Anticipating incoming events: an impaired cognitive process in schizophrenia

Intentions are central to guiding actions to their completion because they generate expectations which precede the realization of a task. This ability to manage time was investigated by using a cognitive task which involves several highly integrated processes: sequential learning, explicit processing, and working memory. In this task, participants are required to explicitly learn a repeating color sequence before receiving an instruction to give an anticipatory motor response concerning the next element. Two types of sequences (temporal and spatial) and three experimental conditions were tested in both a group of normal participants and a group of schizophrenic patients. Schizophrenics were included because their condition is known to alter conscious executive function. Our results showed that schizophrenic patients have a strong deficit in performing anticipation tasks. Although they learned the sequences almost normally, their anticipatory ability was reduced in comparison to normal participants in all the tested conditions. These results expand the notion of a working memory deficit in schizophrenia and bear strong implications for understanding executive disorders observed in such patients.     

The psychiatrist as shaman: Sullivan and schizophrenia.

This paper describes an analogy between the primitive shaman's emotional illness, and its control, and the schizophrenic episodes of Harry Stack Sullivan, the founder of the interpersonal school of psychiatry. Like the primitive shaman, Sullivan partially overcame his illnesses, drawing from his psychoses the insights through which he healed others.     

Improving adaptive display with temporally adaptive rendering.

Making computer imagery more responsive and realistic is one of the most basic goals of graphics researchers, and adaptive display is one of the primary means for achieving it. While previous displays have achieved a spatial adaptivity, our research focuses on achieving temporal adaptivity--sampling some regions not only more densely, but also more often. We use closed loop feedback to guide sampling to image regions that change significantly over space or time. Adaptive reconstruction emphasizes older samples in static settings, resulting in sharper images; and new samples in dynamic settings, resulting in images that may be blurry but are up-to-date. In terms of peak signal-to-noise ratio, this prototype produces much better image streams than nonadaptive renderers with the same simulated sampling rates. This new display also offers new opportunities for adapting to user state, allowing adaptive response both where and when it is needed. Our prototype system already responds interactively to changes in the user's viewpoint, it might also respond to any of a number of other indications of user state, including eye tracking, repeatedly manipulated objects, and biometrics.     

片段弓矫治技术在前牙外伤中的应用

本文探讨片段弓矫治技术在前牙外伤中的应用效果。利用方丝弓矫治器对上前牙外伤68例患者（共89颗外伤牙,其中29颗松动Ⅱ度,51颗松动Ⅲ度,9颗完全脱位）进行复位、固定,并在治疗结束后半年、一年进行随诊观察。一年后固定成功率达到90％以上,患牙及颌骨复位精确,咬合关系恢复良好,并发症少。应用片段弓矫治技术治疗前牙外伤可获得良好的疗效,该技术安全可靠。     

The primacy of cognition in schizophrenia

Cognitive tasks and concepts are used increasingly in schizophrenia science and treatment. Recent meta-analyses show that across a spectrum of research domains only cognitive measures distinguish a majority of schizophrenia patients from healthy people. Average effect sizes derived from common clinical tests of attention, memory, language, and reasoning are twice as large as those obtained in structural magnetic resonance imaging and positron emission tomography studies. Chronic stress, genes, brain disturbances, task structure, gender, and sociocultural background may all enhance the sensitivity of cognitive performance to schizophrenia. At the same time, disease heterogeneity and the presence of endophenotypes and subtypes within the patient population may place upper limits on the strength of any specific cognitive finding. Schizophrenia is a complex biobehavioral disorder that manifests itself primarily in cognition.     

Forms of memory failure in schizophrenia.

Effortful and automatic memory task performances were examined in 36 schizophrenic patients and 18 normal control Ss. Tasks included free recall, recognition, and frequency estimation. Patients demonstrated impairment in recall, in recognition, in semantic encoding, and in frequency estimation. Deficits were observed across tasks despite differences in attentional demands. The results suggest a basic compromise of memory function, which is consistent with recent neuroimaging evidence of structural or physiological abnormalities in frontal and temporal lobe structures in schizophrenia.