胚胎植入前遗传学诊断(PGD)的伦理思考

针对现在研究者往往关注胚胎的生理质量而忽视伦理选择的现象,用伦理的视角审视实施胚胎植入前遗传学诊断(PGD)的行为,赋予生命科学行为必要的伦理思想.综合各种理论流派的观点,结合临床工作,得出人们在伦理道德上比较容易接受PGD中进行胚胎的优选的结论,用以指导PGD的发展.     

Attitudes Toward Pre-implantation Genetic Diagnosis (PGD) for Genetic Disorders Among Potential Users in Malaysia

While pre-implantation genetic diagnosis (PGD) is available and legal in Malaysia, there is an ongoing controversy debate about its use. There are few studies available on individuals’ attitudes toward PGD, particularly among those who have a genetic disease, or whose children have a genetic disease. To the best of our knowledge, this is, in fact, the first study of its kind in Malaysia. We conducted in-depth interviews, using semi-structured questionnaires, with seven selected potential PGD users regarding their knowledge, attitudes and decisions relating to the use PGD. The criteria for selecting potential PGD users were that they or their children had a genetic disease, and they desired to have another child who would be free of genetic disease. All participants had heard of PGD and five of them were considering its use. The participants’ attitudes toward PGD were based on several different considerations that were influenced by various factors. These included: the benefit-risk balance of PGD, personal experiences of having a genetic disease, religious beliefs, personal values and cost. The study’s findings suggest that the selected Malaysian participants, as potential PGD users, were supportive but cautious regarding the use of PGD for medical purposes, particularly in relation to others whose experiences were similar. More broadly, the paper highlights the link between the participants’ personal experiences and their beliefs regarding the appropriateness, for others, of individual decision-making on PGD, which has not been revealed by previous studies.     

The Associations Between Intensive Residential Couple Therapy and Change in a Three-Year Follow-Up Period

This Norwegian couple therapy effectiveness therapy study explored the course and prediction of relationships between depressive symptoms, interpersonal problems, and dyadic adjustment during residential treatment and over a 3-year post-treatment period (N = 117). All measures indicated significant improvement (p < .001) between admission and discharge (effect sizes .25 to .67), and improvement was maintained at 3-year follow-up. The proportion of recovered patients during treatment was stable at follow-up. Finding that initial levels of the Inventory of Interpersonal Problems (IIP) predicted dyadic adjustment change in the follow-up period, we discuss how such interpersonal problems may influence the course of couple therapy.     

Developmental neuropsychological assessment of 4- to 5-year-old children born following Preimplantation Genetic Diagnosis (PGD): A pilot study

The purpose of this pilot study was to evaluate developmental neuropsychological profiles of 4- to 5-year-old children born after Preimplantation Genetic Diagnosis (PGD). Twenty-seven participants received a neurological examination and a battery of neuropsychological assessments including Wechsler Preschool & Primary Scale of Intelligence - Third Edition (WPPSI-III; cognitive development), Preschool Language Scale, Fourth Edition (PLS-4; language development), Wide Range Assessment of Visual Motor Abilities (visual motor abilities), Childhood Autism Rating Scales II (a screening test for autistic spectrum disorders), and the Miles ABC Test (ocular dominance). Parental questionnaires included the Behavior Rating Inventory of Executive Function Preschool Version (BRIEF-P; executive function), Child Behavior Checklist (CBCL) and the Carey Temperament Scales Behavioral Style Questionnaire (socioemotional development and temperament), and the Vineland Adaptive Behavior Scales, Interview Edition, Second Edition (general adaptive behavior). Subjects’ tests results were compared to each test’s norms. Children born after PGD demonstrated scores within the normal or above-normal ranges for all developmental outcomes (mean ± SD): WPPSI-III-VIQ 107.4 ± 14.4 (p = .013), PLS-4-Total 113.2 ± 12.4, p < .001), CBCL-Total 41.1 ± 8.6 (p < .001), BRIEF-P-Global Executive Composite 44.8 ± 9.5 (p = .009). Twelve (44%) of the PGD children had a significant difference between their VIQ and PIQ scores (compared to 27% in the general population). One subject was found to show possible signs of autistic spectrum disorder, although a family history of autism was noted. In conclusion, in this pilot study, children assessed at age 4–5 years and conceived after PGD displayed developmental neuropsychological outcomes within normal limits as compared to their chronologic peers. A larger study is needed to evaluate and follow the neuropsychological development of children born after PGD.     

