Depression and suicide in schizophrenic patients

This study supports the idea that schizophrenic patients represent a distinctive subgroup of patients who can suffer from a major depressive illness and also can commit suicide. The study showed that 22.4% of the schizophrenic population in a medium-sized psychiatric facility showed severe depressive symptoms that met the criteria for the diagnosis of a major depressive episode according to the DSM-III classification. Seven patients committed suicide during the acute phase of the illness--five during hospitalization, and two within a year of discharge. Nine patients attempted suicide during the hospitalization period, and 10 attempted suicide within a year of discharge. Nearly one-third (215) of the patients were readmitted during that year because of a recurrence of acute schizophrenic symptoms; of these, 84 were having severe depressive symptoms. The study also provides indications of the causes of suicide in these patients.     

Changes in the gangliosides of erythrocyte membranes of schizophrenic patients

The pattern of gangliosides in membranes of erythrocytes was examined in healthy donors, in acute schizophrenics without neuroleptic treatment and in alcohol-dependent patients. 7 different gangliosides could be detected after extraction, purification by column chromatography and fractionation by TLC. Healthy donors were characterized by the following pattern of gangliosides: GX = 5.8%, GT1b = 6.7%, FucGD1b = 5.2%, und GD1a = 12.6%, GD3 = 9.2%, SPG = 43.5% and GM3 = 17.0%. In schizophrenic patients the GM3- and GD3-fraction were increased. No difference was found between the control group and the alcoholics.     

Attentional network task performance in schizophrenic patients

Several studies have researched the attentional functioning of schizophrenic patients by means of the Attentional Network Test. The present work reviews these studies and assesses the clinical relevance of their results. Both the reviewed data and our own results suggest that the Attentional Network Test does not provide a clear-cut discrimination of the attentional profile of schizophrenic patients from a clinical point of view. However, after classifying patients according to their psychotic symptoms, it became evident that positive syndrome patients are less efficient at tasks that tap the orientation network.     

Normal auditory negative priming in schizophrenic patients

Performance of 28 schizophrenic patients and 28 matched controls was compared in an auditory priming task. A large auditory negative priming effect was obtained for the patients as well as for the control group, and the size of the negative priming effect was approximately the same for both groups. Under the same conditions, positive or repetition priming for the patients was enhanced compared to that of the control group. The present findings from an auditory priming task are consistent with a growing body of evidence from the visual domain showing normal rather than reduced or eliminated negative priming in schizophrenic patients.     

Normal auditory negative priming in schizophrenic patients

Performance of 28 schizophrenic patients and 28 matched controls was compared in an auditory priming task. A large auditory negative priming effect was obtained for the patients as well as for the control group, and the size of the negative priming effect was approximately the same for both groups. Under the same conditions, positive or repetition priming for the patients was enhanced compared to that of the control group. The present findings from an auditory priming task are consistent with a growing body of evidence from the visual domain showing normal rather than reduced or eliminated negative priming in schizophrenic patients.     

Changes in the health state of schizophrenic patients in neuroleptic therapy

The state of health of 135 schizophrenic patients was examined during therapy with a nigrostriatal (Haloperidol) and a mesolimbic (Clozapin) neuroplegic drug, and compared with the situation during treatment without neuroplegics. Among the methods used was the state of health scale of von Zerssen; the neuroleptic threshold was tested using Haase's handwriting test. There was evidence that the patient's health was primarily affected, but individual differential treatment with neuroplegics produced a significant improvement in this important respect. Contrary to Haase, we noticed nothing to convince us of a link between the antipsychotic efficacy of the neuroplegics under investigation and the neuroleptic threshold.     

Value of neuroleptic therapy in the self assessment of schizophrenic patients

On the basis of clinical self-assessment scales (von Zerssen) and the Frankfurt questionnaire of complaints, it is demonstrated by the comparison of three groups of schizophrenic patients with one control group which is not undergoing therapy with neuroplegics that within the "genuine" groups the psychopathological factors investigated recede, sometimes quite significantly. Cross-over design treatment involving the control group has not revealed any significance. We conclude that when treating schizophrenic psychoses, psychosocial measures must accompany biological measures.     

Control of the behavior of schizophrenic patients by food

Operant-conditioning principles using food as a reinforcer were applied to control the behavior of 45 chronic schizophrenic patients. The investigation was conducted in a psychiatric ward in which there was 24-hr environmental control.

In order to use food as a reinforcer for controlling psychotic behavior, it was necessary first to deal with the eating deficits in the patients. Approximately 50% of the ward population was selected because of a history of refusal to eat. Their refusal to eat had remained relatively unaffected by one or more of these treatments: spoonfeeding, tubefeeding, intravaneous feeding, and electroshock. These treatments were discontinued, and the patients were left alone at mealtimes. The results show that social reinforcement in such forms as coaxing, persuading, and feeding the patient tend to shape patients into eating problems so they are conditioned to eat only with assistance. When refusal to eat was no longer followed by social reinforcement, the patients soon started eating unassisted. When access to the dining room was made dependent upon a chain of responses including a motor and social component, all patients learned these responses.

     

Suicidal tendencies in schizophrenic patients hospitalized for the first time

180 (15%) patients from 1208 first-hospitalized schizophrenic patients had suicidal tendencies. Our findings show that the suicidal tendencies of schizophrenic patients have their own features. These conclusions can be supported by the differences between the determinants of the suicidal tendencies of schizophrenic and non-schizophrenic population; such different determinants are: sex, age, family and suicidal method. Suicidal tendencies are more frequent among patients without formal thought disturbances. We explain this fact with an "incoherence of decision processes". The features of the suicidal tendencies of schizophrenic patients are based on the grounds of psychosis own dynamic.     

Increased semantic and repetition priming in schizophrenic patients

Positive and negative priming (PP and NP) in schizophrenia were studied with a lexical-decision task. Probe words, presented 800 ms after the response to the prime (containing a word and a nonword), were either identical to, semantically related to, or unrelated to the prime target word (PP) or to the prime distractor word (NP). Schizophrenic patients displayed stronger semantic and repetition PP than controls after controlling for their slower responses. Significant NP was observed in both groups for word repetition only. The PP findings contrast with results from studies with similar prime-probe intervals but without prime responses. It is proposed that schizophrenic patients, because of impaired (controlled) processes of response selection, strongly benefit from (or rely on) the automatic retrieval of processing episodes containing response information. Related findings indicating automatic response facilitation in schizophrenia are discussed.