Net effect of memory collaboration: How is collaboration affected by factors such as friendship,gender and age?

The purpose of the study was to investigate explicit spatial and verbal collaborative memory performance. Factors such as friendship, age and gender were chosen for ecological and theoretical reasons. In Experiment 1 friendship and age were studied. The task was to retrieve the location of 25 pictures, which were presented in a 5 x 5-matrix grid. All participants retrieved once individually and once dyadically. Dyads were compared to the predicted base line, i.e., the pooled score from two participants working on their own (the same participants as in the dyad). Based on cognitive development aspects and collaboration data, it was predicted that the young collaborating dyads would not be able to reduce the net negative effects of collaboration to the same extent as older dyads. The findings revealed that, (1) dyadic collaboration affected spatial memory performance negatively, i.e., net negative effects of collaboration; (2) older (15-years-old), as opposed to young (7-years-old) dyads, reduced the net negative effects of collaboration and; (3) friend dyads, regardless of age, were able to reduce the net negative effect. In experiment 2, gender differences were studied in two explicit memory tasks. The purpose was to investigate if earlier findings of collaboration can be generalised to another ecological aspect of group composition, i.e., gender. Gender differences were studied at individual and group level. The results suggest that gender related memory differences exist on an individual and dyadic level in terms of absolute scores. Women remember explicit memory tasks to a greater degree than men. No main effect was found for gender in collaboration, i.e., both genders suffered compared to predicted potential.     

Comparing neurocognitive impairment in schizophrenia and bipolar I disorder using the Screen for Cognitive Impairment in Psychiatry Scale

The purpose of this study was to compare the psychometric properties of the Screen for Cognitive Impairment in Psychiatry (SCIP) when applied to patients diagnosed with schizophrenia (n = 126) or bipolar I disorder (n = 76), and also to compare the cognitive impairment in both samples of patients and a control group (n = 83) using the SCIP and a complete neuropsychological battery. The SCIP is a scale intended to quickly and easily assess cognitive impairment in patients with severe psychiatric disorders. The results showed firstly that, in terms of internal consistency, temporal stability, dimensional structure, and criterion-referenced validity, the SCIP provides reliable and valid scores at an equivalent level in both schizophrenia and bipolar I disorder samples. Secondly, it showed that differential cognitive impairment between the two patient groups occurs only in verbal memory, although the effect size of the difference is small. Finally, compared with the control group, cognitive impairment was present at all levels in both groups of patients using both the SCIP and the neuropsychological battery, which indicates that the SCIP is a good screening tool for cognitive deficits in schizophrenia and bipolar and useful in clinical practice for healthcare professionals.     

Cognitive impairment and whole brain diffusion in patients with neuromyelitis optica after acute relapse

The objective of this study investigated cognitive impairments and their correlations with fractional anisotropy (FA) and mean diffusivity (MD) in patients with neuromyelitis optica (NMO) without visible lesions on conventional brain MRI during acute relapse. Twenty one patients with NMO and 21 normal control subjects received several cognitive tests to assess cognitive function. Head diffusion tensor imaging (DTI) of all patients with NMO were collected with a 3-T MR system. Correlations of cognitive test scores and whole brain FA and MD were examined by voxel-based analysis. Region-of-interest analysis was applied to the significantly correlated regions which the most frequently appeared. We found that NMO patients without visible brain lesions had significantly impaired learning and memory, decreased information processing speed, and damaged attention compared with normal control subjects. These impaired cognitive domains were significantly correlated with FA and MD in local regions of corpus callosum, anterior cingulate and medial frontal cortex. In corpus callosum of NMO patients, mean FA was significantly lower and mean MD higher than normal control subjects. Our findings suggest that cognitive impairments in learning and memory, information processing speed and attention occur in NMO patients without visible brain lesions during acute relapse. The impairments in immediate and short-term memory in NMO patients may be due to information encoding deficits in the process of information acquisition. The corpus callosum of such patients may have local microscopic damages that play a role in cognitive impairments during acute relapse.     

