The Biological Findings in Post-Traumatic Stress Disorder: A Review1

In this paper the authors review the literature on biological and treatment studies of post-traumatic stress disorder (PTSD) and present current unifying hypotheses regarding the pathophysiology. The psychophysiological studies stress overarousal, while endocrine studies suggest a decreased Cortisol production in denial and low symptom states with increases in highly symptomatic states. Suggestive evidence is provided that PTSD is associated with permanent changes in brain mechanisms involving the locus coeruleus, amygdala, and the hypothalamo-pituitary-adrenal axis. Drug treatments are promising but not fully satisfactory as yet. Directions for further research are provided.     

Attitude Certainty: A Review of Past Findings and Emerging Perspectives

Attitude certainty, or the sense of conviction with which one holds one's attitude, has been the subject of considerable research attention. This article provides an overview of past, present, and future research on this topic. First, we review past work on attitude certainty, focusing on what has been learned about the antecedents and consequences of feeling certain or uncertain of one's attitude. Following this review, we examine emerging perspectives on attitude certainty. In particular, we describe recent work exploring the metacognitive appraisals that shape attitude certainty, the different meanings attitude certainty can have, and the dynamic effects of attitude certainty on attitude strength. Along the way, we also highlight important questions that have yet be answered about the certainty construct.     

A Short Review of School Field Trips: Key Findings from the Past and Implications for the Future

ABSTRACT

This review of the literature on field trips to out-of-school settings will briefly summarize key findings and discuss implications for future research and field trip practice. Cognitive and affective learning can occur as a result of class visits to out-of-school settings, and learning outcomes are fundamentally influenced by the structure of the field trip, setting novelty, prior knowledge and interest of the students, the social context of the visit, teacher agendas, student experiences during the field trip, and the presence or absence and quality of preparation and follow-up. Field trips, however, are not ideal for teaching complex concepts or even isolated facts, they are not “better classroom settings”; instead, they serve best as opportunities for exploration, discovery, first-hand and original experiences. Despite systemic pressures to the contrary, teachers and informal educators tend to agree on this broader vision of field trips and this article makes a variety of suggestions for putting such a vision into practice.     

Cultural Participation and Individual Quality of Life: A Review of Research Findings

Objectives

To examine the research evidence for the contribution of cultural participation to individual quality of life; to discuss the utility of different types of QOL conceptualisation and measurement for cultural policy making.

Materials and Methods

A literature review of English language publications over the decade from 1995.

Results

There are few extant QOL studies, and very little empirical evidence to support the claims made by policymakers about culture and individual QOL.

Conclusions

The article suggests that a multi-dimensional, rather than a global, conceptualisation of QOL is best suited to the cultural policymaking context. Securing findings generalisable across all cultural forms, project types and all individuals or populations is not an achievable goal. Methodologies need to be developed and tested to understand how and why cultural participation affects individual QOL domains and these need to take into account differences in types of cultural participation, the quality of the experience, and between individuals in different social circumstances and in different life stages.     

The Ophthalmic Experience: Unanticipated Primary Findings in the Era of Next Generation Sequencing

Next generation sequencing (NGS) technology, with the ability to sequence many genomic regions at once, can provide clinicians with increased information, in the form of more mutations detected. Discussions on broad testing technology have largely been focused on incidental findings, or unanticipated results related to diseases beyond the primary indication for testing. By examining multiple genes that could be responsible for the patient’s presentation, however, there is also the possibility of unexpected results that are related to the reason genetic testing was ordered. We present a case study where multiple potentially causative mutations were detected using NGS technology. This case raises questions of scientific uncertainty, and has important implications for medical management and secondary studies. Clinicians and genetic counselors should be aware of the potential for increased information to affect one’s understanding of genetic risk, and the pre- and post-testing counseling process.     

Clinical Implications for Supporting Caregivers at the End-of-Life: Findings and from a Qualitative Study

Despite families providing considerable care at end of life, there are substantial gaps in the provision of supportive care. A qualitative interview study was conducted with 17 caregivers of people supported by an adult hospice to explore the support needs of families. Family members readily identified the ways in which the diagnosis of a life-limiting illness impacted on them and the family as a whole, not just the patient. Implications for practice demonstrate the need to intervene at a family and relational level prior to bereavement, in order to mitigate complicated grief for the surviving family members. Such an approach offers a fruitful prospective alternative to supporting caregivers post-bereavement.     

Assessment of Adult Relatedness: A Review of Empirical Findings From Object Relations and Attachment Theories

Assessment techniques designed to measure adult behavior and mental representation that emphasize relatedness constructs are reviewed. These measures grow out of two traditions, object relations and attachment theories. Although these two paradigms are fairly well elucidated theoretically, the relevant assessment literature is only more recently expanding, especially that focusing directly on adult attachment as opposed to childhood attachment, in addition to a presentation of various projective and objective measures, this review highlights the clinical and research implications for integration of these two paradigms around the cognitive, affective, and behavioral vicissitudes of adult relatedness.     