Sexual Intimacy-Towards Equal Relationships Between Men and Women (with Treatment Assistance of a Computer Program)

SUMMARY

By rethinking sexual basic concepts we liberate sexology from mere biological and technical models. The sexual focus combined with the Object Relation Theory creates a promising therapeutic perspective for couples. Special attention will be given to male processes. Some vignettes of the computer program Sexpertise illustrate this article.     

Male Narcissism and Attitudes Toward Heterosexual Women and Men, Lesbian Women, and Gay Men: Hostility toward Heterosexual Women Most of All

The present study investigated links between heterosexual men’s narcissism and attitudes toward heterosexual and non-heterosexual women and men. Male narcissism was predicted to be associated with hostility toward heterosexual women more than toward other groups, indicating investment in patriarchal power more than in conservative gender ideology or nonspecific disdain toward all people. Hierarchical regression analyses of responses from 104 male undergraduates (95% Caucasian) from Ohio in the U.S. supported the hypothesis that men’s narcissism is related most robustly to hostility toward women, rather than to equivalent derogation of all groups. Moreover, men’s narcissism is not merely a maker of traditional gender ideology, but instead is associated with favorable attitudes toward lesbian women and is unrelated to attitudes toward gay men.     

Genetic Risk Communication: Experiences of Adolescent Girls and Young Women from Families with Fragile X Syndrome

Little is known about how and what genetic risk information parents communicate to their children and even less is known about what children hear and remember. To address this void, we explored how genetic risk information was learned, what information was given and who primarily provided information to adolescent girls and young adult women in families with fragile X syndrome. We explored three levels of risk knowledge: learning that fragile X syndrome was an inherited disorder, that they could be a carrier, and for those who had been tested, actual carrier status. These data were collected as part of a study that also explored adolescent self concept and age preferences about when to inform about genetic risk. Those findings have been presented separately. The purpose of this paper is to present the communication data. Using a multi-group cross-sectional design this study focused on girls ages 14–25 years from families previously diagnosed with fragile X syndrome, 1) who knew they were carriers (n = 20), 2) noncarriers (n = 18), or 3) at-risk to be carriers (n = 15). For all three stages of information the majority of the study participants were informed by a family member. We identified three different communication styles: open, sought information, and indirect. The content of the remembered conversations varied based on the stage of genetic risk information being disclosed as well as the girls’ knowledge of her own carrier status. Girls who had been tested and knew their actual carrier status were more likely to report an open communication pattern than girls who knew only that they were at-risk.     

Thin,Sexy Women and Strong,Muscular Men: Grade-School Children's Responses to Objectified Images of Women and Men

There are data that show that women are objectified in the media, that girls and women experience a high rate of body dissatisfaction and eating problems, and that exposure to objectified media images of women is related to the experience of self-objectification and body shame among women. Media images of women promote a thin, sexy ideal. The objectification of men in the media has increased, perhaps promoting a “drive for muscularity” among boys. In the present study grade-school girls and boys ages 6 through 12 were shown four pictures of objectified images of women and men, respectively, and asked about their responses to the pictures. Although girls and boys responded equally positively to the objectified images of the people of their gender, girls showed a more consistent response to the pictures. Further, there were stronger relationships between girls' responses to the pictures, awareness and internalization of media images, and body esteem. Girls who consistently showed a rejection response to the pictures had higher body esteem than those girls who were uncertain about how to respond to the pictures. It was concluded that, perhaps due to cultural images and cultural pressures, girls more readily develop a consistent response to objectified images of women (than boys do to objectified images of men) that relates to their feelings about their own bodies.     

Powerless Men and Agentic Women: Gender Bias in Hiring Decisions

Sex Roles - We examined male power-roles as a potential moderator of gender bias in hiring decisions. Drawing from previous work on perceptions of agentic women and precarious manhood theory, we...     

Stress at Work: A Comparison of Men and Women

A research design was constructed to quantify examined estimates of stress resulting from selected work events and perceived differences of its impact among men and women.     