Screening for cognitive impairment in an Australian aged care assessment team as part of comprehensive geriatric assessment

Accurate detection of mild cognitive impairment (MCI) is important to stratify and address risk. Yet, few short cognitive screening instruments are validated for this. . In Australia, all clients referred to an Aged Care Assessment Team (ACAT) receive comprehensive geriatric assessment (CGA) including the Standardized Mini-Mental State Examination (SMMSE). We compared the accuracy of the quick mild cognitive impairment (Qmci) screen to the SMMSE in 283 participants: 195 with dementia, 47 with MCI, and 41 with subjective cognitive decline (SCD) in an Australian community-based ACAT. Both had similar accuracy in identifying dementia, AUC of 0.86 for the Qmci versus 0.93 for the SMMSE (p = 0.10), but the Qmci was more accurate than the SMMSE in differentiating MCI from SCD, AUC of 0.84 versus 0.71, respectively, p = 0.046. These suggest that the new, short (3–5 min) Qmci screenis appropriate for use in an ACAT or other units conducting CGA.     

常态脑老化认知功能障碍及相关代谢机制研究进展

常态脑老化（NBA ）是老年期痴呆的首要危险因素,与病态性脑老化有相似的病理基础,但并不完全相同。虽然单一的“脑老化”因素并不足以成为导致老年期痴呆的独立原因,但脑老化状态确实使得大脑对外界负性刺激的敏感性增加,进而使老年人更容易发生认知障碍。阿尔茨海默病等老年痴呆症状的治疗方面尚无逆转的方法,而是重在预防。因此,我们将重点放在痴呆发生之前更早的阶段---常态脑老化阶段,就常态脑老化状态下与认知功能障碍的表现、发生机理及代谢相关机制进行综述,旨在为早期寻找措施防止老年期痴呆性认知功能下降提供理论基础。     

Development of the Cognitive Dysfunction Questionnaire (CDQ) in a population based sample

The study reports on the development of a questionnaire for assessment of adult cognitive dysfunction (CDQ). Participants in a population-based sample (65±15 years, N=370) responded to a 90-item pilot version covering multiple aspects of memory/cognition. Based on exploratory principal components analyses and correlations with criterion measures of cognitive functioning (MMSE, Block Design, semantic/episodic memory), 20 items loading on 6 components were selected for the final version of the questionnaire. Cronbach's α for the total score was 0.90. There was evidence of construct validity as judged by correlations between CDQ scores, objective cognitive measures, and a subjective memory measure (PRMQ). Discriminant validity was demonstrated by a low and non-significant correlation with depressive symptoms. Further evidence of construct validity was provided by correlations with age and educational attainment. In conclusion, the CDQ is promising as a self-rating screening tool for cognitive dysfunction, and will be the subject of further development and validation.     

A study of mild cognitive impairment in veterans: role of hypertension and other confounding factors

Introduction: Hypertension has shown to be an important risk factor for the decline in cognitive function. Aim of our study is to investigate the presence of cognitive impairment of the elders with hypertension and other confounding factors.

Methods: This study was conducted on 400 veterans who were matched one-to-one with the confounding factors for assessing the presence of mild cognitive impairment using both MMSE and Montreal Cognitive Assessment (MoCA). The 13 related factors of patient data were studied.

Results: The prevalence rate of cognitive impairment was 29.25%. Age (OR 2.679, 95%CI 1.663–6.875), sleep impairment (OR 1.117, 95%CI 1.754–7.422), uncontrolled hypertension (OR 1.522, 95%CI 1.968–4.454), type 2 diabetes (OR 2.464, 95%CI 1.232–4.931), and hyperlipidaemia (OR 1.411, 95%CI 1.221–8.988) are the risk factors for the cognitive deterioration, while the protective factors are high level of education (OR 0.032, 95%CI 0.007–0.149) and regular exercise (OR 0.307, 95%CI 0.115–0.818).

Discussion: Because some vascular disease risk factors, such as hypertension, can be treated effectively, cognitive decline related to these risk factors, and vascular disease per se, may be prevented or its course modified through more aggressive treatment and improved compliance.     