Repetitive Behavior in Neurodevelopmental Disorders: Clinical and Translational Findings

Repetitive behavior refers to a highly heterogeneous set of responses associated with a wide range of conditions, including normative development. Treatment studies for aberrant repetitive behavior are limited although one promising approach involves conceptualizing such behavior as a generalized inflexibility or lack of variability in responding. Relatively little is known about the neurobiological mechanisms that mediate the development and expression of repetitive behavior, information critical to the design of effective pharmacotherapies, early interventions, and prevention strategies. We will review clinical findings in repetitive behavior as well as findings from animal models highlighting environmental factors and the role of cortical-basal ganglia circuitry in mediating the development and expression of these behaviors. Findings from animal models have included identification of a specific neural pathway important in mediating repetitive behavior. Moreover, pharmacological studies that support the importance of this pathway have led to the identification of novel potential therapeutic targets. Expanding the evidence base for environmental enrichment-derived interventions and focusing on generalized variability in responding will aid in addressing the broader problem of rigidity or inflexibility.     

Cowden Syndrome: A Critical Review of the Clinical Literature

Cowden syndrome (CS) is a multi-system disease involving hamartomatous overgrowth of tissues of all three embryonic origins and increased risks for thyroid, breast and possibly other cancers. Benign breast, thyroid, uterine and skin lesions are also common. Approximately 80% of patients with CS have an identifiable germline mutation in the PTEN gene. The majority of the existing data on the frequencies of component clinical features have been obtained from compilations of case reports in the literature, many of which predate the establishment in 1996 of consensus diagnostic criteria. Many of these reports also suffer from ascertainment bias which emphasized the dermatologic features of the disease. This paper presents an overview of Cowden syndrome focusing on a critical evaluation of the major literature on the component cancers, benign features, and molecular findings in CS, noting the limitations of the published data.     

Choices in Life: A Clinical Tool for Facilitating Midlife Review

A critical developmental task of midlife involves reviewing one's past as well as preparing for one's future. The ability to identify past choices, task responsibility for them, and utilize developing patterns in future decision making is seen as a critical component of continued adult development. The Choicemap offers a structured clinical tool to guide such a midlife review. Engaging in this process assists adults in developing choicemaking skills, and provides a powerful clinical intervention.     

The Million Clinical Multiaxial Inventory (MCMI): A Review

This article reviews research conducted to date on the Millon Clinical Multiaxial Inventory (MCMI), a self-report test of psychopathology. The composition of the test and its theoretical basis are described. Data regarding its internal psychometric structure are reviewed. Finally, the article summarizes the research on the validity of the MCMI.     

Incidental picture exposure affects later reading: evidence from the N400

Language comprehenders form a mental representation of the implied shape of objects mentioned in the text. In the present study, the influence of prior visual experience on subsequent reading was assessed. In two separate phases, participants saw a picture of an object and read a text about the object, suggesting the same or a different shape. When the shapes in the two phases mismatched, ERPs during reading showed a larger N400 amplitude than when the shapes matched, suggesting that a picture presented incidentally 15 min earlier affected reading. These results further strengthen the case for the interaction of language and visual experience during language comprehension.     

Synergistic Paths to Happiness: Findings from Seven Countries

Four individual profiles of ways toward happiness were found on a Slovene sample: Full, Empty, Pleasurable, and Meaningful life types. The present study aimed to validate these four types in samples from seven different countries (N = 3690) utilising four different languages. Participants completed the Orientation towards Happiness Scale and measures of hedonic and eudaimonic well-being, and ill-being. A two-step cluster analysis was performed with each of the seven country samples. A highly congruent, highly internally replicable four-cluster solution was found in all seven samples. Full and Empty life individuals have high and low scores on all three orientations to happiness, respectively. Pleasurable and Meaningful types reflect two traditional philosophic orientations: Pleasurable life individuals scored high on pleasure, average on engagement and low on meaning orientation, while Meaningful life individuals had high scores on meaning, average on engagement, and low scores on pleasure orientation. The four types differed in subjective happiness and psychological well-being with full life type characterized by the highest scores on subjective happiness and psychological well-being, and Empty life by the lowest scores. On the other hand, depressive symptoms were likely to be the lowest in the Full life type and the highest in the Empty life type. Meaningful and Pleasurable life types were characterized by moderate well- and ill-being, but the two types tended not to differ from each other on the measures used.     

Ethics in the Humanities: Findings from Focus Groups

This project examined the ethical issues faced by academics and professionals in the Humanities. We conducted focus groups to gather information about the ethical concerns in these fields and used the qualitative data arising from the discussions to create a taxonomy that represents the structure of ethical issues in the Humanities. A key implication of our findings is that while the focus of ethics research and interventions has been primarily on the sciences and engineering, academics and professionals in other fields also encounter some unique critical ethical dilemmas that require further research and methods of intervention.