inerrancy (i.e., the belief that the Bible is inspired by God, free from error, and should be interpreted literally). However, there has been little research on the relationship between biblical inerrancy and mental health outcomes. The purpose of this study is to address this gap in the literature. This is accomplished by estimating a latent variable model that was designed to empirically evaluate the following relationships: (1) Blacks, people with less education, and conservative Christians are more likely to have a strong belief in biblical inerrancy; (2) people with a strong belief in biblical inerrancy are more likely to experience demonic spiritual struggles when they are faced with stressful events; (3) individuals who experience demonic spiritual struggles are more likely to feel that the sacred aspects of their lives have been threatened; and (4) greater sacred loss is associated with more depressive symptoms. Data from a recent nationwide survey (N?=?2332) provide support for each of these relationships.     

Influence of manipulated category knowledge on prototype classification and recognition

The recognition and classification of category members was explored, following a variable number of learning trials. In Experiment 1, subjects received 1 or 9 learning trials, followed by a recognition-then-classification test containing old, new, prototype, and foil patterns. In Experiment 2, subjects received 1, 6, or 12 trials, and made either classification or recognition judgments. In each experiment, classification accuracy for all item types was at near-chance -performance after a single trial but steadily increased with increased learning trials. On the transfer test, oldness judgments were highest for the category prototype after a single trial. However, with increased learning trials, oldness judgments increased for old instances and decreased for the category prototype and new instances. We suggest that false recognition of the category prototype, especially after a single learning trial, need not reflect an abstraction process. We discuss the possibility that an abstracted prototype may emerge with additional learning as an unfamiliar, ideal point.     

Ministry and mental retardation

Conclusion This has been an attempt to show how the parents of the mentally retarded inspired me to take a second look at my theological views, to show the method I used, and to give a few instances out of many in which my theological views have been affected. If space had allowed, it would have been good to show how this human predicament can cast new light on our theological thinking about grace, redemption, and many other categories. On the other hand, each of us has a chance to pursue in depth any single doctrine, using the added perspective of this particular crisis situation.Each of us has the original theological perspective which we had before beginning our pastoral involvements with the mentally retarded and their families. Then, as we focus on this human situation we become aware of an added theological perspective that helps us to take a second look from a different viewpoint. We then find our original view has been reinforced, modified, or enlarged. It is my feeling that a pastor who becomes involved with these particular persons-who need his services very much—will find a golden opportunity to grow theologically.If any of us feel we know all we need to know about God and life and man, this would be a good time to become involved in a pastoral way with a mentally retarded person and his family and get to know them well.     

Culture and mental retardation

The Psychological Record -     

Attributional Style and Depressive Mood Reactions

According to the reformulated learned helplessness model of depression, individuals who characteristically attribute negative events to internal-stable-global causes become depressed when confronted with negative life events. This proposition was tested in a field and a laboratory study in settings with an interpersonal, socially relevant character. In the field study, the attributional style of 86 female college students was investigated before Christmas, and their mood was recorded both before and after Christmas. The laboratory study recorded the mood of 46 female students before and after either success or failure. In both studies changes in depressive mood were predicted by the Attribution X Outcome interaction. The direction and form of the interaction were in line with the diathesis-stress model. In the field study, but not the laboratory study, outcome was a significant predictor of changes in depressive mood.     

Affect regulation and Depressive Personality Disorder

Depressive Personality Disorder (DPD) has been under consideration for inclusion in the Diagnostic and Statistical Manual of Mental Disorders since 1994; yet, few studies have been published that test whether those with DPD have affective experiences that are characterized exclusively by depression and negative affect. One hundred ninety-seven undergraduate students were interviewed for DPD and Borderline Personality Disorder with the Personality Disorder Interview for DSM-IV (Widiger, Mangine, Corbitt, Ellis, & Thomas, 1995), in order to control for frequently co-occurring BPD which is characterized by affective lability. Participants also were administered measures of affective lability, affective intensity, anxious and depressive states, and more trait-like manifestations of depression, anxiety, and anger. Results indicate that those with DPD may be described as having a mood state characterized by transitions from a baseline neutral mood to one of anxiety, with their experiences being more prominently depressed and dysphoric. They also have tendencies toward angry hostility, though they may not report frequent shifts from a baseline neutral mood to anger. Those with DPD also report intense, frequent experiences of depression and dysphoria, with many shifts between depression and anxiety.