竹溪县降低孕产妇死亡率和消除新生儿破伤风项目分析

为实施“降低孕产妇死亡率和消除新生儿破伤风项目”,通过培训乡村产儿科技术服务人员,以改善乡镇卫生院产儿科服务条件,提高育龄妇女住院分娩安全意识,降低孕产妇死亡率和消除新生儿破伤风。开展了人员培训、健康教育、设备配置、贫困救助、监督指导等活动。孕产妇死亡率、新生儿破伤风等重点指标达到终期目标。提出贫困地区妇幼卫生事业建设与发展必需有可行性项目支持。     

Lifecourse Social Conditions and Racial and Ethnic Patterns of Cognitive Aging

A lifecourse perspective is key for understanding and interpreting racial and ethnic patterns in neuropsychological test performance. In this article, we discuss contextual factors that shape the environmental conditions encountered by racial and ethnic minorities in the United States, in particular African-Americans. These conditions include geographic segregation at the level of regions, metropolitan areas, and neighborhoods; intra- and inter-national migration patterns; socioeconomic position, including financial resources, and occupational and educational opportunities; discrimination; and group resources. Each of these exposures sets in course a cascade of individual mediators that ultimately manifest in neuropsychological outcomes. The physiological and behavioral consequences of these pathways likely accumulate across the lifecourse. We focus on cognitive aging, although the processes discussed here begin in infancy and likely influence cognitive outcomes throughout life from childhood into old age. A lifecourse framework can help inform clinical encounters, neuropsychological research, and surveillance regarding the population prevalence of cognitive impairments.     

Processing speed in normal aging: Effects of white matter hyperintensities and hippocampal volume loss

Changes in cognitive functioning are said to be part of normal aging. Quantitative MRI has made it possible to measure structural brain changes during aging which may underlie these decrements which include slowed information processing and memory loss. Much has been written on white matter hyperintensities (WMH), which are associated with cognitive deficits on tasks requiring processing speed and executive functioning, and hippocampal volume loss, which is associated with memory decline. Here we examine volumetric MRI measures of WMH and hippocampal volume loss together in relation to neuropsychological tests considered to be measures of executive functioning and processing speed in 81 non-demented elderly individuals, aged 75–90. Correlational analysis showed that when controlling for age, both greater WMH volume and smaller hippocampal volume were correlated with slower performances on most tests with the exception of a battery of continuous performance tests in which only WMH was correlated with slower reaction time (RT). We then performed a series of hierarchical multiple regression analyses to examine the independent contributions of greater WMH volume and reduced hippocampal volume to executive functioning and processing speed. The results showed that for the four measures requiring executive functioning and speed of processing, WMH volume and hippocampal volume combined predicted between 21.4% and 37% of the explained variance. These results suggest that WM integrity and hippocampal volume influence cognitive decline independently on tasks involving processing speed and executive function independent of age.     

More than meets the eye: a consideration of the influence of a counsellor's visual impairment upon his therapeutic relationships

Other than through personal reflection and anecdotal evidence, I have had little opportunity to explore the influence of my visual impairment upon my therapeutic relationships. In order to address this, I conducted three research conversations with former clients (participants), each of whom had expressed an interest in participating in the research. Potential participants also had to meet the inclusion criteria for the research and provide informed consent prior to their participation. Research conversations were conducted between March and July 2009 and were analysed qualitatively, using a method informed by Moustakas's heuristic inquiry. Participants demonstrated idiosyncratic responses to my visual impairment; their perception of their responses to my visual impairment sometimes differed from mine. Feelings identified included uncertainty, disappointment and relief. My visual impairment appeared to influence the therapeutic relationship in a variety of ways, including resonance with the inner world significance of disability to the participant and interaction with my personal process. While not the therapeutic agent, my visual impairment had the potential to act as a catalyst in therapeutic change. The potential for me to either under-estimate or over-estimate the significance of my visual impairment highlights the need for continued self-awareness and the maintenance of an open and non-defensive attitude.     