Good Women and Bad Men: A Bias in Feminist Research

The variety of feminist thought has produced many fruitful discussions and debates. Liberal, radical, postmodern, psychoanalytic, and other feminists have criticized each others' work and underlying presuppositions. The aim of this paper is to point out a prejudice which has not yet received sufficient attention, although it lies at the base of a fair amount of feminist research: the bias that whereas men are bad and aggressive, women are good and peaceful. Although as an explicit view this contention has been debated, its distortive influence on feminist research has so far remained undiscussed. In what follows I present examples of the effect of this bias on feminist research (sections 1 and 2). Then I suggest why the bias has not yet been discussed (section 3). Finally I argue that feminist research should be as critically received and treated as any other (section 4).     

Men and Women in Indian Magazine Advertisements: A Preliminary Report

Studies from developed nations indicate that women are generally portrayed in advertisements as homemakers, dependent on men, and sex objects while men are portrayed as dominant, authoritative figures. However, very few researchers have examined role portrayals in ads from developing countries. This study examined the portrayal of women and men in Indian magazine ads. Over 1,100 magazine ads from a wide range of magazines in 1987, 1990, and 1994 were examined. Results indicate that although the portrayals of women and men in Indian magazine ads have changed over the period, they are still portrayed in stereotypical ways. Role portrayals in Indian magazine ads seem to be influenced by the nature of the product being advertised. Similarities and differences between role portrayals in Indian magazine ads and those from other nations are also discussed.

     

Fatherhood in the Canadian Context: Perceptions and Experiences of Sudanese Refugee Men

As they attempt to settle and adapt into Canadian society, new immigrants and/or refugees fathers face multiple stressors, some of which include underemployment or unemployment, social isolation, and changing roles within the family. Through a qualitative research involving in-depth interviews with 20 Sudanese refugee men recruited through a criterion sampling process based primarily on length of residency and age of children in Canada, this paper examines their perceptions and experiences as fathers in a large urban centre in Canada. Insights on the meaning of fatherhood, the values that guide their behaviour as fathers, their interactions with and aspirations for their children, and the challenges these men encounter as fathers in Canadian society are also provided.     

Assuming a Position: Women and Men as Moral Critics in Their Own War Zone

In their search for an authentic moral self, women and men may at some time in their lives assume a position of resistance. Men are most likely to assume this position in the sphere of war. It is not clear, however, where or when women would be expected to assume such a position or what the nature of that position might be, and how far it could be likened to that of the resisting man. This paper explores the idea that choosing to be a single mother can be a position by and from which women can voice their moral criticism. Such position is comparable to the (known and well-studied) position taken by men who show their moral criticism by refusing to participate in a specific battle during a morally controversial war. The paper begins with an examination of the philosophical and psychological concepts of separate and connected moral positions available to resisting men and women in the spheres of war and family. The conclusions are based on data from two samples of resisters in the spheres of war and the family: 36 soldiers (30 years old on average) who decided to take a stand as selective conscientious objectors (SCOs) during a morally controversial war and 50 (biologically) mature single women (over age 30) who chose to become pregnant and to remain unwed mothers. The conceptual and methodological questions regarding this comparison are discussed.     

Creativity in Men and Women: Threat,Other-Interest,and Self-Assessment

Previous research into gender and creativity has provided little evidence for consistent differences between men and women in creative performance. This research revisits this topic by proposing a person × situation approach, arguing that gender differences in creative performance only occur in certain contexts, but not others. Based on the assumption that men and women tend to differ in self versus other orientation, experimental instructions varied whether our participants’ (n = 169) creative efforts benefit the self or others, and whether creativity occurred under conditions of threat or not. In the absence of threat, women outperformed men in the originality of their creative efforts when the task was beneficial to others. This effect was eliminated in the presence of competitive threat. In contrast to some previous work, threat also increased creative performance under some circumstances. Results also revealed gender differences in self-assessment of creativity such that women seemed to be somewhat more attuned to the objective level of the originality of their creative performance than men. The discussion focuses on implications for research on gender differences in creativity, arguing that researchers must appreciate that gender differences in creativity, so far as they exist, are likely embedded in specific situational contexts.