When experiments go wrong: the U.S. perspective

The view that once prevailed in the U.S.--that research is no more dangerous than the activities of daily life--no longer holds in light of recent experience. Within the past few years, a number of subjects (including normal volunteers) have been seriously injured or killed in research conducted at prestigious institutions. Plainly, when we are talking about research going wrong, we're talking about something very important. We have seen that experiments can go wrong in several ways. Subjects can be injured--physically, mentally, or by having other interests violated. Investigators can commit fraud in data collection or can abuse subjects. And review mechanisms--such as IRBs--don't always work. The two major issues when research goes wrong in any of these ways are, first: What will be done for subjects who have suffered an injury or other wrong? and second: How will future problems be prevented? The present system in the U.S. is better at the second task than the first one. Part of the difficulty in addressing the first lies in knowing what "caused" an apparent injury. Moreover, since until recently the problem of research-related injuries was thought to be a small one, there was considerable resistance to setting up a non-fault compensation system, for fear that it would lead to payment in many cases where such compensation was not deserved. Now, with a further nudge from the NBAC there is renewed interest in developing a formal system to compensate for research injuries. Finally, I have tried to show that our system of local oversight is only partially effective in improving the design of experiments and the consent process in light of "unexpected (adverse) results." As many observers, including the federal General Accounting Office (GAO), have reported, the requirement for "continuing review" of approved research projects is the weak point in the IRB system. The probable solution would be to more strictly apply the requirement that investigators report back any adverse results, de-emphasizing the "screen" introduced by the present language about "unexpected" findings. Yet, despite its weaknesses, there are good aspects to the local basis of our oversight system, and when problems become severe enough, OHRP is likely to evaluate a system and insist on local improvements. Thus, while the U.S. system is far from perfect in responding when research goes wrong, our experience may be useful to others in crafting a system appropriate to their own circumstances. One of the major tasks will be to adequately define what triggers oversight--that is, who reports what to whom and when? The setting of this trigger needs to balance appropriate incentives and penalties. Any system, including our own, will, in my opinion, work much better once an accreditation process is in place, which will offer much more current and detailed information on how each IRB is functioning and what steps are needed to help avoid "experiments going wrong."     

Future Well-Being Among U.S. Youth Who Attempted Suicide and Survived

To what extent does a suicide attempt impair a person’s future well-being? We estimated the prevalence of future well-being (FWB) among suicide attempt survivors using a nationally representative sample of 15,170 youths. Suicide attempt survivors were classified as having high FWB if they reported (a) a suicide attempt at Wave I, (b) no suicidal ideation or attempts over the past year at Wave III (7 years after), and (c) a well-being profile at or above the top quartile of nonsuicidal peers. Seventy-five of 574 suicide attempt survivors (∼13%) met criteria for FWB at Wave III, compared to 26% of nonsuicidal peers. Wave I well-being levels, not depressive symptoms, predicted the likelihood of FWB at Wave III (OR = 1.23, 95% CI [1.05, 1.44], p < .05). In conclusion, a nonfatal suicide attempt reduced but did not preclude FWB in a large national sample. The observation that a segment of the population of suicide attempt survivors achieves FWB carries implications for the prognosis of suicidal behavior and the value of incorporating well-being into investigations of suicide-related phenomena.     

A Report from the U.S.S.R.: The Problem of Providing Employment to Secondary School Graduates

This article gives an account of the steps taken by the U.S.S.R. to provide employment for its secondary school graduates.     

Authorship Policies at U.S. Doctoral Universities: A Review and Recommendations for Future Policies

Science and Engineering Ethics - Intellectual contribution in the form of authorship is a fundamental component of the academic career. While research has addressed questionable and harmful...     

Measurement invariance in mentoring research: A cross-cultural examination across Taiwan and the U.S.

Workplace mentoring in the international context is an emerging research area with significant potential for global integration. However, although measurement equivalence is a prerequisite for examining cross-cultural differences, this assumption has yet to be examined in mentoring research. This study contributes to the mentoring literature by assessing the measurement equivalence of the Mentoring Functions Questionnaire (MFQ-9) across two diverse cultural settings, the U.S. and Taiwan. Results of a series of multi-group confirmatory factor analyses supported full configural invariance, full metric invariance, and partial scalar invariance across the two groups. These findings suggest MFQ-9 may provide acceptable comparisons and meaningful interpretations across cultures. Implications for future international mentoring research and managerial practice are discussed.     

Touching the base: heart-warming ads from the 2016 U.S. election moved viewers to partisan tears

Some political ads used in the 2016 U.S. election evoked feelings colloquially known as being moved to tears. We conceptualise this phenomenon as a positive social emotion that appraises and motivates communal relations, is accompanied by physical sensations (including lachrymation, piloerection, chest warmth), and often labelled metaphorically. We surveyed U.S. voters in the fortnight before the 2016 U.S. election. Selected ads evoked the emotion completely and reliably, but in a partisan fashion: Clinton voters were moved to tears by three selected Clinton ads, and Trump voters were moved to tears by two Trump ads. Viewers were much less moved by ads of the candidate they did not support. Being moved to tears predicted intention to vote for the candidate depicted. We conclude that some contemporary political advertising is able to move its audience to tears, and thereby motivates support.     

成人期智力的年龄特征：中美比较研究

西方成人期心理发展方面的追踪研究积累了有关成人智力年龄变化模式的重要资料。非西方国家这方面的资料却非常少,因而也就无从得知非西方国家成人智力年龄差异和增龄模式是与此相似还是相异。通过成人期智力发展的跨文化研究,可以了解不同文化背景下智力变化和代际差异的一般规律。本研究旨在探究社会变迁和文化背景会对成人的智力发展产生怎样的影响。     

The eye as an optical instrument: from camera obscura to Helmholtz's perspective.

The era of modern vision research can be thought of as beginning in the seventeenth century with Johannes Kepler's understanding of the optics of the camera obscura with a lens and its relation to the eye. During the nineteenth century, Helmholtz used "The eye as an optical instrument" as the title for one of his Popular Lectures, and such a conception of the eye is now accepted as a fundamental feature of visual science. In analysing the optics of the eye, Helmholtz constructed some novel optical instruments for studying the eye. The development of optometers, ophthalmometers, and ophthalmoscopes is presented historically, with emphasis on how these instruments and camera analogies helped scientists to understand the functions of the eye, especially the enigma of accommodation. "The laws of optics are so well understood, and the knowledge of the eye, when considered as an optical instrument, has been rendered so perfect, that I do not consider myself capable of making any addition to it; but still there is a power in the eye by which it can adapt itself to different distances far too extensive for the simple mechanism of the parts to effect." (John Hunter in a letter to Joseph Banks in 1793, published by Home 1794, page 24).     

U.R.S.S. 1925: Politique et religion

The religious debates of the 1920's in the Soviet Union were marked by an agreement to disagree which no longer seems to exist.