Cognitive Error Questionnaire (CEQ): Psychometric Properties and Factor Structure of the German Translation

A central component of Beck et al.’s (1979) cognitive theory of depression is faulty information processing reflected by so-called cognitive errors. These cognitive errors are the reason why depressed individuals systematically misinterpret the significance of events in a negative way. They are usually assessed with the application of the Cognitive Error Questionnaire (CEQ). This study examines the psychometric properties and factor structure of the German version of the CEQ in a sample of 796 volunteers at a German university. Results confirmed that the German CEQ has satisfactory to very good psychometric properties, like the American original. Confirmatory factor analyses demonstrated that a hierarchical four-factor model with four subscales and 1 s order factor fits the data best. Therefore, besides using the German CEQ in studies with German-speaking samples, the similarities in psychometric properties of the American and German CEQ allow for cross-cultural studies.     

Examination of the processing speed account in a population-based longitudinal study with narrow age cohort design

The processing speed account suggests that general slowing of mental processing speed results in an overall decline, especially age-related decline, in other cognitive domains. Support for the speed account comes mainly from cross-sectional studies with participants that vary in age (age-heterogeneous samples). This study investigated how well variations in processing speed predict change of episodic recall in a longitudinal framework and examined with the Narrow Age Cohort (NAC) design. Data were obtained from Betula, a population-based longitudinal study. Both 5-year (n= 490; Time 3 - Time 4) and 10-year follow-up results (n= 608; Time 1 - Time 3) were used. In both samples, which were subjected to prospective dementia screening, we found considerably weaker associations in longitudinal data compared to cross-sectional, and also weaker associations in age-homogeneous than in age-heterogeneous samples. The results provide little support for the speed account.     

Cognitive therapy outcome: the effects of hopelessness in a naturalistic outcome study

This study prospectively examined the effect of hopelessness on outcome in cognitive therapy. Hopelessness has a central role in cognitive theories of depression, and consistently predicts suicide attempts and suicide completion. Furthermore, there is indirect evidence that hopelessness predicts cognitive therapy outcome, in terms of early termination of therapy, perhaps in part because theories of therapy change suggest that "remoralization" is a critical first phase of change. It was hypothesized that hopelessness non-responsiveness early in therapy would be predictive of eventual outcome, over and above hopelessness severity at intake. In a naturalistic study of 122 patients diagnosed with unipolar depression, it was found that non-responsive hopelessness predicted outcome in cognitive therapy, and this effect is over and above any effect of initial severity of hopelessness or depression. These findings suggest that patients whose level of hope is responsive to early interventions make more rapid and pronounced improvements during "real world" cognitive therapy.     

The usefulness of the story recall test in patients with mild cognitive impairment and Alzheimer's disease

ABSTRACT

Background: The story recall test (SRT) is one of the most reliable neuropsychological assessments for evaluating verbal memory function in order to distinguish between individuals with normal aging, mild cognitive impairment (MCI), and Alzheimer's disease (AD). The SRT is analogous to the logical memory test in Wechsler Memory Scale-III, which has recently been developed and standardized to apply to older adults in Korea. The purpose of this study was to examine the usefulness of the SRT and its ability to discriminate between normal cognitive aging and patients with MCI or AD. Methods: One hundred and twelve patients with MCI, 97 patients with AD, and 53 healthy elderly adults participated in this study. The SRT was compared with the Clinical Dementia Rating (CDR), Global Deterioration Scale (GDS), Korean version of the Mini Mental State Examination (K-MMSE), and the Korean version of the Hopkins Verbal Learning Test (K-HVLT). Results: The SRT was well-correlated with the dementia rating scales and the K-HVLT. However, the sensitivity and specificity of the SRT was greatly influenced by the level of education of the subjects. Conclusions: The SRT is a sensitive measurement of verbal memory function that can be used in clinical settings to discriminate between normal memory functioning and the very early and moderate stages of AD in a Korean population. Moreover, it is important to recognize that the SRT is more appropriate for subjects with a high level of education rather than a low level of education to differentiate normal cognitive aging from MCI or AD.     

Connectionism and the Philosophical Foundations of Cognitive Science

This is an overview of recent philosophical discussion about connectionism and the foundations of cognitive science. Connectionist modeling in cognitive science is described. Three broad conceptions of the mind are characterized, and their comparative strengths and weaknesses are discussed: (1) the classical computation conception in cognitive science; (2) a popular foundational interpretation of connectionism that John Tienson and I call "non-sentential computationalism"; and (3) an alternative interpretation of connectionism we call "dynamical cognition." Also discussed are two recent philosophical attempts to enlist connectionism in defense of eliminativism about folk psychology.     

Connecting the Many Levels and Facets of Cognitive Aging

Basic cognitive mechanisms, such as the abilities to briefly maintain, focus, and process information, decline with age. Related fields of cognitive aging research have been advancing rapidly, but mostly independently, at the biological, information processing, and behavioral levels. To facilitate integration, this article reviews research on cognitive aging at the different levels, and describes a recent integrative theory postulating that aging-related deficiencies in neurotransmission cause increased noise in information processing and less distinctive cortical representation, which in turn lead to cognitive deficits. Aging-related attenuation of catecholaminergic modulation can be modeled by lowering a neural network parameter to reduce the signal-to-noise ratio of information processing. The performance of such models is consistent with benchmark phenomena observed in humans, ranging from age differences in learning rate, asymptotic performance, and interference susceptibility to intra- and interindividual variability and ability dedifferentiation. Although the details of the conjectured sequence of effects linking neuromodulation to cognitive aging deficits await further empirical validation, cross-level theorizing of the kind illustrated here could foster the coevolution of related fields through cross-level data synthesis and hypothesis testing.     

Cognitive processing of body and appearance words as a function of thin-ideal internalization and schematic activation

To better understand how women at risk of body image disturbance respond when their body concerns are activated, we examined attentional and memory biases in undergraduate women with high thin-ideal internalization, an identified risk factor for eating disorders, following priming of body and appearance concerns. Female undergraduates (N = 186) viewed photos of either sports cars or attractive swimsuit models, then completed the Lexical Decision Test, a word recall test, and questionnaires assessing thin-ideal internalization and eating disorder symptomatology. High thin-ideal internalizers did not exhibit cognitive biases predicted by cognitive models of eating disorders, even when their body and appearance concerns were primed by exposure to attractive models. Converging evidence suggests that high-risk non-clinical samples rarely exhibit cognitive biases characteristic of individuals with eating disorders, and, in fact, may actually incorporate ideal appearance into their schemas and preferentially attend to attractive stimuli.     

Cognitive model decomposition of the BART: Assessment and application

The Balloon Analogue Risk Task, or BART, aims to measure risk taking behavior in a controlled setting. In order to quantify the processes that underlie performance on the BART, Wallsten, Pleskac, and Lejuez (2005) proposed a series of mathematical models whose parameters have a clear psychological interpretation. Here we examine a 2-parameter simplification of Wallsten et al.’s preferred 4-parameter model. A parameter recovery study shows that — with plausible restrictions on the number of participants and trials — both parameters (i.e., risk taking γ⁺ and response consistency β) can be estimated accurately. To demonstrate how the 2-parameter model can be used in practice, we implemented a Bayesian hierarchical version and applied it to an empirical data set in which participants performed the BART following various amounts of alcohol intake.     

Grammatical language impairment and the specificity of cognitive domains: relations between auditory and language abilities

Grammatical-specific language impairment (G-SLI) in children, arguably, provides evidence for the existence of a specialised grammatical sub-system in the brain, necessary for normal language development. Some researchers challenge this, claiming that domain-general, low-level auditory deficits, particular to rapid processing, cause phonological deficits and thereby SLI. We investigate this possibility by testing the auditory discrimination abilities of G-SLI children for speech and non-speech sounds, at varying presentation rates, and controlling for the effects of age and language on performance. For non-speech formant transitions, 69% of the G-SLI children showed normal auditory processing, whereas for the same acoustic information in speech, only 31% did so. For rapidly presented tones, 46% of the G-SLI children performed normally. Auditory performance with speech and non-speech sounds differentiated the G-SLI children from their age-matched controls, whereas speed of processing did not. The G-SLI children evinced no relationship between their auditory and phonological/grammatical abilities. We found no consistent evidence that a deficit in processing rapid acoustic information causes or maintains G-SLI. The findings, from at least those G-SLI children who do not exhibit any auditory deficits, provide further evidence supporting the existence of a primary domain-specific deficit underlying G-SLI.